{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:34:16Z","timestamp":1789050856651,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFD1801101-4"],"award-info":[{"award-number":["2022YFD1801101-4"]}]},{"name":"National Key Research and Development Program of China","award":["CAAS-ZDRW202111"],"award-info":[{"award-number":["CAAS-ZDRW202111"]}]},{"name":"National Key Research and Development Program of China","award":["CAAS-ASTIP-2015-LIHPS"],"award-info":[{"award-number":["CAAS-ASTIP-2015-LIHPS"]}]},{"name":"Major scientific research tasks of the Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences","award":["2022YFD1801101-4"],"award-info":[{"award-number":["2022YFD1801101-4"]}]},{"name":"Major scientific research tasks of the Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences","award":["CAAS-ZDRW202111"],"award-info":[{"award-number":["CAAS-ZDRW202111"]}]},{"name":"Major scientific research tasks of the Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences","award":["CAAS-ASTIP-2015-LIHPS"],"award-info":[{"award-number":["CAAS-ASTIP-2015-LIHPS"]}]},{"name":"Innovation Project of Traditional Chinese Veterinary Medicine and Clinical Science","award":["2022YFD1801101-4"],"award-info":[{"award-number":["2022YFD1801101-4"]}]},{"name":"Innovation Project of Traditional Chinese Veterinary Medicine and Clinical Science","award":["CAAS-ZDRW202111"],"award-info":[{"award-number":["CAAS-ZDRW202111"]}]},{"name":"Innovation Project of Traditional Chinese Veterinary Medicine and Clinical Science","award":["CAAS-ASTIP-2015-LIHPS"],"award-info":[{"award-number":["CAAS-ASTIP-2015-LIHPS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to investigate the inhibitory effects of Cordyceps militaris solid medium extract (CME) and cordycepin (COR) on LTA-induced inflammation in MH-S cells and their mechanisms of action. In this study, the establishment of an LTA-induced MH-S inflammation model was determined, the CCK-8 method was used to determine the safe concentration range for a drug for COR and CME, the optimal concentration of COR and CME to exert anti-inflammatory effects was further selected, and the expression of inflammatory factors of TNF-\u03b1, IL-1\u03b2, IL-18, and IL-6 was detected using ELISA. The relative expression of TNF-\u03b1, IL-1\u03b2, IL-18, IL-6, IL-10, TLR2 and MyD88 mRNA was detected using RT-PCR, and the IL-1\u03b2, IL-18, TLR2, MyD88, NF-\u03baB p-p65, NLRP3, pro-caspase-1, Caspase-1 and ASC protein expression in the cells were detected using Western blot; immunofluorescence assay detected the expression of Caspase-1 in MH-S cells. The results revealed that both CME and COR inhibited the levels of IL-1\u03b2, IL-18, IL-6, and TNF-\u03b1 in the supernatants of LTA-induced MH-S cells and the mRNA expression levels of IL-1\u03b2, IL-18, IL-6, TNF-\u03b1, TLR2 and MyD88, down-regulated the LTA-induced IL-1\u03b2, IL-18, TLR2 in MH-S cells, MyD88, NF-\u03baB p-p65\/p65, NLRP3, ASC, pro-caspase-1, and caspase-1 protein expression levels, and inhibited LTA-induced caspase-1 activation in MH-S cells. In conclusion, CME can play a therapeutic role in LTA-induced inflammation in MH-S cells via TLR2\/NF-\u03baB\/NLRP3, and may serve as a potential drug for bacterial pneumonia caused by Gram-positive bacteria.<\/jats:p>","DOI":"10.3390\/ijms242115519","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:28:25Z","timestamp":1698128905000},"page":"15519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2\/NF-\u03baB\/NLRP3 Pathways"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiaoya","family":"Wang","sequence":"first","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Peng","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiting","family":"Guo","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Xu","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Li","sequence":"additional","affiliation":[{"name":"Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref_1","unstructured":"Hesser, A.R. (2020). Mechanism of Staphylococcus aureus Lipoteichoic Acid Length Regulation, Inhibition of Wall Teichoic Acid Biosynthesis, and Physiology of Teichoic Acids, Harvard University."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"112472","DOI":"10.1016\/j.yexcr.2021.112472","article-title":"Lipopolysaccharide and lipoteichoic acid influence milk production ability via different early responses in bovine mammary epithelial cells","volume":"400","author":"Tsugami","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.3892\/mmr.2015.3965","article-title":"Lipoteichoic acid upregulates NF-\u03baB and proinflammatory cytokines by modulating \u03b2-catenin in bronchial epithelial cells","volume":"12","author":"Jang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-\u03baB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100532","DOI":"10.1016\/j.jhepr.2022.100532","article-title":"Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death","volume":"4","author":"Zhan","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10238-013-0231-z","article-title":"Inhibitory effects of simvastatin on staphylococcus aureus lipoteichoic acid-induced inflammation in human alveolar macrophages","volume":"14","author":"Wu","year":"2014","journal-title":"Clin. Exp. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00011-021-01475-w","article-title":"FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3\/IL-1\u03b2 signaling pathway in mice and macrophages","volume":"70","author":"Wang","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.joen.2016.04.018","article-title":"Enterococcus faecalis Lipoteichoic Acid-induced NLRP3 Inflammasome via the Activation of the Nuclear Factor Kappa B Pathway","volume":"42","author":"Wang","year":"2016","journal-title":"J. Endod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 Inflammasome and Reactive Oxygen Species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1002\/jcb.29556","article-title":"Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4\/NF-kB\/NLRP3 pathway","volume":"121","author":"Luo","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4\/NF-\u03baB signaling pathway","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/bph.14938","article-title":"Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3\/NF-\u03baB pathway in mice","volume":"177","author":"Wang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1534735420923756","DOI":"10.1177\/1534735420923756","article-title":"Cordyceps militaris Exerts Anticancer Effect on Non-Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3","volume":"19","author":"Jo","year":"2020","journal-title":"Integr. Cancer Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2017.10.029","article-title":"Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress","volume":"818","author":"Lei","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2119\/molmed.2011.00032","article-title":"Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP","volume":"17","author":"Kim","year":"2011","journal-title":"Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jo, E., Jang, H.J., Yang, K.E., Jang, M.S., Huh, Y.H., Yoo, H.S., Park, J.S., Jang, I.S., and Park, S.J. (2020). Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-\u03b1\/TNFR1-mediated inhibition of NF-\u03baB phosphorylation. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-019-2780-5"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Liao, X.Z., Gao, Y., Zhao, H.W., Zhou, M., Chen, D.L., Tao, L.T., Guo, W., Sun, L.L., Gu, C.Y., and Chen, H.R. (2020). Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.609285"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/jpp\/rgab162","article-title":"Cordycepin induces M1\/M2 macrophage polarization to attenuate the liver and lung damage and immunodeficiency in immature mice with sepsis via NF-\u03baB\/p65 inhibition","volume":"74","author":"Zhang","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3892\/mmr.2012.1248","article-title":"Protective effect of Cordyceps polysaccharide on hydrogen peroxide-induced mitochondrial dysfunction in HL-7702 cells","volume":"7","author":"Liu","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Rupa, E.J., Li, J.F., Arif, M.H., Yaxi, H., Puja, A.M., Chan, A.J., Hoang, V.A., Kaliraj, L., Yang, D.C., and Kang, S.C. (2020). Cordyceps militaris Fungus Extracts-Mediated Nanoemulsion for Improvement Antioxidant, Antimicrobial, and Anti-Inflammatory Activities. Molecules, 25.","DOI":"10.3390\/molecules25235733"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.fitote.2010.07.010","article-title":"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects","volume":"81","author":"Das","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1039\/C5FO01017A","article-title":"Cordyceps militaris fruit body extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-\u03baB pathway","volume":"7","author":"Song","year":"2016","journal-title":"Food Funct."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1875-9572(09)60004-8","article-title":"Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model","volume":"49","author":"Hsu","year":"2008","journal-title":"Pediatr. Neonatol."},{"key":"ref_25","first-page":"153653","article-title":"Comparison of effects on colitis-associated tumorigenesis and gut microbiota in mice between Ophiocordyceps sinensis and Cordyceps militaris","volume":"90","author":"Ji","year":"2021","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111197","DOI":"10.1016\/j.foodres.2022.111197","article-title":"Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice","volume":"157","author":"Huang","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1007\/s00253-019-10074-z","article-title":"Advances in research on Cordyceps militaris degeneration","volume":"103","author":"Lou","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_28","first-page":"342","article-title":"Optimum of polysaccharide distillation on scrap Cordyceps militaris medium","volume":"31","author":"Ren","year":"2008","journal-title":"J. Chin. Med. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jchromb.2009.06.009","article-title":"Column chromatographic extraction and preparation of cordycepin from Cordyceps militaris waster medium","volume":"877","author":"Ni","year":"2009","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_30","first-page":"2159","article-title":"Investigations on cordycepin production by solid culture of Cordyceps militaris","volume":"33","author":"Wei","year":"2008","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3724\/SP.J.1123.2012.02037","article-title":"Fast determination of adenosine and cordycepin in Cordyceps and its deserted solid medium","volume":"30","author":"Li","year":"2012","journal-title":"Chin. J. Chromatogr."},{"key":"ref_32","first-page":"76","article-title":"Regulation of Cordyceps pupa solid fermentation on immune and intestinal flora in mice","volume":"22","author":"Chen","year":"2022","journal-title":"Chin. J. Food Sci."},{"key":"ref_33","unstructured":"He, X.Z. (2022). Application of Solid Fermentation Extract of Cordyceps Pupa in Shampoo, Shanghai University of Applied Technology. (In Chinese)."},{"key":"ref_34","first-page":"154074","article-title":"Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model","volume":"100","author":"Cui","year":"2022","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jim.2015.03.018","article-title":"Simultaneous assessment of NF-\u03baB\/p65 phosphorylation and nuclear localization using imaging flow cytometry","volume":"423","author":"Maguire","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.micinf.2010.05.003","article-title":"Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia","volume":"12","author":"Kapetanovic","year":"2010","journal-title":"Microbes Infect."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-\u03baB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1473-3099(02)00226-8","article-title":"Role of lipoteichoic acid in infection and inflammation","volume":"2","author":"Ginsburg","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1111\/jcmm.13194","article-title":"Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR2-NF\u03baB signalling","volume":"21","author":"Zhao","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sampaio, N.G., Kocan, M., Schofield, L., Pfleger, K.D., and Eriksson, E.M. (2018). Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202408"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.immuni.2006.03.008","article-title":"Alveolar macrophage in the driver\u2019s seat","volume":"24","author":"Lambrecht","year":"2006","journal-title":"Immunity"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1089\/jmf.2014.3350","article-title":"Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men","volume":"18","author":"Kang","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.intimp.2010.09.011","article-title":"Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4489\/MYCO.2010.38.1.046","article-title":"The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage","volume":"38","author":"Jo","year":"2010","journal-title":"Mycobiology"},{"key":"ref_45","first-page":"32","article-title":"Comprehensive extraction and separation of cordycepin, polysaccharide and polypeptide from Cordyceps pupa residue","volume":"67","author":"Lei","year":"2021","journal-title":"Shaanxi Agric. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20090272","article-title":"Pathogen recognition in the innate immune response","volume":"420","author":"Kumar","year":"2009","journal-title":"Biochem. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s12272-016-0804-y","article-title":"Lipoteichoic acids as a major virulence factor causing inflammatory responses via Toll-like receptor 2","volume":"39","author":"Kang","year":"2016","journal-title":"Arch. Pharmacal Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Monie, T. (2017). The Innate Immune System, Academic Press.","DOI":"10.1016\/B978-0-12-804464-3.00001-6"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"790258","DOI":"10.3389\/fimmu.2021.790258","article-title":"Cleavage-mediated regulation of Myd88 signaling by inflammasome-activated caspase-1","volume":"12","author":"Avbelj","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_50","unstructured":"Melehani, J.H. (2016). Mechanisms and Consequences of Staphylococcus aureus Leukocidin AB-Mediated Activation of the Host NLRP3 Inflammasome, The University of North Carolina at Chapel Hill."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.biopha.2017.09.103","article-title":"Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation","volume":"95","author":"Yang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_52","first-page":"3333","article-title":"Extraction and determination of cordycepin from culture residues of Cordyceps pupa by hydrothermal reflux","volume":"49","author":"Peng","year":"2022","journal-title":"Chin. J. Anim. Husb. Vet. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Uchiyama, R., Toyoda, E., Maehara, M., Wasai, S., Omura, H., Watanabe, M., and Sato, M. (2021). Effect of Platelet-Rich Plasma on M1\/M2 Macrophage Polarization. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052336"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tu, Y., Li, X., Fu, Y., Chen, Y., Fang, H., Li, Y., Gu, Y., and Zhang, J. (2023). Isocorydine Ameliorates IL-6 Expression in Bone Marrow-Derived Macrophages and Acute Lung Injury Induced by Lipopolysaccharide. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054629"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Han, Y., Yuan, C., Zhou, X., Han, Y., He, Y., Ouyang, J., Zhou, W., Wang, Z., Wang, H., and Li, G. (2021). Anti-Inflammatory Activity of Three Triterpene from Hippophae rhamnoides L. in Lipopolysaccharide-Stimulated RAW264.7 Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222112009"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Belali, O.M., Ahmed, M.M., Mohany, M., Belali, T.M., Alotaibi, M.M., Al-Hoshani, A., and Al-Rejaie, S.S. (2022). LCZ696 Protects against Diabetic Cardiomyopathy-Induced Myocardial Inflammation, ER Stress, and Apoptosis through Inhibiting AGEs\/NF-\u03baB and PERK\/CHOP Signaling Pathways. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031288"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/21\/15519\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:10:49Z","timestamp":1760130649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/21\/15519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":56,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["ijms242115519"],"URL":"https:\/\/doi.org\/10.3390\/ijms242115519","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]}}}