{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:49:22Z","timestamp":1776156562336,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010751","name":"ANID FONDECYT","doi-asserted-by":"publisher","award":["1200098"],"award-info":[{"award-number":["1200098"]}],"id":[{"id":"10.13039\/501100010751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010751","name":"ANID FONDECYT","doi-asserted-by":"publisher","award":["DI-08-19\/CBC"],"award-info":[{"award-number":["DI-08-19\/CBC"]}],"id":[{"id":"10.13039\/501100010751","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Universidad Andr\u00e9s Bello","award":["1200098"],"award-info":[{"award-number":["1200098"]}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Universidad Andr\u00e9s Bello","award":["DI-08-19\/CBC"],"award-info":[{"award-number":["DI-08-19\/CBC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Emerging epidemiological evidence links atopic dermatitis (AD) and periodontitis, although the mechanisms remain unclear. Th2-derived cytokines are key in the development of both diseases, and different gingival crevicular fluid (GCF) profiles among healthy and diseased subjects have been previously reported. This case\u2013control study examined the GCF levels of interleukins (IL)-13, IL-31, and thymic stromal lymphopoietin (TSLP) in 29 subjects with moderate-to-severe AD and 33 controls. All subjects underwent comprehensive clinical and oral evaluations, followed by GCF collection. GCF levels of IL-13, IL-31, and TSLP were assessed using a multiplex-bead immunoassay. Demographic and periodontal parameters were similar among groups (p &gt; 0.05). The GCF levels of IL-31 and TSLP were higher in AD subjects compared to controls (p &lt; 0.05), whereas no significant differences in the GCF levels of IL-13 were noticed (p = 0.377). Moderate-to-severe AD was positively associated with the GCF levels of IL-31 and TSLP, whereas severe periodontitis was negatively associated with IL-31 (p &lt; 0.05). The GCF levels of IL-13 showed no significant associations with either condition (p = 0.689). There was no significant interaction between AD and periodontitis for IL-31 (p &lt; 0.869). These results suggest that AD and periodontitis independently influence the GCF levels of IL-31 in opposing ways, whereas AD alone influences the levels of TSLP.<\/jats:p>","DOI":"10.3390\/ijms242115592","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:40:07Z","timestamp":1698288007000},"page":"15592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of Periodontitis and Atopic Dermatitis with the Levels of IL-13, IL-31, and TSLP in the Gingival Crevicular Fluid"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-4036","authenticated-orcid":false,"given":"Constanza","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Universidad Andres Bello, Echaurren 237, Santiago 8370133, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"International Center for Clinical Studies (CIEC), Probity Medical Research, Manzano 343, Santiago 8420383, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Aroca","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Universidad Andres Bello, Echaurren 237, Santiago 8370133, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Bordagaray","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Olivos 943, Santiago 8380544, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Olivos 943, Santiago 8380544, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Contador","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Universidad de Los Andes, Av. Plaza 2501, Santiago 7620157, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-7314","authenticated-orcid":false,"given":"Marcela","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Olivos 943, Santiago 8380544, Chile"},{"name":"Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, 943 Olivos Street, Santiago 8380544, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-9347","authenticated-orcid":false,"given":"Fernando","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Universidad de Los Andes, Av. Plaza 2501, Santiago 7620157, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Universidad Andres Bello, Echaurren 237, Santiago 8370133, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jcpe.13506","article-title":"Global, regional, and national burden of severe periodontitis, 1990-2019: An analysis of the Global Burden of Disease Study 2019","volume":"48","author":"Chen","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"709438","DOI":"10.3389\/fphys.2021.709438","article-title":"Periodontal Inflammation and Systemic Diseases: An Overview","volume":"12","year":"2021","journal-title":"Front. 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