{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:55:37Z","timestamp":1762325737253,"version":"build-2065373602"},"reference-count":82,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"],"award-info":[{"award-number":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"]}]},{"name":"FEDER","award":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"],"award-info":[{"award-number":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"]}]},{"name":"CIBERNED","award":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"],"award-info":[{"award-number":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"]}]},{"name":"Ministry of Science, Innovation","award":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"],"award-info":[{"award-number":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"]}]},{"name":"CIBERNED","award":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"],"award-info":[{"award-number":["PI2021\/00679","PI22CIII\/00042","CB05\/06\/0022","PI2021\/03","I+D+i-RETOS-PID2021-124801NB-I00","CB05\/06\/0067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), the most prevalent form of dementia, is a neurodegenerative disorder characterized by different pathological symptomatology, including disrupted circadian rhythm. The regulation of circadian rhythm depends on the light information that is projected from the retina to the suprachiasmatic nucleus in the hypothalamus. Studies of AD patients and AD transgenic mice have revealed AD retinal pathology, including amyloid-\u03b2 (A\u03b2) accumulation that can directly interfere with the regulation of the circadian cycle. Although the cause of AD pathology is poorly understood, one of the main risk factors for AD is female gender. Here, we found that female APP\/PS1 mice at 6- and 12-months old display severe circadian rhythm disturbances and retinal pathological hallmarks, including A\u03b2 deposits in retinal layers. Since brain A\u03b2 transport is facilitated by aquaporin (AQP)4, the expression of AQPs were also explored in APP\/PS1 retina to investigate a potential correlation between retinal A\u03b2 deposits and AQPs expression. Important reductions in AQP1, AQP4, and AQP5 were detected in the retinal tissue of these transgenic mice, mainly at 6-months of age. Taken together, our findings suggest that abnormal transport of A\u03b2, mediated by impaired AQPs expression, contributes to the retinal degeneration in the early stages of AD.<\/jats:p>","DOI":"10.3390\/ijms242115679","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T11:18:52Z","timestamp":1698405532000},"page":"15679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered Clock Gene Expression in Female APP\/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-6253","authenticated-orcid":false,"given":"Laura","family":"Carrero","sequence":"first","affiliation":[{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"},{"name":"PhD Program in Neuroscience, Autonoma de Madrid University, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desire\u00e9","family":"Antequera","sequence":"additional","affiliation":[{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-9240","authenticated-orcid":false,"given":"Ignacio","family":"Alcalde","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega, Universidad de Oviedo, Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, 28012 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0755-0518","authenticated-orcid":false,"given":"Diego","family":"Megias","sequence":"additional","affiliation":[{"name":"Advanced Optical Microscopy Unit, Unidades Centrales Cient\u00edfico-T\u00e9cnicas, Instituto de Salud Carlos III, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-7774","authenticated-orcid":false,"given":"Lara","family":"Ordo\u00f1ez-Gutierrez","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Universidad Aut\u00f3noma de Madrid, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Merayo-Lloves","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega, Universidad de Oviedo, Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, 28012 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-2321","authenticated-orcid":false,"given":"Francisco","family":"Wandosell","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Universidad Aut\u00f3noma de Madrid, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Municio","sequence":"additional","affiliation":[{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-4579","authenticated-orcid":false,"given":"Eva","family":"Carro","sequence":"additional","affiliation":[{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer\u2019s disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The projected effect of risk factor reduction on Alzheimer\u2019s disease prevalence","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. 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