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However, a recent study found a significant difference between the serum Mg isotopic composition of T1DM individuals and controls, indicating that disruptions to Mg homeostasis persist. Significant deviations were also found in samples taken one year apart. To investigate whether the temporal variability in serum Mg isotopic composition is linked to the transient impact of administered insulin, Mg isotope ratios were determined in serum from 15 T1DM individuals before and one hour after insulin injection\/meal consumption using multi-collector inductively coupled plasma-mass spectrometry. Consistent with results of the previous study, significant difference in the serum Mg isotopic composition was found between T1DM individuals and 10 sex-matched controls. However, the average difference between pre- and post-insulin injection\/meal T1DM samples of 0.05 \u00b1 0.13\u2030 (1SD) was not significant. No difference was observed for controls before (\u22120.12 \u00b1 0.16\u2030) and after the meal (\u22120.10 \u00b1 0.13\u2030) either, suggesting a lack of a postprandial Mg isotopic response within one hour of food consumption, and that the timing of the most recent meal may not require controlling for when determining serum Mg isotopic composition.<\/jats:p>","DOI":"10.3390\/ijms242115683","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T11:57:56Z","timestamp":1698407876000},"page":"15683","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-1000","authenticated-orcid":false,"given":"Kaj Vaughan","family":"Sullivan","sequence":"first","affiliation":[{"name":"Atomic and Mass Spectrometry\u2014A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmina","family":"Assantuh","sequence":"additional","affiliation":[{"name":"Atomic and Mass Spectrometry\u2014A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Grigoryan","sequence":"additional","affiliation":[{"name":"The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-9961","authenticated-orcid":false,"given":"Marta","family":"Costas-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Atomic and Mass Spectrometry\u2014A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium"},{"name":"Centro de Investigaci\u00f3n Mari\u00f1a, Departamento de Qu\u00edmica Anal\u00edtica y Alimentaria, Grupo QA2, Universidade de Vigo, 36310 Vigo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Bolea-Fernandez","sequence":"additional","affiliation":[{"name":"Atomic and Mass Spectrometry\u2014A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium"},{"name":"Department of Analytical Chemistry, Arag\u00f3n Institute of Engineering Research (I3A), University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Lapauw","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Van Laecke","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Internal Medicine and Pediatrics, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-3853","authenticated-orcid":false,"given":"Frank","family":"Vanhaecke","sequence":"additional","affiliation":[{"name":"Atomic and Mass Spectrometry\u2014A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019). Classification of Diabetes Mellitus, World Health Organization."},{"key":"ref_2","unstructured":"WHO (2018). The Top 10 Causes of Death, World Health Organization."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s00125-014-3229-5","article-title":"Type 1 Diabetes as an Autoimmune Disease: The Evidence","volume":"57","author":"Paschou","year":"2014","journal-title":"Diabetologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/cmdc.201500373","article-title":"Cardiovascular and Metabolic Disease: Scientific Discoveries and New Therapies. Edited by Philip Peplow, James Adams, Tim Young","volume":"10","author":"Plowright","year":"2015","journal-title":"ChemMedChem"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Poretsky, L. (2010). Principles of Diabetes Mellitus, Springer Science & Business Media. [2nd ed.].","DOI":"10.1007\/978-0-387-09841-8"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/BF00403385","article-title":"Hypomagnesaemia in IDDM Patients with Microalbuminuria and Clinical Proteinuria","volume":"37","author":"Pickup","year":"1994","journal-title":"Diabetologia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2362.1982.tb00942.x","article-title":"Renal Hypomagnesaemia in Human Diabetes Mellitus: Its Relation to Glucose Homeostasis","volume":"12","author":"McNair","year":"1982","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1038\/s41598-022-10436-0","article-title":"The Association between Hypomagnesemia and Poor Glycaemic Control in Type 1 Diabetes Is Limited to Insulin Resistant Individuals","volume":"12","author":"Oost","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.4239\/wjd.v6.i10.1152","article-title":"Magnesium and Type 2 Diabetes","volume":"6","author":"Barbagallo","year":"2015","journal-title":"World J. Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1677\/joe.1.06389","article-title":"Insulin and Glucose Mediate Opposite Intracellular Ionized Magnesium Variations in Human Lymphocytes","volume":"190","author":"Delva","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2042018820980240","DOI":"10.1177\/2042018820980240","article-title":"Hypomagnesemia in Persons with Type 1 Diabetes: Associations with Clinical Parameters and Oxidative Stress","volume":"11","author":"Waanders","year":"2020","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ahmed, F., and Mohammed, A. (2019). Magnesium: The Forgotten Electrolyte\u2014A Review on Hypomagnesemia. Med. Sci., 7.","DOI":"10.3390\/medsci7040056"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00431-007-0586-9","article-title":"Metabolic Control as Reflectet by HbA1c in Children, Adolescents and Young Adults with Type-1 Diabetes Mellitus: Combined Longitudinal Analysis Including 27,035 Patients from 207 Centers in Germany and Austria during the Last Decade","volume":"167","author":"Gerstl","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.dsx.2020.01.015","article-title":"Association between Reduced Serum Levels of Magnesium and the Presence of Poor Glycemic Control and Complications in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis","volume":"14","author":"Rodrigues","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Workinger, J.L., Doyle, R.P., and Bortz, J. (2018). Challenges in the Diagnosis of Magnesium Status. Nutrients, 10.","DOI":"10.3390\/nu10091202"},{"key":"ref_16","unstructured":"McCarthy, J.T., and Kumar, R. (1999). Atlas of Diseases of the Kidney: Divalent Cation: Magnesium; Current Medicine, Wiley-Blackwell."},{"key":"ref_17","first-page":"174","article-title":"Site and Mechanism of Intestinal Magnesium Absorption","volume":"16","author":"Hardwick","year":"1990","journal-title":"Miner. Electrolyte Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/clinchem\/33.11.1965","article-title":"Assessment of Magnesium Status","volume":"33","author":"Elin","year":"1987","journal-title":"Clin. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-2007-978844","article-title":"Intracellular Magnesium Depletion Relates to Increased Urinary Magnesium Loss in Type I Diabetes","volume":"30","author":"Bayraktar","year":"1998","journal-title":"Horm. Metab. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e000668","DOI":"10.1136\/openhrt-2017-000668","article-title":"Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis","volume":"5","author":"DiNicolantonio","year":"2018","journal-title":"Open Heart"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/cclm.1995.33.6.365","article-title":"Measurement of Free Magnesium in Blood, Serum and Plasma with an Ion-Sensitive Electrode","volume":"33","author":"Ising","year":"1995","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2215\/CJN.09750913","article-title":"Renal Control of Calcium, Phosphate, and Magnesium Homeostasis","volume":"10","author":"Blaine","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/jcp.22.4.417","article-title":"Values for Tissue Magnesium as a Guide in Detecting Magnesium Deficiency","volume":"22","author":"Lim","year":"1969","journal-title":"J. Clin. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1684\/mrh.2011.0292","article-title":"Methods of Assessment of Magnesium Status in Humans: A Systematic Review","volume":"24","author":"Witkowski","year":"2011","journal-title":"Magnes. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1039\/C9JA00097F","article-title":"Multi-Collector ICP-Mass Spectrometry Reveals Changes in the Serum Mg Isotopic Composition in Diabetes Type I Patients","volume":"34","author":"Grigoryan","year":"2019","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1515\/pac-2013-1023","article-title":"Assessment of International Reference Materials for Isotope-Ratio Analysis (IUPAC Technical Report)","volume":"86","author":"Brand","year":"2014","journal-title":"Pure Appl. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16389","DOI":"10.1038\/s41598-020-71764-7","article-title":"Cu and Zn Isotope Ratio Variations in Plasma for Survival Prediction in Hematological Malignancy Cases","volume":"10","author":"Hastuti","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1038\/s41598-022-14825-3","article-title":"Magnesium Stable Isotope Composition, but Not Concentration, Responds to Obesity and Early Insulin-Resistant Conditions in Minipig","volume":"12","author":"Godin","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e9074","DOI":"10.1002\/rcm.9074","article-title":"Determination of Magnesium Isotopic Ratios of Biological Reference Materials via Multi-Collector Inductively Coupled Plasma Mass Spectrometry","volume":"35","author":"Albalat","year":"2021","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.aca.2020.07.045","article-title":"High-Precision Isotopic Analysis of Mg and Ca in Biological Samples Using Multi-Collector ICP-Mass Spectrometry after Their Sequential Chromatographic Isolation\u2014Application to the Characterization of the Body Distribution of Mg and Ca Isotopes in Mice","volume":"1130","author":"Grigoryan","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1039\/D0JA00225A","article-title":"Characterization of the new isotopic reference materials IRMM-524A and ERM-AE143 for Fe and Mg isotopic analysis of geological and biological samples","volume":"35","author":"Chernonozhkin","year":"2020","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1039\/C6JA00013D","article-title":"Characterization of a Series of Absolute Isotope Reference Materials for Magnesium: Ab Initio Calibration of the Mass Spectrometers, and Determination of Isotopic Compositions and Relative Atomic Weights","volume":"31","author":"Vogl","year":"2016","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.1464-5491.2002.00745.x","article-title":"The Assessment of Insulin Resistance in Man","volume":"19","author":"Wallace","year":"2002","journal-title":"Diabet. Med."},{"key":"ref_34","unstructured":"Pickup, J., and Williams, G. (1997). Textbook of Diabetes, Blackwell Science."},{"key":"ref_35","unstructured":"Gragossian, A., Bashir, K., Bhutta, B.S., and Friede, R. (2023). Hypomagnesemia, StatPearls Publishing."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/ijem.IJEM_190_16","article-title":"Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria","volume":"21","author":"Odusan","year":"2017","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1039\/d0mt00122h","article-title":"Postprandial Zinc Stable Isotope Response in Human Blood Serum","volume":"9","author":"Sullivan","year":"2020","journal-title":"Metallomics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1039\/C6JA00433D","article-title":"High-Precision Isotopic Analysis of Cu in Blood Serum via Multi-Collector ICP-Mass Spectrometry for Clinical Investigation: Steps towards Improved Robustness and Higher Sample Throughput","volume":"32","author":"Lauwens","year":"2017","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"mfad012","DOI":"10.1093\/mtomcs\/mfad012","article-title":"The Influence of Physiological and Lifestyle Factors on Essential Mineral Element Isotopic Compositions in the Human Body: Implications for the Design of Isotope Metallomics Research","volume":"15","author":"Sullivan","year":"2023","journal-title":"Metallomics"},{"key":"ref_40","first-page":"65","article-title":"Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6\/7","volume":"Volume 176","author":"Gudermann","year":"2019","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology 176"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3945\/jn.115.213918","article-title":"Insulin Modulates the Na+\/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells","volume":"145","author":"Mastrototaro","year":"2015","journal-title":"J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13300-017-0333-9","article-title":"A Review of Insulin Resistance in Type 1 Diabetes: Is There a Place for Adjunctive Metformin?","volume":"9","author":"Priya","year":"2018","journal-title":"Diabetes Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.metabol.2015.09.002","article-title":"Insulin Resistance in Type 1 Diabetes Mellitus","volume":"64","author":"Kaul","year":"2015","journal-title":"Metabolism"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kruschitz, R., Wallner-Liebmann, S.J., Hamlin, M.J., Moser, M., Ludvik, B., Schnedl, W.J., and Tafeit, E. (2013). Detecting Body Fat\u2013A Weighty Problem BMI versus Subcutaneous Fat Patterns in Athletes and Non-Athletes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072002"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/ajcn\/72.3.694","article-title":"Healthy Percentage Body Fat Ranges: An Approach for Developing Guidelines Based on Body Mass Index","volume":"72","author":"Gallagher","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2650342","DOI":"10.1155\/2022\/2650342","article-title":"Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes","volume":"2022","author":"Travis","year":"2022","journal-title":"J. Diabetes Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"664666","DOI":"10.3389\/fmed.2021.664666","article-title":"Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg Isotopic Composition of Biofluids and Tissues in Mice","volume":"8","author":"Grigoryan","year":"2021","journal-title":"Front. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/157340108783497427","article-title":"Dietary Factors Influencing Magnesium Absorption in Humans","volume":"4","author":"Bohn","year":"2008","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_49","first-page":"260","article-title":"Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-an Update","volume":"13","author":"Hahn","year":"2017","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/ajcn\/26.5.510","article-title":"Metabolic Responses of Adolescent Boys to Two Levels of Dietary Magnesium and Protein. I. Magnesium and Nitrogen Retention","volume":"26","author":"Schwartz","year":"1973","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/ajcn\/79.3.418","article-title":"Phytic Acid Added to White-Wheat Bread Inhibits Fractional Apparent Magnesium Absorption in Humans","volume":"79","author":"Bohn","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1073\/pnas.1417792112","article-title":"Magnesium Stable Isotope Ecology Using Mammal Tooth Enamel","volume":"112","author":"Martin","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.gca.2013.12.029","article-title":"Natural Variation of Magnesium Isotopes in Mammal Bones and Teeth from Two South African Trophic Chains","volume":"130","author":"Martin","year":"2014","journal-title":"Geochim. Cosmochim. Acta."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5942\/jawwa.2017.109.0095","article-title":"Adjusted Fluoride Concentrations and Control Ranges in 34 States: 2006\u20132010 and 2015","volume":"109","author":"Barker","year":"2017","journal-title":"J. Am. Water Works Assoc."},{"key":"ref_55","first-page":"175","article-title":"Fluoride-Magnesium Interaction","volume":"28","year":"1995","journal-title":"Fluoride"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s12011-010-8892-x","article-title":"Serum Copper, Zinc, and Magnesium Levels in Patients with Chronic Fluorosis","volume":"143","author":"Ersoy","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/003655101316911459","article-title":"Moderate Alcohol Consumption and Urinary Excretion of Magnesium and Calcium","volume":"61","author":"Rylander","year":"2001","journal-title":"Scand. J. Clin. Lab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/07315724.1994.10718436","article-title":"Effect of Caffeine on Circadian Excretion of Urinary Calcium and Magnesium","volume":"13","author":"Massey","year":"1994","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jcph.672","article-title":"Magnesium Deficiency and Proton-Pump Inhibitor Use: A Clinical Review","volume":"56","author":"William","year":"2016","journal-title":"J. Clin. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/bcp.12846","article-title":"Proton Pump Inhibitor Associated Hypomagnasaemia-a Cause for Concern?","volume":"81","author":"Begley","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/0002-9343(89)90028-4","article-title":"Drug-Drug Interactions with Ciprofloxacin and Other Fluoroquinolones","volume":"87","author":"Polk","year":"1989","journal-title":"Am. J. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5455\/2320-1770.ijrcog20140301","article-title":"Vitamin and Mineral Needs during the Oral Contraceptive Therapy: A Systematic Review","volume":"3","author":"Dante","year":"2014","journal-title":"Int. J. Reprod. Contracept. Obstet. Gynecol."},{"key":"ref_63","first-page":"308","article-title":"Effects of Contraceptives on Serum Trace Elements, Calcium and Phosphorus Levels","volume":"60","author":"Akinloye","year":"2011","journal-title":"West Indian Med. J."},{"key":"ref_64","first-page":"1","article-title":"Magnesium and Potassium Deficiency. Its Diagnosis, Occurrence and Treatment in Diuretic Therapy and Its Consequences for Growth, Protein Synthesis and Growth Factors","volume":"618","year":"1994","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/bmj.3.5827.620","article-title":"Magnesium Deficiency in Patients on Long-Term Diuretic Therapy for Heart Failure","volume":"3","author":"Lim","year":"1972","journal-title":"Br. Med. J."},{"key":"ref_66","first-page":"89","article-title":"Insulin Resistance Markers in Type 1 Diabetes Mellitus","volume":"22","author":"Vladu","year":"2015","journal-title":"Rom. J. Diabetes Nutr. Metab. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1039\/D0JA00438C","article-title":"To Shift, or Not to Shift: Adequate Selection of an Internal Standard in Mass-Shift Approaches Using Tandem ICP-Mass Spectrometry (ICP-MS\/MS)","volume":"36","author":"Resano","year":"2021","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1039\/C8JA00210J","article-title":"A Critical Review on Isotopic Fractionation Correction Methods for Accurate Isotope Amount Ratio Measurements by MC-ICP-MS","volume":"33","author":"Yang","year":"2018","journal-title":"J. Anal. At. 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