{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:45Z","timestamp":1787028525103,"version":"build-2736575974"},"reference-count":98,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Recovery and Resilience Plan (NRRP)","award":["0001052"],"award-info":[{"award-number":["0001052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Human skin has long been known as a protective organ, acting as a mechanical barrier towards the external environment. More recent is the acquisition that in addition to this fundamental role, the complex architecture of the skin hosts a variety of immune and non-immune cells playing preeminent roles in immunological processes aimed at blocking infections, tumor progression and migration, and elimination of xenobiotics. On the other hand, dysregulated or excessive immunological response into the skin leads to autoimmune reactions culminating in a variety of skin pathological manifestations. Among them is psoriasis, a multifactorial, immune-mediated disease with a strong genetic basis. Psoriasis affects 2\u20133% of the population; it is associated with cardiovascular comorbidities, and in up to 30% of the cases, with psoriatic arthritis. The pathogenesis of psoriasis is due to the complex interplay between the genetic background of the patient, environmental factors, and both innate and adaptive responses. Moreover, an autoimmune component and the comprehension of the mechanisms linking chronic skin inflammation with systemic and joint manifestations in psoriatic patients is still a major challenge. The understanding of these mechanisms may offer a valuable chance to find targetable molecules to treat the disease and prevent its progression to severe systemic conditions.<\/jats:p>","DOI":"10.3390\/ijms242115707","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:27:28Z","timestamp":1698658048000},"page":"15707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["From the Skin to Distant Sites: T Cells in Psoriatic Disease"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-1356","authenticated-orcid":false,"given":"Eva","family":"Reali","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-9204","authenticated-orcid":false,"given":"Davide","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biotechnology, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.autrev.2014.01.008","article-title":"Diagnosis and classification of psoriasis","volume":"13","author":"Raychaudhuri","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.freeradbiomed.2019.11.031","article-title":"Redox regulation of cutaneous inflammasome by ozone exposure","volume":"152","author":"Ferrara","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ferrari, D., Casciano, F., Secchiero, P., and Reali, E. (2021). Purinergic Signaling and Inflammasome Activation in Psoriasis Pathogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179449"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12016-018-8668-1","article-title":"Psoriasis: From Pathogenesis to Targeted Therapies","volume":"54","author":"Conrad","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12016-017-8634-3","article-title":"Unmet Needs in the Field of Psoriasis: Pathogenesis and Treatment","volume":"55","author":"Boehncke","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3899\/jrheum.101124","article-title":"Cardiovascular comorbidities in psoriasis and psoriatic arthritis: Pathogenesis, consequences for patient management, and future research agenda: A report from the GRAPPA 2009 annual meeting","volume":"38","author":"Boehncke","year":"2011","journal-title":"J. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/jdv.12222","article-title":"New developments in our understanding of psoriatic arthritis and their impact on the diagnosis and clinical management of the disease","volume":"28","author":"Boehncke","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40257-013-0032-x","article-title":"Burden of disease: Psoriasis and psoriatic arthritis","volume":"14","author":"Boehncke","year":"2013","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fimmu.2018.00579","article-title":"Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences","volume":"9","author":"Boehncke","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide","volume":"449","author":"Lande","year":"2007","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(15)61134-5","article-title":"Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): A randomised, double-blind, placebo-controlled, phase 3 trial","volume":"386","author":"McInnes","year":"2015","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa1412679","article-title":"Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis","volume":"373","author":"Mease","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","article-title":"Preventing psoriatic arthritis: Focusing on patients with psoriasis at increased risk of transition","volume":"15","author":"Scher","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41584-022-00776-6","article-title":"Psoriatic arthritis from a mechanistic perspective","volume":"18","author":"Schett","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1080\/09546634.2021.1942423","article-title":"A clinical perspective on risk factors and signs of subclinical and early psoriatic arthritis among patients with psoriasis","volume":"33","author":"Gottlieb","year":"2022","journal-title":"J. Dermatol. Treat."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature25177","article-title":"Skin microbiota-host interactions","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"a015339","DOI":"10.1101\/cshperspect.a015339","article-title":"Immunology and skin in health and disease","volume":"4","author":"Richmond","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri.2017.101","article-title":"\u03b3\u03b4 T cells in homeostasis and host defence of epithelial barrier tissues","volume":"17","author":"Nielsen","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.jid.2018.05.018","article-title":"Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis","volume":"138","author":"Killeen","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fenini, G., Karakaya, T., and Hennig, P. (2020). The NLRP1 Inflammasome in Human Skin and Beyond. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134788"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1080\/1744666X.2022.2011720","article-title":"Cytokine alterations in psoriasis: An updated review","volume":"17","author":"Seyedmirzaei","year":"2021","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00011-021-01528-0","article-title":"Non-immune functions of inflammatory cytokines targeted by anti-psoriatic biologics: A review","volume":"71","author":"Lee","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/jid.2008.194","article-title":"Psoriasis is characterized by accumulation of immunostimulatory and Th1\/Th17 cell-polarizing myeloid dendritic cells","volume":"129","author":"Zaba","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.jaci.2010.03.018","article-title":"Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis","volume":"125","author":"Zaba","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI32282","article-title":"Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages","volume":"117","author":"Zaba","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/jid.2008.225","article-title":"Resident and \u201cinflammatory\u201d dendritic cells in human skin","volume":"129","author":"Zaba","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10723","DOI":"10.1073\/pnas.1307569110","article-title":"Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice","volume":"110","author":"Wohn","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.1724","article-title":"Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells","volume":"10","author":"Bedoui","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000056357","article-title":"Alternatively activated antigen-presenting cells: Molecular repertoire, immune regulation, and healing","volume":"14","author":"Gratchev","year":"2001","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.immuni.2023.03.008","article-title":"Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup","volume":"56","author":"Weckel","year":"2023","journal-title":"Immunity"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/jid.2009.247","article-title":"Skin-resident T cells: The ups and downs of on site immunity","volume":"130","author":"Clark","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.jid.5700199","article-title":"A novel method for the isolation of skin resident T cells from normal and diseased human skin","volume":"126","author":"Clark","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"875076","DOI":"10.3389\/fimmu.2022.875076","article-title":"Skin \u03b3\u03b4 T Cells and Their Function in Wound Healing","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1084\/jem.20081787","article-title":"A role for human skin-resident T cells in wound healing","volume":"206","author":"Toulon","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cellimm.2015.04.008","article-title":"Human gamma delta T cells: Evolution and ligand recognition","volume":"296","author":"Adams","year":"2015","journal-title":"Cell. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00018-020-03613-9","article-title":"Epidermal resident \u03b3\u03b4 T cell development and function in skin","volume":"78","author":"Xu","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"627139","DOI":"10.3389\/fimmu.2021.627139","article-title":"Gamma Delta T Cells and Their Pathogenic Role in Psoriasis","volume":"12","author":"Qi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-015-1835-0","article-title":"Molecular mechanisms of CD8(+) T cell trafficking and localization","volume":"72","author":"Nolz","year":"2015","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41590-023-01538-6","article-title":"Human circulating and tissue-resident memory CD8(+) T cells","volume":"24","author":"Buggert","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1084\/jem.20181365","article-title":"CD4(+) resident memory T cells dominate immunosurveillance and orchestrate local recall responses","volume":"216","author":"Beura","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.1200402","article-title":"Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues","volume":"188","author":"Casey","year":"2012","journal-title":"J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1254536","article-title":"T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"346","author":"Schenkel","year":"2014","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ni.2568","article-title":"Sensing and alarm function of resident memory CD8+ T cells","volume":"14","author":"Schenkel","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.immuni.2014.12.007","article-title":"Tissue-resident memory T cells","volume":"41","author":"Schenkel","year":"2014","journal-title":"Immunity"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","article-title":"Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis","volume":"192","author":"Cheuk","year":"2014","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"eaav8995","DOI":"10.1126\/sciimmunol.aav8995","article-title":"Human CD4(+)CD103(+) cutaneous resident memory T cells are found in the circulation of healthy individuals","volume":"4","author":"Klicznik","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"279ra239","DOI":"10.1126\/scitranslmed.3010302","article-title":"Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells","volume":"7","author":"Watanabe","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nm.3962","article-title":"Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma","volume":"21","author":"Adachi","year":"2015","journal-title":"Nat. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.4049\/jimmunol.1300212","article-title":"Cutting Edge: Memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues","volume":"190","author":"Gratz","year":"2013","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"970","DOI":"10.4049\/jimmunol.1202805","article-title":"Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern","volume":"190","author":"Bromley","year":"2013","journal-title":"J. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.immuni.2019.03.002","article-title":"Keratinocyte-Mediated Activation of the Cytokine TGF-\u03b2 Maintains Skin Recirculating Memory CD8(+) T Cells","volume":"50","author":"Hirai","year":"2019","journal-title":"Immunity"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fimmu.2017.00385","article-title":"Grand Challenges in Immunological Memory","volume":"8","author":"Mueller","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-immunol-032712-095954","article-title":"Memory T cell subsets, migration patterns, and tissue residence","volume":"31","author":"Mueller","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1084\/jem.20041059","article-title":"A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations","volume":"201","author":"Baekkevold","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1016\/j.ajpath.2011.02.031","article-title":"Chemokine receptor requirements for epidermal T-cell trafficking","volume":"178","author":"Tubo","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1182\/blood-2002-07-2348","article-title":"CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking","volume":"101","author":"Soler","year":"2003","journal-title":"Blood"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/23495","article-title":"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells","volume":"400","author":"Campbell","year":"1999","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.194.10.1541","article-title":"CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin","volume":"194","author":"Reiss","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.4049\/jimmunol.178.6.3358","article-title":"Cutting Edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions","volume":"178","author":"Campbell","year":"2007","journal-title":"J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1365-2133.2003.05505.x","article-title":"Expression of the T-helper 2-specific chemokine receptor CCR4 on CCR10-positive lymphocytes in atopic dermatitis skin but not in psoriasis skin","volume":"149","author":"Vestergaard","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/intimm\/dxp019","article-title":"Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines","volume":"21","author":"Kondo","year":"2009","journal-title":"Int. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fimmu.2020.00529","article-title":"CCR4(+) Skin-Tropic Phenotype as a Feature of Central Memory CD8(+) T Cells in Healthy Subjects and Psoriasis Patients","volume":"11","author":"Casciano","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e2149702","DOI":"10.1002\/eji.202149702","article-title":"CCR4(+) CD8(+) T cells clonally expand to differentiated effectors in murine psoriasis and in human psoriatic arthritis","volume":"53","author":"Montico","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3389\/fimmu.2018.01390","article-title":"T Cell Hierarchy in the Pathogenesis of Psoriasis and Associated Cardiovascular Comorbidities","volume":"9","author":"Casciano","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/jid.2011.198","article-title":"Skin as a peripheral lymphoid organ: Revisiting the concept of skin-associated lymphoid tissues","volume":"131","author":"Egawa","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nm.3860","article-title":"Common clonal origin of central and resident memory T cells following skin immunization","volume":"21","author":"Gaide","year":"2015","journal-title":"Nat. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.jid.2018.02.030","article-title":"Resident T cells in resolved psoriasis steer tissue responses that stratify clinical outcome","volume":"138","author":"Classon","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jid.2016.11.033","article-title":"Dynamic Changes in Resident and Infiltrating Epidermal Dendritic Cells in Active and Resolved Psoriasis","volume":"137","author":"Martini","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri1689","article-title":"Getting under the skin: The immunogenetics of psoriasis","volume":"5","author":"Bowcock","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"eadc9584","DOI":"10.1126\/sciimmunol.adc9584","article-title":"CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration","volume":"8","author":"Alanko","year":"2023","journal-title":"Sci. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/jid.2012.33","article-title":"Combined use of laser capture microdissection and cDNA microarray analysis identifies locally expressed disease-related genes in focal regions of psoriasis vulgaris skin lesions","volume":"132","author":"Mitsui","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ajpath.2013.04.021","article-title":"Inhibition of CCR7\/CCL19 axis in lesional skin is a critical event for clinical remission induced by TNF blockade in patients with psoriasis","volume":"183","author":"Bose","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41577-019-0162-3","article-title":"T cells and the skin: From protective immunity to inflammatory skin disorders","volume":"19","author":"Ho","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/cmi.2017.13","article-title":"Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy","volume":"14","author":"Tang","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"ref_77","first-page":"147","article-title":"Review. TNF\/VEGF cross-talk in chronic inflammation-related cancer initiation and progression: An early target in anticancer therapeutic strategy","volume":"21","author":"Guadagni","year":"2007","journal-title":"In Vivo"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/ard.2006.062042","article-title":"Ectopic lymphoid neogenesis in psoriatic arthritis","volume":"66","author":"Canete","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/imm.12399","article-title":"Human Th1 dichotomy: Origin, phenotype and biologic activities","volume":"144","author":"Annunziato","year":"2014","journal-title":"Immunology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7692024","DOI":"10.1155\/2016\/7692024","article-title":"T Helper Cell Subsets in Clinical Manifestations of Psoriasis","volume":"2016","author":"Diani","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"10870","DOI":"10.1038\/s41598-019-47310-5","article-title":"Increased frequency of activated CD8(+) T cell effectors in patients with psoriatic arthritis","volume":"9","author":"Diani","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.clim.2017.04.001","article-title":"Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease","volume":"180","author":"Diani","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/art.38355","article-title":"Brief report: Etanercept inhibits the tumor necrosis factor \u03b1-driven shift of Th17 lymphocytes toward a nonclassic Th1 phenotype in juvenile idiopathic arthritis","volume":"66","author":"Maggi","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/ced.12251","article-title":"Differential expression of interleukin-2 by anti-CD3-stimulated peripheral blood mononuclear cells in patients with psoriatic arthritis and patients with cutaneous psoriasis","volume":"39","author":"Capsoni","year":"2014","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12016-012-8302-6","article-title":"Psoriatic arthritis: A critical review","volume":"44","author":"Dhir","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2013.06.010","article-title":"The critical role of interleukin-23 in spondyloarthropathy","volume":"57","author":"Sherlock","year":"2014","journal-title":"Mol. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nm.2817","article-title":"IL-23 induces spondyloarthropathy by acting on ROR-\u03b3t+ CD3+CD4-CD8- entheseal resident T cells","volume":"18","author":"Sherlock","year":"2012","journal-title":"Nat. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1038\/ncomms6621","article-title":"The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis","volume":"5","author":"Lande","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1084\/jem.20160258","article-title":"Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a","volume":"213","author":"Cheung","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1084\/jem.20151093","article-title":"Melanocyte antigen triggers autoimmunity in human psoriasis","volume":"212","author":"Arakawa","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.4049\/jimmunol.172.3.1935","article-title":"Nucleotide sequencing of psoriatic arthritis tissue before and during methotrexate administration reveals a complex inflammatory T cell infiltrate with very few clones exhibiting features that suggest they drive the inflammatory process by recognizing autoantigens","volume":"172","author":"Curran","year":"2004","journal-title":"J. Immunol."},{"key":"ref_92","first-page":"1117","article-title":"Predominance of CD8+ T lymphocytes in psoriatic arthritis","volume":"26","author":"Costello","year":"1999","journal-title":"J. Rheumatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/art.38376","article-title":"Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression","volume":"66","author":"Menon","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/art.23655","article-title":"Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides","volume":"58","author":"Jandus","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1038\/s41467-019-12980-2","article-title":"CXCR3 enables recruitment and site-specific bystander activation of memory CD8(+) T cells","volume":"10","author":"Maurice","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1038\/s41467-020-18513-6","article-title":"Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis","volume":"11","author":"Penkava","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jaut.2016.03.019","article-title":"A role for CCR5(+)CD4 T cells in cutaneous psoriasis and for CD103(+) CCR4(+) CD8 Teff cells in the associated systemic inflammation","volume":"70","author":"Sgambelluri","year":"2016","journal-title":"J. Autoimmun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/eji.200323630","article-title":"Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes","volume":"33","author":"Azukizawa","year":"2003","journal-title":"Eur. J. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/21\/15707\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:13:27Z","timestamp":1760130807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/21\/15707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,28]]},"references-count":98,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["ijms242115707"],"URL":"https:\/\/doi.org\/10.3390\/ijms242115707","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,28]]}}}