{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:48:01Z","timestamp":1769060881460,"version":"3.49.0"},"reference-count":59,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","award":["AMX-19-IET-007"],"award-info":[{"award-number":["AMX-19-IET-007"]}]},{"name":"Institut MarMaRa","award":["AMX-19-IET-007"],"award-info":[{"award-number":["AMX-19-IET-007"]}]},{"name":"PACA regional council","award":["AMX-19-IET-007"],"award-info":[{"award-number":["AMX-19-IET-007"]}]},{"name":"French government","award":["AMX-19-IET-007"],"award-info":[{"award-number":["AMX-19-IET-007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Antibodies play a crucial role in activating protective immunity against malaria by interacting with Fc-gamma receptors (Fc\u03b3Rs). Genetic variations in genes encoding Fc\u03b3Rs can affect immune cell responses to the parasite. In this study, our aim was to investigate whether non-coding variants that regulate Fc\u03b3R expression could influence the prevalence of Plasmodium falciparum infection. Through bioinformatics approaches, we selected expression quantitative trait loci (eQTL) for FCGR2A, FCGR2B, FCGR2C, FCGR3A, and FCGR3B genes encoding Fc\u03b3Rs (FCGR), in whole blood. We prioritized two regulatory variants, rs2099684 and rs1771575, located in open genomic regions. These variants were identified using RegVar, ImmuNexUT, and transcription factor annotations specific to immune cells. In addition to these, we genotyped the coding variants FCGR2A\/rs1801274 and FCGR2B\/rs1050501 in 234 individuals from a malaria-endemic area in Burkina Faso. We conducted age and family-based analyses to evaluate associations with the prevalence of malarial infection in both children and adults. The analysis revealed that the regulatory rs1771575-CC genotype was predicted to influence FCGR2B\/FCGR2C\/FCGR3A transcripts in immune cells and was the sole variant associated with a higher prevalence of malarial infection in children. In conclusion, this study identifies the rs1771575 cis-regulatory variant affecting several Fc\u03b3Rs in myeloid and neutrophil cells and associates it with the inter-individual capacity of children living in Burkina Faso to control malarial infection.<\/jats:p>","DOI":"10.3390\/ijms242115711","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:01:08Z","timestamp":1698555668000},"page":"15711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso"],"prefix":"10.3390","volume":"24","author":[{"given":"Jules","family":"Cretin","sequence":"first","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"},{"name":"Institut MarMaRa, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Adjemout","sequence":"additional","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"},{"name":"Institut MarMaRa, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Dieppois","sequence":"additional","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Gallardo","sequence":"additional","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Torres","sequence":"additional","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Merard","sequence":"additional","affiliation":[{"name":"ADES UMR, Aix Marseille University, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge Aim\u00e9","family":"Sawadogo","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation en Sciences de la Sant\u00e9 (UFR\/SDS), Universit\u00e9 Joseph KI-ZERBO, Ouagadougou 03 BP 7021, Burkina Faso"},{"name":"Centre Pr\u00efmO-Nelson Mandela, 84 rue Sao Tom\u00e9 et Principe, Ouagadougou 09 BP 706, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Picard","sequence":"additional","affiliation":[{"name":"ADES UMR, Aix Marseille University, 13288 Marseille, France"},{"name":"Immunogenetics Laboratory, Etablissement Fran\u00e7ais du Sang PACA-Corse, 13001 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-3905","authenticated-orcid":false,"given":"Pascal","family":"Rihet","sequence":"additional","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-4479","authenticated-orcid":false,"given":"Pascale","family":"Paul","sequence":"additional","affiliation":[{"name":"INSERM 1090, TAGC Theories and Approaches of Genomic Complexity, Campus de Luminy, Aix Marseille University, 13288 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"ref_1","unstructured":"(2023, April 04). 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