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The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments.<\/jats:p>","DOI":"10.3390\/ijms242216025","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T10:52:47Z","timestamp":1699354367000},"page":"16025","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-3504","authenticated-orcid":false,"given":"Milka","family":"Jadranin","sequence":"first","affiliation":[{"name":"University of Belgrade\u2014Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njego\u0161eva 12, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7338-0161","authenticated-orcid":false,"given":"Nata\u0161a","family":"Avramovi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Medicine, Institute of Medical Chemistry, Vi\u0161egradska 26, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2086-9064","authenticated-orcid":false,"given":"Zoran","family":"Miladinovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of General and Physical Chemistry, Studentski trg 12\u201316, 11158 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Gavrilovi\u0107","sequence":"additional","affiliation":[{"name":"Special Hospital for Psychiatric Diseases \u201cKovin\u201d, Cara Lazara 253, 26220 Kovin, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-7332","authenticated-orcid":false,"given":"Ljubica","family":"Tasic","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Organic Chemistry Department, State University of Campinas, Campinas 13083-970, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7060-9055","authenticated-orcid":false,"given":"Vele","family":"Te\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Mandi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","article-title":"Bipolar disorder","volume":"387","author":"Grande","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. 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