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EU","award":["2019\/00286\/001"],"award-info":[{"award-number":["2019\/00286\/001"]}]},{"name":"Uni\u00f3n Europea-Next Generation EU","award":["MARSALAS21-35"],"award-info":[{"award-number":["MARSALAS21-35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ischemia is the main cause of cell death in retinal diseases such as vascular occlusions, diabetic retinopathy, glaucoma, or retinopathy of prematurity. Although excitotoxicity is considered the primary mechanism of cell death during an ischemic event, antagonists of glutamatergic receptors have been unsuccessful in clinical trials with patients suffering ischemia or stroke. Our main purpose was to analyze if the transient receptor potential channel 7 (TRPM7) could contribute to retinal dysfunction in retinal pathologies associated with ischemia. By using an experimental model of acute retinal ischemia, we analyzed the changes in retinal function by electroretinography and the changes in retinal morphology by optical coherence tomography (OCT) and OCT-angiography (OCTA). Immunohistochemistry was performed to assess the pattern of TRPM7 and its expression level in the retina. Our results show that ischemia elicited a decrease in retinal responsiveness to light stimuli along with reactive gliosis and a significant increase in the expression of TRPM7 in M\u00fcller cells. TRPM7 could emerge as a new drug target to be explored in retinal pathologies associated with ischemia.<\/jats:p>","DOI":"10.3390\/ijms242216068","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T01:54:30Z","timestamp":1699408470000},"page":"16068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-5602","authenticated-orcid":false,"given":"Natalia","family":"Mart\u00ednez-Gil","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-6916","authenticated-orcid":false,"given":"Oksana","family":"Kutsyr","sequence":"additional","affiliation":[{"name":"Departamento de \u00d3ptica, Farmacolog\u00eda y Anatom\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-0156","authenticated-orcid":false,"given":"Laura","family":"Fern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de \u00d3ptica, Farmacolog\u00eda y Anatom\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-0979","authenticated-orcid":false,"given":"Xavier","family":"S\u00e1nchez-S\u00e1ez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-9887","authenticated-orcid":false,"given":"Henar","family":"Albertos-Arranz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-5825","authenticated-orcid":false,"given":"Carla","family":"S\u00e1nchez-Castillo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Vidal-Gil","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-5710","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Cuenca","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-1008","authenticated-orcid":false,"given":"Pedro","family":"Lax","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-1361","authenticated-orcid":false,"given":"Victoria","family":"Maneu","sequence":"additional","affiliation":[{"name":"Departamento de \u00d3ptica, Farmacolog\u00eda y Anatom\u00eda, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: Mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mohite, A.A., Perais, J.A., McCullough, P., and Lois, N. (2023). Retinal Ischemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge. J. Clin. Med., 12.","DOI":"10.3390\/jcm12062406"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/APO.0000000000000598","article-title":"Update on Retinal Vein Occlusion","volume":"12","author":"Romano","year":"2023","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.survophthal.2022.11.007","article-title":"Retinopathy of prematurity: A review of pathophysiology and signaling pathways","volume":"68","author":"Bicho","year":"2023","journal-title":"Surv. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.18240\/ijo.2022.06.20","article-title":"Etiology, pathogenesis, and diagnosis of neovascular glaucoma","volume":"15","author":"Calugaru","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nm0102-5a","article-title":"Future of neuroprotective drugs in doubt","volume":"8","author":"Birmingham","year":"2002","journal-title":"Nat. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(02)00164-3","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nn.2951","article-title":"Emerging mechanisms of disrupted cellular signaling in brain ischemia","volume":"14","author":"Tymianski","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"121814","DOI":"10.1016\/j.lfs.2023.121814","article-title":"Molecular mechanisms of ischemia and glutamate excitotoxicity","volume":"328","author":"Neves","year":"2023","journal-title":"Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/aps.2011.60","article-title":"TRPM7 in cerebral ischemia and potential target for drug development in stroke","volume":"32","author":"Bae","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tins.2005.12.001","article-title":"Paradox of Ca2+ signaling, cell death and stroke","volume":"29","author":"MacDonald","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tips.2008.02.003","article-title":"Beyond NMDA and AMPA glutamate receptors: Emerging mechanisms for ionic imbalance and cell death in stroke","volume":"29","author":"Besancon","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1113\/JP273709","article-title":"Role of TRPM7 in cerebral ischemia and hypoxia","volume":"595","author":"Sun","year":"2017","journal-title":"J. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"101114","DOI":"10.1016\/j.preteyeres.2022.101114","article-title":"Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration","volume":"92","author":"Cordeiro","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/224285a0","article-title":"Abnormal Electroretinogram from a Drosophila Mutant","volume":"224","author":"Cosens","year":"1969","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.visres.2011.10.009","article-title":"TRP channel gene expression in the mouse retina","volume":"51","author":"Gilliam","year":"2011","journal-title":"Vision Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhang, P., Li, W., Liu, Y., Gao, Y., and Abumaria, N. (2022). Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia. Cells, 11.","DOI":"10.3390\/cells11071178"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e753","DOI":"10.1002\/iid3.753","article-title":"Sevoflurane participates in the protection of rat renal ischemia-reperfusion injury by down-regulating the expression of TRPM7","volume":"11","author":"Xu","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.transproceed.2011.11.068","article-title":"Expression of Transient Receptor Potential Melastatin 7 Up-regulated in the Early Stage of Renal Ischemia-Reperfusion","volume":"44","author":"Meng","year":"2012","journal-title":"Transpl. Proc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16323","DOI":"10.1073\/pnas.0701149104","article-title":"TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations","volume":"104","author":"Wei","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1007\/s11033-014-3139-0","article-title":"Evaluation of TRPM (transient receptor potential melastatin) genes expressions in myocardial ischemia and reperfusion","volume":"41","author":"Demir","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3109\/0886022X.2014.900405","article-title":"Expressions of TRPM6 and TRPM7 and histopathological evaluation of tissues in ischemia reperfusion performed rats","volume":"36","author":"Dokuyucu","year":"2014","journal-title":"Ren. Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neulet.2018.01.047","article-title":"Electrophysiological characterization of M\u00fcller cells from the ischemic retina of mice deficient in the leukemia inhibitory factor","volume":"670","author":"Pannicke","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/glia.23144","article-title":"Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration","volume":"65","author":"Wagner","year":"2017","journal-title":"Glia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1750-1326-8-21","article-title":"Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia\/reperfusion injury in mice","volume":"8","author":"Kim","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1167\/iovs.04-0940","article-title":"Aquaporin-4 Gene Disruption in Mice Protects against Impaired Retinal Function and Cell Death after Ischemia","volume":"45","author":"Da","year":"2004","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0014-4835(91)90215-Z","article-title":"Quantitation of ischemic damage in the rat retina","volume":"53","author":"Hughes","year":"1991","journal-title":"Exp. Eye Res."},{"key":"ref_29","first-page":"2570","article-title":"Irregular retinal and RPE damage after pressure-induced ischemia in the rabbit","volume":"34","author":"Marmor","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0014-4835(05)80048-X","article-title":"Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion","volume":"61","author":"Wilson","year":"1995","journal-title":"Exp. Eye Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"175180","DOI":"10.1016\/j.ejphar.2022.175180","article-title":"Transient receptor potential melastatin 7 and their modulators","volume":"931","author":"Cheng","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1085\/jgp.20028740","article-title":"TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions","volume":"121","author":"Hermosura","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4196\/kjpp.2014.18.1.15","article-title":"The Pathophysiologic Roles of TRPM7 Channel","volume":"18","author":"Park","year":"2014","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/978-3-540-34891-7_19","article-title":"The Mg2+ and Mg2+-Nucleotide-Regulated Channel-Kinase TRPM7","volume":"Volume 179","author":"Penner","year":"2007","journal-title":"Transient Receptor Potential (TRP) Channels"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"66709","DOI":"10.7554\/eLife.66709","article-title":"TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis","volume":"10","author":"Jiang","year":"2021","journal-title":"eLife"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2017.11.026","article-title":"Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation","volume":"48","author":"Schappe","year":"2018","journal-title":"Immunity"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1016\/j.celrep.2018.05.069","article-title":"TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages","volume":"23","author":"Liu","year":"2018","journal-title":"Cell Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zou, Z.-G., Rios, F.J., Montezano, A.C., and Touyz, R.M. (2019). TRPM7, Magnesium, and Signaling. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081877"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Numata, T., Sato-Numata, K., Hermosura, M.C., Mori, Y., and Okada, Y. (2021). TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02127-9"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0024-3205(01)01142-0","article-title":"Glutamate release and neuronal damage in ischemia","volume":"69","author":"Nishizawa","year":"2001","journal-title":"Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/1073858404272966","article-title":"TRPM7 and Ischemic CNS Injury","volume":"11","author":"Aarts","year":"2005","journal-title":"Neuroscientist"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s001090000077","article-title":"Molecular mechanisms of calcium-dependent excitotoxicity","volume":"78","author":"Sattler","year":"2000","journal-title":"J. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00424-005-1439-x","article-title":"TRPMs and neuronal cell death","volume":"451","author":"Aarts","year":"2005","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/aps.2012.94","article-title":"Current understanding of TRPM7 pharmacology and drug development for stroke","volume":"34","author":"Bae","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fendo.2013.00048","article-title":"GABA and Glutamate Uptake and Metabolism in Retinal Glial (M\u00fcller) Cells","volume":"4","author":"Bringmann","year":"2013","journal-title":"Front. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108689","DOI":"10.1016\/j.exer.2021.108689","article-title":"Neuroprotective effects of glial mediators in interactions between retinal neurons and M\u00fcller cells","volume":"209","author":"Zwanzig","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1600-0420.2005.00565.x","article-title":"Neuronal versus glial cell swelling in the ischemic retina","volume":"83","author":"Bringmann","year":"2005","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/glia.20627","article-title":"Identification of a molecular target for glutamate regulation of astrocyte water permeability","volume":"56","author":"Gunnarson","year":"2008","journal-title":"Glia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(03)01017-1","article-title":"A Key Role for TRPM7 Channels in Anoxic Neuronal Death","volume":"115","author":"Aarts","year":"2003","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/jn.00083.2022","article-title":"Mechanism of Stat1 in the neuronal Ca 2+ overload after intracerebral hemorrhage via the H3K27ac\/ Trpm7 axis","volume":"128","author":"Li","year":"2022","journal-title":"J. Neurophysiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","article-title":"Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","article-title":"Cellular signaling and factors involved in M\u00fcller cell gliosis: Neuroprotective and detrimental effects","volume":"28","author":"Bringmann","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zudaire, E., Gambardella, L., Kurcz, C., and Vermeren, S. (2011). A Computational Tool for Quantitative Analysis of Vascular Networks. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027385"},{"key":"ref_55","first-page":"949","article-title":"Alpha synuclein gene expression profile in the retina of vertebrates","volume":"13","author":"Angulo","year":"2007","journal-title":"Mol. Vis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41419-018-0355-x","article-title":"Systemic inflammation induced by lipopolysaccharide aggravates inherited retinal dystrophy","volume":"9","author":"Noailles","year":"2018","journal-title":"Cell Death Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16068\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:19:10Z","timestamp":1760131150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":56,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["ijms242216068"],"URL":"https:\/\/doi.org\/10.3390\/ijms242216068","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,8]]}}}