{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:27:53Z","timestamp":1791581273557,"version":"4.3.4"},"reference-count":39,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lynch syndrome is one of the most common hereditary cancer sensitivity syndromes and is caused by autosomal-dominant germline mutations in DNA mismatch repair genes. In patients affected by this syndrome, pre-implantation genetic testing for monogenic disorders (PGT-M) could be the elective technique used to prevent the transmission of this hereditary syndrome to offspring. Notably, despite the severity of the condition, some authors have observed a markedly lower demand for PGT-M in these patients compared to those with other hereditary conditions. A 34-year-old woman with a medical history of Lynch syndrome associated with endometrial cancer came to the Villa Mafalda fertility center in Rome in order to conceive a healthy baby. In a pre-implantation genetic testing for aneuploidy (PGT-A) + PGT-M cycle, eight blastocysts were formed. Six out of eight blastocysts were affected by the same mother syndrome. One of the other two was aneuploid and the other one was a mosaic embryo, which resulted in a healthy pregnancy. The aim of this report is to emphasize the importance of a multidisciplinary approach to managing patients with this condition. In vitro fertilization (IVF), specifically PGT-M, is a tool that allow patients to conceive biological children with lower risk of inheriting the disease.<\/jats:p>","DOI":"10.3390\/ijms242216114","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T03:42:08Z","timestamp":1699501328000},"page":"16114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PGT-M, a Useful Tool to Manage the Lynch Syndrome Transmission"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1854-6464","authenticated-orcid":false,"given":"Ilaria","family":"Listorti","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy"},{"name":"Faculty of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Manzo","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Arrivi","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Mencacci","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Biricik","sequence":"additional","affiliation":[{"name":"Eurofins GENOMA Group, Molecular Genetics Laboratories, 00138 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Greco","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy"},{"name":"Faculty of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy"},{"name":"Eurofins GENOMA Group, Molecular Genetics Laboratories, 00138 Rome, Italy"},{"name":"Department of Obstetrician and Genecology, Saint Camillus International University of Health and Medical Sciences (Unicamillus), 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-4567","authenticated-orcid":false,"given":"Pierfrancesco","family":"Greco","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3390\/genes5030497","article-title":"Lynch Syndrome: An Updated Review","volume":"5","author":"Sehgal","year":"2014","journal-title":"Genes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103604","DOI":"10.1016\/j.critrevonc.2022.103604","article-title":"Fertility counseling in women with hereditary cancer syndromes","volume":"171","author":"Somigliana","year":"2022","journal-title":"Crit. 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