{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:57:39Z","timestamp":1768075059158,"version":"3.49.0"},"reference-count":67,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2020\/10462-5"],"award-info":[{"award-number":["2020\/10462-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["309408\/2020-2"],"award-info":[{"award-number":["309408\/2020-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research productivity scholarship","award":["2020\/10462-5"],"award-info":[{"award-number":["2020\/10462-5"]}]},{"name":"Research productivity scholarship","award":["309408\/2020-2"],"award-info":[{"award-number":["309408\/2020-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Postmenopausal osteoporosis and poor dietary habits can lead to overweightness and obesity. Bisphosphonates are the first-line treatment for osteoporosis. However, some studies show that they may increase the risk of osteonecrosis of the jaw. Considering the antimicrobial, angiogenic and vasodilatory potential of nitric oxide, this study aims to evaluate the local activity of this substance during the placement of surface-treated implants. Seventy-two Wistar rats were divided into three groups: SHAM (SHAM surgery), OVX + HD (ovariectomy + cafeteria diet), and OVX + HD + RIS (ovariectomy + cafeteria diet + sodium risedronate treatment), which were further subdivided according to the surface treatment of the future implant: CONV (conventional), TE10, or TE100 (TERPY at 10 or 100 \u03bcM concentration); n = 8 per subgroup. The animals underwent surgery for implant installation in the proximal tibia metaphysis and were euthanized after 28 days. Data obtained from removal torque and RT-PCR (OPG, RANKL, ALP, IBSP and VEGF expression) were subjected to statistical analysis at 5% significance level. For biomechanical analysis, TE10 produced better results in the OVX + HD group (7.4 N\/cm, SD = 0.6819). Molecular analysis showed: (1) significant increase in OPG gene expression in OVX groups with TE10; (2) decreased RANKL expression in OVX + HD + RIS compared to OVX + HD; (3) significantly increased expressions of IBSP and VEGF for OVX + HD + RIS TE10. At its lowest concentration, TERPY has the potential to improve peri-implant conditions.<\/jats:p>","DOI":"10.3390\/ijms242216153","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T01:17:51Z","timestamp":1699579071000},"page":"16153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis"],"prefix":"10.3390","volume":"24","author":[{"given":"Bruna Kaori Namba","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-8604","authenticated-orcid":false,"given":"Laura Vidoto","family":"Paludetto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-9195","authenticated-orcid":false,"given":"Naara Gabriela","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Roberto de Souza","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Lebedenco","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Federal Institute of Education, Science and Technology of S\u00e3o Paulo (IFSP), Birigui 16201-407, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-2255","authenticated-orcid":false,"given":"Roberto Santana","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo\u2014USP, Ribeir\u00e3o Preto 14040-403, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-6161","authenticated-orcid":false,"given":"Cristina","family":"Antoniali","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-4069","authenticated-orcid":false,"given":"Paulo Noronha","family":"Lisboa Filho","sequence":"additional","affiliation":[{"name":"Department of Physics and Meteorology, Bauru Sciences School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Bauru 17033-360, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrrheum.2009.260","article-title":"Osteoporosis: Impact on health and economics","volume":"6","author":"Harvey","year":"2012","journal-title":"Nat. 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