{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:15:03Z","timestamp":1789193703267,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA-NIFA Sustainable Agriculture Systems","doi-asserted-by":"publisher","award":["2019-69012-29905"],"award-info":[{"award-number":["2019-69012-29905"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"USDA-NIFA Sustainable Agriculture Systems","doi-asserted-by":"publisher","award":["PAPIIT IG200923"],"award-info":[{"award-number":["PAPIIT IG200923"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DGAPA-UNAM","award":["2019-69012-29905"],"award-info":[{"award-number":["2019-69012-29905"]}]},{"name":"DGAPA-UNAM","award":["PAPIIT IG200923"],"award-info":[{"award-number":["PAPIIT IG200923"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The selection of components within a formulation or for treatment must stop being arbitrary and must be focused on scientific evidence that supports the inclusion of each one. Therefore, the objective of the present study was to obtain a formulation based on ascorbic acid (AA) and Eudragit FS 30D microparticles containing curcumin\u2013boric acid (CUR\u2013BA) considering interaction studies between the active components carried out via Fourier transform infrared spectrometry (FTIR) and differential scanning calorimetry (DSC) to minimize antagonistic effects, and comprehensively and effectively treat turkey poults infected with Salmonella\u00a0enteritidis (S.\u00a0enteritidis). The DSC and FTIR studies clearly demonstrated the interactions between AA, BA, and CUR. Consequently, the combination of AA with CUR and\/or BA should be avoided, but not CUR and BA. Furthermore, the Eudragit FS 30D microparticles containing CUR\u2013BA (SD CUR\u2013BA MP) showed a limited release of CUR\u2013BA in an acidic medium, but they were released at a pH 6.8\u20137.0, which reduced the interactions between CUR\u2013BA and AA. Finally, in the S.\u00a0enteritidis infection model, turkey poults treated with the combination of AA and SD CUR\u2013BA MP presented lower counts of S.\u00a0enteritidis in cecal tonsils after 10 days of treatment. These results pointed out that the use of an adequate combination of AA and CUR\u2013BA as an integral treatment of S.\u00a0enteritidis infections could be a viable option to replace the indiscriminate use of antibiotics.<\/jats:p>","DOI":"10.3390\/ijms242216186","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:02:42Z","timestamp":1699840962000},"page":"16186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin\u2013Boric Acid Solid Dispersion in Turkey Poults Infected with Salmonella\u00a0enteritidis: A Therapeutic 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Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-6119","authenticated-orcid":false,"given":"Raquel","family":"L\u00f3pez-Arellano","sequence":"additional","affiliation":[{"name":"Laboratory 5: LEDEFAR, Multidisciplinary Research Unit, Superior Studies Faculty at Cuautitlan (FESC), National Autonomous University of Mexico (UNAM), Cuautitlan Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-5216","authenticated-orcid":false,"given":"Abraham","family":"M\u00e9ndez-Albores","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria L14 (Alimentos, Micotoxinas y Micotoxicosis), Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy 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