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Office","award":["2020-4.1.1-TKP2020"],"award-info":[{"award-number":["2020-4.1.1-TKP2020"]}]},{"name":"Hungarian National Research, Development, and Innovation Office","award":["2020.1.16-J\u00f6v\u0151-2021-00013"],"award-info":[{"award-number":["2020.1.16-J\u00f6v\u0151-2021-00013"]}]},{"name":"Hungarian National Research, Development, and Innovation Office","award":["TKP2021-EGA-23"],"award-info":[{"award-number":["TKP2021-EGA-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The need for stable and well-defined magnetic nanoparticles is constantly increasing in biomedical applications; however, their preparation remains challenging. We used two different solvothermal methods (12 h reflux and a 4 min microwave, MW) to synthesize amine-functionalized zinc ferrite (ZnFe2O4-NH2) superparamagnetic nanoparticles. The morphological features of the two ferrite samples were the same, but the average particle size was slightly larger in the case of MW activation: 47 \u00b1 14 nm (Refl.) vs. 63 \u00b1 20 nm (MW). Phase identification measurements confirmed the exclusive presence of zinc ferrite with virtually the same magnetic properties. The Refl. samples had a zeta potential of \u221223.8 \u00b1 4.4 mV, in contrast to the +7.6 \u00b1 6.8 mV measured for the MW sample. To overcome stability problems in the colloidal phase, the ferrite nanoparticles were embedded in polyvinylpyrrolidone and could be easily redispersed in water. Two PVP-coated zinc ferrite samples were administered (1 mg\/mL ZnFe2O4) in X BalbC mice and were compared as contrast agents in magnetic resonance imaging (MRI). After determining the r1\/r2 ratio, the samples were compared to other commercially available contrast agents. Consistent with other SPION nanoparticles, our sample exhibits a concentrated presence in the hepatic region of the animals, with comparable biodistribution and pharmacokinetics suspected. Moreover, a small dose of 1.3 mg\/body weight kg was found to be sufficient for effective imaging. It should also be noted that no toxic side effects were observed, making ZnFe2O4-NH2 advantageous for pharmaceutical formulations.<\/jats:p>","DOI":"10.3390\/ijms242216203","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:02:42Z","timestamp":1699840962000},"page":"16203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Development of Polymer-Encapsulated, Amine-Functionalized Zinc Ferrite Nanoparticles as MRI Contrast Agents"],"prefix":"10.3390","volume":"24","author":[{"given":"\u00c1gnes M.","family":"Ilosvai","sequence":"first","affiliation":[{"name":"Institute of Chemistry, University of Miskolc, 3515 Miskolc, Hungary"},{"name":"Higher Education and Industrial Cooperation Centre, University of Miskolc, 3515 Miskolc, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-9124","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Forg\u00e1ch","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary"},{"name":"In Vivo Imaging Advanced Core Facility, Hungarian Center of Excellence for Molecular Medicine (HCEMM), 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Heydari","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-9828","authenticated-orcid":false,"given":"Kriszti\u00e1n","family":"Szigeti","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-0413","authenticated-orcid":false,"given":"Domokos","family":"M\u00e1th\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary"},{"name":"In Vivo Imaging Advanced Core Facility, Hungarian Center of Excellence for Molecular Medicine (HCEMM), 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-5994","authenticated-orcid":false,"given":"Ferenc","family":"Krist\u00e1ly","sequence":"additional","affiliation":[{"name":"Institute of Mineralogy and Geology, University of Miskolc, 3515 Miskolc, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Dar\u00f3czi","sequence":"additional","affiliation":[{"name":"Department of Solid State Physics, University of Debrecen, P.O. 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Magn. Magn. Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.jmmm.2006.11.143","article-title":"A New Mn\u2013Zn Ferrite for High-Speed Data Transmission Applications in Telecommunication Networks","volume":"310","author":"Tsakaloudi","year":"2007","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1039\/C6TC03518C","article-title":"Small Magnetic Co-Doped NiZn Ferrite\/Graphene Nanocomposites and Their Dual-Region Microwave Absorption Performance","volume":"4","author":"Liu","year":"2016","journal-title":"J. Mater. Chem. C"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"103486","DOI":"10.1016\/j.micron.2023.103486","article-title":"Optically Active Organic and Inorganic Nanomaterials for Biological Imaging Applications: A Review","volume":"172","author":"Sowmiya","year":"2023","journal-title":"Micron"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"126117","DOI":"10.1016\/j.matchemphys.2022.126117","article-title":"A Mini-Review on AFe2O4 (A = Zn, Mg, Mn, Co, Cu, and Ni) Nanoparticles: Photocatalytic, Magnetic Hyperthermia and Cytotoxicity Study","volume":"286","author":"Manohar","year":"2022","journal-title":"Mater. Chem. Phys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbrc.2015.08.022","article-title":"Magnetic Nanoparticle-Based Drug Delivery for Cancer Therapy","volume":"468","author":"Tietze","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chroma.2004.08.090","article-title":"Isolation of Genomic DNA Using Magnetic Cobalt Ferrite and Silica Particles","volume":"1056","author":"Rittich","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/02726351.2022.2085217","article-title":"Synthesis of Magnetic Fe3O4@Al3+ Particles and Its Application in DNA Extraction","volume":"41","author":"Chen","year":"2022","journal-title":"Part. Sci. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3390\/chemistry4030063","article-title":"Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI","volume":"4","author":"Comanescu","year":"2022","journal-title":"Chemistry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1039\/D0RA09409A","article-title":"A One Step Method for Isolation of Genomic DNA Using Multi-Amino Modified Magnetic Nanoparticles","volume":"11","author":"Xu","year":"2021","journal-title":"RSC Adv."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.colsurfb.2015.12.054","article-title":"Adsorption and Desorption Characteristics of DNA onto the Surface of Amino Functional Mesoporous Silica with Various Particle Morphologies","volume":"140","author":"Hikosaka","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.apsusc.2016.07.061","article-title":"Amine-Functionalized Magnetic Mesoporous Silica Nanoparticles for DNA Separation","volume":"387","author":"Sheng","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1021\/acsanm.0c02044","article-title":"Dysprosium-Modified Gold Nanoparticles as T2exContrast Agents for Magnetic Resonance Imaging","volume":"3","author":"Wan","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.biomaterials.2013.11.032","article-title":"Manipulating the Surface Coating of Ultra-Small Gd2O3 Nanoparticles for Improved T1-Weighted MR Imaging","volume":"35","author":"Fang","year":"2014","journal-title":"Biomaterials"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ebrahimi, P., and Barbieri, M. (2019). Gadolinium as an Emerging Microcontaminant in Water Resources: Threats and Opportunities. Geosciences, 9.","DOI":"10.3390\/geosciences9020093"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.mric.2020.06.001","article-title":"MR Imaging Safety Considerations of Gadolinium-Based Contrast Agents: Gadolinium Retention and Nephrogenic Systemic Fibrosis","volume":"28","author":"McDonald","year":"2020","journal-title":"Magn. Reson. Imaging Clin. N. Am."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Vallabani, N.V.S., and Singh, S. (2018). Recent Advances and Future Prospects of Iron Oxide Nanoparticles in Biomedicine and Diagnostics. 3 Biotech, 8.","DOI":"10.1007\/s13205-018-1286-z"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"170065","DOI":"10.1016\/j.jmmm.2022.170065","article-title":"Study of the Suitability of Manganese-Substituted Cobalt Ferrites Nanoparticles as MRI Contrast Agent and Treatment by Employing Hyperthermia Temperature","volume":"564","author":"Nasrin","year":"2022","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.nano.2018.01.014","article-title":"Immunological Effects of Iron Oxide Nanoparticles and Iron-Based Complex Drug Formulations: Therapeutic Benefits, Toxicity, Mechanistic Insights, and Translational Considerations","volume":"14","author":"Shah","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_21","first-page":"35","article-title":"Superparamagnetic Iron Oxide Based MRI Contrast Agents: Current Status of Clinical Application","volume":"1","author":"Wang","year":"2011","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.21037\/qims.2017.02.09","article-title":"A Comprehensive Literatures Update of Clinical Researches of Superparamagnetic Resonance Iron Oxide Nanoparticles for Magnetic Resonance Imaging","volume":"7","year":"2017","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nnano.2009.242","article-title":"Towards a Definition of Inorganic Nanoparticles from an Environmental, Health and Safety Perspective","volume":"4","author":"Auffan","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/cr068445e","article-title":"Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications","volume":"108","author":"Laurent","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.addr.2019.01.005","article-title":"Iron Oxide Nanoparticles: Diagnostic, Therapeutic and Theranostic Applications","volume":"138","author":"Dadfar","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jnr.20280","article-title":"Peroxide Detoxification by Brain Cells","volume":"79","author":"Dringen","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Maiorino, F.M., Brigelius-Floh\u00e9, R., Aumann, K.D., Roveri, A., Schomburg, D., and Floh\u00e9, L. (1995). Diversity of Glutathione Peroxidases, Academic Press.","DOI":"10.1016\/0076-6879(95)52007-4"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Aebi, H. (1984). Catalase In Vitro, Academic Press.","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: Role of Lipid Peroxidation, Iron and Ferritinophagy","volume":"1861","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1002\/pat.5344","article-title":"Layer by Layer Controlled Synthesis at Room Temperature of Tri-Modal (MRI, Fluorescence and CT) Core\/Shell Superparamagnetic IO\/Human Serum Albumin Nanoparticles for Diagnostic Applications","volume":"32","author":"Ganguly","year":"2021","journal-title":"Polym. Adv. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ganguly, S., and Margel, S. (2021). Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery. Polymers, 13.","DOI":"10.3390\/polym13234259"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.7150\/thno.25220","article-title":"Shape-, Size- and Structure-Controlled Synthesis and Biocompatibility of Iron Oxide Nanoparticles for Magnetic Theranostics","volume":"8","author":"Xie","year":"2018","journal-title":"Theranostics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41565-019-0523-x","article-title":"On the Issue of Transparency and Reproducibility in Nanomedicine","volume":"14","author":"Leong","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11295","DOI":"10.1038\/s41598-018-29618-w","article-title":"Magnetite-Gold Nanohybrids as Ideal All-in-One Platforms for Theranostics","volume":"8","author":"Efremova","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"26039","DOI":"10.1021\/acsami.8b08555","article-title":"Keratin-Templated Synthesis of Metallic Oxide Nanoparticles as MRI Contrast Agents and Drug Carriers","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17236","DOI":"10.1039\/C8NR03741H","article-title":"An All-in-One Nanoparticle (AION) Contrast Agent for Breast Cancer Screening with DEM-CT-MRI-NIRF Imaging","volume":"10","author":"Hsu","year":"2018","journal-title":"Nanoscale"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"31947","DOI":"10.1021\/acsami.8b10564","article-title":"Ternary-Responsive Drug Delivery with Activatable Dual Mode Contrast-Enhanced in Vivo Imaging","volume":"10","author":"Ren","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cbi.2018.08.027","article-title":"Development of a Magnetic Nano-Graphene Oxide Carrier for Improved Glioma-Targeted Drug Delivery and Imaging: In Vitro and in Vivo Evaluations","volume":"295","author":"Shirvalilou","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e16601","DOI":"10.1016\/j.heliyon.2023.e16601","article-title":"Review on Magnetic Spinel Ferrite (MFe2O4) Nanoparticles: From Synthesis to Application","volume":"9","author":"Salih","year":"2023","journal-title":"Heliyon"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100303","DOI":"10.1016\/j.cscee.2023.100303","article-title":"Recent Trends of Spinel Ferrites (MFe2O4: Mn, Co, Ni, Cu, Zn) Applications as an Environmentally Friendly Catalyst in Multicomponent Reactions: A Review","volume":"7","author":"Liandi","year":"2023","journal-title":"Case Stud. Chem. Environ. Eng."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Sonia, L.C., and Phanjoubam, S. (2023). Optical, Magnetic and Spin Resonance Studies of MFe2O4 (M = Mn, Co, Zn) Ferrites. Mater. Today Proc., in press.","DOI":"10.1016\/j.matpr.2023.05.494"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.matpr.2022.07.429","article-title":"Synthesis, Characterization and Photo-Catalytic Activity of Magnetic CoFe2O4 Nanoparticles Prepared by Temperature Controlled Co-Precipitation Method","volume":"68","author":"Vishwas","year":"2022","journal-title":"Mater. Today Proc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jmmm.2019.02.048","article-title":"Structural, Morphological, Magnetic and Optical Study of Co-Precipitated Nd3+ Doped Mn-Zn Ferrite Nanoparticles","volume":"479","author":"Thakur","year":"2019","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/00150193.2018.1449440","article-title":"Characterization of As-Deposited and Sintered Mn0.5Zn0.5Fe2O4 Films Formed by Sol-Gel","volume":"528","author":"Duan","year":"2018","journal-title":"Ferroelectrics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1021\/acsanm.9b01305","article-title":"Amine-Functionalized and Hydroxyl-Functionalized Magnesium Ferrite Nanoparticles for Congo Red Adsorption","volume":"2","author":"Aoopngan","year":"2019","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"163403","DOI":"10.1016\/j.jallcom.2021.163403","article-title":"Structural and Magnetic Studies of NiFe2O4 and NiFe2O4@SiO2-Silane Agent Samples Useful for the Removal of Cu2+ Ions","volume":"899","author":"Ferrer","year":"2022","journal-title":"J. Alloys Compd."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Guo, P., Lv, M., Han, G., Wen, C., Wang, Q., Li, H., and Zhao, X.S. (2016). Solvothermal Synthesis of Hierarchical Colloidal Nanocrystal Assemblies of ZnFe2O4 and Their Application in Water Treatment. Materials, 9.","DOI":"10.3390\/ma9100806"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1250.e5","DOI":"10.1088\/2053-1591\/ab65e0","article-title":"Controlled Synthesis and Self-Assembly of ZnFe2O4 Nanoparticles into Microspheres by Solvothermal Method","volume":"6","author":"Shaterian","year":"2020","journal-title":"Mater. Res. Express"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s10965-021-02416-1","article-title":"Controllable synthesis of ZnFe2O4 sub-microparticles by poly(diallyldimethylammonium chloride)-assisted solvothermal method","volume":"28","author":"Shaterian","year":"2021","journal-title":"J. Polym. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1016\/j.ceramint.2015.03.072","article-title":"Finite Size Effect on Sm3+ Doped Mn0.5Zn0.5SmxFe2\u2212xO4 (0 \u2264 x \u2264 0.5) Ferrite Nanoparticles","volume":"41","author":"Yadav","year":"2015","journal-title":"Ceram. Int."},{"key":"ref_51","unstructured":"Saleh, T.A., Majeed, S., Nayak, A., and Bhushan, B. (2017). Advanced Nanomaterials for Water Engineering, Treatment, and Hydraulics, IGI Global."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12421","DOI":"10.1016\/j.ijhydene.2018.09.183","article-title":"Spinel-Type Ferrite Nanoparticles: Synthesis by the Oil-in-Water Microemulsion Reaction Method and Photocatalytic Water-Splitting Evaluation","volume":"44","year":"2019","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"14657","DOI":"10.1007\/s10854-018-9602-2","article-title":"Hydrothermal Synthesis of Nickel Doped Cobalt Ferrite Nanoparticles: Optical and Magnetic Properties","volume":"29","author":"Melo","year":"2018","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jallcom.2012.06.068","article-title":"Microwave Assisted Synthesis and Characterization of Co Doped Cu Ferrite Nanoparticles","volume":"540","author":"Azam","year":"2012","journal-title":"J. Alloys Compd."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF03353657","article-title":"Development of an Amperometric Hydrogen Peroxide Biosensor Based on the Immobilization of Horseradish Peroxidase onto Nickel Ferrite Nanoparticle-Chitosan Composite","volume":"3","author":"Baykal","year":"2011","journal-title":"Nano-Micro Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"161411","DOI":"10.1063\/1.5008733","article-title":"Microwave Assisted Scalable Synthesis of Titanium Ferrite Nanomaterials","volume":"123","author":"Shukla","year":"2018","journal-title":"J. Appl. Phys."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jallcom.2009.06.128","article-title":"Microwave Synthesis and Characterization of Zn-Doped Nickel Ferrite Nanoparticles","volume":"486","author":"Sertkol","year":"2009","journal-title":"J. Alloys Compd."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41598-018-38434-1","article-title":"Thermal Decomposition and Nonisothermal Kinetics of Monoethanolamine Mixed with Various Metal Ions","volume":"9","author":"Wei","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1021\/ie010697c","article-title":"Oxidative Degradation of Monoethanolamine","volume":"41","author":"Chi","year":"2002","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11270-020-4437-x","article-title":"Photocatalytic Performance of Zinc Ferrite Magnetic Nanostructures for Efficient Eriochrome Black-T Degradation from the Aqueous Environment under Unfiltered Sunlight","volume":"231","author":"Ikramullah","year":"2020","journal-title":"Water Air. Soil Pollut."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ultsonch.2017.08.024","article-title":"Sonochemical Synthesis of Gd3+ Doped CoFe2O4 Spinel Ferrite Nanoparticles and Its Physical Properties","volume":"40","author":"Yadav","year":"2018","journal-title":"Ultrason. Sonochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.colsurfa.2013.01.064","article-title":"Facile Synthesis of Cobalt Ferrite Submicrospheres with Tunable Magnetic and Electrocatalytic Properties","volume":"423","author":"Cui","year":"2013","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1166\/jnn.2015.10347","article-title":"Synthesis and Characterization of Cobalt Substituted Zinc Ferrite Nanoparticles by Microwave Combustion Method","volume":"15","author":"Sundararajan","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_64","unstructured":"Vahak, M. (2015). Magnetic Properties of Nano-Glass Ceramics, William Andrew Publishing."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00339-019-2760-0","article-title":"Dielectric, Magnetic Hyperthermia, and Photocatalytic Properties of ZnFe2O4 Nanoparticles Synthesized by Solvothermal Reflux Method","volume":"125","author":"Manohar","year":"2019","journal-title":"Appl. Phys. A Mater. Sci. Process."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.physb.2011.02.072","article-title":"Synthesis, Structural, Magnetic and Optical Properties of Nanocrystalline ZnFe2O4","volume":"406","author":"Lemine","year":"2011","journal-title":"Phys. B Condens. Matter"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8654","DOI":"10.1007\/s10854-016-4886-6","article-title":"Hydrothermal Method for Synthesizing ZnFe2O4 Nanoparticles, Photo-Degradation of Rhodamine B by ZnFe2O4 and Thermal Stable PS-Based Nanocomposite","volume":"27","author":"Golsefidi","year":"2016","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1007\/s10948-017-4153-y","article-title":"Structural and Magnetic Studies of Nano-Crystalline Ferrites MFe2O4 (M = Zn, Ni, Cu, and Co) Synthesized Via Citrate Gel Autocombustion Method","volume":"30","author":"Ramesh","year":"2017","journal-title":"J. Supercond. Nov. Magn."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1166\/jnn.2016.11037","article-title":"The Role of Mn2+-Doping on Structural, Morphological, Optical, Magnetic and Catalytic Properties of Spinel ZnFe2O4 Nanoparticles","volume":"16","author":"Hema","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1016\/j.ceramint.2019.11.045","article-title":"Structural, Dielectric and Magnetic Properties of (ZnFe2O4\/Polystyrene) Nanocomposites Synthesized by Micro-Emuslion Technique","volume":"46","author":"Abbas","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1021\/jp0732763","article-title":"ZnFe2O4 Nanocrystals:\u2009 Synthesis and Magnetic Properties","volume":"111","author":"Yao","year":"2007","journal-title":"J. Phys. Chem. C"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"459","DOI":"10.17586\/2220-8054-2016-7-3-459-463","article-title":"The Characterization of Nanosized ZnFe2O4 Material Prepared by Coprecipitation","volume":"7","author":"Nguyen","year":"2016","journal-title":"Nanosyst. Phys. Chem. Math."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Chen, C., Ge, J., Gao, Y., Chen, L., Cui, J., Zeng, J., and Gao, M. (2022). Ultrasmall Superparamagnetic Iron Oxide Nanoparticles: A next Generation Contrast Agent for Magnetic Resonance Imaging. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 14.","DOI":"10.1002\/wnan.1740"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1148\/rg.254055027","article-title":"AAPM\/RSNA Physics Tutorial for Residents: Fundamental Physics of MR Imaging","volume":"25","author":"Pooley","year":"2005","journal-title":"Radiographics"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1148\/rg.295095034","article-title":"Principles, Techniques, and Applications of T2*-Based MR Imaging and Its Special Applications","volume":"29","author":"Chavhan","year":"2009","journal-title":"Radiographics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-2004-861764","article-title":"Cartilage MRI T2 Relaxation Time Mapping: Overview and Applications","volume":"8","author":"Mosher","year":"2004","journal-title":"Semin. Musculoskelet. Radiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cis.2014.07.015","article-title":"Aggregation Kinetics and Colloidal Stability of Functionalized Nanoparticles","volume":"222","author":"Gambinossi","year":"2015","journal-title":"Adv. Colloid Interface Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16203\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:21:27Z","timestamp":1760131287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,11]]},"references-count":77,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["ijms242216203"],"URL":"https:\/\/doi.org\/10.3390\/ijms242216203","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,11]]}}}