{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:07:55Z","timestamp":1785337675755,"version":"3.55.0"},"reference-count":130,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leducq Foundation","award":["19CV03"],"award-info":[{"award-number":["19CV03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a role in post-transcriptional gene regulation. It is generally accepted that their main mechanism of action is the negative regulation of gene expression, through binding to specific regions in messenger RNA (mRNA) and repressing protein translation. By interrupting protein synthesis, miRNAs can effectively turn genes off and influence many basic processes in the body, such as developmental and apoptotic behaviours of cells and cardiac organogenesis. Their importance is highlighted by inhibiting or overexpressing certain miRNAs, which will be discussed in the context of coronary artery disease, atrial fibrillation, bradycardia, and heart failure. Dysregulated levels of miRNAs in the body can exacerbate or alleviate existing disease, and their omnipresence in the body makes them reliable as quantifiable markers of disease. This review aims to provide a summary of miRNAs as biomarkers and their interactions with targets that affect cardiac health, and intersperse it with current therapeutic knowledge. It intends to succinctly inform on these topics and guide readers toward more comprehensive works if they wish to explore further through a wide-ranging citation list.<\/jats:p>","DOI":"10.3390\/ijms242216207","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:02:42Z","timestamp":1699840962000},"page":"16207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment"],"prefix":"10.3390","volume":"24","author":[{"given":"Emman","family":"Asjad","sequence":"first","affiliation":[{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-5975","authenticated-orcid":false,"given":"Halina","family":"Dobrzynski","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK"},{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0300985813502820","article-title":"MicroRNAs: History, Biogenesis, and Their Evolving Role in Animal Development and Disease","volume":"51","author":"Bhaskaran","year":"2014","journal-title":"Vet. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00268-008-9836-x","article-title":"MicroRNAs: Control and Loss of Control in Human Physiology and Disease","volume":"33","author":"Li","year":"2009","journal-title":"World J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.108.192872","article-title":"MicroRNA Regulation of Cardiovascular Development","volume":"104","author":"Cordes","year":"2009","journal-title":"Circ. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Laggerbauer, B., and Engelhardt, S. (2022). MicroRNAs as therapeutic targets in cardiovascular disease. J. Clin. Investig., 132.","DOI":"10.1172\/JCI159179"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Colpaert, R.M.W., and Calore, M. (2019). MicroRNAs in Cardiac Diseases. Cells, 8.","DOI":"10.3390\/cells8070737"},{"key":"ref_8","first-page":"794898","article-title":"MicroRNAs in vascular biology","volume":"2012","author":"Yamakuchi","year":"2012","journal-title":"Int. J. Vasc. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Gregorova, J., Vychytilova-Faltejskova, P., and Sevcikova, S. (2021). Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development. Cancers, 13.","DOI":"10.3390\/cancers13061333"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Catalanotto, C., Cogoni, C., and Zardo, G. (2016). MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101712"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Rauhut","year":"2001","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.tig.2015.09.002","article-title":"microRNA nomenclature: A view incorporating genetic origins, biosynthetic pathways, and sequence variants","volume":"31","author":"Desvignes","year":"2015","journal-title":"Trends Genet."},{"key":"ref_13","unstructured":"(2023, March 27). Cardiovascular Diseases (CVDs). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Szyde\u0142ko, J., and Matyjaszek-Matuszek, B. (2023). MicroRNAs as Biomarkers for Coronary Artery Disease Related to Type 2 Diabetes Mellitus\u2014From Pathogenesis to Potential Clinical Application. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010616"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kumar, D., Narang, R., Sreenivas, V., Rastogi, V., Bhatia, J., Saluja, D., and Srivastava, K. (2020). Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease. Genes, 11.","DOI":"10.3390\/genes11020164"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fphar.2019.00463","article-title":"miR-155 in the Resolution of Atherosclerosis","volume":"10","author":"Pompella","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_17","first-page":"179","article-title":"Circulating microRNAs as possible biomarkers for coronary artery disease: A narrative review","volume":"30","author":"Melak","year":"2019","journal-title":"EJIFCC"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nm1569","article-title":"The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2","volume":"13","author":"Yang","year":"2007","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1161\/CIRCULATIONAHA.110.958967","article-title":"MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation","volume":"122","author":"Lu","year":"2010","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E28980","DOI":"10.1097\/MD.0000000000028980","article-title":"Upregulated miR-328-3p and its high risk in atrial fibrillation: A systematic review and meta-analysis with meta-regression","volume":"101","author":"Huang","year":"2022","journal-title":"Medicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jjcc.2015.12.007","article-title":"Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation","volume":"68","author":"Soeki","year":"2016","journal-title":"J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.11.007","article-title":"Finding Ms or Mr Right: Which miRNA to target in AF?","volume":"102","author":"Molina","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCULATIONAHA.112.001207","article-title":"MicroRNA29: A mechanistic contributor and potential biomarker in atrial fibrillation","volume":"127","author":"Dawson","year":"2013","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1681\/ASN.2010121308","article-title":"TGF-\u03b2\/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29","volume":"22","author":"Qin","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/FJC.0000000000000732","article-title":"MicroRNA-200a-3p Is a Positive Regulator in Cardiac Hypertrophy through Directly Targeting WDR1 as Well as Modulating PTEN\/PI3K\/AKT\/CREB\/WDR1 Signaling","volume":"74","author":"Yang","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1007\/s11033-022-07468-0","article-title":"Interplay between PI3K\/AKT pathway and heart disorders","volume":"49","author":"Sasi","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/CIRCHEARTFAILURE.113.000266","article-title":"MicroRNAs in Heart Failure","volume":"7","author":"Melman","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/CIRCRESAHA.110.218297","article-title":"MiR423-5p As a Circulating Biomarker for Heart Failure","volume":"106","author":"Tijsen","year":"2010","journal-title":"Circ. Res."},{"key":"ref_29","first-page":"4736","article-title":"Plasma levels of microRNA-21,-126 and-423-5p alter During clinical improvement and are associated with the prognosis of acute heart failure","volume":"17","author":"Silvello","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/eurheartj\/ehaa898","article-title":"Novel antisense therapy targeting microRNA-132 in patients with heart failure: Results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study","volume":"42","author":"Hauke","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e016590","DOI":"10.1161\/JAHA.120.016590","article-title":"Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node","volume":"9","author":"Petkova","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19328","DOI":"10.1038\/s41598-021-98580-x","article-title":"Altered microRNA and mRNA profiles during heart failure in the human sinoatrial node","volume":"11","author":"Li","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Aminu, A.J., Petkova, M., Chen, W., Yin, Z., Kuzmin, V.S., Atkinson, A.J., and Dobrzynski, H. (2021). MiR-486-3p and MiR-938\u2014Important Inhibitors of Pacemaking Ion Channels and\/or Markers of Immune Cells. Appl. Sci., 11.","DOI":"10.3390\/app112311366"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20045","DOI":"10.1074\/jbc.M801035200","article-title":"Down-regulation of miR-1\/miR-133 Contributes to Re-expression of Pacemaker Channel Genes HCN2 and HCN4 in Hypertrophic Heart","volume":"283","author":"Luo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yjmcc.2015.02.003","article-title":"Sick sinus syndrome and atrial fibrillation in older persons\u2014A view from the sinoatrial nodal myocyte","volume":"83","author":"Monfredi","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yjmcc.2019.06.018","article-title":"MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels","volume":"134","author":"Zhang","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.117.311607","article-title":"Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia","volume":"121","author":"Pearman","year":"2017","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11279","DOI":"10.1038\/s41598-020-67790-0","article-title":"Silencing miR-370-3p rescues funny current and sinus node function in heart failure","volume":"10","author":"Yanni","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.hrthm.2023.01.021","article-title":"miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure","volume":"20","author":"Kang","year":"2023","journal-title":"Heart Rhythm"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature09783","article-title":"Pervasive roles of microRNAs in cardiovascular biology","volume":"469","author":"Small","year":"2011","journal-title":"Nature."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/heartjnl-2013-305402","article-title":"MicroRNAs in cardiovascular disease: An introduction for clinicians","volume":"101","author":"Romaine","year":"2015","journal-title":"Heart"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-12-398459-3.00006-X","article-title":"Roles of MicroRNAs and Myocardial Cell Differentiation","volume":"111","author":"Takaya","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2007.03.030","article-title":"Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2","volume":"129","author":"Zhao","year":"2007","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1161\/CIRCULATIONAHA.120.050098","article-title":"MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel","volume":"143","author":"Yang","year":"2021","journal-title":"Circulation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yjmcc.2021.05.001","article-title":"Dual role of miR-1 in the development and function of sinoatrial cells","volume":"157","author":"Benzoni","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"010621188335","DOI":"10.2174\/1573403X16999201124201021","article-title":"Potential Roles of MyomiRs in Cardiac Development and Related Diseases","volume":"17","author":"Abkhooie","year":"2021","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yjmcc.2016.03.015","article-title":"Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction)","volume":"94","author":"Chistiakov","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_48","unstructured":"Carter, M., and Shieh, J. (2015). Guide to Research Techniques in Neuroscience, Academic Press."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhou, W., Cai, H., Li, J., Xu, H., Wang, X., Men, H., Zheng, Y., and Cai, L. (2021). Potential roles of mediator Complex Subunit 13 in Cardiac Diseases. Int. J. Biol. Sci., 17.","DOI":"10.7150\/ijbs.52290"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1365-2362.2007.01878.x","article-title":"MicroRNAs in the broken heart","volume":"37","author":"Bauersachs","year":"2007","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.jacc.2004.09.044","article-title":"Impact of beta-myosin heavy chain expression on cardiac function during stress","volume":"44","author":"Krenz","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"116547","DOI":"10.1016\/j.lfs.2019.116547","article-title":"Value of the expression of miR-208, miR-494, miR-499 and miR-1303 in early diagnosis of acute myocardial infarction","volume":"232","author":"Li","year":"2019","journal-title":"Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0735-1097(17)33479-4","article-title":"MIR-499 protects the rat heart against ischemia\/reperfusion injury through pdcd4 during ischemic postconditioning-regulated","volume":"69","author":"Zhu","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_54","unstructured":"Cristina Caroleo, M., and De Sarro, G. (2022). MicroRNA: From Bench to Bedside, Academic Press."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.mcb.2019.05.006","article-title":"Manipulation of renal gene expression using oligonucleotides","volume":"154","author":"Lakhia","year":"2019","journal-title":"Methods Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4939-6563-2_3","article-title":"Non-nucleotide Modification of Anti-miRNA Oligonucleotides","volume":"1517","author":"Lennox","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/17460441.2020.1765770","article-title":"Challenges identifying efficacious miRNA therapeutics for cancer","volume":"15","author":"Segal","year":"2020","journal-title":"Expert Opin Drug Discov."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fphar.2016.00329","article-title":"MicroRNA-based therapy in animal models of selected gastrointestinal cancers","volume":"7","author":"Merhautova","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1007\/s11095-011-0550-2","article-title":"The therapeutic potential of microRNAs: Disease modulators and drug targets","volume":"28","author":"McDermott","year":"2011","journal-title":"Pharm. Res."},{"key":"ref_61","unstructured":"Y\u00fcce, M., Kurt, H., Hussain, B., and Budak, H. (2018). Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation, Elsevier."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/emmm.201100191","article-title":"MicroRNA therapeutics in cardiovascular medicine","volume":"4","author":"Thum","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.6061\/clinics\/2013(01)OA12","article-title":"Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction","volume":"68","author":"Li","year":"2013","journal-title":"Clinics."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5847\/wjem.j.issn.1920-8642.2014.03.004","article-title":"Comparison of plasma microRNA-1 and cardiac troponin T in early diagnosis of patients with acute myocardial infarction","volume":"5","author":"Li","year":"2014","journal-title":"World J. Emerg. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kramna, D., Riedlova, P., and Jirik, V. (2023). MicroRNAs as a Potential Biomarker in the Diagnosis of Cardiovascular Diseases. Medicina, 59.","DOI":"10.3390\/medicina59071329"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.3390\/ijms24065192","article-title":"miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives","volume":"24","author":"Sessa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref_67","unstructured":"(2023, April 05). Heart Statistics\u2014Heart and Circulatory Diseases in the UK\u2013BHF. Available online: https:\/\/www.bhf.org.uk\/what-we-do\/our-research\/heart-statistics."},{"key":"ref_68","first-page":"e9349","article-title":"Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"key":"ref_69","unstructured":"(2023, April 05). Atherosclerosis\u2014BHF. Available online: https:\/\/www.bhf.org.uk\/informationsupport\/conditions\/atherosclerosis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3389\/fcvm.2021.738325","article-title":"The Role of the VEGF Family in Coronary Heart Disease","volume":"8","author":"Zhou","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and Atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.18103\/mra.v8i5.2133","article-title":"An integrated hypothesis for miR-126 in vascular disease","volume":"8","author":"Yu","year":"2020","journal-title":"Med. Res. Arch."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2174\/1381612824666171227220815","article-title":"The Role of Angiogenesis in Coronary Artery Disease: A Double-Edged Sword: Intraplaque Angiogenesis in Physiopathology and Therapeutic Angiogenesis for Treatment","volume":"24","author":"Wu","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_74","first-page":"63","article-title":"Therapeutic Angiogenesis for Coronary Artery Disease","volume":"4","author":"Kopff","year":"2002","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/ATVBAHA.112.300279","article-title":"MicroRNA-126, -145, and -155","volume":"33","author":"Wei","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"10","DOI":"10.20517\/2347-8659.2018.01","article-title":"MicroRNA-126 is a prospective target for vascular disease","volume":"5","author":"Qu","year":"2018","journal-title":"Neuroimmunol. Neuroinflamm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.0707493105","article-title":"MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1","volume":"105","author":"Harris","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Fazmin, I.T., Achercouk, Z., Edling, C.E., Said, A., and Jeevaratnam, K. (2020). Circulating microRNA as a Biomarker for Coronary Artery Disease. Biomolecules, 10.","DOI":"10.3390\/biom10101354"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3389\/fcvm.2021.767064","article-title":"miR-21 in Human Cardiomyopathies","volume":"8","author":"Surina","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"632392","DOI":"10.3389\/fcvm.2021.632392","article-title":"Role of microRNAs in the pathogenesis of coronary artery disease","volume":"8","author":"Gholipour","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kong, A.S.-Y., Lai, K.-S., Lim, S.-H.E., Sivalingam, S., Loh, J.-Y., and Maran, S. (2022). miRNA in Ischemic Heart Disease and Its Potential as Biomarkers: A Comprehensive Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169001"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ehjqcco\/qcaa093","article-title":"Atrial fibrillation in the UK: Predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs","volume":"8","author":"Burdett","year":"2022","journal-title":"Eur. Heart J. Qual. Care Clin. Outcomes"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1137230","DOI":"10.3389\/fpubh.2023.1137230","article-title":"Estimates of the global, regional, and national burden of atrial fibrillation in older adults from 1990 to 2019: Insights from the Global Burden of Disease study 2019","volume":"11","author":"Jiao","year":"2023","journal-title":"Front. Public Health"},{"key":"ref_84","unstructured":"Nesheiwat, Z., Goyal, A., Jagtap, M., Shammas, A., and Atrial Fibrillation (Nursing) (2023, August 25). StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK568719\/."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fphys.2014.00015","article-title":"Atrial fibrillation and microRNAs","volume":"5","author":"Santulli","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_86","unstructured":"Goyal, A., Basit, H., Bhyan, P., and Zeltser, R. (2023, April 13). Reentry Arrhythmia. StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537089\/."},{"key":"ref_87","unstructured":"Issa, Z.F., Miller, J.M., and Zipes, D.P. (2012). Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald\u2019s Heart Disease, Elsevier."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"173131","DOI":"10.1016\/j.ejphar.2020.173131","article-title":"Metformin ameliorates cardiac conduction delay by regulating microRNA-1 in mice","volume":"881","author":"Lv","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.87.5.346","article-title":"Role of Gap Junctions in Cardiac Conduction and Development","volume":"87","author":"Lo","year":"2000","journal-title":"Circ. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI200317959","article-title":"Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression","volume":"111","author":"Miake","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pbiomolbio.2020.09.007","article-title":"MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation","volume":"159","author":"Ravelli","year":"2021","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/j.1540-8159.2010.02838.x","article-title":"The Anatomy and Physiology of the Sinoatrial Node\u2014A Contemporary Review","volume":"33","author":"Monfredi","year":"2010","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00003495-200767002-00003","article-title":"The funny current: Cellular basis for the control of heart rate","volume":"67","author":"DiFrancesco","year":"2007","journal-title":"Drugs."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pbiomolbio.2021.04.008","article-title":"Further insights into the molecular complexity of the human sinus node\u2014The role of \u2018novel\u2019 transcription factors and microRNAs","volume":"166","author":"Aminu","year":"2021","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pbiomolbio.2022.11.005","article-title":"Pacemaker activity and ion channels in the sinoatrial node cells: MicroRNAs and arrhythmia","volume":"177","author":"Fan","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1038\/s41598-017-07694-8","article-title":"High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling","volume":"7","author":"Stephenson","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.3892\/mmr.2015.3831","article-title":"Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4097\/kjae.2015.68.4.415","article-title":"Tachycardia-bradycardia syndrome in a patient with atrial fibrillation: A case report","volume":"68","author":"Choi","year":"2015","journal-title":"Korean J. Anesthesiol."},{"key":"ref_99","first-page":"30","article-title":"Sinus Node Dysfunction in Atrial Fibrillation: Cause or Effect?","volume":"1","author":"Kezerashvili","year":"2008","journal-title":"J. Atr. Fibrillation."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1073\/pnas.1405411111","article-title":"Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/B978-0-12-385118-5.00006-2","article-title":"Quantitative real-time PCR-based analysis of gene expression","volume":"500","author":"Jozefczuk","year":"2011","journal-title":"Methods Enzymol."},{"key":"ref_102","unstructured":"Hafeez, Y., and Grossman, S.A. (2023, July 31). Sinus Bradycardia. StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK493201\/."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"B\u00f6hm, A., Vachalcova, M., Snopek, P., Bacharova, L., Komarova, D., and Hatala, R. (2020). Molecular Mechanisms, Diagnostic Aspects and Therapeutic Opportunities of Micro Ribonucleic Acids in Atrial Fibrillation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082742"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/cvr\/cvq350","article-title":"MicroRNAs and atrial fibrillation: New fundamentals","volume":"89","author":"Wang","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.120.019338","article-title":"Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease","volume":"10","author":"Hall","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/ATVBAHA.112.300137","article-title":"MicroRNAs in Myocardial Infarction","volume":"33","author":"Fiedler","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_107","unstructured":"(2023, April 19). Definition | Background Information|Heart Failure\u2014Chronic|CKS|NICE. Available online: https:\/\/cks.nice.org.uk\/topics\/heart-failure-chronic\/background-information\/definition\/."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.bbadis.2016.11.034","article-title":"The role of microRNAs in heart failure","volume":"1863","author":"Wang","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/CIRCRESAHA.108.183087","article-title":"The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure","volume":"103","author":"Editor","year":"2008","journal-title":"Circ. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ejhf.495","article-title":"MicroRNAs in heart failure: From biomarker to target for therapy","volume":"18","author":"Vegter","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_111","unstructured":"Coronado, R.E. (2018). Perinatal Stem Cells: Research and Therapy, Academic Press."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the Heart","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/CIRCULATIONAHA.112.000882","article-title":"MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors","volume":"127","author":"Ganesan","year":"2013","journal-title":"Circulation"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/hrt.2005.071233","article-title":"Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine","volume":"92","author":"Weber","year":"2006","journal-title":"Heart."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbadis.2012.12.014","article-title":"Biomarkers and diagnostics in heart failure","volume":"1832","author":"Gaggin","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCULATIONAHA.119.042474","article-title":"Regulatory RNAs in Heart Failure","volume":"141","author":"Gomes","year":"2020","journal-title":"Circulation"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Chan, C.S., Lin, Y.K., Chen, Y.C., Lu, Y.Y., Chen, S.A., and Chen, Y.J. (2019). Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133224"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1136\/heartjnl-2021-319605","article-title":"Heart failure with preserved ejection fraction: Recent concepts in diagnosis, mechanisms and management","volume":"108","author":"Gevaert","year":"2022","journal-title":"Heart"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/CIRCULATIONAHA.121.054976","article-title":"Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction","volume":"145","author":"Mesquita","year":"2022","journal-title":"Circulation"},{"key":"ref_120","first-page":"33","article-title":"Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome","volume":"5","author":"Tran","year":"2019","journal-title":"J. Clin. Transl. Res."},{"key":"ref_121","first-page":"510","article-title":"Acute Decompensated Heart Failure: Contemporary Medical Management","volume":"36","author":"Joseph","year":"2009","journal-title":"Tex. Heart Inst. J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1007\/s00204-021-03150-9","article-title":"Systems analysis of miRNA biomarkers to inform drug safety","volume":"95","author":"Schofield","year":"2021","journal-title":"Arch. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ijcard.2012.01.075","article-title":"Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction","volume":"167","author":"Olivieri","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.healun.2022.06.019","article-title":"Circulating microRNAs in cellular and antibody-mediated heart transplant rejection","volume":"41","author":"Shah","year":"2022","journal-title":"J. Heart Lung Transplant."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1038\/s41598-020-70848-8","article-title":"Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury","volume":"10","author":"Florijn","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ahj.2012.08.004","article-title":"Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction","volume":"164","author":"Eitel","year":"2012","journal-title":"Am. Heart J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1536\/ihj.18-306","article-title":"Serum Circulating miR-150 is a Predictor of Post-Acute Myocardial Infarction Heart Failure","volume":"60","author":"Lin","year":"2019","journal-title":"Int. Heart J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/cvr\/cvab210","article-title":"Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure","volume":"118","author":"Couch","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","article-title":"Idiopathic Dilated Cardiomyopathy","volume":"331","author":"Dec","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1002\/ehf2.13458","article-title":"Circulating microRNA-29-5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease","volume":"8","author":"Brundin","year":"2021","journal-title":"ESC Heart Fail."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:21:29Z","timestamp":1760131289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,11]]},"references-count":130,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["ijms242216207"],"URL":"https:\/\/doi.org\/10.3390\/ijms242216207","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,11]]}}}