{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:43:41Z","timestamp":1785422621905,"version":"3.56.0"},"reference-count":156,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020407","name":"ERA-CVD","doi-asserted-by":"publisher","award":["ANR-19-ECVD-0002"],"award-info":[{"award-number":["ANR-19-ECVD-0002"]}],"id":[{"id":"10.13039\/501100020407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Congenital heart defects (CHDs) are the most common form of birth defects in humans. They occur in 9 out of 1000 live births and are defined as structural abnormalities of the heart. Understanding CHDs is difficult due to the heterogeneity of the disease and its multifactorial etiology. Advances in genomic sequencing have made it possible to identify the genetic factors involved in CHDs. However, genetic origins have only been found in a minority of CHD cases, suggesting the contribution of non-inherited (environmental) risk factors to the etiology of CHDs. Maternal pregestational diabetes is associated with a three- to five-fold increased risk of congenital cardiopathies, but the underlying molecular mechanisms are incompletely understood. According to current hypotheses, hyperglycemia is the main teratogenic agent in diabetic pregnancies. It is thought to induce cell damage, directly through genetic and epigenetic dysregulations and\/or indirectly through production of reactive oxygen species (ROS). The purpose of this review is to summarize key findings on the molecular mechanisms altered in cardiac development during exposure to hyperglycemic conditions in utero. It also presents the various in vivo and in vitro techniques used to experimentally model pregestational diabetes. Finally, new approaches are suggested to broaden our understanding of the subject and develop new prevention strategies.<\/jats:p>","DOI":"10.3390\/ijms242216258","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T08:35:52Z","timestamp":1699864552000},"page":"16258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Maternal Pre-Existing Diabetes: A Non-Inherited Risk Factor for Congenital Cardiopathies"],"prefix":"10.3390","volume":"24","author":[{"given":"St\u00e9phanie","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Aix Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-158X","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Gaborit","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolic Diseases and Nutrition, P\u00f4le ENDO, APHM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-5753","authenticated-orcid":false,"given":"Marien","family":"Lenoir","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery, La Timone Children Hospital, APHM, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenaelle","family":"Collod-Beroud","sequence":"additional","affiliation":[{"name":"Aix Marseille University, INSERM, Marseille Medical Genetics, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-2534","authenticated-orcid":false,"given":"Sonia","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Aix Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF Diabetes Atlas: Global Estimates for the Prevalence of Diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cll.2013.03.017","article-title":"New Concepts in Diabetic Embryopathy","volume":"33","author":"Zhao","year":"2013","journal-title":"Clin. Lab. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000371628","article-title":"Gestational Diabetes Mellitus and Macrosomia: A Literature Review","volume":"66","author":"Kc","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth Prevalence of Congenital Heart Disease Worldwide","volume":"58","author":"Konings","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e011541","DOI":"10.1161\/JAHA.119.011541","article-title":"Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring","volume":"9","author":"Helle","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cjca.2017.01.024","article-title":"Cost of Congenital Heart Disease Hospitalizations in Canada: A Population-Based Study","volume":"33","author":"Mackie","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/CIRCRESAHA.116.309140","article-title":"Genetics and Genomics of Congenital Heart Disease","volume":"120","author":"Zaidi","year":"2017","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.115.017465","article-title":"Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease: A Nationwide Cohort Study","volume":"133","author":"Diaz","year":"2016","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nature06801","article-title":"The Developmental Genetics of Congenital Heart Disease","volume":"451","author":"Bruneau","year":"2008","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kalisch-Smith, J.I., Ved, N., and Sparrow, D.B. (2020). Environmental Risk Factors for Congenital Heart Disease. Cold Spring Harb. Perspect. Biol., 12.","DOI":"10.1101\/cshperspect.a037234"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1750-1172-3-27","article-title":"Transposition of the Great Arteries","volume":"3","author":"Martins","year":"2008","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jmg.2008.057984","article-title":"Double Outlet Right Ventricle: Aetiologies and Associations","volume":"45","author":"Obler","year":"2008","journal-title":"J. Med. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0167-5273(91)90329-N","article-title":"Morphogenetic Considerations on Congenital Malformations of the Outflow Tract. Part 1: Common Arterial Trunk and Tetralogy of Fallot","volume":"32","author":"Bartelings","year":"1991","journal-title":"Int. J. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(13)62145-5","article-title":"Atrial Septal Defects","volume":"383","author":"Geva","year":"2014","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ijcard.2015.09.081","article-title":"Atrioventricular Septal Defect: From Embryonic Development to Long-Term Follow-Up","volume":"202","author":"Calkoen","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0140-6736(09)60563-8","article-title":"Hypoplastic Left Heart Syndrome","volume":"374","author":"Barron","year":"2009","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1016\/j.jacc.2009.12.068","article-title":"Bicuspid Aortic Valve Disease","volume":"55","author":"Siu","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1017\/S1047951117002244","article-title":"Nomenclature for Congenital and Paediatric Cardiac Disease: The International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Iteration of the International Classification of Diseases (ICD-11)","volume":"27","author":"Franklin","year":"2017","journal-title":"Cardiol. Young"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/CIRCGENETICS.115.001324","article-title":"Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease","volume":"9","author":"LaHaye","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00246-011-0034-5","article-title":"The Contribution of Chromosomal Abnormalities to Congenital Heart Defects: A Population-Based Study","volume":"32","author":"Hartman","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/B978-0-12-387786-4.00008-7","article-title":"Transcription Factor Pathways and Congenital Heart Disease","volume":"Volume 100","author":"McCulley","year":"2012","journal-title":"Current Topics in Developmental Biology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCRESAHA.112.300853","article-title":"Genetics of Congenital Heart Disease: The Glass Half Empty","volume":"112","author":"Fahed","year":"2013","journal-title":"Circ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"a008292","DOI":"10.1101\/cshperspect.a008292","article-title":"Signaling and Transcriptional Networks in Heart Development and Regeneration","volume":"5","author":"Bruneau","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/35065105","article-title":"Tbx1 Haploinsufficiency in the DiGeorge Syndrome Region Causes Aortic Arch Defects in Mice","volume":"410","author":"Lindsay","year":"2001","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1096-8628(19990319)83:3<201::AID-AJMG11>3.0.CO;2-V","article-title":"GATA4 Haploinsufficiency in Patients with Interstitial Deletion of Chromosome Region 8p23.1 and Congenital Heart Disease","volume":"83","author":"Pehlivan","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ng.2637","article-title":"Genome-Wide Association Study of Multiple Congenital Heart Disease Phenotypes Identifies a Susceptibility Locus for Atrial Septal Defect at Chromosome 4p16","volume":"45","author":"Cordell","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.aac9396","article-title":"De Novo Mutations in Congenital Heart Disease with Neurodevelopmental and Other Congenital Anomalies","volume":"350","author":"Homsy","year":"2015","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/bdrc.21096","article-title":"Thalidomide-induced Teratogenesis: History and Mechanisms","volume":"105","author":"Vargesson","year":"2015","journal-title":"Birth Defect. Res. C"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.15171\/apb.2018.044","article-title":"Isotretinoin; A Review on the Utilization Pattern in Pregnancy","volume":"8","author":"Khiali","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0140-6736(74)91918-7","article-title":"Lithium, Ebstein\u2019s Anomaly, and Other Congenital Heart Defects","volume":"304","author":"Nora","year":"1974","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium Inhibits Glycogen Synthase Kinase-3 Activity and Mimics Wingless Signalling in Intact Cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdra.20621","article-title":"An Update on Cardiovascular Malformations in Congenital Rubella Syndrome","volume":"88","author":"Oster","year":"2009","journal-title":"Birth Defect. Res. A"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/tera.1420020406","article-title":"Congenital Defects in Guinea Pigs: Fetal Resorptions, Abortions, and Malformations Following Induced Hyperthermia during Early Gestation","volume":"2","author":"Edwards","year":"1969","journal-title":"Teratology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijcard.2009.11.008","article-title":"Periconceptional Tobacco Smoking and Xisolated Congenital Heart Defects in the Neonatal Period","volume":"148","author":"Karatza","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jpeds.2021.09.005","article-title":"Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997\u20132011","volume":"240","author":"Bolin","year":"2022","journal-title":"J. Pediatr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1747-0803.2007.00105.x","article-title":"Congenital Heart Defects and Fetal Alcohol Spectrum Disorders","volume":"2","author":"Burd","year":"2007","journal-title":"Congenit. Heart Dis."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yang, J., Qiu, H., Qu, P., Zhang, R., Zeng, L., and Yan, H. (2015). Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130681"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mao, B., Qiu, J., Zhao, N., Shao, Y., Dai, W., He, X., Cui, H., Lin, X., Lv, L., and Tang, Z. (2017). Maternal Folic Acid Supplementation and Dietary Folate Intake and Congenital Heart Defects. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187996"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00404-019-05376-6","article-title":"Risk of Congenital Heart Defects in Offspring Exposed to Maternal Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis","volume":"300","author":"Chen","year":"2019","journal-title":"Arch. Gynecol. Obs."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/aje\/kwx033","article-title":"Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes","volume":"186","author":"Hoang","year":"2017","journal-title":"Am. J. Epidemiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0084-3954(09)79344-3","article-title":"Maternal Overweight and Obesity and the Risk of Congenital Anomalies: A Systematic Review and Meta-Analysis","volume":"2010","author":"Stockman","year":"2010","journal-title":"Yearb. Pediatr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10995-022-03538-8","article-title":"Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis","volume":"27","author":"Wu","year":"2023","journal-title":"Matern. Child. Health J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/ajmg.a.35896","article-title":"Development of the Human Heart","volume":"164","author":"Sylva","year":"2014","journal-title":"Am. J. Med. Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41569-018-0086-9","article-title":"The Deployment of Cell Lineages That Form the Mammalian Heart","volume":"15","author":"Meilhac","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ajmg.c.31778","article-title":"Development of the Human Heart","volume":"184","author":"Buijtendijk","year":"2020","journal-title":"Am. J. Med. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/dbio.2000.9753","article-title":"Chamber Formation and Morphogenesis in the Developing Mammalian Heart","volume":"223","author":"Christoffels","year":"2000","journal-title":"Dev. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/dvdy.21725","article-title":"Origin and Fate of Cardiac Mesenchyme","volume":"237","author":"Snarr","year":"2008","journal-title":"Dev. Dyn."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1242\/dev.124883","article-title":"The Formation and Function of the Cardiac Conduction System","volume":"143","author":"Christoffels","year":"2016","journal-title":"Development"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/179827","article-title":"Regulation of Nutrient Transport across the Placenta","volume":"2012","author":"Lager","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/01.CIR.99.4.578","article-title":"Glucose for the Heart","volume":"99","author":"Depre","year":"1999","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"30409","DOI":"10.1074\/jbc.R200006200","article-title":"The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function","volume":"277","author":"Owen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/jcp.27164","article-title":"A Review of the Molecular Mechanisms of Hyperglycemia-induced Free Radical Generation Leading to Oxidative Stress","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0003-9861(71)90367-5","article-title":"Studies of Mitochondrial Development during Embryogenesis in the Rat","volume":"144","author":"Mackler","year":"1971","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_56","first-page":"235","article-title":"Metabolite Utilization by Isolated Embryonic Rat Hearts in Vitro","volume":"28","author":"Cox","year":"1972","journal-title":"J. Embryol. Exp. Morphol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e29330","DOI":"10.7554\/eLife.29330","article-title":"Glucose Inhibits Cardiac Muscle Maturation through Nucleotide Biosynthesis","volume":"6","author":"Nakano","year":"2017","journal-title":"eLife"},{"key":"ref_58","first-page":"1554","article-title":"Glucose Transporter Protein Expression in Human Placenta throughout Gestation and in Intrauterine Growth Retardation","volume":"77","author":"Jansson","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2741\/1216","article-title":"Glucose Transport in the Heart","volume":"9","author":"Abel","year":"2004","journal-title":"Front. Biosci."},{"key":"ref_60","unstructured":"Terjung, R. (2015). Comprehensive Physiology, John Wiley & Sons."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF00400202","article-title":"Myo-Inositol and Prostaglandins Reverse the Glucose Inhibition of Neural Tube Fusion in Cultured Mouse Embryos","volume":"33","author":"Baker","year":"1990","journal-title":"Diabetologia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/bdra.20704","article-title":"Understanding Diabetic Teratogenesis: Where Are We Now and Where Are We Going?","volume":"88","author":"Zabihi","year":"2010","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00279946","article-title":"Effects of Glucose on Rat Embryos in Culture","volume":"25","author":"Garnham","year":"1983","journal-title":"Diabetologia"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1055\/s-0043-109696","article-title":"High Glucose Level Induces Cardiovascular Dysplasia During Early Embryo Development","volume":"127","author":"Jin","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2018.10.010","article-title":"A Short Periconceptional Exposure to Maternal Type-1 Diabetes Is Sufficient to Disrupt the Feto-Placental Phenotype in a Rabbit Model","volume":"480","author":"Thieme","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lock, M., Botting, K., Tellam, R., Brooks, D., and Morrison, J. (2017). Adverse Intrauterine Environment and Cardiac MiRNA Expression. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122628"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.bbagen.2014.05.017","article-title":"Diabetes, Oxidative Stress and Therapeutic Strategies","volume":"1840","author":"Rochette","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Gen. Subj."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00059-010-3244-3","article-title":"Congenital Heart Disease in Pregnancies Complicated by Maternal Diabetes Mellitus. An International Clinical Collaboration, Literature Review, and Meta-Analysis","volume":"35","author":"Lisowski","year":"2010","journal-title":"Herz"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/CIRCULATIONAHA.112.001054","article-title":"Association between Maternal Chronic Conditions and Congenital Heart Defects: A Population-Based Cohort Study","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e55124","DOI":"10.7554\/eLife.55124","article-title":"Hox-Dependent Coordination of Mouse Cardiac Progenitor Cell Patterning and Differentiation","volume":"9","author":"Stefanovic","year":"2020","journal-title":"eLife"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Stefanovic, S., Etchevers, H.C., and Zaffran, S. (2021). Outflow Tract Formation\u2014Embryonic Origins of Conotruncal Congenital Heart Disease. J. Cardiovasc. Dev. Dis., 8.","DOI":"10.3390\/jcdd8040042"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"112931","DOI":"10.1016\/j.yexcr.2021.112931","article-title":"Emergence of Heart and Branchiomeric Muscles in Cardiopharyngeal Mesoderm","volume":"410","author":"Lescroart","year":"2022","journal-title":"Exp. Cell Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"dev185256","DOI":"10.1242\/dev.185256","article-title":"Cardiopharyngeal Mesoderm Origins of Musculoskeletal and Connective Tissues in the Mammalian Pharynx","volume":"147","author":"Adachi","year":"2020","journal-title":"Development"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/j.yexcr.2010.04.029","article-title":"Core Issues in Craniofacial Myogenesis","volume":"316","author":"Kelly","year":"2010","journal-title":"Exp. Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Funato, N. (2022). Craniofacial Phenotypes and Genetics of DiGeorge Syndrome. J. Dev. Biol., 10.","DOI":"10.3390\/jdb10020018"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41569-021-00587-4","article-title":"Genomic Frontiers in Congenital Heart Disease","volume":"19","author":"Morton","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Manivannan, S., Mansfield, C., Zhang, X., Kodigepalli, K.M., Majumdar, U., Garg, V., and Basu, M. (2022). Single-Cell Transcriptomic Profiling Unveils Dysregulation of Cardiac Progenitor Cells and Cardiomyocytes in a Mouse Model of Maternal Hyperglycemia. Commun. Biol., 5.","DOI":"10.1038\/s42003-022-03779-x"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Han, S., Wang, G., Jin, Y., Ma, Z., Jia, W., Wu, X., Wang, X., He, M., Cheng, X., and Li, W. (2015). Investigating the Mechanism of Hyperglycemia-Induced Fetal Cardiac Hypertrophy. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139141"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S1047951108002138","article-title":"Assessment of Diastolic Ventricular Function in Fetuses of Diabetic Mothers Using Tissue Doppler","volume":"18","author":"Zielinsky","year":"2008","journal-title":"Cardiol. Young"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1080\/14767058.2017.1320544","article-title":"Transitional Hemodynamics in Infants of Diabetic Mothers by Targeted Neonatal Echocardiography, Electrocardiography and Peripheral Flow Study","volume":"31","author":"Schierz","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.earlhumdev.2012.02.006","article-title":"Myocardial Hypertrophy and Dysfunction in Maternal Diabetes","volume":"88","author":"Zielinsky","year":"2012","journal-title":"Early Hum. Dev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"290.e1","DOI":"10.1016\/j.ajog.2014.05.011","article-title":"Elevated Neonatal Insulin-like Growth Factor I Is Associated with Fetal Hypertrophic Cardiomyopathy in Diabetic Women","volume":"211","author":"Gonzalez","year":"2014","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1399-5448.2011.00811.x","article-title":"Infants of Diabetic Mothers: Echocardiographic Measurements and Cord Blood IGF-I and IGFBP-1","volume":"13","author":"Anwar","year":"2012","journal-title":"Pediatr. Diabetes"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1089\/dia.2014.0255","article-title":"Continuous Glucose Monitoring in Type 1 Diabetes Pregnancy Shows That Fetal Heart Rate Correlates with Maternal Glycemia","volume":"17","author":"Cypryk","year":"2015","journal-title":"Diabetes Technol. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/uog.26017","article-title":"Implications of Fetal Premature Atrial Contractions: Systematic Review","volume":"60","author":"Bet","year":"2022","journal-title":"Ultrasound Obs. Gyne"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/pr.2014.128","article-title":"A Detailed Comparison of Mouse and Human Cardiac Development","volume":"76","author":"Krishnan","year":"2014","journal-title":"Pediatr. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2840-6-34","article-title":"Maternal Diabetes Induces Congenital Heart Defects in Mice by Altering the Expression of Genes Involved in Cardiovascular Development","volume":"6","author":"Kumar","year":"2007","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"E611","DOI":"10.1152\/ajpendo.00043.2013","article-title":"Maternal Hyperglycemia Leads to Fetal Cardiac Hyperplasia and Dysfunction in a Rat Model","volume":"305","author":"Lehtoranta","year":"2013","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1096-9926(199610)54:4<183::AID-TERA2>3.0.CO;2-2","article-title":"Influence of Genetic and Maternal Diabetes in the Pathogenesis of Visceroatrial Heterotaxy in Mice","volume":"54","author":"Morishima","year":"1996","journal-title":"Teratology"},{"key":"ref_90","first-page":"800","article-title":"Timed Interruption of Insulin Therapy in Diabetic BB\/E Rat Pregnancy: Effect on Maternal Metabolism and Fetal Outcome","volume":"120","author":"Eriksson","year":"1989","journal-title":"Acta Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/15604280214933","article-title":"The Role of Reactive Oxygen Species in Diabetes-Induced Anomalies in Embryos of Cohen Diabetic Rats","volume":"3","author":"Zangen","year":"2002","journal-title":"Int. J. Exp. Diabetes Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.1038\/srep16917","article-title":"Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain","volume":"5","author":"Salbaum","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.2337\/db14-1683","article-title":"Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy","volume":"64","author":"Wu","year":"2015","journal-title":"Diabetes"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Jaime-Cruz, R., S\u00e1nchez-G\u00f3mez, C., Villavicencio-Guzm\u00e1n, L., Lazzarini-Lechuga, R., Pati\u00f1o-Morales, C.C., Garc\u00eda-Lorenzana, M., Ram\u00edrez-Fuentes, T.C., and Salazar-Garc\u00eda, M. (2023). Embryonic Hyperglycemia Disrupts Myocardial Growth, Morphological Development, and Cellular Organization: An In Vivo Experimental Study. Life, 13.","DOI":"10.3390\/life13030768"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/bdra.20654","article-title":"Elevated Glucose Induces Congenital Heart Defects by Altering the Expression of Tbx5, Tbx20, and Has2 in Developing Zebrafish Embryos","volume":"88","author":"Liang","year":"2010","journal-title":"Birth Defects Res. Part. A Clin. Mol. Teratol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-4939-8994-2_19","article-title":"Characterization of the Goto-Kakizaki (GK) Rat Model of Type 2 Diabetes","volume":"1916","author":"Guest","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1038\/s41467-021-25329-5","article-title":"Self-Assembling Human Heart Organoids for the Modeling of Cardiac Development and Congenital Heart Disease","volume":"12","author":"Wasserman","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e95085","DOI":"10.1172\/jci.insight.95085","article-title":"Epigenetic Mechanisms Underlying Maternal Diabetes-Associated Risk of Congenital Heart Disease","volume":"2","author":"Basu","year":"2017","journal-title":"JCI Insight"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13287-016-0446-5","article-title":"High Glucose Suppresses Embryonic Stem Cell Differentiation into Cardiomyocytes: High Glucose Inhibits ES Cell Cardiogenesis","volume":"7","author":"Yang","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"D\u00edaz Del Moral, S., Benaouicha, M., Mu\u00f1oz-Ch\u00e1puli, R., and Carmona, R. (2021). The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010234"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Pavlinkova, G., Salbaum, J.M., and Kappen, C. (2009). Maternal Diabetes Alters Transcriptional Programs in the Developing Embryo. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-274"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.gene.2012.12.071","article-title":"Differential Gene Expression Profiles during Embryonic Heart Development in Diabetic Mice Pregnancy","volume":"516","author":"Vijaya","year":"2013","journal-title":"Gene"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"919293","DOI":"10.3389\/fcvm.2022.919293","article-title":"Pregestational Diabetes Alters Cardiac Structure and Function of Neonatal Rats through Developmental Plasticity","volume":"9","author":"Alam","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2013.04.015","article-title":"Increased Susceptibility of HIF-1\u03b1 Heterozygous-Null Mice to Cardiovascular Malformations Associated with Maternal Diabetes","volume":"60","author":"Bohuslavova","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e009624","DOI":"10.1161\/JAHA.118.009624","article-title":"Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice","volume":"7","author":"Engineer","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/bdrb.20212","article-title":"Late-Gestation Ventricular Myocardial Reduction in Fetuses of Hyperglycemic CD1 Mice Is Associated with Increased Apoptosis","volume":"86","author":"Gutierrez","year":"2009","journal-title":"Birth Defect. Res. B"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.3181\/0806-RM-186","article-title":"Cardiac Malformations Are Associated with Altered Expression of Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase Genes in Embryos of Diabetic Mice","volume":"233","author":"Kumar","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_108","first-page":"3697","article-title":"Identification of Key Genes Associated with Congenital Heart Defects in Embryos of Diabetic Mice","volume":"17","author":"Lin","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1475-2840-13-46","article-title":"N-Acetylcysteine Prevents Congenital Heart Defects Induced by Pregestational Diabetes","volume":"13","author":"Moazzen","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2337\/db07-1016","article-title":"Specific Local Cardiovascular Changes of N\u025b-(Carboxymethyl)Lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes\u2013Induced Congenital Heart Defects","volume":"58","author":"Roest","year":"2009","journal-title":"Diabetes"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1111\/jcmm.14439","article-title":"Maternal Voluntary Exercise Mitigates Oxidative Stress and Incidence of Congenital Heart Defects in Pre-gestational Diabetes","volume":"23","author":"Saiyin","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2337\/db12-0161","article-title":"Hyperglycemia Slows Embryonic Growth and Suppresses Cell Cycle via Cyclin D1 and P21","volume":"62","author":"Rugonyi","year":"2013","journal-title":"Diabetes"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"E487","DOI":"10.1152\/ajpendo.00121.2015","article-title":"ASK1 Mediates the Teratogenicity of Diabetes in the Developing Heart by Inducing ER Stress and Inhibiting Critical Factors Essential for Cardiac Development","volume":"309","author":"Wang","year":"2015","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/CIRCGENETICS.115.001138","article-title":"Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus\u2013Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt Signaling","volume":"8","author":"Wang","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"650.e1","DOI":"10.1016\/j.ajog.2015.01.014","article-title":"Oxidative Stress Is Responsible for Maternal Diabetes-Impaired Transforming Growth Factor Beta Signaling in the Developing Mouse Heart","volume":"212","author":"Wang","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"366.e1","DOI":"10.1016\/j.ajog.2016.03.036","article-title":"Type 2 Diabetes Mellitus Induces Congenital Heart Defects in Murine Embryos by Increasing Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis","volume":"215","author":"Wu","year":"2016","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/bdrb.21120","article-title":"TGF\u03b2 and Wnt in Cardiac Outflow Tract Defects in Offspring of Diabetic Pregnancies: OFT MALFORMATIONS IN DIABETIC EMBRYOPATHY","volume":"101","author":"Zhao","year":"2014","journal-title":"Birth Defects Res. B"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/bdrb.20225","article-title":"Cardiac Malformations and Alteration of TGF\u03b2 Signaling System in Diabetic Embryopathy","volume":"89","author":"Zhao","year":"2010","journal-title":"Birth Defect. Res. B"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Zhao, J., Hakvoort, T.B.M., Willemsen, A.M., Jongejan, A., Sokolovic, M., Bradley, E.J., de Boer, V.C.J., Baas, F., van Kampen, A.H.C., and Lamers, W.H. (2016). Effect of Hyperglycemia on Gene Expression during Early Organogenesis in Mice. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158035"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/bdra.20457","article-title":"Oxidative Stress during Diabetic Pregnancy Disrupts Cardiac Neural Crest Migration and Causes Outflow Tract Defects","volume":"82","author":"Morgan","year":"2008","journal-title":"Birth Defect. Res. A"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.2337\/db08-0830","article-title":"Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats","volume":"57","author":"Wentzel","year":"2008","journal-title":"Diabetes"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Herb, M., Gluschko, A., and Schramm, M. (2021). Reactive Oxygen Species: Not Omnipresent but Important in Many Locations. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.716406"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and Molecular Cell Biology of Diabetic Complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.freeradbiomed.2012.07.008","article-title":"Zinc Supplementation Prevents Cardiomyocyte Apoptosis and Congenital Heart Defects in Embryos of Diabetic Mice","volume":"53","author":"Kumar","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"130.e1","DOI":"10.1016\/j.ajog.2007.06.070","article-title":"Activation of Oxidative Stress Signaling That Is Implicated in Apoptosis with a Mouse Model of Diabetic Embryopathy","volume":"198","author":"Yang","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bbrc.2016.11.076","article-title":"Maternal Diabetes and High Glucose in Vitro Trigger Sca1+ Cardiac Progenitor Cell Apoptosis through FoxO3a","volume":"482","author":"Yang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1096-9926(199712)56:6<343::AID-TERA1>3.0.CO;2-X","article-title":"Free Radical Scavenging Enzymes in Fetal Dysmorphogenesis among Offspring of Diabetic Rats","volume":"56","author":"Sivan","year":"1997","journal-title":"Teratology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"111999","DOI":"10.1016\/j.mce.2023.111999","article-title":"Maternal Diabetes Increases FOXO1 Activation during Embryonic Cardiac Development","volume":"575","author":"Sato","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Kostina, A., Lewis-Israeli, Y.R., Abdelhamid, M., Gabalski, M.A., Volmert, B.D., Lankerd, H., Huang, A.R., Wasserman, A.H., Lydic, T., and Chan, C. (2023). ER Stress and Lipid Imbalance Drive Embryonic Cardiomyopathy in a Human Heart Organoid Model of Pregestational Diabetes. bioRxiv, preprint.","DOI":"10.1101\/2023.06.07.544081"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/32419","article-title":"Role of the NF-ATc Transcription Factor in Morphogenesis of Cardiac Valves and Septum","volume":"392","author":"Timmerman","year":"1998","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.200710067","article-title":"Slug Is a Direct Notch Target Required for Initiation of Cardiac Cushion Cellularization","volume":"182","author":"Niessen","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"E5300","DOI":"10.1073\/pnas.1504529112","article-title":"Hyperglycemia Impairs Left\u2013Right Axis Formation and Thereby Disturbs Heart Morphogenesis in Mouse Embryos","volume":"112","author":"Hachisuga","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/01.CIR.0000024114.82981.EA","article-title":"Development of Heart Failure and Congenital Septal Defects in Mice Lacking Endothelial Nitric Oxide Synthase","volume":"106","author":"Feng","year":"2002","journal-title":"Circulation"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1242\/dev.00164","article-title":"Dishevelled 2 Is Essential for Cardiac Outflow Tract Development, Somite Segmentation and Neural Tube Closure","volume":"129","author":"Hamblet","year":"2002","journal-title":"Development"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","article-title":"TGFbeta2 Knockout Mice Have Multiple Developmental Defects That Are Non-Overlapping with Other TGFbeta Knockout Phenotypes","volume":"124","author":"Sanford","year":"1997","journal-title":"Development"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/cvr\/cvr138","article-title":"Epigenetic Factors and Cardiac Development","volume":"91","author":"Kwon","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.4161\/15592294.2014.971580","article-title":"Chromatin Regulation: How Complex Does It Get?","volume":"9","author":"Meier","year":"2014","journal-title":"Epigenetics"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.CIR.38.3.604","article-title":"Multifactorial Inheritance Hypothesis for the Etiology of Congenital Heart Diseases. The Genetic-Environmental Interaction","volume":"38","author":"Nora","year":"1968","journal-title":"Circulation"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1399-0004.2009.01174.x","article-title":"Importance of Gene-Environment Interactions in the Etiology of Selected Birth Defects","volume":"75","author":"Zhu","year":"2009","journal-title":"Clin. Genet."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"dev172957","DOI":"10.1242\/dev.172957","article-title":"Gene-Environment Interaction Impacts on Heart Development and Embryo Survival","volume":"146","author":"Moreau","year":"2019","journal-title":"Development"},{"key":"ref_141","first-page":"228","article-title":"Maternal diabetes and fetal hypoxia","volume":"129","author":"Teramo","year":"2013","journal-title":"Duodecim"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3854630","DOI":"10.1155\/2020\/3854630","article-title":"Association of Maternal Diabetes Mellitus and Polymorphisms of the NKX2.5 Gene in Children with Congenital Heart Disease: A Single Centre-Based Case-Control Study","volume":"2020","author":"Zhao","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/aje\/kwx228","article-title":"Update on the State of the Science for Analytical Methods for Gene-Environment Interactions","volume":"186","author":"Gauderman","year":"2017","journal-title":"Am. J. Epidemiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e003500","DOI":"10.1161\/CIRCGEN.121.003500","article-title":"Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity","volume":"15","author":"Morton","year":"2022","journal-title":"Circ. Genom. Precis. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/hmg\/ddz270","article-title":"Functional Genomics and Gene-Environment Interaction Highlight the Complexity of Congenital Heart Disease Caused by Notch Pathway Variants","volume":"29","author":"Chapman","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1471-0528.2005.00437.x","article-title":"Pre-Pregnancy Weight and the Risk of Stillbirth and Neonatal Death","volume":"112","author":"Kristensen","year":"2005","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1542\/peds.111.S1.1152","article-title":"Maternal Obesity and Risk for Birth Defects","volume":"111","author":"Watkins","year":"2003","journal-title":"Pediatrics"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1747-0803.2012.00714.x","article-title":"Prepregnancy Body Mass Index and Congenital Heart Defects among Offspring: A Population-Based Study: Prepregnancy BMI and Congenital Heart Defects","volume":"8","author":"Madsen","year":"2013","journal-title":"Congenit. Heart Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.15585\/mmwr.mm665152a3","article-title":"Prevalence and Trends in Prepregnancy Normal Weight\u201448 States, New York City, and District of Columbia, 2011\u20132015","volume":"66","author":"Deputy","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jacc.2018.10.050","article-title":"Maternal Overweight and Obesity and Risk of Congenital Heart Defects","volume":"73","author":"Persson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jdi.13666","article-title":"Pregestational Diabetes Mediates the Association between Maternal Obesity and the Risk of Congenital Heart Defects","volume":"13","author":"Wu","year":"2022","journal-title":"J. Diabetes Invest."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated Analysis of Multimodal Single-Cell Data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41576-022-00509-1","article-title":"Characterizing Cis-Regulatory Elements Using Single-Cell Epigenomics","volume":"24","author":"Preissl","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_154","first-page":"21","article-title":"DOHaD: Les Apports R\u00e9cents de l\u2019\u00e9pid\u00e9miologie","volume":"32","author":"Delpierre","year":"2016","journal-title":"Med. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1530\/REP-22-0453","article-title":"DOHaD: A MENAGERIE OF ADAPTATIONS AND PERSPECTIVES: Large Animal Models of Developmental Programming: Sustenance, Stress, and Sex Matter","volume":"165","author":"Hammer","year":"2023","journal-title":"Reproduction"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"S655","DOI":"10.1016\/j.dsx.2017.04.021","article-title":"Maternal and Paternal Periconceptional Nutrition as an Indicator of Offspring Metabolic Syndrome Risk in Later Life through Epigenetic Imprinting: A Systematic Review","volume":"11","author":"Dunford","year":"2017","journal-title":"Diabetes Metab. 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