{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:33:57Z","timestamp":1787592837706,"version":"build-2736575974"},"reference-count":22,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Research Activity the Nicolaus Copernicus University in Toru\u0144 Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is an inflammatory skin disease that affects 1\u20132% of the general population. The pathomechanism is based on type 1 immunological reactions. Hyperplasia of the epidermis in psoriasis is a result of disrupted epidermal architecture due to increased synthesis and expression of extracellular matrix proteins. In our study, we analyzed the involvement of periostin (POSTN) in the pathogenesis of psoriasis, as one of the extracellular matrix proteins belonging to the fasciclin family. The study group consisted of 70 patients with psoriasis, while the control group comprised 30 healthy individuals. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-\u03b1 and IFN-\u03b3 were measured in all participants. The severity of psoriasis was determined using the PASI (Psoriasis Area and Severity Index) score. The presence of POSTN in biopsy samples of 50 patients was assessed using the direct immunofluorescence method. The results were subjected to statistical analysis. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-\u03b1 and IFN-\u03b3 in the study group are significantly higher than in the control group. Positive correlation has been demonstrated between the PASI score and the investigated cytokines, but not with POSTN. There was no statistically significant correlation between the POSTN level and the cytokines levels. POSTN deposits were localized in the epidermis in 66% of patients with psoriasis. The role of POSTN in the pathogenesis of psoriasis remains unclear. The mechanisms inducing the synthesis and expression of POSTN in psoriatic skin are not yet fully understood. Further research is needed to enhance our understanding of the mechanism underlying epidermal hyperplasia in psoriasis.<\/jats:p>","DOI":"10.3390\/ijms242216295","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:12:39Z","timestamp":1699953159000},"page":"16295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Unknown Role of Periostin in Psoriatic Epidermal Hyperplasia"],"prefix":"10.3390","volume":"24","author":[{"given":"Milena","family":"Wojciechowska","sequence":"first","affiliation":[{"name":"Department of Social and Medical Sciences, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-077 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"\u015acibior","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-088 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-9242","authenticated-orcid":false,"given":"Monika","family":"Betyna-Bia\u0142ek","sequence":"additional","affiliation":[{"name":"Center for Specialist Languages in Medicine, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-088 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0536-0441","authenticated-orcid":false,"given":"Ewa","family":"Kostrzewska","sequence":"additional","affiliation":[{"name":"Statistical Analysis Center, Nicolaus Copernicus University in Toru\u0144, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-7382","authenticated-orcid":false,"given":"Oliwia","family":"McFarlane","sequence":"additional","affiliation":[{"name":"Department of Social and Medical Sciences, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-077 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4103\/sjamf.sjamf_104_20","article-title":"Expression of interleukin-6 receptor, tumor necrosis factor receptor-associated factor-2, and tumor necrosis factor receptor-associated factor-5 as new reliable markers in psoriasis vulgaris","volume":"4","author":"Basma","year":"2020","journal-title":"Sci. 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