{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:54:39Z","timestamp":1783698879465,"version":"3.55.0"},"reference-count":129,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research (NIDCR)","doi-asserted-by":"publisher","award":["R01 DE028536"],"award-info":[{"award-number":["R01 DE028536"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>T. forsythia is a subgingival periodontal bacterium constituting the subgingival pathogenic polymicrobial milieu during periodontitis (PD). miRNAs play a pivotal role in maintaining periodontal tissue homeostasis at the transcriptional, post-transcriptional, and epigenetic levels. The aim of this study was to characterize the global microRNAs (miRNA, miR) expression kinetics in 8- and 16-week-old T. forsythia-infected C57BL\/6J mouse mandibles and to identify the miRNA bacterial biomarkers of disease process at specific time points. We examined the differential expression (DE) of miRNAs in mouse mandibles (n = 10) using high-throughput NanoString nCounter\u00ae miRNA expression panels, which provided significant advantages over specific candidate miRNA or pathway analyses. All the T. forsythia-infected mice at two specific time points showed bacterial colonization (100%) in the gingival surface, along with a significant increase in alveolar bone resorption (ABR) (p &lt; 0.0001). We performed a NanoString analysis of specific miRNA signatures, miRNA target pathways, and gene network analysis. A total of 115 miRNAs were DE in the mandible tissue during 8 and 16 weeks The T. forsythia infection, compared with sham infection, and the majority (99) of DE miRNAs were downregulated. nCounter miRNA expression kinetics identified 67 downregulated miRNAs (e.g., miR-375, miR-200c, miR-200b, miR-34b-5p, miR-141) during an 8-week infection, whereas 16 upregulated miRNAs (e.g., miR-1902, miR-let-7c, miR-146a) and 32 downregulated miRNAs (e.g., miR-2135, miR-720, miR-376c) were identified during a 16-week infection. Two miRNAs, miR-375 and miR-200c, were highly downregulated with &gt;twofold change during an 8-week infection. Six miRNAs in the 8-week infection (miR-200b, miR-141, miR-205, miR-423-3p, miR-141-3p, miR-34a-5p) and two miRNAs in the 16-week infection (miR-27a-3p, miR-15a-5p) that were downregulated have also been reported in the gingival tissue and saliva of periodontitis patients. This preclinical in vivo study identified T. forsythia-specific miRNAs (miR-let-7c, miR-210, miR-146a, miR-423-5p, miR-24, miR-218, miR-26b, miR-23a-3p) and these miRs have also been reported in the gingival tissues and saliva of periodontitis patients. Further, several DE miRNAs that are significantly upregulated (e.g., miR-101b, miR-218, miR-127, miR-24) are also associated with many systemic diseases such as atherosclerosis, Alzheimer\u2019s disease, rheumatoid arthritis, osteoarthritis, diabetes, obesity, and several cancers. In addition to DE analysis, we utilized the XGBoost (eXtreme Gradient boost) and Random Forest machine learning (ML) algorithms to assess the impact that the number of miRNA copies has on predicting whether a mouse is infected. XGBoost found that miR-339-5p was most predictive for mice infection at 16 weeks. miR-592-5p was most predictive for mice infection at 8 weeks and also when the 8-week and 16-week results were grouped together. Random Forest predicted miR-592 as most predictive at 8 weeks as well as the combined 8-week and 16-week results, but miR-423-5p was most predictive at 16 weeks. In conclusion, the expression levels of miR-375 and miR-200c family differed significantly during disease process, and these miRNAs establishes a link between T. forsythia and development of periodontitis genesis, offering new insights regarding the pathobiology of this bacterium.<\/jats:p>","DOI":"10.3390\/ijms242216393","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T01:56:29Z","timestamp":1700099789000},"page":"16393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Unique miRomics Expression Profiles in Tannerella forsythia-Infected Mandibles during Periodontitis Using Machine Learning"],"prefix":"10.3390","volume":"24","author":[{"given":"Chairmandurai","family":"Aravindraja","sequence":"first","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-8619","authenticated-orcid":false,"given":"Syam","family":"Jeepipalli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-1899","authenticated-orcid":false,"given":"William","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-400X","authenticated-orcid":false,"given":"Krishna Mukesh","family":"Vekariya","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshee","family":"Bahadekar","sequence":"additional","affiliation":[{"name":"Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-9503","authenticated-orcid":false,"given":"Edward K. L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-8656","authenticated-orcid":false,"given":"Lakshmyya","family":"Kesavalu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"},{"name":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.7150\/thno.42640","article-title":"RNA-based scaffolds for bone regeneration: Application and mechanisms of mRNA, miRNA and siRNA","volume":"10","author":"Leng","year":"2020","journal-title":"Theranostics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1042\/CS20220056","article-title":"Circulating cell-free micro-RNA as biomarkers: From myocardial infarction to hypertension","volume":"136","author":"Faulkner","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/labinvest.2013.157","article-title":"Robust global microRNA expression profiling using next-generation sequencing technologies","volume":"94","author":"Tam","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: From microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12296","article-title":"The role of the microbiota in periodontal disease","volume":"83","author":"Curtis","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1099\/mic.0.048975-0","article-title":"Tannerella forsythia invasion in oral epithelial cells requires phosphoinositide 3-kinase activation and clathrin-mediated endocytosis","volume":"157","author":"Mishima","year":"2011","journal-title":"Microbiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"ftv009","DOI":"10.1093\/femspd\/ftv009","article-title":"Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers","volume":"73","author":"Chukkapalli","year":"2015","journal-title":"Pathog. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1399-302X.2004.00175.x","article-title":"Synergy between Tannerella forsythia and Fusobacterium nucleatum in biofilm formation","volume":"20","author":"Sharma","year":"2005","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Honap, T.P., Monroe, C.R., Johnson, S.J., Jacobson, D.K., Abin, C.A., Austin, R.M., Sandberg, P., Levine, M., Sankaranarayanan, K., and Lewis, C.M. (2023). Oral metagenomes from Native American Ancestors reveal distinct microbial lineages in the pre-contact era. Am. J. Biol. Anthropol.","DOI":"10.1002\/ajpa.24735"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.molimm.2018.05.008","article-title":"MicroRNA-21 down-regulates inflammation and inhibits periodontitis","volume":"101","author":"Zhou","year":"2018","journal-title":"Mol. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4248\/IJOS11046","article-title":"Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues","volume":"3","author":"Xie","year":"2011","journal-title":"Int. J. Oral Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mahendra, J., Mahendra, L., Fageeh, H.N., Fageeh, H.I., Ibraheem, W., Abdulkarim, H.H., Kanakamedala, A., Prakash, P., Srinivasan, S., and Balaji, T.M. (2021). miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis. Materials, 14.","DOI":"10.3390\/ma14164692"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1902\/jop.2015.150319","article-title":"Evaluation of MicroRNA-146a and Its Targets in Gingival Tissues of Patients With Chronic Periodontitis","volume":"86","author":"Motedayyen","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/odi.12994","article-title":"Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis","volume":"25","author":"Amaral","year":"2019","journal-title":"Oral Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"587381","DOI":"10.3389\/fphys.2020.587381","article-title":"Plasma- and Saliva Exosome Profile Reveals a Distinct MicroRNA Signature in Chronic Periodontitis","volume":"11","author":"Awang","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Kashef, M.R., Vekariya, K.M., Ghanta, R.K., Karanth, S., Chan, E.K.L., and Kesavalu, L. (2022). Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095107"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Vekariya, K.M., Botello-Escalante, R., Rahaman, S.O., Chan, E.K.L., and Kesavalu, L. (2023). Specific microRNA Signature Kinetics in Porphyromonas gingivalis-Induced Periodontitis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032327"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Jeepipalli, S., Vekariya, K.M., Botello-Escalante, R., Chan, E.K., and Kesavalu, L. (2023). Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202307.0887.v1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1423-0127-20-2","article-title":"Circulating microRNA signatures in mice exposed to lipoteichoic acid","volume":"20","author":"Hsieh","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17227","DOI":"10.18632\/aging.203201","article-title":"miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts","volume":"13","author":"Law","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.scr.2013.11.008","article-title":"Cardiomyogenesis is controlled by the miR-99a\/let-7c cluster and epigenetic modifications","volume":"12","author":"Coppola","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41598-022-26421-6","article-title":"TNF\u03b1, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each other and at different stages of the disease","volume":"13","author":"Costantini","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/jcpe.13040","article-title":"Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects","volume":"46","author":"Naqvi","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"955461","DOI":"10.3389\/fnagi.2022.955461","article-title":"Exploring the role of non-coding RNAs as potential candidate biomarkers in the cross-talk between diabetes mellitus and Alzheimer\u2019s disease","volume":"14","author":"Ghiam","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/0022034511425045","article-title":"MicroRNA modulation in obesity and periodontitis","volume":"91","author":"Perri","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2010.09.029","article-title":"Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans","volume":"412","author":"Li","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kang, L., Li, N., and Wang, L. (2021). The Expression of miR-23a and miR-146a in the Saliva of Patients with Periodontitis and Its Clinical Significance. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/5135278"},{"key":"ref_32","first-page":"6670","article-title":"Expression of miR-155 and miR-146a in the saliva of patients with periodontitis and its clinical value","volume":"13","author":"Wu","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jre.12538","article-title":"Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity","volume":"54","author":"Ghotloo","year":"2019","journal-title":"J. Periodontal Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1074\/jbc.C112.439778","article-title":"Mycobacterium tuberculosis controls microRNA-99b (miR-99b) expression in infected murine dendritic cells to modulate host immunity","volume":"288","author":"Singh","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1002\/jcp.26391","article-title":"Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis","volume":"233","author":"Venugopal","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/eurheartj\/ehu437","article-title":"Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster","volume":"36","author":"Aavik","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCRESAHA.110.228437","article-title":"Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98\/let-7","volume":"108","author":"Yang","year":"2011","journal-title":"Circ. Res."},{"key":"ref_38","first-page":"1184","article-title":"Correlation of miR-24-3p and miR-595 expression with CCL3, CCL4, IL1-\u03b2, TNF\u03b1IP3, and NF-\u03baBI\u03b1 genes in PBMCs of patients with coronary artery disease","volume":"21","author":"Kazemian","year":"2022","journal-title":"EXCLI J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3233\/CBM-210413","article-title":"An integrative approach toward identification and analysis of therapeutic targets involved in HPV pathogenesis with a focus on carcinomas","volume":"36","author":"Gupta","year":"2023","journal-title":"Cancer Biomark."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.oraloncology.2009.12.005","article-title":"miR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis","volume":"46","author":"Lin","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41389-019-0153-z","article-title":"Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma","volume":"8","author":"Ursu","year":"2019","journal-title":"Oncogenesis"},{"key":"ref_42","unstructured":"(2020). Expression of Concern. Cell. Microbiol., 22."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Chen, J., Tang, Z., Chen, Z., Wei, Y., Liang, H., Zhang, X., Gao, Z., and Zhu, H. (2023). MicroRNA-218-5p regulates inflammation response via targeting TLR4 in atherosclerosis. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03124-y"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"118893","DOI":"10.1016\/j.lfs.2020.118893","article-title":"Inhibited microRNA-218-5p attenuates synovial inflammation and cartilage injury in rats with knee osteoarthritis by promoting sclerostin","volume":"267","author":"Liao","year":"2021","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ymthe.2017.01.018","article-title":"Targeting the HDAC2\/HNF-4A\/miR-101b\/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer\u2019s Disease","volume":"25","author":"Liu","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.7150\/ijms.64312","article-title":"miR-23b mediates TNF-\u03b1-Inhibited Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting Runx2","volume":"18","author":"Sun","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lo, C.H., Li, L.C., Yang, S.F., Tsai, C.F., Chuang, Y.T., Chu, H.J., and Ueng, K.C. (2022). MicroRNA Let-7a, -7e and -133a Attenuate Hypoxia-Induced Atrial Fibrosis via Targeting Collagen Expression and the JNK Pathway in HL1 Cardiomyocytes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179636"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/jcpe.13715","article-title":"Downregulation of miRNA-26 in chronic periodontitis interferes with innate immune responses and cell migration by targeting phospholipase C beta 1","volume":"50","author":"Uttamani","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/odi.12118","article-title":"Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma","volume":"20","author":"Siow","year":"2014","journal-title":"Oral Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Mitani, Y., Roberts, D.B., Fatani, H., Weber, R.S., Kies, M.S., Lippman, S.M., and El-Naggar, A.K. (2013). MicroRNA profiling of salivary adenoid cystic carcinoma: Association of miR-17-92 upregulation with poor outcome. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066778"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.omtn.2021.01.030","article-title":"Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice","volume":"23","author":"Krongbaramee","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"59S","DOI":"10.1177\/0022034514568197","article-title":"Upregulation of gingival tissue miR-200b in obese periodontitis subjects","volume":"94","author":"Kalea","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_53","first-page":"2273","article-title":"MiR-34b-5p knockdown attenuates bleomycin-induced pulmonary fibrosis by targeting tissue inhibitor of metalloproteinase 3 (TIMP3)","volume":"23","author":"Hu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/0022034512456551","article-title":"MicroRNAs and their target genes in gingival tissues","volume":"91","author":"Guarnieri","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1038\/onc.2013.226","article-title":"Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer","volume":"33","author":"Li","year":"2014","journal-title":"Oncogene"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"34423","DOI":"10.18632\/oncotarget.5406","article-title":"Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer","volume":"6","author":"Yu","year":"2015","journal-title":"Oncotarget"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000519600","article-title":"Increased Expression of miR-7a-5p and miR-592 during Expansion of Rat Dental Pulp Stem Cells and Their Implication in Osteogenic Differentiation","volume":"211","author":"Rong","year":"2022","journal-title":"Cells Tissues Organs"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17590914211042220","DOI":"10.1177\/17590914211042220","article-title":"Identification of miRNAs That Mediate Protective Functions of Anti-Cancer Drugs During White Matter Ischemic Injury","volume":"13","author":"Baltan","year":"2021","journal-title":"ASN Neuro"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"625318","DOI":"10.3389\/fimmu.2021.625318","article-title":"Differential miRNA Profiles Correlate With Disparate Immunity Outcomes Associated With Vaccine Immunization and Chlamydial Infection","volume":"12","author":"Howard","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_60","first-page":"59","article-title":"Differential expression of microRNAs in cardiac myocytes compared to undifferentiated P19 cells","volume":"28","author":"Hu","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbrc.2010.11.079","article-title":"Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs","volume":"404","author":"Zhou","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.31083\/j.rcm2302047","article-title":"Circulating microRNAs in the prediction of BAV aortopathy: Do the expression patterns correlate between blood and aortic tissue?","volume":"23","author":"Naito","year":"2022","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Na, J., Jin, H., Wang, X., Huang, K., Sun, S., Li, Q., and Zhang, W. (2021). The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure. Cell Biosci., 11.","DOI":"10.1186\/s13578-020-00523-y"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1474-9726.2011.00714.x","article-title":"MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure","volume":"10","author":"Verhesen","year":"2011","journal-title":"Aging Cell"},{"key":"ref_65","first-page":"810241","article-title":"MiR-29a Increase in Aging May Function as a Compensatory Mechanism Against Cardiac Fibrosis Through SERPINH1 Downregulation","volume":"8","author":"Lupan","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/FJC.0000000000000623","article-title":"MicroRNA-18a Expression in Female Coronary Heart Disease and Regulatory Mechanism on Endothelial Cell by Targeting Estrogen Receptor","volume":"72","author":"Yuan","year":"2018","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.2147\/JIR.S410339","article-title":"NEAT1\/microRNA 339-5p\/SPI1 Axis Feedback Loop Contributes to Osteogenic Differentiation in Acute Suppurative Osteomyelitis in Children","volume":"16","author":"Zhu","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"632891","DOI":"10.3389\/fnagi.2021.632891","article-title":"Serum miR-96-5P and miR-339-5P Are Potential Biomarkers for Multiple System Atrophy and Parkinson\u2019s Disease","volume":"13","author":"Vallelunga","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/cbin.11731","article-title":"MiRNA-339-5p promotes isoproterenol-induced cardiomyocyte hypertrophy by targeting VCP to activate the mTOR signaling","volume":"46","author":"Bi","year":"2022","journal-title":"Cell Biol. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/eurjpc\/zwaa142","article-title":"Circulating microRNA as predictors for exercise response in heart failure with reduced ejection fraction","volume":"28","author":"Witvrouwen","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/physiolgenomics.00049.2015","article-title":"Integrated microRNA and mRNA responses to acute human left ventricular ischemia","volume":"47","author":"Saddic","year":"2015","journal-title":"Physiol. Genom."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.2147\/OTT.S236514","article-title":"miR-423 Promotes Breast Cancer Invasion by Activating NF-\u03baB Signaling","volume":"13","author":"Dai","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/jre.13081","article-title":"Six miRNA expressions in the saliva of smokers and non-smokers with periodontal disease","volume":"58","author":"Gokmenoglu","year":"2023","journal-title":"J. Periodontal Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Al-Rawi, N.H., Al-Marzooq, F., Al-Nuaimi, A.S., Hachim, M.Y., and Hamoudi, R. (2020). Salivary microRNA 155, 146a\/b and 203: A pilot study for potentially non-invasive diagnostic biomarkers of periodontitis and diabetes mellitus. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237004"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"994575","DOI":"10.3389\/fnins.2022.994575","article-title":"Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging","volume":"16","author":"Ye","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_76","first-page":"519","article-title":"Effect of miR-433-3p and miR-883b-5p on murine CYP 3A family enzymes in AML12 cells","volume":"73","author":"Sugino","year":"2018","journal-title":"Pharmazie"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhang, C., Yao, J., Liu, C., Yang, K., Zhang, W., Sun, D., and Gu, W. (2023). The Role of Thyroid Hormone Synthesis Gene-Related miRNAs Profiling in Structural and Functional Changes of The Thyroid Gland Induced by Excess Iodine. Biol. Trace Elem. Res.","DOI":"10.1007\/s12011-023-03691-3"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Yehya, N., Yerrapureddy, A., Tobias, J., and Margulies, S.S. (2012). MicroRNA modulate alveolar epithelial response to cyclic stretch. BMC Genom., 13.","DOI":"10.1186\/1471-2164-13-154"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4014\/jmb.1811.11062","article-title":"Novel miR-1958 Promotes Mycobacterium tuberculosis Survival in RAW264.7 Cells by Inhibiting Autophagy Via Atg5","volume":"29","author":"Ding","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Fujimori, K., Yoneda, T., Tomofuji, T., Ekuni, D., Azuma, T., Maruyama, T., Mizuno, H., Sugiura, Y., and Morita, M. (2019). Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. Molecules, 24.","DOI":"10.3390\/molecules24061034"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Zhang, B., Lin, T., and He, H. (2015). Comparative analysis of blood and saliva expression profiles in chronic and refractory periodontitis patients. BMC Oral Health, 15.","DOI":"10.1186\/s12903-015-0150-3"},{"key":"ref_82","first-page":"1439","article-title":"Protective effect of microRNA-381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4","volume":"21","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/jor.25189","article-title":"Mg2+-mediated autophagy-dependent polarization of macrophages mediates the osteogenesis of bone marrow stromal stem cells by interfering with macrophage-derived exosomes containing miR-381","volume":"40","author":"Zhu","year":"2022","journal-title":"J. Orthop. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.7150\/ijbs.82287","article-title":"microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK\/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis","volume":"19","author":"Qi","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"729929","DOI":"10.3389\/fvets.2021.729929","article-title":"Identification and Characterization of Circulating MicroRNAs as Novel Biomarkers in Dogs With Heart Diseases","volume":"8","author":"Ro","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.omtn.2020.11.001","article-title":"A set of miRNAs predicts T2DM remission in patients with coronary heart disease: From the CORDIOPREV study","volume":"23","author":"Krylova","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"28101","DOI":"10.1038\/srep28101","article-title":"Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/os.12883","article-title":"CircCDR1as Suppresses Bone Microvascular Endothelial Cell Activity and Angiogenesis Through Targeting miR-135b\/ FIH-1 Axis","volume":"13","author":"Mao","year":"2021","journal-title":"Orthop. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.12659\/MSM.917038","article-title":"miRNA-339-5p Plays an Important Role in Invasion and Migration of Pancreatic Cancer Cells","volume":"25","author":"Yu","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_90","first-page":"29","article-title":"Down-regulation of miR-339 promotes differentiation of BMSCs and alleviates osteoporosis by targeting DLX5","volume":"23","author":"Zhou","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"104449","DOI":"10.1016\/j.yexmp.2020.104449","article-title":"MiRNA-339-5p suppresses the malignant development of gastric cancer via targeting ALKBH1","volume":"115","author":"Wang","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3892\/etm.2021.9821","article-title":"Prognostic value of miR-339-5p in patients with prostate cancer and its effects on tumor progression","volume":"21","author":"Pan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1172\/JCI124923","article-title":"A protective role for microRNA-688 in acute kidney injury","volume":"128","author":"Chun","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.celrep.2012.02.008","article-title":"A resource for the conditional ablation of microRNAs in the mouse","volume":"1","author":"Park","year":"2012","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"19355","DOI":"10.1039\/C9RA01031A","article-title":"miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis","volume":"9","author":"Yu","year":"2019","journal-title":"RSC Adv."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/physiolgenomics.00222.2010","article-title":"Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation","volume":"43","author":"Xie","year":"2011","journal-title":"Physiol. Genom."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.semcdb.2021.05.030","article-title":"MicroRNAs: Harbingers and shapers of periodontal inflammation","volume":"124","author":"Luan","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/JPER.18-0729","article-title":"Identification of a novel salivary biomarker miR-143-3p for periodontal diagnosis: A proof of concept study","volume":"90","author":"Nisha","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1128\/IAI.01062-10","article-title":"Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE\u2212\/\u2212 mice during experimental periodontal disease","volume":"79","author":"Nahid","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"386","DOI":"10.5051\/jpis.2007540377","article-title":"MicroRNAs and periodontal disease: A qualitative systematic review of human studies","volume":"51","year":"2021","journal-title":"J. Periodontal Implant. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/jre.12989","article-title":"Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs","volume":"57","author":"Yu","year":"2022","journal-title":"J. Periodontal Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s10571-023-01327-7","article-title":"The Role of MicroRNAs in Predicting the Neurological Outcome of Patients with Subarachnoid Hemorrhage: A Meta-analysis","volume":"43","author":"Li","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1399-302X.2003.00071.x","article-title":"In vitro environmental regulation of Porphyromonas gingivalis growth and virulence","volume":"18","author":"Kesavalu","year":"2003","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Rivera, M.F., Lee, J.Y., Aneja, M., Goswami, V., Liu, L., Velsko, I.M., Chukkapalli, S.S., Bhattacharyya, I., Chen, H., and Lucas, A.R. (2013). Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoEnull mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057178"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1128\/IAI.00733-06","article-title":"Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease","volume":"75","author":"Kesavalu","year":"2007","journal-title":"Infect. Immun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13075-016-1056-4","article-title":"Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice","volume":"18","author":"Chukkapalli","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Sakthivel, R., Liu, X., Goodwin, M., Veena, P., Godovikova, V., Fenno, J.C., Levites, Y., Golde, T.E., and Kesavalu, L. (2022). Intracerebral but Not Peripheral Infection of Live Porphyromonas gingivalis Exacerbates Alzheimer\u2019s Disease like Amyloid Pathology in APP-TgCRND8 Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063328"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1128\/iai.60.4.1455-1464.1992","article-title":"Porphyromonas gingivalis virulence in mice: Induction of immunity to bacterial components","volume":"60","author":"Kesavalu","year":"1992","journal-title":"Infect. Immun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1261\/rna.034710.112","article-title":"Systematic evaluation of medium-throughput mRNA abundance platforms","volume":"19","author":"Prokopec","year":"2013","journal-title":"RNA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1158\/0008-5472.CAN-15-0262","article-title":"Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples","volume":"75","author":"Brant","year":"2015","journal-title":"Cancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"814","DOI":"10.20517\/cdr.2022.56","article-title":"Butein-instigated miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenergetics of Malignant Pleural Mesothelioma cells","volume":"5","author":"Cioce","year":"2022","journal-title":"Cancer Drug Resist."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: Deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: An informative resource for experimentally validated miRNA-target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_114","unstructured":"Gillies, S.O. (2023, August 11). Shapely: Manipulation and Analysis of Geometric Objects. Available online: https:\/\/github.com\/Toblerity\/Shapely."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Chen, T., and Guestrin, C. (2016, January 13\u201317). XGBoost: A Scalable Tree Boosting System. Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, San Francisco, CA, USA.","DOI":"10.1145\/2939672.2939785"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8225966","DOI":"10.1155\/2022\/8225966","article-title":"The Clinical Value of Blood miR-654-5p, miR-126, miR-10b, and miR-144 in the Diagnosis of Colorectal Cancer","volume":"2022","author":"Du","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Pradhan, U.K., Sharma, N.K., Kumar, P., Kumar, A., Gupta, S., and Shankar, R. (2021). miRbiom: Machine-learning on Bayesian causal nets of RBP-miRNA interactions successfully predicts miRNA profiles. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258550"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Gholizadeh, M., Lapczuk-Romanska, J., Post, M., Komaniecka, N., Mazlooman, S.R., Kaderali, L., and Drozdzik, M. (2023). A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087207"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"979525","DOI":"10.3389\/frai.2022.979525","article-title":"Developing and testing a prediction model for periodontal disease using machine learning and big electronic dental record data","volume":"5","author":"Patel","year":"2022","journal-title":"Front. Artif. Intell."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1244578","DOI":"10.3389\/fonc.2023.1244578","article-title":"Proposing new early detection indicators for pancreatic cancer: Combining machine learning and neural networks for serum miRNA-based diagnostic model","volume":"13","author":"Chi","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1195145","DOI":"10.3389\/fendo.2023.1195145","article-title":"Text mining-based identification of promising miRNA biomarkers for diabetes mellitus","volume":"14","author":"Li","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/carcin\/bgt330","article-title":"miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1","volume":"35","author":"Li","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Iwaki, J., Kikuchi, K., Mizuguchi, Y., Kawahigashi, Y., Yoshida, H., Uchida, E., and Takizawa, T. (2013). MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069496"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41419-020-03121-5","article-title":"MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Che, Q., Wang, W., Duan, P., Fang, F., Liu, C., Zhou, T., Li, H., Xiong, C., and Zhao, K. (2019). Downregulation of miR-322 promotes apoptosis of GC-2 cell by targeting Ddx3x. Reprod. Biol. Endocrinol., 17.","DOI":"10.1186\/s12958-019-0506-7"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1182\/blood-2018-06-855502","article-title":"miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels","volume":"132","author":"Musilova","year":"2018","journal-title":"Blood"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/CBM-190156","article-title":"Downregulation of serum exosomal miR-150-5p is associated with poor prognosis in patients with colorectal cancer","volume":"26","author":"Zou","year":"2019","journal-title":"Cancer Biomark."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1073\/pnas.1909145117","article-title":"Identification of Ppar\u03b3-modulated miRNA hubs that target the fibrotic tumor microenvironment","volume":"117","author":"Winkler","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/carcin\/bgaa089","article-title":"Apelin enhances biological functions in lung cancer A549 cells by downregulating exosomal miR-15a-5p","volume":"42","author":"Ran","year":"2021","journal-title":"Carcinogenesis"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:23:52Z","timestamp":1760131432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/22\/16393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":129,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["ijms242216393"],"URL":"https:\/\/doi.org\/10.3390\/ijms242216393","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]}}}