{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:14:49Z","timestamp":1787163289766,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"publisher","award":["S2945890"],"award-info":[{"award-number":["S2945890"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study investigated the neuroprotective effects of Dendropanax morbifera leaves and stems (DMLS) water extract on scopolamine (SCO)-induced memory impairment in mice. First, we conducted experiments to determine the protective effect of DMLS on neuronal cells. Treatment with DMLS showed a significant protective effect against neurotoxicity induced by A\u03b2(25\u201335) or H2O2. After confirming the neuroprotective effects of DMLS, we conducted animal studies. We administered DMLS orally at concentrations of 125, 250, and 375 mg\/kg for 3 weeks. In the Y-maze test, SCO decreased spontaneous alternation, but treatment with DMLS or donepezil increased spontaneous alternation. In the Morris water-maze test, the SCO-treated group showed increased platform reach time and decreased swim time on the target platform. The passive avoidance task found that DMLS ingestion increased the recognition index in short-term memory. Furthermore, memory impairment induced by SCO reduced the ability to recognize novel objects. In the Novel Object Recognition test, recognition improved with DMLS or donepezil treatment. In the mouse brain, except for the cerebellum, acetylcholinesterase activity increased in the SCO group and decreased in the DMLS and donepezil groups. We measured catalase and malondialdehyde, which are indicators of antioxidant effectiveness, and found that oxidative stress increased with SCO but was mitigated by DMLS or donepezil treatment. Thus, our findings suggest that ingestion of DMLS restored memory impairment by protecting neuronal cells from A\u03b2(25\u201335) or H2O2-induced neurotoxicity, and by reducing oxidative stress.<\/jats:p>","DOI":"10.3390\/ijms242216444","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:10:38Z","timestamp":1700212238000},"page":"16444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Neuroprotective Effects of Dendropanax morbifera Water Extract on Scopolamine-Induced Memory Impairment in Mice"],"prefix":"10.3390","volume":"24","author":[{"given":"Sung Bae","family":"Kim","sequence":"first","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Yeoul","family":"Ryu","sequence":"additional","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo","family":"Nam","sequence":"additional","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4899-0336","authenticated-orcid":false,"given":"So Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ran","family":"Jang","sequence":"additional","affiliation":[{"name":"Huons Foodience Co., Ltd., Geumsan-gun 32724, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Gil","family":"Kwak","sequence":"additional","affiliation":[{"name":"Huons Foodience Co., Ltd., Geumsan-gun 32724, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyoo Il","family":"Kang","sequence":"additional","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Seok","family":"Song","sequence":"additional","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-3377","authenticated-orcid":false,"given":"Jae Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Conformity Laboratories, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00401-017-1709-7","article-title":"Interactions of pathological proteins in neurodegenerative diseases","volume":"134","author":"Attems","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.emcn.2005.07.003","article-title":"Memory and related disorders","volume":"2","author":"Deschamps","year":"2005","journal-title":"EMC-Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-642-23274-9_7","article-title":"Muscarinic receptor pharmacology and circuitry for the modulation of cognition","volume":"208","author":"Bubser","year":"2012","journal-title":"Muscarinic Recept."},{"key":"ref_4","unstructured":"Vandesquille, M. 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