{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:15:52Z","timestamp":1788365752896,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish National Agency for Academic Exchange","award":["PPI\/APM\/2018\/1\/00049\/U\/001"],"award-info":[{"award-number":["PPI\/APM\/2018\/1\/00049\/U\/001"]}]},{"name":"Polish National Agency for Academic Exchange","award":["1843616"],"award-info":[{"award-number":["1843616"]}]},{"name":"National Science Foundation SBIR","award":["PPI\/APM\/2018\/1\/00049\/U\/001"],"award-info":[{"award-number":["PPI\/APM\/2018\/1\/00049\/U\/001"]}]},{"name":"National Science Foundation SBIR","award":["1843616"],"award-info":[{"award-number":["1843616"]}]},{"name":"University of Science and Technology","award":["PPI\/APM\/2018\/1\/00049\/U\/001"],"award-info":[{"award-number":["PPI\/APM\/2018\/1\/00049\/U\/001"]}]},{"name":"University of Science and Technology","award":["1843616"],"award-info":[{"award-number":["1843616"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mixed manganese\u2013zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 \u00b0C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg\/mL of Fe, the spin\u2013spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal\/spatial resolution of 3.2 \u00b0C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.<\/jats:p>","DOI":"10.3390\/ijms242216458","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:10:38Z","timestamp":1700212238000},"page":"16458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aqueous Dispersion of Manganese\u2013Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-5297","authenticated-orcid":false,"given":"Dorota","family":"Lachowicz","sequence":"first","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Krakow, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-2084","authenticated-orcid":false,"given":"Angelika","family":"Kmita","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Krakow, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-3768","authenticated-orcid":false,"given":"Marta","family":"Gajewska","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Krakow, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Trynkiewicz","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Krakow, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-7886","authenticated-orcid":false,"given":"Marek","family":"Przybylski","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Krakow, 30-059 Krakow, Poland"},{"name":"Faculty of Physics and Applied Computer Science, AGH University of Krakow, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-2442","authenticated-orcid":false,"given":"Stephen E.","family":"Russek","sequence":"additional","affiliation":[{"name":"National Institute of Standards and Technology, 325 Broadway St, Boulder, CO 80305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl F.","family":"Stupic","sequence":"additional","affiliation":[{"name":"National Institute of Standards and Technology, 325 Broadway St, Boulder, CO 80305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Woodrum","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof R.","family":"Gorny","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew J.","family":"Celinski","sequence":"additional","affiliation":[{"name":"Center for the BioFrontiers Institute, University of Colorado Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-3907","authenticated-orcid":false,"given":"Janusz H.","family":"Hankiewicz","sequence":"additional","affiliation":[{"name":"Center for the BioFrontiers Institute, University of Colorado Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"ref_1","first-page":"289","article-title":"Lois exp\u00e9rimentales du magn\u00e9tisme. 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