{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:48:19Z","timestamp":1791589699382,"version":"4.3.4"},"reference-count":115,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Program of Belt and Road Innovative Talents Exchange of the Chinese Ministry of Science and Technology","award":["DL2023173001L"],"award-info":[{"award-number":["DL2023173001L"]}]},{"name":"National Program of Belt and Road Innovative Talents Exchange of the Chinese Ministry of Science and Technology","award":["2022ZDLSF05-11\/2023-3-1-1"],"award-info":[{"award-number":["2022ZDLSF05-11\/2023-3-1-1"]}]},{"name":"National Program of Belt and Road Innovative Talents Exchange of the Chinese Ministry of Science and Technology","award":["202305AF150118"],"award-info":[{"award-number":["202305AF150118"]}]},{"name":"Key Research and Development Program of Shaanxi Province and Ankang City (Key Laboratory of Se-enriched Products Development and Quality Control of Ministry of Agriculture and Rural Affairs and National-Local Joint Engineering Laboratory of Se-enriched Food Development) in China","award":["DL2023173001L"],"award-info":[{"award-number":["DL2023173001L"]}]},{"name":"Key Research and Development Program of Shaanxi Province and Ankang City (Key Laboratory of Se-enriched Products Development and Quality Control of Ministry of Agriculture and Rural Affairs and National-Local Joint Engineering Laboratory of Se-enriched Food Development) in China","award":["2022ZDLSF05-11\/2023-3-1-1"],"award-info":[{"award-number":["2022ZDLSF05-11\/2023-3-1-1"]}]},{"name":"Key Research and Development Program of Shaanxi Province and Ankang City (Key Laboratory of Se-enriched Products Development and Quality Control of Ministry of Agriculture and Rural Affairs and National-Local Joint Engineering Laboratory of Se-enriched Food Development) in China","award":["202305AF150118"],"award-info":[{"award-number":["202305AF150118"]}]},{"name":"Program of Academician and Expert Workstation in Puer City of Yunnan Province in China","award":["DL2023173001L"],"award-info":[{"award-number":["DL2023173001L"]}]},{"name":"Program of Academician and Expert Workstation in Puer City of Yunnan Province in China","award":["2022ZDLSF05-11\/2023-3-1-1"],"award-info":[{"award-number":["2022ZDLSF05-11\/2023-3-1-1"]}]},{"name":"Program of Academician and Expert Workstation in Puer City of Yunnan Province in China","award":["202305AF150118"],"award-info":[{"award-number":["202305AF150118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alcohol use accounts for a large variety of diseases, among which alcoholic liver injury (ALI) poses a serious threat to human health. In order to overcome the limitations of chemotherapeutic agents, some natural constituents, especially polysaccharides from edible medicinal plants (PEMPs), have been applied for the prevention and treatment of ALI. In this review, the protective effects of PEMPs on acute, subacute, subchronic, and chronic ALI are summarized. The pathogenesis of alcoholic liver injury is analyzed. The structure\u2013activity relationship (SAR) and safety of PEMPs are discussed. In addition, the mechanism underlying the hepatoprotective activity of polysaccharides from edible medicinal plants is explored. PEMPs with hepatoprotective activities mainly belong to the families Orchidaceae, Solanaceae, and Liliaceae. The possible mechanisms of PEMPs include activating enzymes related to alcohol metabolism, attenuating damage from oxidative stress, regulating cytokines, inhibiting the apoptosis of hepatocytes, improving mitochondrial function, and regulating the gut microbiota. Strategies for further research into the practical application of PEMPs for ALI are proposed. Future studies on the mechanism of action of PEMPs will need to focus more on the utilization of multi-omics approaches, such as proteomics, epigenomics, and lipidomics.<\/jats:p>","DOI":"10.3390\/ijms242216530","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:32:32Z","timestamp":1700476352000},"page":"16530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Protective Effects and Mechanism of Polysaccharides from Edible Medicinal Plants in Alcoholic Liver Injury: A Review"],"prefix":"10.3390","volume":"24","author":[{"given":"Zhuo-Wen","family":"Su","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Food Engineering and Nutritional Science, International Joint Research Center of Shaanxi Province for Food and Health Sciences, Shaanxi Normal University, Xi\u2019an 710119, China"},{"name":"Academician and Expert Workstations in Puer City of Yunnan Province, Puer 665600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Food Engineering and Nutritional Science, International Joint Research Center of Shaanxi Province for Food and Health Sciences, Shaanxi Normal University, Xi\u2019an 710119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Food Engineering and Nutritional Science, International Joint Research Center of Shaanxi Province for Food and Health Sciences, Shaanxi Normal University, Xi\u2019an 710119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Food Engineering and Nutritional Science, International Joint Research Center of Shaanxi Province for Food and Health Sciences, Shaanxi Normal University, Xi\u2019an 710119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Food Engineering and Nutritional Science, International Joint Research Center of Shaanxi Province for Food and Health Sciences, Shaanxi Normal University, Xi\u2019an 710119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5745-1783","authenticated-orcid":false,"given":"Hua-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Food Engineering and Nutritional Science, International Joint Research Center of Shaanxi Province for Food and Health Sciences, Shaanxi Normal University, Xi\u2019an 710119, China"},{"name":"Academician and Expert Workstations in Puer City of Yunnan Province, Puer 665600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref_1","first-page":"11","article-title":"Alcohol dependence mediated by monoamine neurotransmitters in the central nervous system","volume":"36","author":"Yang","year":"2014","journal-title":"Hereditas"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s42255-021-00357-z","article-title":"Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication","volume":"3","author":"Jin","year":"2021","journal-title":"Nat. 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