{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:31:20Z","timestamp":1761294680225,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007076","name":"AIRC (Associazione Italiana Ricerca Cancro)","doi-asserted-by":"publisher","award":["IG 2021-25920","2017N8CK4K"],"award-info":[{"award-number":["IG 2021-25920","2017N8CK4K"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Progetti di Ricerca di Interesse Nazionale (PRIN)","award":["IG 2021-25920","2017N8CK4K"],"award-info":[{"award-number":["IG 2021-25920","2017N8CK4K"]}]},{"name":"Italian Ministry of Health to Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico","award":["IG 2021-25920","2017N8CK4K"],"award-info":[{"award-number":["IG 2021-25920","2017N8CK4K"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The insulin-like growth factor 2 (IGF2) promotes cell growth by overactivating the IGF system in an autocrine loop in adrenocortical carcinomas (ACCs). The cytoskeleton protein filamin A (FLNA) acts as a repressor of IGF2 mitogenic signalling in ACC cells. The aims of this study were to test FLNA expression by immunohistochemistry in 119 ACCs and 26 adrenocortical adenomas (ACAs) and to evaluate its relationship with clinicopathological features and outcome in ACCs. We found that 71.4% of ACCs did not express FLNA, whereas FLNA absence was a rare event in ACAs (15.4%, p &lt; 0.001 vs. ACCs). In addition, the expression of FLNA was associated with a less aggressive tumour behaviour in ACCs. Indeed, the subgroup of ACCs with high FLNA showed a lower ENSAT stage, Weiss score, and S-GRAS score compared to ACCs with low FLNA expression (p &lt; 0.05). Moreover, patients with high FLNA had a longer overall survival than those with low FLNA (p &lt; 0.05). In conclusion, our data suggest that FLNA may represent a \u201cprotective\u201d factor in ACCs, and the integration of FLNA immunohistochemical expression in ACC tissues along with other clinical and molecular markers could be helpful to improve diagnostic accuracy and prognosis prediction in ACCs.<\/jats:p>","DOI":"10.3390\/ijms242316573","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T10:24:13Z","timestamp":1700562253000},"page":"16573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Rosa","family":"Catalano","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-3249","authenticated-orcid":false,"given":"Barbara","family":"Altieri","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0906-3617","authenticated-orcid":false,"given":"Anna","family":"Angelousi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"51st Department of Propaedeutic Internal Medicine, National University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-3616","authenticated-orcid":false,"given":"Maura","family":"Arosio","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"Endocrinology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-5319","authenticated-orcid":false,"given":"Francesca","family":"Bravi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-8108","authenticated-orcid":false,"given":"Letizia","family":"Canu","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, 50139 Florence, Italy"},{"name":"Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-7841","authenticated-orcid":false,"given":"Giorgio A.","family":"Croci","sequence":"additional","affiliation":[{"name":"Pathology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-6125","authenticated-orcid":false,"given":"Mario","family":"Detomas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"Ph.D. Program in Experimental Medicine, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-7650","authenticated-orcid":false,"given":"Emanuele","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Pathology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmina T.","family":"Fuss","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kaltsas","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"51st Department of Propaedeutic Internal Medicine, National University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otilia","family":"Kimpel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-4176","authenticated-orcid":false,"given":"Laura-Sophie","family":"Landwehr","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-064X","authenticated-orcid":false,"given":"Michaela","family":"Luconi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, 50139 Florence, Italy"},{"name":"Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-3045","authenticated-orcid":false,"given":"Valentina","family":"Morelli","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-944X","authenticated-orcid":false,"given":"Gabriella","family":"Nesi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, 50139 Florence, Italy"},{"name":"Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Nozza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"Ph.D. Program in Experimental Medicine, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-5533","authenticated-orcid":false,"given":"Silviu","family":"Sbiera","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea L.","family":"Serban","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-2071","authenticated-orcid":false,"given":"Cristina L.","family":"Ronchi","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and System Research, University of Birmingham, Birmingham B15 2TT, UK"},{"name":"Centre for Endocrinology, Diabetes and Metabolism (CEDAM), Birmingham Health Partners, Birmingham B15 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-3886","authenticated-orcid":false,"given":"Giovanna","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"Endocrinology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-7895","authenticated-orcid":false,"given":"Erika","family":"Peverelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"Endocrinology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-198403000-00001","article-title":"Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors","volume":"8","author":"Weiss","year":"1984","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mizdrak, M. (2021). The Role of Biomarkers in Adrenocortical Carcinoma: A Review of Current Evidence and Future Perspectives. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020174"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/ERC-12-0403","article-title":"TOP2A is overexpressed and is a therapeutic target for adrenocortical carcinoma","volume":"20","author":"Jain","year":"2013","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.beem.2008.10.008","article-title":"Clinical management of adrenocortical carcinoma","volume":"23","author":"Fassnacht","year":"2009","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metabol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41574-019-0221-7","article-title":"Adrenocortical carcinoma\u2014Towards genomics guided clinical care","volume":"15","author":"Crona","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/cncr.24030","article-title":"Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: Proposal for a revised TNM classification","volume":"115","author":"Fassnacht","year":"2009","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1210\/jc.2014-3182","article-title":"Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection","volume":"100","author":"Beuschlein","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1210\/jc.2018-01348","article-title":"Targeted Molecular Analysis in Adrenocortical Carcinomas: A Strategy Toward Improved Personalized Prognostication","volume":"103","author":"Lippert","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1530\/EJE-21-0510","article-title":"S-GRAS score for prognostic classification of adrenocortical carcinoma: An international, multicenter ENSAT study","volume":"186","author":"Elhassan","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/ejendo\/lvad112","article-title":"Performance of DNA-based biomarkers for classification of adrenocortical carcinoma: A prognostic study","volume":"189","author":"Lippert","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"ref_11","first-page":"43","article-title":"The role of insulin-like growth factor system in the adrenocortical tumors","volume":"44","author":"Altieri","year":"2019","journal-title":"Minerva Endocrinol."},{"key":"ref_12","first-page":"1444","article-title":"Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors","volume":"78","author":"Gicquel","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","first-page":"2559","article-title":"Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: Study on a series of 82 tumors","volume":"82","author":"Gicquel","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","first-page":"1713","article-title":"Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors","volume":"83","author":"Boulle","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0002-9440(10)63846-1","article-title":"Distinct Transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis","volume":"162","author":"Giordano","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1210\/jc.2004-1075","article-title":"Gene Expression Profiling of Human Adrenocortical Tumors Using Complementary Deoxyribonucleic Acid Microarrays Identifies Several Candidate Genes as Markers of Malignancy","volume":"90","author":"Cherradi","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1210\/jc.2008-0065","article-title":"Expression of Insulin-Like Growth Factor-II and Its Receptor in Pediatric and Adult Adrenocortical Tumors","volume":"93","author":"Almeida","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1210\/jc.2008-1456","article-title":"Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma","volume":"94","author":"Barlaskar","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2020.10.022","article-title":"The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells","volume":"497","author":"Catalano","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4161\/cam.5.2.14401","article-title":"The filamins: Organizers of cell structure and function","volume":"5","author":"Nakamura","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1158\/1078-0432.CCR-08-1402","article-title":"Nuclear versus Cytoplasmic Localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with Metastases","volume":"15","author":"Bedolla","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1111\/j.1349-7006.2009.01244.x","article-title":"Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma","volume":"100","author":"Alper","year":"2009","journal-title":"Cancer Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3892\/ol.2013.1454","article-title":"Differential expression of filamin A and its clinical significance in breast cancer","volume":"6","author":"Tian","year":"2013","journal-title":"Oncol. Lett."},{"key":"ref_24","first-page":"3939","article-title":"A positive relationship between filamin and VEGF in patients with lung cancer","volume":"30","author":"Uramoto","year":"2010","journal-title":"Anticancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/j.1349-7006.2008.00978.x","article-title":"Irradiated fibroblast-induced bystander effects on invasive growth of squamous cell carcinoma under cancer-stromal cell interaction","volume":"99","author":"Kamochi","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jhep.2009.03.017","article-title":"Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas","volume":"51","author":"Guedj","year":"2009","journal-title":"J. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1530\/EJE-21-0668","article-title":"Filamin A and parafibromin expression in parathyroid carcinoma","volume":"185","author":"Storvall","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.3892\/or.2020.7819","article-title":"Role and mechanism of FLNa and UCP2 in the development of cervical cancer","volume":"44","author":"Wang","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"77330","DOI":"10.18632\/oncotarget.20473","article-title":"FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression","volume":"8","author":"Vitali","year":"2017","journal-title":"Oncotarget"},{"key":"ref_30","first-page":"3424","article-title":"Overexpression of calpain-1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA","volume":"41","author":"Xu","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11255-017-1772-y","article-title":"Filamin A (FLNA) regulates autophagy of bladder carcinoma cell and affects its proliferation, invasion and metastasis","volume":"50","author":"Wang","year":"2018","journal-title":"Int. Urol. Nephrol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s13277-013-1381-z","article-title":"Absent expression of FLNA is correlated with poor prognosis of nasopharyngeal cancer","volume":"35","author":"Sun","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1007\/s13277-013-1347-1","article-title":"An antiproliferative gene FLNA regulates migration and invasion of gastric carcinoma cell in vitro and its clinical significance","volume":"35","author":"Sun","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.humpath.2015.08.012","article-title":"Pitfalls in the diagnosis of adrenocortical tumors: A lesson from 300 consultation cases","volume":"46","author":"Duregon","year":"2015","journal-title":"Hum. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00261-019-02082-4","article-title":"Mimics, pitfalls, and misdiagnoses of adrenal masses on CT and MRI","volume":"45","author":"Elsayes","year":"2020","journal-title":"Abdom. Radiol."},{"key":"ref_36","first-page":"7395050","article-title":"Was It an Adrenocortical Adenoma or an Adrenocortical Carcinoma? Limitation of the Weiss Scoring System in Determining the Malignant Potential of Adrenocortical Tumor: Report on Two Cases","volume":"2022","author":"Wong","year":"2022","journal-title":"Case Rep. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"R249","DOI":"10.1530\/EJE-15-1118","article-title":"ENDOCRINE TUMOURS: The genomics of adrenocortical tumors","volume":"174","author":"Faillot","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12020-015-0694-7","article-title":"Preexisting adrenal masses in patients with adrenocortical carcinoma: Clinical and radiological factors contributing to delayed diagnosis","volume":"51","author":"Ozsari","year":"2016","journal-title":"Endocrine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12022-023-09760-6","article-title":"Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma","volume":"34","author":"Luconi","year":"2023","journal-title":"Endocr. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00432-014-1722-3","article-title":"Filamin A expression correlates with proliferation and invasive properties of human metastatic melanoma tumors: Implications for survival in patients","volume":"140","author":"Zhang","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14282","DOI":"10.1016\/S0021-9258(18)71675-X","article-title":"In situ phosphorylation of platelet actin-binding protein by cAMP-dependent protein kinase stabilizes it against proteolysis by calpain","volume":"264","author":"Chen","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/abbi.2000.1762","article-title":"Determination of a cAMP-dependent protein kinase phosphorylation site in the C-terminal region of human endothelial actin-binding protein","volume":"377","author":"Jay","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/B:MCBI.0000026052.76418.55","article-title":"In situ determination of a PKA phosphorylation site in the C-terminal region of filamin","volume":"260","author":"Jay","year":"2004","journal-title":"Mol. Cell Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/23\/16573\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:26:18Z","timestamp":1760131578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/23\/16573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,21]]},"references-count":43,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["ijms242316573"],"URL":"https:\/\/doi.org\/10.3390\/ijms242316573","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2023,11,21]]}}}