{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:46Z","timestamp":1787028526502,"version":"build-2736575974"},"reference-count":67,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University College London (UCL)","award":["#A"],"award-info":[{"award-number":["#A"]}]},{"name":"University of Catania, Catania, Italy, Department of Clinical and Experimental Medicine","award":["#A"],"award-info":[{"award-number":["#A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Host genetic variants may affect oral biofilms, playing a role in the periodontitis\u2013systemic disease axis. This is the first study to assess the associations between host genetic variants and subgingival microbiota in patients with metabolic syndrome (MetS); 103 patients with MetS underwent medical and periodontal examinations and had blood and subgingival plaque samples taken. DNA was extracted and processed, assessing a panel of selected single nucleotide polymorphisms (SNPs) first (hypothesis testing) and then expanding to a discovery phase. The subgingival plaque microbiome from these patients was profiled. Analysis of associations between host genetic and microbial factors was performed and stratified for periodontal diagnosis. Specific SNPs within RUNX2, CAMTA1 and VDR genes were associated with diversity metrics with no genome-wide associations detected for periodontitis severity or Mets components at p &lt; 10\u22127. Severe periodontitis was associated with pathogenic genera and species. Some SNPs correlated with specific bacterial genera as well as with microbial taxa, notably VDR (rs12717991) with Streptococcus mutans and RUNX2 (rs3749863) with Porphyromonas gingivalis. In conclusion, variation in host genotypes may play a role in the dysregulated immune responses characterizing periodontitis and thus the oral microbiome, suggesting that systemic health-associated host traits further interact with oral health and the microbiome.<\/jats:p>","DOI":"10.3390\/ijms242316649","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T06:06:23Z","timestamp":1700719583000},"page":"16649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic Syndrome"],"prefix":"10.3390","volume":"24","author":[{"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abish S.","family":"Stephen","sequence":"additional","affiliation":[{"name":"Centre for Immunobiology & Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London (QMUL), London E1 4NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Allaker","sequence":"additional","affiliation":[{"name":"Centre for Immunobiology & Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London (QMUL), London E1 4NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Di Pino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Terranova","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Cannizzaro Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Cannizzaro Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Di Marca","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Cannizzaro Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cell.2006.02.003","article-title":"Infectogenomics: Insights from the Host Genome into Infectious Diseases","volume":"124","author":"Weiss","year":"2006","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nibali, L., Henderson, B., Sadiq, S.T., and Donos, N. 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