{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:20:11Z","timestamp":1789068011423,"version":"build-2803163510"},"reference-count":87,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia","award":["194\/442"],"award-info":[{"award-number":["194\/442"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In this study, novel selective antitumor compounds were synthesized based on their fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular hybridization approach was employed to design and prepare a range of 4H-chromene-3-carboxylates 7a\u2013g, 8, and 11a\u2013e derivatives, each incorporating a sulfonamide moiety. The structures of these hybrid molecules were verified using comprehensive analytical and spectroscopic techniques. During the assessment of the newly synthesized compounds for their anticancer properties against three tumor cell lines (HepG-2, MCF-7, and HCT-116), compounds 7f and 7g displayed remarkable antitumor activity against all tested cell lines, outperforming the reference drug Cisplatin in terms of efficacy. Consequently, these promising candidates were selected for further investigation of their anti-EGFR, hCAII, and MMP-2 potential, which exhibited remarkable effectiveness against EGFR and MMP2 when compared to Sorafenib. Additionally, docking investigations regarding the EGFR binding site were implemented for the targeted derivatives in order to attain better comprehension with respect to the pattern in which binding mechanics occur between the investigated molecules and the active site, which illustrated a higher binding efficacy in comparison with Sorafenib.<\/jats:p>","DOI":"10.3390\/ijms242316716","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T06:51:28Z","timestamp":1700808688000},"page":"16716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, hCAII, and MMP-2 Inhibitors Based on Molecular Docking Assays"],"prefix":"10.3390","volume":"24","author":[{"given":"Fawzia F.","family":"Alblewi","sequence":"first","affiliation":[{"name":"Chemistry Department, College of Science, Taibah University, Medina 30002, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosa H.","family":"Alsehli","sequence":"additional","affiliation":[{"name":"Chemistry Department, College of Science, Taibah University, Medina 30002, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab M.","family":"Hritani","sequence":"additional","affiliation":[{"name":"Chemistry Department, College of Science, Taibah University, Medina 30002, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej","family":"Eskandrani","sequence":"additional","affiliation":[{"name":"Chemistry Department, College of Science, Taibah University, Medina 30002, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael H.","family":"Alsaedi","sequence":"additional","affiliation":[{"name":"Chemistry Department, College of Science, Taibah University, Medina 30002, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-7694","authenticated-orcid":false,"given":"Majed O.","family":"Alawad","sequence":"additional","affiliation":[{"name":"Center of Excellence for Nanomaterials for Clean Energy Applications, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-0376","authenticated-orcid":false,"given":"Ahmed A.","family":"Elhenawy","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Egypt"},{"name":"Chemistry Department, Faculty of Science and Art, AlBaha University, Al Bahah 65731, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-7769","authenticated-orcid":false,"given":"Hanaa Y.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"The Regional Center for Mycology and Biotechnology, Al-Azhar University, Nasr City 11884, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S. 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