{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:14Z","timestamp":1792789454219,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174012"],"award-info":[{"award-number":["82174012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021-I2M-1-031"],"award-info":[{"award-number":["2021-I2M-1-031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["82174012"],"award-info":[{"award-number":["82174012"]}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["2021-I2M-1-031"],"award-info":[{"award-number":["2021-I2M-1-031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ginsenoside Rg3 extracted from Panax notoginseng has therapeutic effects on diabetes and heart diseases. However, the underlying mechanism of ginsenoside Rg3 on diabetic cardiomyopathy (DCM) remains unclear. 24-week-old diabetic db\/db mice were treated with ginsenoside Rg3 for 12 weeks, then body weight, serum lipids, adiponectin levels, as well as cardiac function and pathological morphology, were measured. The targets of ginsenoside Rg3 and its regulation of the adiponectin pathway were also evaluated on 3T3-L1 or H9c2 cells. Ginsenoside Rg3 directly bound to PPAR-\u03b3, improving adiponectin secretion and promoting adiponectin signaling. Significantly attenuated overweight, hyperglycemia, and hyperlipidemia, as well as alleviated lipid accumulation and dysfunction in adipose, liver, and heart tissues, were observed in the ginsenoside Rg3-treated group. Ginsenoside Rg3 could be a promising drug targeting PPAR-\u03b3 to treat diabetic cardiomyopathy.<\/jats:p>","DOI":"10.3390\/ijms242316736","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:32:03Z","timestamp":1701055923000},"page":"16736","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Ginsenoside Rg3 Protects against Diabetic Cardiomyopathy and Promotes Adiponectin Signaling via Activation of PPAR-\u03b3"],"prefix":"10.3390","volume":"24","author":[{"given":"Chenyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxue","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongna","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibo","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.118.314665","article-title":"Diabetic Cardiomyopathy","volume":"124","author":"Dillmann","year":"2019","journal-title":"Circ. Res."},{"key":"ref_2","first-page":"1160","article-title":"Diabetic cardiomyopathy: A hyperglycaemia- and insulin-resistance-induced heart disease","volume":"124","author":"Jia","year":"2019","journal-title":"Diabetologia"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nakamura, K., Miyoshi, T., Yoshida, M., Akagi, S., Saito, Y., Ejiri, K., Matsuo, N., Ichikawa, K., Iwasaki, K., and Naito, T. (2022). Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073587"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pcad.2019.03.003","article-title":"Diabetic cardiomyopathy\u2014A comprehensive updated review","volume":"62","author":"Murtaza","year":"2019","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1194\/jlr.R024505","article-title":"PPAR-gamma as a therapeutic target in cardiovascular disease: Evidence and uncertainty","volume":"53","author":"Huang","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cardiores.2004.12.008","article-title":"Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock","volume":"65","author":"Abdelrahman","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11892-019-1270-y","article-title":"Thiazolidinediones: The Forgotten Diabetes Medications","volume":"19","author":"Lebovitz","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1142\/S0192415X18500519","article-title":"Panax notoginseng for Inflammation-Related Chronic Diseases: A Review on the Modulations of Multiple Pathways","volume":"46","author":"Xu","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2018.05.005","article-title":"Identification of certain Panax species to be potential substitutes for Panax notoginseng in hemostatic treatments","volume":"134","author":"Yang","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"105263","DOI":"10.1016\/j.phrs.2020.105263","article-title":"Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy","volume":"161","author":"Liu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/JIR.S348866","article-title":"Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway","volume":"15","author":"Zhang","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e023540","DOI":"10.1161\/JAHA.121.023540","article-title":"Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation","volume":"11","author":"Zhang","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fphar.2020.00130","article-title":"Relationship Between Ginsenoside Rg3 and Metabolic Syndrome","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"975784","DOI":"10.3389\/fphar.2022.975784","article-title":"Pharmacological properties, molecular mechanisms and therapeutic potential of ginsenoside Rg3 as an antioxidant and anti-inflammatory agent","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1530\/JOE-17-0233","article-title":"Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARgamma","volume":"235","author":"Lee","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41419-020-2597-7","article-title":"Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhu, X., Yang, J., Zhu, W., Yin, X., Yang, B., Wei, Y., and Guo, X. (2018). Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123903"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/CIRCULATIONAHA.119.040551","article-title":"Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure-A Report from the 2018 National Heart, Lung, and Blood Institute Workshop","volume":"140","author":"Tian","year":"2019","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1172\/JCI129187","article-title":"Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome","volume":"129","author":"Kahn","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"108008","DOI":"10.1016\/j.pharmthera.2021.108008","article-title":"The adiponectin signalling pathway\u2014A therapeutic target for the cardiac complications of type 2 diabetes?","volume":"232","author":"Sharma","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G.A., Beguinot, F., and Miele, C. (2019). Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092358"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ya, H., and Yoshida, H. (2019). Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051190"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Achari, A.E., and Jain, S.K. (2017). Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061321"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2174\/092986712799320583","article-title":"Adiponectin and cardiovascular disease: Mechanisms and new therapeutic approaches","volume":"19","author":"Siasos","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.21775\/cimb.028.029","article-title":"PGC-1: The Energetic Regulator in Cardiac Metabolism","volume":"28","author":"Di","year":"2018","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcvm.2020.00002","article-title":"Multiple Levels of PGC-1alpha Dysregulation in Heart Failure","volume":"7","author":"Oka","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bhagani, H., Nasser, S.A., Dakroub, A., El-Yazbi, A.F., Eid, A.A., Kobeissy, F., Pintus, G., and Eid, A.H. (2020). The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144962"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"152774","DOI":"10.1016\/j.phymed.2018.11.034","article-title":"Luteolin protects against diabetic cardiomyopathy by inhibiting NF-kappaB-mediated inflammation and activating the Nrf2-mediated antioxidant responses","volume":"59","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2417418","DOI":"10.1155\/2019\/2417418","article-title":"Ginsenoside Rg3 (Shenyi Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A Meta-Analysis and Systematic Review","volume":"2019","author":"Pan","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jgr.2018.10.001","article-title":"Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats","volume":"44","author":"Li","year":"2020","journal-title":"J. Ginseng Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104522","DOI":"10.1016\/j.yrtph.2019.104522","article-title":"A 26-week 20(S)-ginsenoside Rg3 oral toxicity study in Beagle dogs","volume":"110","author":"Gao","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/23\/16736\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:29:54Z","timestamp":1760131794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/23\/16736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,24]]},"references-count":31,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["ijms242316736"],"URL":"https:\/\/doi.org\/10.3390\/ijms242316736","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,24]]}}}