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They can penetrate the blood\u2013brain barrier, specifically affecting synaptic plasticity and the learning and memory ability of hippocampal neurons. Temporal lobe epilepsy often occurs in the hippocampus. Thus, the possible influence of AsHCs exposure to temporal lobe epilepsy garnered attention. The present study investigated the effects of epileptiform discharges (EDs) signals introduced by low-magnesium ACSF in the hippocampus of infantile male rats in vitro, using electrophysiological techniques with multi-electrode arrays under AsHC 360 exposure. In our study of the effects of AsHC 360 on EDs signals, we found that inter-ictal discharges (IIDs) were not significantly impacted. When AsHC 360 was removed, any minor effects observed were reversed. However, when we examined the impact of AsHC 360 on ictal discharges (IDs), distinct patterns emerged based on the concentration levels. For low-concentration groups (5, 20, 60 \u03bcg As L\u22121), both the frequency and duration effects on IDs returned to normal post-elimination of AsHC 360. However, this recovery was not evident for concentrations of 100 \u03bcg As L\u22121 or higher. IDs were only observed in EDs signals during exposures to AsHC 360 concentrations up to 60 \u03bcg As L\u22121. In these conditions, ID frequencies significantly enhanced with the increased of AsHC 360 concentration. At high concentrations of AsHC 360 (\u2265100 \u03bcg As L\u22121), the transition from IIDs or pre-ictal discharges (PIDs) to IDs was notably inhibited. Additional study on co-exposure of AsHC 360 (100 \u03bcg As L\u22121) and agonist (10 nM (S)-(-)-Bay-K-8644) indicated that the regulation of EDs signals under AsHC 360 exposure could be due to directly interference with the \u03b1-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) expression which influences the binding of excitatory glutamate neurotransmitter to AMPAR. The results suggest that EDs activities in the hippocampus of infantile Sprague Dawley rats are concentration-dependent on AsHC 360 exposure. Thus, it provides a basis for the seafood intake with AsHCs for epileptic patients and those with potential seizures.<\/jats:p>","DOI":"10.3390\/ijms242316806","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:48:17Z","timestamp":1701056897000},"page":"16806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["AsHC 360 Exposure Influence on Epileptiform Discharges in Hippocampus of Infantile Male Rats In Vitro"],"prefix":"10.3390","volume":"24","author":[{"given":"Lei","family":"Dong","sequence":"first","affiliation":[{"name":"School of Life Sciences, Tiangong University, Tianjin 300387, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tiangong University, Tianjin 300387, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-7203","authenticated-orcid":false,"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tiangong University, Tianjin 300387, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tiangong University, Tianjin 300387, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-945X","authenticated-orcid":false,"given":"Chan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, NAWI Graz, University of Graz, Graz 8010, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-9127","authenticated-orcid":false,"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tiangong University, Tianjin 300387, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1126\/science.1081903","article-title":"The ecology of arsenic","volume":"300","author":"Oremland","year":"2003","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.aogh.2014.09.005","article-title":"The developmental neurotoxicity of arsenic: Cognitive and behavioral consequences of early life exposure","volume":"80","author":"Tolins","year":"2014","journal-title":"Ann. 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