{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:15:42Z","timestamp":1791688542246,"version":"4.3.4"},"reference-count":169,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI22\/00347"],"award-info":[{"award-number":["PI22\/00347"]}]},{"name":"Instituto de Salud Carlos III","award":["PI19\/00744"],"award-info":[{"award-number":["PI19\/00744"]}]},{"name":"Instituto de Salud Carlos III","award":["CP15\/00053"],"award-info":[{"award-number":["CP15\/00053"]}]},{"name":"Instituto de Salud Carlos III","award":["CPII20\/00017"],"award-info":[{"award-number":["CPII20\/00017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The purinergic system has a dual role: the maintenance of energy balance and signaling within cells. Adenosine and adenosine triphosphate (ATP) are essential for maintaining these functions. Sarcopenia is characterized by alterations in the control of energy and signaling in favor of catabolic pathways. This review details the association between the purinergic system and muscle and adipose tissue homeostasis, discussing recent findings in the involvement of purinergic receptors in muscle wasting and advances in the use of the purinergic system as a novel therapeutic target in the management of sarcopenia.<\/jats:p>","DOI":"10.3390\/ijms242316904","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:48:24Z","timestamp":1701229704000},"page":"16904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Energy Regulation in Inflammatory Sarcopenia by the Purinergic System"],"prefix":"10.3390","volume":"24","author":[{"given":"Miguel","family":"Marco-Bonilla","sequence":"first","affiliation":[{"name":"Bone and Joint Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fresnadillo","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-2944","authenticated-orcid":false,"given":"Raquel","family":"Largo","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-991X","authenticated-orcid":false,"given":"Gabriel","family":"Herrero-Beaumont","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-574X","authenticated-orcid":false,"given":"Ar\u00e1nzazu","family":"Mediero","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1038\/ijo.2008.246","article-title":"Energy Metabolism, Fuel Selection and Body Weight Regulation","volume":"32","author":"Galgani","year":"2008","journal-title":"Int. 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