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Limited studies have investigated the therapeutic effects of corylin, a flavonoid extracted from Psoralea corylifolia L. (Fabaceae), on liver fibrosis. Therefore, we evaluated the anti-inflammatory activity of corylin and investigated its efficacy and mechanism of action in ameliorating liver fibrosis. Corylin significantly inhibited inflammatory responses by inhibiting the activation of mitogen-activated protein kinase signaling pathways and the expression of interleukin (IL)-1\u03b2, IL-6, and tumor necrosis factor-alpha in human THP-1 and mouse RAW264.7 macrophages. Furthermore, corylin inhibited the expression of growth arrest-specific gene 6 in human hepatic stellate cells (HSCs) and the activation of the downstream phosphoinositide 3-kinase\/protein kinase B pathway. This inhibited the activation of HSCs and the expression of extracellular matrix proteins, including \u03b1-smooth muscle actin and type I collagen. Additionally, corylin induced caspase 9 and caspase 3 activation, which promoted apoptosis in HSCs. Moreover, in vivo experiments confirmed the regulatory effects of corylin on these proteins, and corylin alleviated the symptoms of carbon tetrachloride-induced liver fibrosis in mice. These findings revealed that corylin has anti-inflammatory activity and inhibits HSC activation; thus, it presents as a potential adjuvant in the treatment of liver fibrosis.<\/jats:p>","DOI":"10.3390\/ijms242316936","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:00:18Z","timestamp":1701248418000},"page":"16936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Corylin Attenuates CCl4-Induced Liver Fibrosis in Mice by Regulating the GAS6\/AXL Signaling Pathway in Hepatic Stellate Cells"],"prefix":"10.3390","volume":"24","author":[{"given":"Chin-Chuan","family":"Chen","sequence":"first","affiliation":[{"name":"Biobank, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"Graduate Institute of Natural Products, Chang Gung University, Tao-Yuan 33303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Biobank, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"Graduate Institute of Health Industry and Technology, Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Tao-Yuan 33303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau-Ting","family":"Yeh","sequence":"additional","affiliation":[{"name":"Liver Research Center, Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tsen","family":"Liu","sequence":"additional","affiliation":[{"name":"Biobank, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-6798","authenticated-orcid":false,"given":"Yann-Lii","family":"Leu","sequence":"additional","affiliation":[{"name":"Biobank, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"Graduate Institute of Natural Products, Chang Gung University, Tao-Yuan 33303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yu","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"College of Medicine, Chang Gung University, Tao-Yuan 33303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-4185","authenticated-orcid":false,"given":"Yin-Hwa","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration, Asia University, Taichung 41354, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fang","family":"Chou","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-9120","authenticated-orcid":false,"given":"Tzong-Ming","family":"Shieh","sequence":"additional","affiliation":[{"name":"School of Dentistry, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9248-9031","authenticated-orcid":false,"given":"Tong-Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Biobank, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"Graduate Institute of Natural Products, Chang Gung University, Tao-Yuan 33303, Taiwan"},{"name":"Graduate Institute of Health Industry and Technology, Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Tao-Yuan 33303, Taiwan"},{"name":"Liver Research Center, Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Roehlen, N., Crouchet, E., and Baumert, T.F. 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