{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:06:21Z","timestamp":1792033581377,"version":"4.4.0"},"reference-count":63,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Education of the Republic of Croatia","award":["219-0061194-2158"],"award-info":[{"award-number":["219-0061194-2158"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gangliosides are major glycans on vertebrate nerve cells, and their metabolic disruption results in congenital disorders with marked cognitive and motor deficits. The sialyltransferase gene St3gal2 is responsible for terminal sialylation of two prominent brain gangliosides in mammals, GD1a and GT1b. In this study, we analyzed the expression of calcium-binding interneurons in primary sensory (somatic, visual, and auditory) and motor areas of the neocortex, hippocampus, and striatum of St3gal2-null mice as well as St3gal3-null and St3gal2\/3-double null. Immunohistochemistry with highly specific primary antibodies for GABA, parvalbumin, calretinin, and calbindin were used for interneuron detection. St3gal2-null mice had decreased expression of all three analyzed types of calcium-binding interneurons in all analyzed regions of the neocortex. These results implicate gangliosides GD1a and GT1b in the process of interneuron migration and maturation.<\/jats:p>","DOI":"10.3390\/ijms242417218","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T03:35:31Z","timestamp":1701920131000},"page":"17218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum"],"prefix":"10.3390","volume":"24","author":[{"given":"Senka","family":"Bla\u017eeti\u0107","sequence":"first","affiliation":[{"name":"Department of Biology, Josip Juraj Strossmayer University of Osijek, Ulica cara Hadrijana 8A, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinko","family":"Krajina","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-5131","authenticated-orcid":false,"given":"Irena","family":"Labak","sequence":"additional","affiliation":[{"name":"Department of Biology, Josip Juraj Strossmayer University of Osijek, Ulica cara Hadrijana 8A, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Viljeti\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry and Clinical Chemistry, School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-1755","authenticated-orcid":false,"given":"Valentina","family":"Pavi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology, Josip Juraj Strossmayer University of Osijek, Ulica cara Hadrijana 8A, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedrana","family":"Ivi\u0107","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Balog","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-5484","authenticated-orcid":false,"given":"Ronald L.","family":"Schnaar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6770-7359","authenticated-orcid":false,"given":"Marija","family":"Heffer","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref_1","unstructured":"(2022, June 22). 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