{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:55:35Z","timestamp":1787320535673,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["PCN-1-096\/K\/1\/Z"],"award-info":[{"award-number":["PCN-1-096\/K\/1\/Z"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vascular endothelial growth factor (VEGF) is implicated in both the etiology of tendinopathy and its healing process. Polymorphic variants of the VEGFA gene exhibit varied expression, which can influence the phenotype and treatment effectiveness. The aim of the present study was to analyze the influence of VEGFA gene variants on the effectiveness of tennis elbow therapy using platelet-rich plasma (PRP), measured through common patient-reported outcome measures (PROMs). A cohort of 107 patients (132 elbows) with tennis elbow was prospectively analyzed, with a two-year follow-up (at weeks 2, 4, 8, 12, 24, 52, and 104 after PRP injection). PROMs values were compared between variants of five VEGFA gene polymorphisms (rs699947 A&gt;C, rs2010963 C&gt;G, rs1413711 C&gt;T, rs3024998 C&gt;T and rs3025021 C&gt;T) at each follow-up point. Patients with genotypes GG (rs2010963) and CC (rs3024998) had better response to PRP therapy (significantly fewer symptoms and limitations in the upper limb compared to carriers of alleles C and T, respectively). Polymorphisms influenced also selected hematological parameters. VEGFA gene polymorphisms (rs2010963 and rs3024998) appear to be significant treatment modifiers for tendinopathy, and their genotyping may serve as an effective tool for personalized patient selection for PRP therapy.<\/jats:p>","DOI":"10.3390\/ijms242417292","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T03:25:31Z","timestamp":1702265131000},"page":"17292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic Variability in VEGFA Gene Influences the Effectiveness of Tennis Elbow Therapy with PRP: A Two-Year Prospective Cohort Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Pawe\u0142","family":"Niemiec","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, the Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-6437","authenticated-orcid":false,"given":"Alicja","family":"Jarosz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, the Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-7796","authenticated-orcid":false,"given":"Anna","family":"Balcerzyk-Mati\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, the Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-9554","authenticated-orcid":false,"given":"Joanna","family":"Iwanicka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, the Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, the Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-3162","authenticated-orcid":false,"given":"Tomasz","family":"Iwanicki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, the Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-9692","authenticated-orcid":false,"given":"Marcin","family":"Gierek","sequence":"additional","affiliation":[{"name":"Center for Burns Treatment, Jana Paw\u0142a II Str., 41-100 Siemianowice \u015al\u0105skie, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Kalita","sequence":"additional","affiliation":[{"name":"District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 Piekary \u015al\u0105skie, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5343-1205","authenticated-orcid":false,"given":"Wojciech","family":"Garczorz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-6090","authenticated-orcid":false,"given":"Tomasz","family":"Francuz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia in Katowice, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-7216","authenticated-orcid":false,"given":"Sylwia","family":"G\u00f3rczy\u0144ska-Kosiorz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Diabetology and Nephrology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Kania","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopedic Surgery, Multidisciplinary Hospital in Jaworzno, Che\u0142mo\u0144skiego 28 Str., 43-600 Jaworzno, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-9014","authenticated-orcid":false,"given":"Karol","family":"Szyluk","sequence":"additional","affiliation":[{"name":"District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 Piekary \u015al\u0105skie, Poland"},{"name":"Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyk\u00f3w 12 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-020-00234-1","article-title":"Tendinopathy","volume":"7","author":"Millar","year":"2021","journal-title":"Nat. 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