{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:48Z","timestamp":1787028528709,"version":"build-2736575974"},"reference-count":186,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-74-30011"],"award-info":[{"award-number":["19-74-30011"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lung cancer is the leading cause of cancer-related death worldwide. Its high mortality is partly due to chronic inflammation that accompanies the disease and stimulates cancer progression. In this review, we analyzed recent studies and highlighted the role of the epithelial\u2013mesenchymal transition (EMT) as a link between inflammation and lung cancer. In the inflammatory tumor microenvironment (iTME), fibroblasts, macrophages, granulocytes, and lymphocytes produce inflammatory mediators, some of which can induce EMT. This leads to increased invasiveness of tumor cells and self-renewal of cancer stem cells (CSCs), which are associated with metastasis and tumor recurrence, respectively. Based on published data, we propose that inflammation-induced EMT may be a potential therapeutic target for the treatment of lung cancer. This prospect is partially realized in the development of EMT inhibitors based on pentacyclic triterpenoids (PTs), described in the second part of our study. PTs reduce the metastatic potential and stemness of tumor cells, making PTs promising candidates for lung cancer therapy. We emphasize that the high diversity of molecular mechanisms underlying inflammation-induced EMT far exceeds those that have been implicated in drug development. Therefore, analysis of information on the relationship between the iTME and EMT is of great interest and may provide ideas for novel treatment approaches for lung cancer.<\/jats:p>","DOI":"10.3390\/ijms242417325","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T03:25:31Z","timestamp":1702265131000},"page":"17325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Nexus of Inflammation-Induced Epithelial-Mesenchymal Transition and Lung Cancer Progression: A Roadmap to Pentacyclic Triterpenoid-Based Therapies"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-0014","authenticated-orcid":false,"given":"Kirill V.","family":"Odarenko","sequence":"first","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"},{"name":"Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-1049","authenticated-orcid":false,"given":"Marina A.","family":"Zenkova","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-9555","authenticated-orcid":false,"given":"Andrey V.","family":"Markov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"69","article-title":"Algorithms of non-invasive, minimally-invasive and invasive diagnostics for lung cancer (review)","volume":"2","author":"Arseniev","year":"2021","journal-title":"Prev. Clin. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100773","DOI":"10.1016\/j.tranon.2020.100773","article-title":"Epithelial-Mesenchymal Transition in Cancer: A Historical Overview","volume":"13","author":"Ribatti","year":"2020","journal-title":"Transl. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s11748-021-01595-4","article-title":"Lung cancer and epithelial-mesenchymal transition","volume":"69","author":"Menju","year":"2021","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.21873\/anticanres.11510","article-title":"Epithelial-Mesenchymal Transition in Non Small-cell Lung Cancer","volume":"37","author":"Tsoukalas","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_6","first-page":"1687","article-title":"The relationship between chronic lung diseases and lung cancer-a narrative review","volume":"25","author":"Trandafir","year":"2020","journal-title":"JBUON"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Szalontai, K., G\u00e9mes, N., Fur\u00e1k, J., Varga, T., Neuperger, P., Balog, J.\u00c1., Pusk\u00e1s, L.G., and Szebeni, G.J. (2021). Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132889"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-11375-x","article-title":"\u03b2-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction","volume":"7","author":"Mahmood","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"663303","DOI":"10.3389\/fimmu.2021.663303","article-title":"Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis","volume":"12","author":"Pandolfi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2174\/0929867324666170112115313","article-title":"Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives","volume":"24","author":"Markov","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kozak, J., Forma, A., Czeczelewski, M., Kozyra, P., Sitarz, E., Radzikowska-B\u00fcchner, E., Sitarz, M., and Baj, J. (2021). Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010277"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2017.01.029","article-title":"Potential therapeutic targets of epithelial\u2013mesenchymal transition in melanoma","volume":"391","author":"Pearlman","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tang, Z.Y., Li, Y., Tang, Y.T., Ma, X.D., and Tang, Z.Y. (2022). Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action. Biomed. Pharmacother., 145.","DOI":"10.1016\/j.biopha.2021.112397"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105224","DOI":"10.1016\/j.phrs.2020.105224","article-title":"Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms","volume":"163","author":"He","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35376","DOI":"10.18632\/oncotarget.15686","article-title":"Epithelial-mesenchymal transition in prostate cancer: An overview","volume":"8","author":"Montanari","year":"2017","journal-title":"Oncotarget"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"714","DOI":"10.4161\/cbt.11.8.15274","article-title":"EMT: A new vision of hypoxia promoting cancer progression","volume":"11","author":"Jiang","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12935-014-0129-1","article-title":"Acidic extracellular ph promotes epithelial mesenchymal transition in lewis lung carcinoma model","volume":"14","author":"Suzuki","year":"2014","journal-title":"Cancer Cell Int."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Deng, Z., Fear, M.W., Suk Choi, Y., Wood, F.M., Allahham, A., Mutsaers, S.E., and Pr\u00eale, C.M. (2020). The extracellular matrix and mechanotransduction in pulmonary fibrosis. Int. J. Biochem. Cell Biol., 126.","DOI":"10.1016\/j.biocel.2020.105802"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Debnath, P., Huirem, R.S., Dutta, P., and Palchaudhuri, S. (2021). Epithelial\u2013mesenchymal transition and its transcription factors. Biosci. Rep., 42.","DOI":"10.1042\/BSR20211754"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Loh, C.Y., Chai, J.Y., Tang, T.F., Wong, W.F., Sethi, G., Shanmugam, M.K., Chong, P.P., and Looi, C.Y. (2019). The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells, 8.","DOI":"10.3390\/cells8101118"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15966","DOI":"10.18632\/oncotarget.3862","article-title":"Vimentin contributes to epithelial-mesenchymal transition ancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.matbio.2017.01.001","article-title":"Fibronectin fibrils regulate TGF-\u03b21-induced Epithelial-Mesenchymal Transition","volume":"60\u201361","author":"Griggs","year":"2017","journal-title":"Matrix Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ncb2743","article-title":"The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis","volume":"15","author":"Zhang","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial\u2013mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rajasegaran, T., How, C.W., Saud, A., Ali, A., and Lim, J.C. (2023). Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing. Pharmaceuticals, 16.","DOI":"10.3390\/ph16030451"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrc3477","article-title":"Mechanistic links between COPD and lung cancer","volume":"13","author":"Houghton","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1164\/ajrccm.161.1.ed14-99","article-title":"Does idiopathic pulmonary fibrosis increase lung cancer risk?","volume":"161","author":"Samet","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.semcancer.2021.01.003","article-title":"Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19","volume":"83","author":"Ahmad","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Islam, M.S., Morshed, M.R., Babu, G., and Khan, M.A. (2022). The role of inflammations and EMT in carcinogenesis. Adv. Cancer Biol.-Metastasis, 5.","DOI":"10.1016\/j.adcanc.2022.100055"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41417-021-00318-4","article-title":"Cancer-associated fibroblasts: Overview, progress, challenges, and directions","volume":"28","author":"Ping","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12307-011-0089-0","article-title":"The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis","volume":"5","author":"Heinrich","year":"2012","journal-title":"Cancer Microenviron."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.athoracsur.2013.03.092","article-title":"Pulmonary Fibroblasts Induce Epithelial Mesenchymal Transition and Some Characteristics of Stem Cells in Non-Small Cell Lung Cancer","volume":"96","author":"Shintani","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbadis.2017.12.021","article-title":"Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF\/IGF-1\/ANXA2 signaling","volume":"1864","author":"Yi","year":"2018","journal-title":"Biochim. Biophys. Acta-Mol. Basis Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jtho.2016.05.025","article-title":"IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling","volume":"11","author":"Shintani","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"76116","DOI":"10.18632\/oncotarget.18814","article-title":"Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6\/STAT3 signaling pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41419-021-03509-x","article-title":"Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4\/\u03b2-catenin\/PPAR\u03b4 signalling","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41419-021-04150-4","article-title":"Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NF\u03baB signaling","volume":"12","author":"Ren","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/qjmed\/hcz093","article-title":"Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes","volume":"112","author":"You","year":"2019","journal-title":"QJM Int. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109675","DOI":"10.1016\/j.cellsig.2020.109675","article-title":"MiR-210 in exosomes derived from CAFs promotes non-small cell lung cancer migration and invasion through PTEN\/PI3K\/AKT pathway","volume":"73","author":"Yang","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9918379","DOI":"10.1155\/2021\/9918379","article-title":"Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer","volume":"2021","author":"Chattopadhyay","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000509280","article-title":"The Role of miR-210 in the Biological System: A Current Overview","volume":"84","author":"Hui","year":"2020","journal-title":"Hum. Hered."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1038\/s41598-018-21061-1","article-title":"Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)","volume":"8","author":"Chae","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/bjc.2015.29","article-title":"Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune- modulatory properties in cancer cells","volume":"116","author":"Ricciardi","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of TAN phenotype by TGFb: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGF\u03b2 in Cancer","volume":"134","year":"2008","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1007\/s13277-015-3484-1","article-title":"Intratumoral neutrophil granulocytes contribute to epithelial-mesenchymal transition in lung adenocarcinoma cells","volume":"36","author":"Hu","year":"2015","journal-title":"Tumor Biol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Yasukawa, A., Hosoki, K., Toda, M., Miyake, Y., Matsushima, Y., Matsumoto, T., Boveda-Ruiz, D., Gil-Bernabe, P., Nagao, M., and Sugimoto, M. (2013). Eosinophils Promote Epithelial to Mesenchymal Transition of Bronchial Epithelial Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064281"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbrc.2014.05.033","article-title":"Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils","volume":"449","author":"Hosoki","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/17476348.2019.1670640","article-title":"Asthma pharmacotherapy: An update on leukotriene treatments","volume":"13","author":"Trinh","year":"2019","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/imcb.12236","article-title":"Macrophages in wound healing: Activation and plasticity","volume":"97","author":"Kim","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2006.01.007","article-title":"Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis","volume":"124","author":"Condeelis","year":"2006","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1158\/0008-5472.CAN-11-0156","article-title":"IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells","volume":"71","author":"Fernando","year":"2011","journal-title":"Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s13277-014-2717-z","article-title":"The CCL2\/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling","volume":"36","author":"Chen","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2014.03.004","article-title":"Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6","volume":"160","author":"Dehai","year":"2014","journal-title":"Immunol. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/0960327119881678","article-title":"Lipopolysaccharide induces epithelial\u2013mesenchymal transition of alveolar epithelial cells cocultured with macrophages possibly via the JAK2\/STAT3 signaling pathway","volume":"39","author":"Qin","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.3892\/ol.2017.6048","article-title":"IL-6 and TNF-\u03b1 promote metastasis of lung cancer by inducing epithelial-mesenchymal transition","volume":"13","author":"Shang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12931-020-01346-8","article-title":"Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells","volume":"21","author":"Yin","year":"2020","journal-title":"Respir. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.3892\/ol.2017.6487","article-title":"Mast cell chymase affects the proliferation and metastasis of lung carcinoma cells in vitro","volume":"14","author":"Jiang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41598-019-57285-y","article-title":"Chronic IL-1 \u03b2 -induced inflammation regulates epithelial- to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_63","first-page":"440","article-title":"IL-17 induces EMT via Stat3 in lung adenocarcinoma","volume":"6","author":"Huang","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/cm.20315","article-title":"Inflammatory cytokines augments TGF-\u03b21-induced epithelial-mesenchymal transition in A549 cells by up-regulating T\u03b2R-I","volume":"65","author":"Liu","year":"2008","journal-title":"Cell Motil. Cytoskelet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.imlet.2012.10.011","article-title":"IL-17 promoted metastasis of non-small-cell lung cancer cells","volume":"148","author":"Li","year":"2012","journal-title":"Immunol. Lett."},{"key":"ref_66","first-page":"1169","article-title":"Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-\u03baB\/ZEB1 signal pathway","volume":"5","author":"Gu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kumar, M., Allison, D.F., Baranova, N.N., Wamsley, J.J., Katz, A.J., Bekiranov, S., Jones, D.R., and Mayo, M.W. (2013). NF-\u03baB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068597"},{"key":"ref_68","first-page":"3761","article-title":"Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas","volume":"58","author":"Hida","year":"1998","journal-title":"Cancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1158\/0008-5472.CAN-05-3635","article-title":"Cyclooxygenase-2-dependent regulation of E-cadherin: Prostaglandin E 2 induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer","volume":"66","author":"Dohadwala","year":"2006","journal-title":"Cancer Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Takai, E., Tsukimoto, M., and Kojima, S. (2013). TGF-\u03b21 Downregulates COX-2 Expression Leading to Decrease of PGE2 Production in Human Lung Cancer A549 Cells, Which Is Involved in Fibrotic Response to TGF-\u03b21. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076346"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.33594\/000000506","article-title":"Regulation of Epithelial-Mesenchymal Transition of A549 Cells by Prostaglandin D2","volume":"56","author":"Vafaeinik","year":"2022","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fimmu.2014.00101","article-title":"Hyaluronan, a Crucial Regulator of Inflammation","volume":"5","author":"Petrey","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Marozzi, M., Parnigoni, A., Negri, A., Viola, M., Vigetti, D., Passi, A., Karousou, E., and Rizzi, F. (2021). Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158102"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chow, G., Tauler, J., and Mulshine, J.L. (2010). Cytokines and Growth Factors Stimulate Hyaluronan Production: Role of Hyaluronan in Epithelial to Mesenchymal-Like Transition in Non-Small Cell Lung Cancer. J. Biomed. Biotechnol., 2010.","DOI":"10.1155\/2010\/485468"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1016\/j.biomaterials.2014.09.010","article-title":"Acquisition of epithelial\u2013mesenchymal transition and cancer stem-like phenotypes within chitosan-hyaluronan membrane-derived 3D tumor spheroids","volume":"35","author":"Huang","year":"2014","journal-title":"Biomaterials"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.actbio.2016.06.014","article-title":"Chitosan-hyaluronan based 3D co-culture platform for studying the crosstalk of lung cancer cells and mesenchymal stem cells","volume":"42","author":"Han","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1158\/1535-7163.MCT-17-1279","article-title":"CD44 Facilitates Epithelial-to-Mesenchymal Transition Phenotypic Change at Acquisition of Resistance to EGFR Kinase Inhibitors in Lung Cancer","volume":"17","author":"Suda","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3934\/mbe.2020114","article-title":"RHAMM regulates the growth and migration of lung adenocarcinoma A549 cell line by regulating Cdc2\/CyclinB1 and MMP9 genes","volume":"17","author":"Chen","year":"2020","journal-title":"Math. Biosci. Eng."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/mc.22443","article-title":"CD44 is functionally crucial for driving lung cancer stem cells metastasis through Wnt\/\u03b2-catenin-FoxM1-Twist signaling","volume":"55","author":"Su","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ijmm.2015.2222","article-title":"Transforming growth factor-\u03b21 induces EMT by the transactivation of epidermal growth factor signaling through HA\/CD44 in lung and breast cancer cells","volume":"36","author":"Li","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_81","first-page":"228","article-title":"CD44 silencing decreases the expression of stem cell-related factors induced by transforming growth factor \u03b21 and tumor necrosis factor \u03b1 in lung cancer: Preliminary findings","volume":"17","author":"Nurwidya","year":"2017","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/JCMA.0000000000000056","article-title":"The subpopulation of CD44-positive cells promoted tumorigenicity and metastatic ability in lung adenocarcinoma","volume":"82","author":"Wang","year":"2019","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Monle\u00f3n-Guinot, I., Milian, L., Mart\u00ednez-Vallejo, P., Sancho-Tello, M., Llop-Miguel, M., Galbis, J.M., Cremades, A., Carda, C., and Mata, M. (2023). Morphological Characterization of Human Lung Cancer Organoids Cultured in Type I Collagen Hydrogels: A Histological Approach. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210131"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"818437","DOI":"10.3389\/fonc.2022.818437","article-title":"Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models","volume":"12","author":"Lotsberg","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1038\/onc.2016.358","article-title":"ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis","volume":"36","author":"Peng","year":"2017","journal-title":"Oncogene"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/rcmb.2007-0071OC","article-title":"Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor\u2013\u03b2 Signaling","volume":"38","author":"Shintani","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.18632\/oncotarget.11208","article-title":"Collagen XVII\/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"18652","DOI":"10.1038\/srep18652","article-title":"The microRNA-200\/Zeb1 axis regulates ECM-dependent \u03b21-integrin\/FAK signaling, cancer cell invasion and metastasis through CRKL","volume":"6","author":"Ungewiss","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Liu, L., Stephens, B., Bergman, M., May, A., and Chiang, T. (2021). Role of Collagen in Airway Mechanics. Bioengineering, 8.","DOI":"10.3390\/bioengineering8010013"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fonc.2020.00352","article-title":"The Role of Collagen XVII in Cancer: Squamous Cell Carcinoma and Beyond","volume":"10","author":"Jones","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jaad.2019.08.045","article-title":"BP180-specific IgG is associated with skin adverse events, therapy response, and overall survival in non-small cell lung cancer patients treated with checkpoint inhibitors","volume":"82","author":"Bomze","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/cbf.3320","article-title":"Mesenchymal stem cells promote cell invasion and migration and autophagy-induced epithelial-mesenchymal transition in A549 lung adenocarcinoma cells","volume":"36","author":"Luo","year":"2018","journal-title":"Cell Biochem. Funct."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s11033-021-06268-2","article-title":"TGF-\u03b2 promote epithelial-mesenchymal transition via NF-\u03baB\/NOX4\/ROS signal pathway in lung cancer cells","volume":"48","author":"Ma","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s12272-020-01298-z","article-title":"NRF2 level is negatively correlated with TGF-\u03b21-induced lung cancer motility and migration via NOX4-ROS signaling","volume":"43","author":"Ryu","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/carcin\/bgt132","article-title":"TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways","volume":"34","author":"Hu","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12943-020-01209-2","article-title":"Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection","volume":"19","author":"Kong","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.7150\/jca.49462","article-title":"Expression of the SAR2-Cov-2 receptor ACE2 reveals the susceptibility of COVID-19 in non-small cell lung cancer","volume":"11","author":"Zhang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1029830","DOI":"10.3389\/fonc.2022.1029830","article-title":"Biological effects of COVID-19 on lung cancer: Can we drive our decisions","volume":"12","author":"Aramini","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"100406","DOI":"10.1016\/j.ctarc.2021.100406","article-title":"COVID-19 patients\u2019 sera induce epithelial mesenchymal transition in cancer cells","volume":"28","author":"Saygideger","year":"2021","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"153419","DOI":"10.1016\/j.prp.2021.153419","article-title":"Endothelial-Mesenchymal Transition in COVID-19 lung lesions","volume":"221","author":"Falleni","year":"2021","journal-title":"Pathol.-Res. Pract."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biochi.2023.05.014","article-title":"Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?","volume":"213","author":"Jahankhani","year":"2023","journal-title":"Biochimie"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhang, X., Deng, X., Wang, P., Mo, Y., Zhang, Y., and Tong, X. (2023). Cytokines as drivers: Unraveling the mechanisms of epithelial-mesenchymal transition in COVID-19 lung fibrosis. Biochem. Biophys. Res. Commun., 686.","DOI":"10.1016\/j.bbrc.2023.10.050"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1218059","DOI":"10.3389\/fphar.2023.1218059","article-title":"Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition","volume":"14","author":"Pi","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Liapis, I., and Baritaki, S. (2022). COVID-19 vs. Cancer Immunosurveillance: A Game of Thrones within an Inflamed Microenviroment. Cancers, 14.","DOI":"10.3390\/cancers14174330"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cytogfr.2021.10.005","article-title":"Cancer and Covid-19: Collectively catastrophic","volume":"63","author":"Fourie","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pharmthera.2015.12.001","article-title":"Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways","volume":"158","author":"Leon","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bcp.2018.12.010","article-title":"Lung cancer stem cells: Origin, features, maintenance mechanisms and therapeutic targeting","volume":"160","author":"Heng","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bbrc.2018.01.164","article-title":"TGF\u03b21-induced down-regulation of microRNA-138 contributes to epithelial-mesenchymal transition in primary lung cancer cells","volume":"496","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3892\/ijo.2021.5261","article-title":"Epithelial membrane protein 3 regulates lung cancer stem cells via the TGF-\u03b2 signaling pathway","volume":"59","author":"Kahm","year":"2021","journal-title":"Int. J. Oncol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/ijc.32151","article-title":"IL-10 derived from M2 macrophage promotes cancer stemness via JAK1\/STAT1\/NF-\u03baB\/Notch1 pathway in non-small cell lung cancer","volume":"145","author":"Yang","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1158\/0008-5472.CAN-13-2702","article-title":"Activin upregulation by NF-\u03baB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer","volume":"75","author":"Wamsley","year":"2015","journal-title":"Cancer Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1158\/0008-5472.CAN-19-0596","article-title":"Low-Dose IFN\u03b3 Induces Tumor Cell Stemness in Tumor Microenvironment of Non\u2013Small Cell Lung Cancer","volume":"79","author":"Song","year":"2019","journal-title":"Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.18632\/oncotarget.6570","article-title":"IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ijc.29033","article-title":"IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation","volume":"136","author":"Liu","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e1461303","DOI":"10.1080\/2162402X.2018.1461303","article-title":"Th17 cell-derived IL-17A promoted tumor progression via STAT3\/NF-\u03baB\/Notch1 signaling in non-small cell lung cancer","volume":"7","author":"Wang","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1038\/s41388-018-0411-0","article-title":"USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2\/TRAF3 complex formation","volume":"37","author":"Lu","year":"2018","journal-title":"Oncogene"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fonc.2018.00166","article-title":"Inhibition of NF-\u03baB signaling reduces the stemness characteristics of lung cancer stem cells","volume":"8","author":"Zakaria","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1183\/09031936.00129306","article-title":"Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer","volume":"30","author":"Zeni","year":"2007","journal-title":"Eur. Respir. J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/onc.2015.274","article-title":"CXCR7 mediates TGF\u03b21-promoted EMT and tumor-initiating features in lung cancer","volume":"35","author":"Wu","year":"2016","journal-title":"Oncogene"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1158\/0008-5472.CAN-14-3265","article-title":"Diverse targets of \u03b2-catenin during the epithelial\u2013mesenchymal transition define cancer stem cells and predict disease relapse","volume":"75","author":"Chang","year":"2015","journal-title":"Cancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-022-01569-x","article-title":"Targeting TGF-\u03b2 signal transduction for fibrosis and cancer therapy","volume":"21","author":"Peng","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Uckun, F.M., Qazi, S., Hwang, L., and Trieu, V.N. (2019). Recurrent or Refractory High-Grade Gliomas Treated by Convection-Enhanced Delivery of a TGF\u03b22-Targeting RNA Therapeutic: A Post-Hoc Analysis with Long-Term Follow-Up. Cancers, 11.","DOI":"10.3390\/cancers11121892"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.ejca.2015.07.035","article-title":"A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer","volume":"51","author":"Giaccone","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/neuonc\/now009","article-title":"A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma","volume":"18","author":"Brandes","year":"2016","journal-title":"Neuro. Oncol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Giannelli, G., Santoro, A., Kelley, R.K., Gane, E., Paradis, V., Cleverly, A., Smith, C., Estrem, S.T., Man, M., and Wang, S. (2020). Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-\u03b2RI inhibitor galunisertib. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0222259"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Huang, C.-Y., Chung, C.-L., Hu, T.-H., Chen, J.-J., Liu, P.-F., and Chen, C.-L. (2021). Recent progress in TGF-\u03b2 inhibitors for cancer therapy. Biomed. Pharmacother., 134.","DOI":"10.1016\/j.biopha.2020.111046"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1158\/1078-0432.CCR-17-3322","article-title":"Focal Irradiation and Systemic TGF\u03b2 Blockade in Metastatic Breast Cancer","volume":"24","author":"Formenti","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e8857","DOI":"10.1097\/MD.0000000000008857","article-title":"Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer","volume":"96","author":"Guo","year":"2017","journal-title":"Medicine"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Legge, F., Paglia, A., D\u2019Asta, M., Fuoco, G., Scambia, G., and Ferrandina, G. (2011). Phase II study of the combination carboplatin plus celecoxib in heavily pre-treated recurrent ovarian cancer patients. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-214"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1158\/1078-0432.CCR-05-2255","article-title":"Phase II Clinical Trial Results Involving Treatment with Low-Dose Daily Oral Cyclophosphamide, Weekly Vinblastine, and Rofecoxib in Patients with Advanced Solid Tumors","volume":"12","author":"Young","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S2468-1253(21)00018-2","article-title":"Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): A multicentre, double-blind, randomised, two-by-two factorial design trial","volume":"6","author":"Ishikawa","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Lu, J., Kornmann, M., and Traub, B. (2023). Role of Epithelial to Mesenchymal Transition in Colorectal Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914815"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s12957-023-03247-8","article-title":"The use of non-steroid anti-inflammatory drugs during radical resection correlated with the outcome in non-small cell lung cancer","volume":"21","author":"Cai","year":"2023","journal-title":"World J. Surg. Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"155850","DOI":"10.1016\/j.cyto.2022.155850","article-title":"Interleukin-1 (IL-1) and the inflammasome in cancer","volume":"153","author":"Pretre","year":"2022","journal-title":"Cytokine"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0140-6736(17)32247-X","article-title":"Effect of interleukin-1\u03b2 inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: Exploratory results from a randomised, double-blind, placebo-controlled trial","volume":"390","author":"Ridker","year":"2017","journal-title":"Lancet"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.bbrc.2017.09.117","article-title":"Arctigenin represses TGF-\u03b2-induced epithelial mesenchymal transition in human lung cancer cells","volume":"493","author":"Xu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1007\/s00210-023-02553-y","article-title":"Berberine nanostructures attenuate \u00df-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma","volume":"396","author":"Malyla","year":"2023","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12032-021-01508-8","article-title":"Luteolin and cancer metastasis suppression: Focus on the role of epithelial to mesenchymal transition","volume":"38","author":"Hussain","year":"2021","journal-title":"Med. Oncol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1039\/D0FO02105A","article-title":"Eugenol emerges as an elixir by targeting \u03b2-catenin, the central cancer stem cell regulator in lung carcinogenesis: An in vivo and in vitro rationale","volume":"12","author":"Choudhury","year":"2021","journal-title":"Food Funct."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tox.2012.09.017","article-title":"Resveratrol inhibits TGF-\u03b21-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis","volume":"303","author":"Wang","year":"2013","journal-title":"Toxicology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s13402-019-00442-2","article-title":"Curcumin: A potent agent to reverse epithelial-to-mesenchymal transition","volume":"42","author":"Bahrami","year":"2019","journal-title":"Cell. Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/med.21948","article-title":"Mechanism of epithelial-mesenchymal transition in cancer and its regulation by natural compounds","volume":"43","author":"Ang","year":"2023","journal-title":"Med. Res. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Anwar, S., Malik, J.A., Ahmed, S., Kameshwar, V.A., Alanazi, J., Alamri, A., and Ahemad, N. (2022). Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics?. Molecules, 27.","DOI":"10.3390\/molecules27227668"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1049888","DOI":"10.3389\/fonc.2022.1049888","article-title":"The function of natural compounds in important anticancer mechanisms","volume":"12","author":"Nan","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1039\/D2NP00063F","article-title":"Natural products of pentacyclic triterpenoids: From discovery to heterologous biosynthesis","volume":"40","author":"Li","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Lou, H., Li, H., Zhang, S., Lu, H., and Chen, Q. (2021). A Review on Preparation of Betulinic Acid and Its Biological Activities. Molecules, 26.","DOI":"10.3390\/molecules26185583"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Gudoityte, E., Arandarcikaite, O., Mazeikiene, I., Bendokas, V., and Liobikas, J. (2021). Ursolic and oleanolic acids: Plant metabolites with neuroprotective potential. Int. J. Mol. Sci., 22.","DOI":"10.20944\/preprints202103.0783.v1"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"104503","DOI":"10.1016\/j.fitote.2020.104503","article-title":"Novel nortriterpenoids with new skeletons and limonoids from the fruits of Evodia rutaecarpa and their bioactivities","volume":"142","author":"Shi","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e8514","DOI":"10.7717\/peerj.8514","article-title":"Glycyrrhizin suppresses epithelial-mesenchymal transition by inhibiting high-mobility group box1 via the TGF-\u03b21\/Smad2\/3 pathway in lung epithelial cells","volume":"8","author":"Gui","year":"2020","journal-title":"PeerJ"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Ayeleso, T.B., Matumba, M.G., and Mukwevho, E. (2017). Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases. Molecules, 22.","DOI":"10.3390\/molecules22111915"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.7150\/jca.44431","article-title":"Pristimerin induces apoptosis and inhibits proliferation, migration in H1299 Lung Cancer Cells","volume":"11","author":"Li","year":"2020","journal-title":"J. Cancer"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbrc.2013.06.113","article-title":"Celastrol inhibits TGF-\u03b21-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression","volume":"437","author":"Kang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Mannino, G., Iovino, P., Lauria, A., Genova, T., Asteggiano, A., Notarbartolo, M., Porcu, A., Serio, G., Chinig\u00f2, G., and Occhipinti, A. (2021). Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052664"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Oboh, M., Govender, L., Siwela, M., and Mkhwanazi, B.N. (2021). Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability. Molecules, 26.","DOI":"10.3390\/molecules26237243"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2015.03.077","article-title":"Anxiolytic-like effects of ursolic acid in mice","volume":"758","author":"Colla","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1248\/bpb.29.82","article-title":"Oleanolic acid, a pentacyclic triterpene attenuates the mustard oil-induced colonic nociception in mice","volume":"29","author":"Maia","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/ptr.7359","article-title":"Antiinflammatory activity of natural triterpenes\u2014An overview from 2006 to 2021","volume":"36","author":"Miranda","year":"2022","journal-title":"Phyther. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"113340","DOI":"10.1016\/j.phytochem.2022.113340","article-title":"Selected plant triterpenoids and their amide derivatives in cancer treatment: A review","volume":"203","author":"Wimmer","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Borella, R., Forti, L., Gibellini, L., De Gaetano, A., De Biasi, S., Nasi, M., Cossarizza, A., and Pinti, M. (2019). Synthesis and anticancer activity of CDDO and CDDO-me, two derivatives of natural triterpenoids. Molecules, 24.","DOI":"10.3390\/molecules24224097"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/cam4.2719","article-title":"Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN\/PI3K\/Akt pathway","volume":"9","author":"Zhu","year":"2020","journal-title":"Cancer Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1158\/1535-7163.MCT-18-0448","article-title":"Oleanolic acid inhibits epithelial\u2013mesenchymal transition of hepatocellular carcinoma by promoting iNOS dimerization","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1080\/09168451.2020.1813543","article-title":"The anti-tumor effect of ursolic acid on papillary thyroid carcinoma via suppressing Fibronectin-1","volume":"84","author":"Cao","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"8781690","DOI":"10.1155\/2019\/8781690","article-title":"Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway","volume":"2019","author":"Zheng","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_164","first-page":"4285","article-title":"Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF-\u03b21","volume":"17","author":"Cui","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.biopha.2017.03.005","article-title":"Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways","volume":"89","author":"Dong","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/CAD.0b013e328360093b","article-title":"Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells","volume":"24","author":"Liu","year":"2013","journal-title":"Anticancer Drugs"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3727\/096504017X15051723858706","article-title":"Ursolic acid attenuates TGF-b1-induced epithelial-mesenchymal transition in NSCLC by targeting integrin Avb5\/MMPs signaling","volume":"27","author":"Ruan","year":"2019","journal-title":"Oncol. Res."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Lin, L., Hou, G., Han, D., Yin, Y., Kang, J., and Wang, Q. (2019). Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats. BMC Pulm. Med., 19.","DOI":"10.1186\/s12890-019-0826-6"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3389\/fphar.2019.00700","article-title":"Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract","volume":"10","author":"Lin","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Kang, D.Y., Sp, N., Lee, J.-M., and Jang, K.-J. (2021). Antitumor effects of ursolic acid through mediating the inhibition of STAT3\/PD-L1 signaling in non-small cell lung cancer cells. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030297"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1111\/bph.14793","article-title":"Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations","volume":"176","author":"Yang","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Son, J., and Lee, S.Y. (2020). Ursonic acid exerts inhibitory effects on matrix metalloproteinases via ERK signaling pathway. Chem. Biol. Interact., 315.","DOI":"10.1016\/j.cbi.2019.108910"},{"key":"ref_173","first-page":"3163","article-title":"Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice","volume":"9","author":"Wang","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/bcpt.12975","article-title":"Regulation of Transforming Growth Factor-\u03b2\/Smad-mediated Epithelial\u2013Mesenchymal Transition by Celastrol Provides Protection against Bleomycin-induced Pulmonary Fibrosis","volume":"123","author":"Divya","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.2147\/IJN.S119839","article-title":"Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105\/d-\u03b1-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment","volume":"11","author":"Wu","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Markov, A.V., Odarenko, K.V., Sen\u2019kova, A.V., Salomatina, O.V., Salakhutdinov, N.F., and Zenkova, M.A. (2020). Cyano enone-bearing triterpenoid soloxolone methyl inhibits epithelial-mesenchymal transition of human lung adenocarcinoma cells in vitro and metastasis of murine melanoma in vivo. Molecules, 25.","DOI":"10.3390\/molecules25245925"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1158\/1940-6207.CAPR-13-0216","article-title":"V \u03b2-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA\/Rock expression in A\/J mice and growth of H460 human lung cancer cells","volume":"6","author":"Patlolla","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Bang, I.J., Kim, H.R., Jeon, Y., Jeong, M.H., Park, Y.J., Kwak, J.H., and Chung, K.H. (2019). \u03b2-Peltoboykinolic Acid from Astilbe rubra Attenuates TGF-\u03b21-Induced Epithelial-to-Mesenchymal Transitions in Lung Alveolar Epithelial Cells. Molecules, 24.","DOI":"10.3390\/molecules24142573"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1111\/cas.15005","article-title":"Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non\u2013small cell lung cancer","volume":"112","author":"He","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"13671","DOI":"10.18632\/oncotarget.3701","article-title":"A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy","volume":"6","author":"Hsu","year":"2015","journal-title":"Oncotarget"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1152\/japplphysiol.00503.2012","article-title":"Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling","volume":"114","author":"Pansters","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"37732","DOI":"10.1074\/jbc.M112.389015","article-title":"Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer","volume":"287","author":"Hance","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bmc.2013.10.049","article-title":"Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells","volume":"22","author":"Salomatina","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncb1400","article-title":"Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling","volume":"8","author":"Asanuma","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Zhang, W., Ren, Z., Jia, L., Li, X., Jia, X., and Han, Y. (2019). Fbxw7 and Skp2 regulate stem cell switch between quiescence and mitotic division in lung adenocarcinoma. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/9648269"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3904645","DOI":"10.1155\/2019\/3904645","article-title":"Aldehyde dehydrogenases: Not just markers, but functional regulators of stem cells","volume":"2019","author":"Vassalli","year":"2019","journal-title":"Stem Cells Int."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/24\/17325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:36:17Z","timestamp":1760132177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/24\/17325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,10]]},"references-count":186,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["ijms242417325"],"URL":"https:\/\/doi.org\/10.3390\/ijms242417325","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,10]]}}}