{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:48:26Z","timestamp":1782337706768,"version":"3.54.5"},"reference-count":86,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Food and Agriculture","award":["2018-67015-27613"],"award-info":[{"award-number":["2018-67015-27613"]}]},{"name":"National Institute of Food and Agriculture","award":["2023-67012-39788"],"award-info":[{"award-number":["2023-67012-39788"]}]},{"name":"USDA National Institute of Food and Agriculture","award":["2018-67015-27613"],"award-info":[{"award-number":["2018-67015-27613"]}]},{"name":"USDA National Institute of Food and Agriculture","award":["2023-67012-39788"],"award-info":[{"award-number":["2023-67012-39788"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We have reported that selenium (Se) provided to grazing beef cattle in an inorganic (ISe) form versus a 1:1 mixture (MIX) of inorganic and organic (OSe) forms affects cholesterol biosynthesis in the corpus luteum (CL), the abundance of interferon tau (IFN\u03c4) and progesterone (P4)-induced mRNAs in the caruncular (CAR) tissue of the endometrium, and conceptus length at maternal recognition of pregnancy (MRP). In this study, beef heifers were supplemented with a vitamin\u2013mineral mix containing 35 ppm Se as ISe or MIX to achieve a Se-adequate status. Inseminated heifers were killed at MRP (d 17, n = 6 per treatment) for tissue collection. In CAR samples from MIX versus ISe heifers, qPCR revealed that mRNA encoding the thyroid regulating DIO2 and DIO3 was decreased (p &lt; 0.05) and a complete transcriptomic analysis revealed effects on the interferon JAK-STAT1\/2 pathway, including decreased expression of mRNAs encoding the classical interferon stimulated genes IFIT1, IFIT2, IFIT3, IRF1, IRF9, ISG15, OAS2, and RSAD2 (p &lt; 0.05). Treatment also affected the abundance of mRNAs contributing to the immunotolerant environment (p &lt; 0.05). In combination, these findings suggest more advanced preparation of the CAR and developing conceptus for implantation and to evade immune rejection by the maternal system in MIX- vs. ISe-treated heifers.<\/jats:p>","DOI":"10.3390\/ijms242417327","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T03:25:31Z","timestamp":1702265131000},"page":"17327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcriptomic Changes in Response to Form of Selenium on the Interferon-Tau Signaling Mechanism in the Caruncular Tissue of Beef Heifers at Maternal Recognition of Pregnancy"],"prefix":"10.3390","volume":"24","author":[{"given":"Sarah N.","family":"Carr","sequence":"first","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Crites","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-1575","authenticated-orcid":false,"given":"Harshraj","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"Bridges","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/jn\/8.5.597","article-title":"A new toxicant occurring naturally in certain samples of plant foodstuffs","volume":"8","author":"Franke","year":"1934","journal-title":"J. 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