{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:28Z","timestamp":1791925708600,"version":"4.3.4"},"reference-count":178,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH National Heart, Lung, and Blood Institute","award":["R56 HL137912-01"],"award-info":[{"award-number":["R56 HL137912-01"]}]},{"name":"NIH National Heart, Lung, and Blood Institute","award":["16GRNT30960027"],"award-info":[{"award-number":["16GRNT30960027"]}]},{"name":"American Heart Association Grant-In-Aid","award":["R56 HL137912-01"],"award-info":[{"award-number":["R56 HL137912-01"]}]},{"name":"American Heart Association Grant-In-Aid","award":["16GRNT30960027"],"award-info":[{"award-number":["16GRNT30960027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The circadian rhythm is a 24 h internal clock within the body that regulates various factors, including sleep, body temperature, and hormone secretion. Circadian rhythm disruption is an important risk factor for many diseases including neurodegenerative illnesses. The central and peripheral oscillators\u2019 circadian clock network controls the circadian rhythm in mammals. The clock genes govern the central clock in the suprachiasmatic nucleus (SCN) of the brain. One function of the circadian clock is regulating lipid metabolism. However, investigations of the circadian regulation of lipid metabolism-associated apolipoprotein genes in the brain are lacking. This review summarizes the rhythmic expression of clock genes and lipid metabolism-associated apolipoprotein genes within the SCN in Mus musculus. Nine of the twenty apolipoprotein genes identified from searching the published database (SCNseq and CircaDB) are highly expressed in the SCN. Most apolipoprotein genes (ApoE, ApoC1, apoA1, ApoH, ApoM, and Cln) show rhythmic expression in the brain in mice and thus might be regulated by the master clock. Therefore, this review summarizes studies on lipid-associated apolipoprotein genes in the SCN and other brain locations, to understand how apolipoproteins associated with perturbed cerebral lipid metabolism cause multiple brain diseases and disorders. This review describes recent advancements in research, explores current questions, and identifies directions for future research.<\/jats:p>","DOI":"10.3390\/ijms242417415","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T04:14:42Z","timestamp":1702440882000},"page":"17415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Chaeeun Hannah","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Ellzabeth","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-5857","authenticated-orcid":false,"given":"Xiaoyue","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA"},{"name":"Diabetes and Obesity Research Center, NYU Langone Hospital-Long Island, Mineola, NY 11501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R432","DOI":"10.1016\/j.cub.2016.04.011","article-title":"The Circadian Clock and Human Health","volume":"26","author":"Roenneberg","year":"2016","journal-title":"Curr. 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