{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:04:33Z","timestamp":1791921873452,"version":"4.3.4"},"reference-count":73,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Universities and Research","award":["PRIN-2017ATZ2YK"],"award-info":[{"award-number":["PRIN-2017ATZ2YK"]}]},{"name":"Ministry of Education, Universities and Research","award":["DM 1557 11.10.2022"],"award-info":[{"award-number":["DM 1557 11.10.2022"]}]},{"name":"Next Generation EU","award":["PRIN-2017ATZ2YK"],"award-info":[{"award-number":["PRIN-2017ATZ2YK"]}]},{"name":"Next Generation EU","award":["DM 1557 11.10.2022"],"award-info":[{"award-number":["DM 1557 11.10.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis causes immune dysregulation and endotheliitis, with an increase in mid-regional pro-adrenomedullin (MR-proADM). The aim of the study is to determine an MR-proADM value that, in addition to clinical diagnosis, can identify patients with localized infection or those with sepsis\/septic shock, with specific organ damage or with the need for intensive care unit (ICU) transfer and prognosis. The secondary aim is to correlate the MR-proADM value with the length of stay (LOS). In total, 301 subjects with sepsis (124\/301 with septic shock) and 126 with localized infection were retrospectively included. In sepsis, MR-proADM \u2265 3.39 ng\/mL identified acute kidney injury (AKI); \u22652.99 ng\/mL acute respiratory distress syndrome (ARDS); \u22652.28 ng\/mL acute heart failure (AHF); \u22652.55 ng\/mL Glascow Coma Scale (GCS) &lt; 15; \u22653.38 multi-organ involvement; \u22653.33 need for ICU transfer; \u22652.0 Sequential Organ Failure Assessment (SOFA) score \u2265 2; and \u22653.15 ng\/mL non-survivors. The multivariate analysis showed that MR-proADM \u2265 2 ng\/mL correlates with AKI, anemia and SOFA score \u2265 2, and MR-proADM \u2265 3 ng\/mL correlates with AKI, GCS &lt; 15 and SOFA score \u2265 2. A correlation between mortality and AKI, GCS &lt; 15, ICU transfer and cathecolamine administration was found. In localized infection, MR-proADM at admission \u2265 1.44 ng\/mL identified patients with AKI; \u22651.0 ng\/mL with AHF; and \u22651.44 ng\/mL with anemia and SOFA score \u2265 2. In the multivariate analysis, MR-proADM \u2265 1.44 ng\/mL correlated with AKI, anemia, SOFA score \u2265 2 and AHF. MR-proADM is a marker of oxidative stress due to an infection, reflecting severity proportionally to organ damage.<\/jats:p>","DOI":"10.3390\/ijms242417429","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T04:14:42Z","timestamp":1702440882000},"page":"17429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?"],"prefix":"10.3390","volume":"24","author":[{"given":"Silvia","family":"Spoto","sequence":"first","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6987-1926","authenticated-orcid":false,"given":"Stefania","family":"Basili","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-2061","authenticated-orcid":false,"given":"Roberto","family":"Cangemi","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"D\u2019Avanzo","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica Marika","family":"Lupoi","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3788-8942","authenticated-orcid":false,"given":"Giulio Francesco","family":"Romiti","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University, Viale dell\u2019Universit\u00e0, 30, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josepmaria","family":"Argemi","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Clinica Universidad de Navarra, Avda. P\u00edo XII, 36, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-9539","authenticated-orcid":false,"given":"Jos\u00e9 Ram\u00f3n","family":"Yuste","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Faculty of Medicine, University of Navarra, Clinica Universidad de Navarra, Avda. P\u00edo XII, 36, 31008 Pamplona, Spain"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Navarra, Clinica Universidad de Navarra, Avda. P\u00edo XII, 36, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-6753","authenticated-orcid":false,"given":"Felipe","family":"Lucena","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Clinica Universidad de Navarra, Avda. P\u00edo XII, 36, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Locorriere","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Masini","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Testorio","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Calarco","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-5884","authenticated-orcid":false,"given":"Marta","family":"Fogolari","sequence":"additional","affiliation":[{"name":"Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"},{"name":"Research Unit of Clinical Laboratory Science, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Francesconi","sequence":"additional","affiliation":[{"name":"Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"},{"name":"Research Unit of Clinical Laboratory Science, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Battifoglia","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Costantino","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Angeletti","sequence":"additional","affiliation":[{"name":"Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy"},{"name":"Research Unit of Clinical Laboratory Science, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41440-021-00806-y","article-title":"Translational Studies of Adrenomedullin and Related Peptides Regarding Cardiovascular Diseases","volume":"45","author":"Kita","year":"2022","journal-title":"Hypertens. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kita, T., and Kitamura, K. (2022). Adrenomedullin Therapy in Moderate to Severe COVID-19. Biomedicines, 10.","DOI":"10.3390\/biomedicines10030533"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.2019.5791","article-title":"Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis","volume":"321","author":"Seymour","year":"2019","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","article-title":"Adrenomedullin: A Novel Hypotensive Peptide Isolated from Human Pheochromocytoma","volume":"192","author":"Kitamura","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.21037\/atm.2016.08.65","article-title":"New Role of Biomarkers: Mid-Regional pro-Adrenomedullin, the Biomarker of Organ Failure","volume":"4","year":"2016","journal-title":"Ann. Transl. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Spoto, S., Daniel Markley, J., Valeriani, E., Abbate, A., Argemi, J., Markley, R., Fogolari, M., Locorriere, L., Anguissola, G.B., and Battifoglia, G. (2022). Active Surveillance Cultures and Procalcitonin in Combination with Clinical Data to Guide Empirical Antimicrobial Therapy in Hospitalized Medical Patients with Sepsis. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.797932"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16605","DOI":"10.1038\/s41598-020-73676-y","article-title":"Best Diagnostic Accuracy of Sepsis Combining SIRS Criteria or qSOFA Score with Procalcitonin and Mid-Regional pro-Adrenomedullin Outside ICU","volume":"10","author":"Spoto","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e13511","DOI":"10.1111\/eci.13511","article-title":"MR-proADM as Marker of Endotheliitis Predicts COVID-19 Severity","volume":"51","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijid.2021.08.058","article-title":"Circulating MR-proADM Levels, as an Indicator of Endothelial Dysfunction, for Early Risk Stratification of Mid-Term Mortality in COVID-19 Patients","volume":"111","author":"Alcaraz","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"929408","DOI":"10.3389\/fmed.2022.929408","article-title":"Synergistic Effect of Myocardial Injury and Mid-Regional proAdrenomedullin Elevation in Determining Clinical Outcomes of SARS-CoV-2 Patients","volume":"9","author":"Spoto","year":"2022","journal-title":"Front. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1002\/jmv.26676","article-title":"High Value of Mid-regional Proadrenomedullin in COVID-19: A Marker of Widespread Endothelial Damage, Disease Severity, and Mortality","volume":"93","author":"Spoto","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/ejhf.1437","article-title":"Bio-adrenomedullin as a Marker of Congestion in Patients with New-onset and Worsening Heart Failure","volume":"21","author":"Kremer","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ijcha.2019.02.011","article-title":"Plasma Bio-Adrenomedullin Is a Marker of Acute Heart Failure Severity in Patients with Acute Coronary Syndrome","volume":"22","author":"Arrigo","year":"2019","journal-title":"IJC Heart Vasc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13613-016-0229-2","article-title":"Adrenomedullin: A Marker of Impaired Hemodynamics, Organ Dysfunction, and Poor Prognosis in Cardiogenic Shock","volume":"7","author":"Tolppanen","year":"2017","journal-title":"Ann. Intensive Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.peptides.2004.06.019","article-title":"Identification of an Adrenomedullin Precursor Fragment in Plasma of Sepsis Patients","volume":"25","author":"Struck","year":"2004","journal-title":"Peptides"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.23736\/S0375-9393.21.15585-3","article-title":"The Diagnostic Accuracy of Mid-Regional pro-Adrenomedullin for Sepsis: A Systematic Review and Meta-Analysis","volume":"87","author":"Li","year":"2021","journal-title":"Minerva Anestesiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Spoto, S., Lupoi, D.M., Valeriani, E., Fogolari, M., Locorriere, L., Beretta Anguissola, G., Battifoglia, G., Caputo, D., Coppola, A., and Costantino, S. (2021). Diagnostic Accuracy and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Septic Patients outside the Intensive Care Unit. Medicina, 57.","DOI":"10.3390\/medicina57080811"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2217\/bmm-2019-0414","article-title":"How Biomarkers Can Improve Pneumonia Diagnosis and Prognosis: Procalcitonin and Mid-Regional-pro-Adrenomedullin","volume":"14","author":"Spoto","year":"2020","journal-title":"Biomark. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103763","DOI":"10.1016\/j.micpath.2019.103763","article-title":"Procalcitonin and MR-proAdrenomedullin Combination in the Etiological Diagnosis and Prognosis of Sepsis and Septic Shock","volume":"137","author":"Spoto","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4081\/itjm.2020.1215","article-title":"An Algorithm of Good Clinical Practice to Reduce Intra-Hospital 90-Day Mortality and Need for Intensive Care Unit Transfer: A New Approach for Septic Patient Management: A New Clinical Algorithm for Sepsis Management","volume":"14","author":"Spoto","year":"2020","journal-title":"Ital. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e9496","DOI":"10.1097\/MD.0000000000009496","article-title":"The Role of Procalcitonin in the Diagnosis of Bacterial Infection after Major Abdominal Surgery: Advantage from Daily Measurement","volume":"97","author":"Spoto","year":"2018","journal-title":"Medicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/SHK.0000000000001023","article-title":"Procalcitonin and MR-Proadrenomedullin Combination with SOFA and qSOFA Scores for Sepsis Diagnosis and Prognosis: A Diagnostic Algorithm","volume":"50","author":"Spoto","year":"2018","journal-title":"Shock"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e17978","DOI":"10.1097\/MD.0000000000017978","article-title":"Use of Sacubitril\/Valsartan in Marfan Syndrome\u2013Related Cardiomyopathy: The First Case Report","volume":"98","author":"Spoto","year":"2019","journal-title":"Medicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jcrc.2021.07.017","article-title":"Endothelium-Associated Biomarkers Mid-Regional Proadrenomedullin and C-Terminal Proendothelin-1 Have Good Ability to Predict 28-Day Mortality in Critically Ill Patients with SARS-CoV-2 Pneumonia: A Prospective Cohort Study","volume":"66","author":"Kluiters","year":"2021","journal-title":"J. Crit. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cca.2021.09.016","article-title":"Endothelial Dysfunction and Mid-Regional proAdrenomedullin: What Role in SARS-CoV-2 Infected Patients?","volume":"523","author":"Zaninotto","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/labmed\/lmab032","article-title":"Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19","volume":"52","author":"Gambino","year":"2021","journal-title":"Lab. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/1354750X.2021.1905067","article-title":"MR-proAdrenomedullin as a Predictor of Renal Replacement Therapy in a Cohort of Critically Ill Patients with COVID-19","volume":"26","author":"Roedl","year":"2021","journal-title":"Biomarkers"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12931-022-02151-1","article-title":"Identification of COVID-19 Patients at Risk of Hospital Admission and Mortality: A European Multicentre Retrospective Analysis of Mid-Regional pro-Adrenomedullin","volume":"23","author":"Sozio","year":"2022","journal-title":"Respir. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"170347","DOI":"10.1016\/j.peptides.2020.170347","article-title":"Adrenomedullin\u2013Current Perspective on a Peptide Hormone with Significant Therapeutic Potential","volume":"131","author":"Fischer","year":"2020","journal-title":"Peptides"},{"key":"ref_30","first-page":"1449","article-title":"Increased Circulating Adrenomedullin, a Novel Vasodilatory Peptide, in Sepsis","volume":"81","author":"Hirata","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jemt.10052","article-title":"Adrenomedullin and PAMP: Discovery, Structures, and Cardiovascular Functions","volume":"57","author":"Kitamura","year":"2002","journal-title":"Microsc. Res. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ejhf.1366","article-title":"Adrenomedullin in Heart Failure: Pathophysiology and Therapeutic Application","volume":"21","author":"Voors","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mirijello, A., Tosoni, A., and on behalf of the Internal Medicine Sepsis Study Group (2020). New Strategies for Treatment of Sepsis. Medicina, 56.","DOI":"10.3390\/medicina56100527"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s13054-018-2243-2","article-title":"Circulating Adrenomedullin Estimates Survival and Reversibility of Organ Failure in Sepsis: The Prospective Observational Multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) Study","volume":"22","author":"Mebazaa","year":"2018","journal-title":"Crit. Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1058235","DOI":"10.3389\/fmed.2022.1058235","article-title":"Effects of Enrichment Strategies on Outcome of Adrecizumab Treatment in Septic Shock: Post-Hoc Analyses of the Phase II Adrenomedullin and Outcome in Septic Shock 2 Trial","volume":"9","author":"Picod","year":"2022","journal-title":"Front. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"16730","DOI":"10.1074\/jbc.273.27.16730","article-title":"Production of Adrenomedullin in Macrophage Cell Line and Peritoneal Macrophage","volume":"273","author":"Kubo","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3180241","article-title":"A Rat Skeletal Muscle Cell Line (L6) Expresses Specific Adrenomedullin Binding Sites but Activates Adenylate Cyclase via Calcitonin Gene-Related Peptide Receptors","volume":"318","author":"Coppock","year":"1996","journal-title":"Biochem. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1210\/endo.136.5.7720662","article-title":"An Abundant and Specific Binding Site for the Novel Vasodilator Adrenomedullin in the Rat","volume":"136","author":"Owji","year":"1995","journal-title":"Endocrinology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(00)00148-0","article-title":"Adrenomedullin Receptors in Rat Cerebral Microvessels","volume":"81","author":"Kobayashi","year":"2000","journal-title":"Mol. Brain Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0304-3940(00)01706-7","article-title":"Adrenomedullin Receptors in Rat Choroid Plexus","volume":"297","author":"Kobayashi","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/jphp.12299","article-title":"Pharmacological Characterisation of the Mechanisms Underlying the Relaxant Effect of Adrenomedullin in the Rat Carotid Artery","volume":"66","author":"Passaglia","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2015.12.005","article-title":"Endothelium-Derived Intermedin\/Adrenomedullin-2 Protects Human Ventricular Cardiomyocytes from Ischaemia-Reoxygenation Injury Predominantly via the AM 1 Receptor","volume":"76","author":"Bell","year":"2016","journal-title":"Peptides"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liang, J., Cai, Y., and Shao, Y. (2023). Comparison of Presepsin and Mid-Regional pro-Adrenomedullin in the Diagnosis of Sepsis or Septic Shock: A Systematic Review and Meta-Analysis. BMC Infect. Dis., 23.","DOI":"10.1186\/s12879-023-08262-4"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Baldir\u00e0, J., Ruiz-Rodr\u00edguez, J.C., Ruiz-Sanmartin, A., Chiscano, L., Cortes, A., Sistac, D.\u00c1., Ferrer-Costa, R., Comas, I., Villena, Y., and Larrosa, M.N. (2023). Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA \u2264 6. Biomedicines, 11.","DOI":"10.20944\/preprints202307.0010.v1"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"951532","DOI":"10.1155\/2015\/951532","article-title":"Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination","volume":"2015","author":"Angeletti","year":"2015","journal-title":"Dis. Markers"},{"key":"ref_48","first-page":"1147","article-title":"Role of Biomarkers in Adult Sepsis and Their Application for a Good Laboratory Practice: A Pilot Study","volume":"31","author":"Sargentini","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_49","first-page":"366","article-title":"Plasma Levels of Mid-Regional pro-Adrenomedullin in Sepsis Are Associated with Risk of Death","volume":"85","author":"Rello","year":"2019","journal-title":"Minerva Anestesiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1160\/TH07-02-0128","article-title":"Adrenomedullin and Endothelial Barrier Function","volume":"98","author":"Hocke","year":"2007","journal-title":"Thromb. Haemost."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/JLB.5A0817-324R","article-title":"Adrenomedullin Surges Are Linked to Acute Episodes of the Systemic Capillary Leak Syndrome (Clarkson Disease)","volume":"103","author":"Xie","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s13054-016-1540-x","article-title":"Mid-Regional pro-Adrenomedullin (MR-proADM), a Marker of Positive Fluid Balance in Critically Ill Patients: Results of the ENVOL Study","volume":"20","author":"Leblanc","year":"2016","journal-title":"Crit. Care"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00199506","article-title":"The Role of the Microcirculation in Multiple Organ Dysfunction Syndrome (MODS): A Review and Perspective","volume":"427","author":"Kirkpatrick","year":"1996","journal-title":"Vichows Arch. A Pathol. Anat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/01.CCM.0000217961.75225.E9","article-title":"Duration of Hypotension before Initiation of Effective Antimicrobial Therapy Is the Critical Determinant of Survival in Human Septic Shock","volume":"34","author":"Kumar","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1156732","DOI":"10.3389\/fmed.2023.1156732","article-title":"Sepsis and Infection: Two Words That Should Not Be Confused","volume":"10","author":"Vincent","year":"2023","journal-title":"Front. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mirijello, A., and Tosoni, A. (2021). Sepsis: New Challenges and Future Perspectives for an Evolving Disease\u2014Precision Medicine Is the Way!. Medicina, 57.","DOI":"10.3390\/medicina57101109"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"392","DOI":"10.7861\/clinmed.2022-0346","article-title":"Sepsis and the Brain: A Review for Acute and General Physicians","volume":"22","author":"Carter","year":"2022","journal-title":"Clin. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e2124","DOI":"10.1097\/MD.0000000000002124","article-title":"Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study","volume":"95","author":"Mazzone","year":"2016","journal-title":"Medicine"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Mirijello, A., Fontana, A., Greco, A.P., Tosoni, A., D\u2019Agruma, A., Labonia, M., Copetti, M., Piscitelli, P., De Cosmo, S., and on behalf of the Internal Medicine Sepsis Study Group (2023). Identifying Predictors Associated with Risk of Death or Admission to Intensive Care Unit in Internal Medicine Patients with Sepsis: A Comparison of Statistical Models and Machine Learning Algorithms. Antibiotics, 12.","DOI":"10.3390\/antibiotics12050925"},{"key":"ref_60","first-page":"4033","article-title":"MEDS Score and Vitamin D Status Are Independent Predictors of Mortality in a Cohort of Internal Medicine Patients with Microbiological Identified Sepsis","volume":"23","author":"Mirijello","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1164\/rccm.201609-1848OC","article-title":"The Timing of Early Antibiotics and Hospital Mortality in Sepsis","volume":"196","author":"Liu","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e020337","DOI":"10.1136\/bmjopen-2017-020337","article-title":"Can mid-regional proadrenomedullin (MR-proADM) increase the prognostic accuracy of NEWS in predicting deterioration in patients admitted to hospital with mild to moderately severe illness? A prospective single-centre observational study","volume":"8","author":"Graziadio","year":"2018","journal-title":"BMJ Open"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of Coma and Impaired Consciousness","volume":"304","author":"Teasdale","year":"1974","journal-title":"Lancet"},{"key":"ref_64","unstructured":"ARDS Definition of Task Force, Ranieri, V.M., Rubenfeld, G.D., Thompson, B.T., Ferguson, N.D., Caldwell, E., Fan, E., Camporota, L., and Slutsky, A.S. (2012). Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA, 307, 2526\u20132533."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute Renal Failure-Definition, Outcome Measures, Animal Models, Fluid Therapy and Information Technology Needs: The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"8","author":"Bellomo","year":"2004","journal-title":"Crit. Care"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.moh.0000154030.13020.85","article-title":"Anemia in Older Adults","volume":"4","author":"Woodman","year":"2005","journal-title":"Curr. Opin. Intern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1373\/clinchem.2005.051110","article-title":"Measurement of Midregional Proadrenomedullin in Plasma with an Immunoluminometric Assay","volume":"51","author":"Morgenthaler","year":"2005","journal-title":"Clin. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"American Thoracic Society, and Infectious Diseases Society of America (2005). Guidelines for the Management of Adults with Hospital-Acquired, Ventilator-Associated, and Healthcare-Associated Pneumonia. Am. J. Respir. Crit. Care Med., 171, 388\u2013416.","DOI":"10.1164\/rccm.200405-644ST"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1164\/rccm.201908-1581ST","article-title":"Diagnosis and Treatment of Adults with Community-Acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America","volume":"200","author":"Metlay","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1086\/649554","article-title":"Diagnosis and Management of Complicated Intra-Abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America","volume":"50","author":"Solomkin","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_73","unstructured":"Sabih, A., and Leslie, S.W. (2023). Complicated Urinary Tract Infections, StatPearls."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/24\/17429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:37:53Z","timestamp":1760132273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/24\/17429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":73,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["ijms242417429"],"URL":"https:\/\/doi.org\/10.3390\/ijms242417429","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]}}}