{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:04:45Z","timestamp":1778335485181,"version":"3.51.4"},"reference-count":119,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Organ transplantation has enhanced the length and quality of life of patients suffering from life-threatening organ failure. Donors deceased after brain death (DBDDs) have been a primary source of organs for transplantation for a long time, but the need to find new strategies to face organ shortages has led to the broadening of the criteria for selecting DBDDs and advancing utilization of donors deceased after circulatory death. These new sources of organs come with an elevated risk of procuring organs of suboptimal quality. Whatever the source of organs for transplant, one constant issue is the occurrence of ischemia\u2013reperfusion (IR) injury. The latter results from the variation of oxygen supply during the sequence of ischemia and reperfusion, from organ procurement to the restoration of blood circulation, triggering many deleterious interdependent processes involving biochemical, immune, vascular and coagulation systems. In this review, we focus on the roles of thrombo-inflammation and coagulation as part of IR injury, and we give an overview of the state of the art and perspectives on anticoagulant therapies in the field of transplantation, discussing benefits and risks and proposing a strategic guide to their use during transplantation procedures.<\/jats:p>","DOI":"10.3390\/ijms242417491","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T03:16:33Z","timestamp":1702610193000},"page":"17491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tissue Injury Protection: The Other Face of Anticoagulant Treatments in the Context of Ischemia and Reperfusion Injury with a Focus on Transplantation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-0888","authenticated-orcid":false,"given":"Julie","family":"Carr\u00e9","sequence":"first","affiliation":[{"name":"Service D\u2019H\u00e9matologie Biologique, Centre Hospitalo-Universitaire de Poitiers, 86000 Poitiers, France"},{"name":"INSERM 1313 Isch\u00e9mie Reperfusion, M\u00e9tabolisme, Inflammation St\u00e9rile en Transplantation (IRMETIST), Universit\u00e9 de Poitiers, 86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kerforne","sequence":"additional","affiliation":[{"name":"INSERM 1313 Isch\u00e9mie Reperfusion, M\u00e9tabolisme, Inflammation St\u00e9rile en Transplantation (IRMETIST), Universit\u00e9 de Poitiers, 86000 Poitiers, France"},{"name":"Service D\u2019Anesth\u00e9sie-R\u00e9animation et M\u00e9decine P\u00e9ri-Op\u00e9ratoire, Centre Hospitalo-Universitaire de Poitiers, 86000 Poitiers, France"},{"name":"FHU Survival Optimization in Organ Transplantation (SUPORT), 86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-071X","authenticated-orcid":false,"given":"Thierry","family":"Hauet","sequence":"additional","affiliation":[{"name":"INSERM 1313 Isch\u00e9mie Reperfusion, M\u00e9tabolisme, Inflammation St\u00e9rile en Transplantation (IRMETIST), Universit\u00e9 de Poitiers, 86000 Poitiers, France"},{"name":"FHU Survival Optimization in Organ Transplantation (SUPORT), 86000 Poitiers, France"},{"name":"Service de Biochimie, Centre Hospitalo-Universitaire de Poitiers, 86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Macchi","sequence":"additional","affiliation":[{"name":"Service D\u2019H\u00e9matologie Biologique, Centre Hospitalo-Universitaire de Poitiers, 86000 Poitiers, France"},{"name":"INSERM 1313 Isch\u00e9mie Reperfusion, M\u00e9tabolisme, Inflammation St\u00e9rile en Transplantation (IRMETIST), Universit\u00e9 de Poitiers, 86000 Poitiers, France"},{"name":"FHU Survival Optimization in Organ Transplantation (SUPORT), 86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s40271-013-0033-0","article-title":"Quality of Life in Organ Transplant Recipients Participating in an Online Transplant Community","volume":"7","author":"Wicks","year":"2014","journal-title":"Patient"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/liv.12553","article-title":"Liver Transplantation: A Systematic Review of Long-term Quality of Life","volume":"34","author":"Yang","year":"2014","journal-title":"Liver Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12871-019-0704-z","article-title":"Organ Transplantation in the Modern Era","volume":"19","author":"Bezinover","year":"2019","journal-title":"BMC Anesth."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/thorax.56.3.218","article-title":"Assessment of Quality of Life in Lung Transplantation Using a Simple Generic Tool","volume":"56","author":"Anyanwu","year":"2001","journal-title":"Thorax"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-6143.2004.00703.x","article-title":"The Survival Benefit of Liver Transplantation","volume":"5","author":"Merion","year":"2005","journal-title":"Am. 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