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Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic potential of multi-wavelength light-emitting diode (LED) irradiation of mice with dry eye. First, we showed that multi-wavelength LED irradiation was non-toxic to human corneal epithelial cells and improved cell viability. We then used a scopolamine-induced mouse model of dry eye to assess the effects of multi-wavelength LED irradiation on various clinical parameters. This treatment increased the tear volume and reduced corneal irregularity, thus improving dry eye. Histological analysis revealed that multi-wavelength LED irradiation protected against corneal epithelial damage and the associated reduction in epithelial thickness and would thus improve the corneal health of dry eye patients. Multi-wavelength LED irradiation significantly reduced the corneal levels of pro-inflammatory cytokines IL-6, IL-1\u03b2, and TNF-\u03b1; the treatment was thus anti-inflammatory. Our results suggest that multi-wavelength LED irradiation may serve as a safe and effective treatment for dry eye, alleviating symptoms, reducing inflammation, and promoting corneal health.<\/jats:p>","DOI":"10.3390\/ijms242417493","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T03:16:33Z","timestamp":1702610193000},"page":"17493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3846-4260","authenticated-orcid":false,"given":"Hyeyoon","family":"Goo","sequence":"first","affiliation":[{"name":"Department of Medical Laser, Graduate School of Medicine, Dankook University, Cheonan 31116, Republic of Korea"},{"name":"Beckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yea-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-6774","authenticated-orcid":false,"given":"Sangkeun","family":"Lee","sequence":"additional","affiliation":[{"name":"MEDI-IOT Co., Ltd., Seoul 02708, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namgue","family":"Hong","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2147\/OPTH.S5555","article-title":"Etiology, prevalence, and treatment of dry eye disease","volume":"3","author":"Gayton","year":"2009","journal-title":"Clin. 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