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Miguel Hern\u00e1ndez de Elche","award":["SOE3\/P1\/E750"],"award-info":[{"award-number":["SOE3\/P1\/E750"]}]},{"name":"University Miguel Hern\u00e1ndez de Elche","award":["AVI-GVA-COVID19-068"],"award-info":[{"award-number":["AVI-GVA-COVID19-068"]}]},{"name":"University Miguel Hern\u00e1ndez de Elche","award":["GVA-COVID19\/2021-047"],"award-info":[{"award-number":["GVA-COVID19\/2021-047"]}]},{"name":"University Miguel Hern\u00e1ndez de Elche","award":["BM1305"],"award-info":[{"award-number":["BM1305"]}]},{"name":"University Miguel Hern\u00e1ndez de Elche","award":["Act 12\/1995-111340"],"award-info":[{"award-number":["Act 12\/1995-111340"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Globally, a leg is amputated approximately every 30 seconds, with an estimated 85 percent of these amputations being attributed to complications arising from diabetic foot ulcers (DFU), as stated by the American Diabetes Association. Peripheral arterial disease (PAD) is a risk factor resulting in DFU and can, either independently or in conjunction with diabetes, lead to recurring, slow-healing ulcers and amputations. According to guidelines amputation is the recommended treatment for patients with no-option critical ischemia of the limb (CTLI). In this article we propose cell therapy as an alternative strategy for those patients. We also suggest the optimal time-frame for an effective therapy, such as implanting autologous mononuclear cells (MNCs), autologous and allogeneic mesenchymal stromal cells (MSC) as these treatments induce neuropathy relief, regeneration of the blood vessels and tissues, with accelerated ulcer healing, with no serious side effects, proving that advanced therapy medicinal product (ATMPs) application is safe and effective and, hence, can significantly prevent limb amputation.<\/jats:p>","DOI":"10.3390\/ijms242417512","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:53:16Z","timestamp":1702623196000},"page":"17512","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cell Therapy of Vascular and Neuropathic Complications of Diabetes: Can We Avoid Limb Amputation?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-0380","authenticated-orcid":false,"given":"Bernat","family":"Soria","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research ISABIAL of the University Miguel Hern\u00e1ndez, Dr. Balmis General and University Hospital, 03010 Alicante, Spain"},{"name":"Institute of Bioengineering, University Miguel Hern\u00e1ndez, 03202 Elche, Spain"},{"name":"CIBERDEM Network Research Center for Diabetes and Associated Metabolic Diseases, Carlos III Health Institute, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-2149","authenticated-orcid":false,"given":"Natalia","family":"Escacena","sequence":"additional","affiliation":[{"name":"Fresci Consultants, Human Health Innovation, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research ISABIAL of the University Miguel Hern\u00e1ndez, Dr. Balmis General and University Hospital, 03010 Alicante, Spain"},{"name":"Institute of Bioengineering, University Miguel Hern\u00e1ndez, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Soria-Juan","sequence":"additional","affiliation":[{"name":"Reseaux H\u00f4pitalieres Neuchatelois et du Jura, 2000 Neuch\u00e2tel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etelvina","family":"Andreu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research ISABIAL of the University Miguel Hern\u00e1ndez, Dr. Balmis General and University Hospital, 03010 Alicante, Spain"},{"name":"Department of Applied Physics, University Miguel Hern\u00e1ndez Elche, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkrim","family":"Hmadcha","sequence":"additional","affiliation":[{"name":"Biosanitary Research Institute (IIB-VIU), Valencian International University (VIU), 46002 Valencia, Spain"},{"name":"Department of Molecular Biology, University Pablo de Olavide, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-4022","authenticated-orcid":false,"given":"Ana Maria","family":"Gutierrez-Vilchez","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, University Miguel Hern\u00e1ndez, 03202 Elche, Spain"},{"name":"Department of Pharmacology, Pediatrics and Organic Chemistry, University Miguel Hern\u00e1ndez, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Cahuana","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University Pablo de Olavide, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8434-7516","authenticated-orcid":false,"given":"Juan R.","family":"Tejedo","sequence":"additional","affiliation":[{"name":"CIBERDEM Network Research Center for Diabetes and Associated Metabolic Diseases, Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Department of Molecular Biology, University Pablo de Olavide, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De la Cuesta","sequence":"additional","affiliation":[{"name":"Hospital Victoria Eugenia, Cruz Roja, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Miralles","sequence":"additional","affiliation":[{"name":"University and Polytechnic Hospital La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Garc\u00eda-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cell Therapy Centre, Nottingham Trent University, Nottingham NG1 4FQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Hern\u00e1ndez-Blasco","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research ISABIAL of the University Miguel Hern\u00e1ndez, Dr. Balmis General and University Hospital, 03010 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","unstructured":"IHME (2019). 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