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Furthermore, studies have shown that NAFLD is inextricably linked to the development of extrahepatic diseases. However, there is currently no effective treatment to cure NAFLD. In addition, in 2020, NAFLD was renamed metabolic dysfunction fatty liver disease (MAFLD) to show that its pathogenesis is closely related to metabolic disorders. Recent studies have reported that the development of MAFLD is inextricably associated with mitochondrial dysfunction in hepatocytes and hepatic stellate cells (HSCs). Simultaneously, mitochondrial stress caused by structural and functional disorders stimulates the occurrence and accumulation of fat and lipo-toxicity in hepatocytes and HSCs. In addition, the interaction between mitochondrial dysfunction and the liver\u2013gut axis has also become a new point during the development of MAFLD. In this review, we summarize the effects of several potential treatment strategies for MAFLD, including antioxidants, reagents, and intestinal microorganisms and metabolites.<\/jats:p>","DOI":"10.3390\/ijms242417514","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:53:16Z","timestamp":1702623196000},"page":"17514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Mitochondrial Dysfunction in Metabolic Dysfunction Fatty Liver Disease (MAFLD)"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-2227","authenticated-orcid":false,"given":"Ying","family":"Zhao","sequence":"first","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfu","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"NHC Key Laboratory of Transplant Engineering and Immunology, West China Hospital Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Long","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"NHC Key Laboratory of Transplant Engineering and Immunology, West China Hospital Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Regeneration Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s13679-022-00473-1","article-title":"Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver Disease","volume":"11","author":"Legaki","year":"2022","journal-title":"Curr. Obes. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Prasun, P. (2020). Mitochondrial dysfunction in metabolic syndrome. Biochim. Biophys. Acta Mol. Basis Dis., 1866.","DOI":"10.1016\/j.bbadis.2020.165838"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Longo, M., Paolini, E., Meroni, M., and Dongiovanni, P. (2021). Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD\/NASH to HCC. Int. J. Mol. Sci., 22.","DOI":"10.20944\/preprints202103.0714.v1"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.semcancer.2023.04.010","article-title":"Nonalcoholic fatty liver disease and hepatocellular carcinoma:Insights in epidemiology, pathogenesis, imaging, prevention and therapy","volume":"93","author":"Polyzos","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3748\/wjg.v26.i2.109","article-title":"Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C","volume":"26","author":"Tanwar","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.metabol.2015.12.009","article-title":"Nonalcoholic fatty future disease","volume":"65","author":"Polyzos","year":"2016","journal-title":"Metabolism"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S2468-1253(19)30349-8","article-title":"The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Collaborators","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3748\/wjg.v28.i3.310","article-title":"Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link","volume":"28","author":"Chrysavgis","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/liv.15139","article-title":"Systematically comparing epidemiological and clinical features of MAFLD and NAFLD by meta-analysis: Focusing on the non-overlap groups","volume":"42","author":"Ayada","year":"2022","journal-title":"Liver Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wang, K., Zhang, Y., Wang, G., Hao, H., and Wang, H. (2023). FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid. Med. Res. Rev., 1\u201319.","DOI":"10.1002\/med.21991"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chao, H.W., Chao, S.W., Lin, H., Ku, H.C., and Cheng, C.F. (2019). Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020298"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.dld.2020.09.021","article-title":"Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD","volume":"53","author":"Mosca","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"780496","DOI":"10.3389\/fphar.2022.780496","article-title":"The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2005.10.004","article-title":"Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it","volume":"6","author":"Begriche","year":"2006","journal-title":"Mitochondrion"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","volume":"76","author":"Bessone","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic fatty liver disease: The interplay between metabolism, microbes and immunity","volume":"3","author":"Tilg","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105484","DOI":"10.1016\/j.phrs.2021.105484","article-title":"Epigenetics in NAFLD\/NASH: Targets and therapy","volume":"167","author":"Sodum","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1038\/s41467-020-16092-0","article-title":"Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis","volume":"11","author":"An","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/gutjnl-2012-302962","article-title":"Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease","volume":"62","author":"Pirola","year":"2013","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2017.08.015","article-title":"Mitochondrial adaptation in steatotic mice","volume":"40","author":"Einer","year":"2018","journal-title":"Mitochondrion"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1053\/j.gastro.2022.01.058","article-title":"Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective","volume":"162","author":"Bauer","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1927633","DOI":"10.1080\/19490976.2021.1927633","article-title":"Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis","volume":"13","author":"Rao","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110916","DOI":"10.1016\/j.fct.2019.110916","article-title":"Alteration of mitochondrial DNA homeostasis in drug-induced liver injury","volume":"135","author":"Fromenty","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.metabol.2013.06.012","article-title":"Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice","volume":"62","author":"Malloy","year":"2013","journal-title":"Metabolism"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.nutres.2016.06.015","article-title":"Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRalpha and PPARalpha","volume":"36","author":"Zhang","year":"2016","journal-title":"Nutr. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3109\/10715762.2015.1078461","article-title":"Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease","volume":"49","author":"Ashraf","year":"2015","journal-title":"Free Radic. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbabio.2018.05.019","article-title":"Mitochondrial uncoupling, ROS generation and cardioprotection","volume":"1859","author":"Cadenas","year":"2018","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/path.4803","article-title":"Mitochondrial genome architecture in non-alcoholic fatty liver disease","volume":"240","author":"Sookoian","year":"2016","journal-title":"J. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.freeradbiomed.2020.11.009","article-title":"Physiological evidence of mitochondrial permeability transition pore opening caused by lipid deposition leading to hepatic steatosis in db\/db mice","volume":"162","author":"Li","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.18632\/aging.102972","article-title":"Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease","volume":"12","author":"Li","year":"2020","journal-title":"Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","article-title":"Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice","volume":"58","author":"Lin","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"G324","DOI":"10.1152\/ajpgi.00108.2015","article-title":"Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice","volume":"309","author":"Williams","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S2468-1253(23)00206-6","article-title":"MetALD: New opportunities to understand the role of alcohol in steatotic liver disease","volume":"8","author":"Israelsen","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/hepr.12893","article-title":"Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug-induced liver injury by direct acting antivirals","volume":"48","author":"Kakisaka","year":"2018","journal-title":"Hepatol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2016.04.025","article-title":"Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice","volume":"65","author":"Ni","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/tox.22331","article-title":"Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice","volume":"32","author":"Buron","year":"2017","journal-title":"Environ. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1139\/apnm-2015-0470","article-title":"Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis","volume":"41","author":"Goncalves","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/ars.2016.6776","article-title":"Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis","volume":"26","author":"Spahis","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cell.2020.08.009","article-title":"Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output","volume":"183","author":"Zhao","year":"2020","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: Signaling pathways and novel therapeutic targets","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Protasoni, M., and Zeviani, M. (2021). Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020586"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1136\/gutjnl-2020-321767","article-title":"RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease","volume":"70","author":"Afonso","year":"2021","journal-title":"Gut"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Dabravolski, S.A., Bezsonov, E.E., Baig, M.S., Popkova, T.V., Nedosugova, L.V., Starodubova, A.V., and Orekhov, A.N. (2021). Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094459"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/joim.13147","article-title":"Liver mitochondrial DNA damage and genetic variability of Cytochrome b-a key component of the respirasome-drive the severity of fatty liver disease","volume":"289","author":"Pirola","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jamwal, R., and Barlock, B.J. (2020). Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes. Pharmaceuticals, 13.","DOI":"10.3390\/ph13090222"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Massart, J., Begriche, K., Hartman, J.H., and Fromenty, B. (2022). Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver. Cells, 11.","DOI":"10.3390\/cells11020288"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e21620","DOI":"10.1096\/fj.202100067R","article-title":"Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis","volume":"35","author":"Adebayo","year":"2021","journal-title":"FASEB J."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Al Ojaimi, M., Salah, A., and El-Hattab, A.W. (2022). Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders. Membranes, 12.","DOI":"10.3390\/membranes12090893"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2021.08.232","article-title":"Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1","volume":"175","author":"Jadhav","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"L34","DOI":"10.1186\/2193-1801-4-S1-L34","article-title":"Principles of mitochondrial fusion and fission cycle in neurons","volume":"4","author":"Kaasik","year":"2015","journal-title":"Springerplus"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"154708","DOI":"10.1016\/j.metabol.2021.154708","article-title":"Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): New perspectives for a fairy-tale ending?","volume":"117","author":"Longo","year":"2021","journal-title":"Metabolism"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2018.06.014","article-title":"Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease","volume":"28","author":"Yamada","year":"2018","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"106608","DOI":"10.1016\/j.phrs.2022.106608","article-title":"ALKBH5 attenuates mitochondrial fission and ameliorates liver fibrosis by reducing Drp1 methylation","volume":"187","author":"Wang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"103996","DOI":"10.1016\/j.isci.2022.103996","article-title":"Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver","volume":"25","author":"Yamada","year":"2022","journal-title":"iScience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.7150\/thno.21400","article-title":"Pro-Inflammatory CXCR3 Impairs Mitochondrial Function in Experimental Non-Alcoholic Steatohepatitis","volume":"7","author":"Du","year":"2017","journal-title":"Theranostics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cell.2019.04.010","article-title":"Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease","volume":"177","author":"Sebastian","year":"2019","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41419-022-05088-x","article-title":"Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105449","DOI":"10.1016\/j.actatropica.2020.105449","article-title":"Lipoic acid alleviates schistosomiasis-induced liver fibrosis by upregulating Drp1 phosphorylation","volume":"206","author":"Luo","year":"2020","journal-title":"Acta Trop."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1007\/s00125-021-05488-2","article-title":"Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor","volume":"64","author":"Takeichi","year":"2021","journal-title":"Diabetologia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"101566","DOI":"10.1016\/j.molmet.2022.101566","article-title":"The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR","volume":"64","author":"Steffen","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1111\/bph.15083","article-title":"Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice","volume":"177","author":"Li","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e12731","DOI":"10.1111\/cpr.12731","article-title":"TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1\/Mitophagy signalling pathway","volume":"53","author":"Wu","year":"2020","journal-title":"Cell Prolif."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1515\/med-2021-0394","article-title":"MitoQ inhibits hepatic stellate cell activation and liver fibrosis by enhancing PINK1\/parkin-mediated mitophagy","volume":"16","author":"Dou","year":"2021","journal-title":"Open Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zhou, T., Chang, L., Luo, Y., Zhou, Y., and Zhang, J. (2019). Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy. Redox Biol., 21.","DOI":"10.1016\/j.redox.2019.101120"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/RES.0b013e3182194c29","article-title":"AMPK activates autophagy by phosphorylating ULK1","volume":"108","author":"Mao","year":"2011","journal-title":"Circ. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: Role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Ma, X., McKeen, T., Zhang, J., and Ding, W.X. (2020). Role and Mechanisms of Mitophagy in Liver Diseases. Cells, 9.","DOI":"10.3390\/cells9040837"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s12013-014-0245-5","article-title":"The interplay between apoptosis, mitophagy and mitochondrial biogenesis induced by resveratrol can determine activated hepatic stellate cells death or survival","volume":"71","author":"Vieira","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Torres, S., Segales, P., Garcia-Ruiz, C., and Fernandez-Checa, J.C. (2022). Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis. Cells, 11.","DOI":"10.3390\/cells11091475"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12944-016-0192-9","article-title":"Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice","volume":"15","author":"Berge","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12020-017-1323-4","article-title":"Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice","volume":"57","author":"Ou","year":"2017","journal-title":"Endocrine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jhep.2021.08.009","article-title":"Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure","volume":"76","author":"Zhang","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Li, X., Zhang, Q., Wang, Z., Zhuang, Q., and Zhao, M. (2021). Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis?. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.802251"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.3389\/fimmu.2018.02795","article-title":"Macrophages in the Aging Liver and Age-Related Liver Disease","volume":"9","author":"Stahl","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molmet.2019.08.008","article-title":"miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease","volume":"29","author":"Simon","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"952056","DOI":"10.3389\/fnut.2022.952056","article-title":"Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD","volume":"9","author":"Hu","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8571","DOI":"10.1128\/MCB.22.24.8571-8579.2002","article-title":"The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis","volume":"22","author":"Tang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-kappaB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/biof.1797","article-title":"Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action","volume":"48","author":"Videla","year":"2022","journal-title":"Biofactors"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Zhou, J., Zheng, Q., and Chen, Z. (2022). The Nrf2 Pathway in Liver Diseases. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.826204"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2013.06.020","article-title":"Bidirectional regulation of NF-kappaB by reactive oxygen species: A role of unfolded protein response","volume":"65","author":"Nakajima","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-kappaB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00246-011-9889-8","article-title":"Peroxisome proliferator activated receptor-alpha (PPARalpha) and PPAR gamma coactivator-1alpha (PGC-1alpha) regulation of cardiac metabolism in diabetes","volume":"32","author":"Duncan","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1111\/bph.15099","article-title":"Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21\/PGC-1alpha pathway","volume":"177","author":"Wu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"Drori","year":"2006","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1074\/jbc.274.9.5692","article-title":"Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion","volume":"274","author":"Chavin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1113883","DOI":"10.3389\/fimmu.2023.1113883","article-title":"Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages","volume":"14","author":"Drummer","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.32324","article-title":"Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD","volume":"76","author":"Moore","year":"2022","journal-title":"Hepatology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/ncb3233","article-title":"Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis","volume":"17","author":"Cardaci","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature10363","article-title":"Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase","volume":"477","author":"Frezza","year":"2011","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Di Ciaula, A., Passarella, S., Shanmugam, H., Noviello, M., Bonfrate, L., Wang, D.Q., and Portincasa, P. (2021). Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105375"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2036205","article-title":"A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH","volume":"385","author":"Francque","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/carcin\/bgx023","article-title":"PPARalpha regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C","volume":"38","author":"Chen","year":"2017","journal-title":"Carcinogenesis"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"E710","DOI":"10.1152\/ajpendo.00052.2019","article-title":"Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2alpha\/PPARalpha pathway","volume":"317","author":"Chen","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jcmgh.2020.07.006","article-title":"Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes","volume":"11","author":"Saeed","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"E1369","DOI":"10.1073\/pnas.1202464109","article-title":"Protection from liver fibrosis by a peroxisome proliferator-activated receptor delta agonist","volume":"109","author":"Iwaisako","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1089\/ars.2021.0157","article-title":"Inhibition of Fatty Acid Translocase (FAT\/CD36) Palmitoylation Enhances Hepatic Fatty Acid beta-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetase 1","volume":"36","author":"Zeng","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jhep.2011.05.029","article-title":"The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies","volume":"56","author":"Anstee","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.metabol.2009.09.004","article-title":"Relation of -55CT polymorphism of uncoupling protein 3 gene with fat mass and insulin resistance in morbidly obese patients","volume":"59","author":"Aller","year":"2010","journal-title":"Metabolism"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fct.2013.07.008","article-title":"Glutathione defense mechanism in liver injury: Insights from animal models","volume":"60","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Lin, Y., Jiang, M., Chen, W., Zhao, T., and Wei, Y. (2019). Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response. Biomed. Pharmacother., 118.","DOI":"10.1016\/j.biopha.2019.109249"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_113","first-page":"e16855","article-title":"The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review","volume":"13","author":"Abe","year":"2021","journal-title":"Cureus"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e13622","DOI":"10.1111\/eci.13622","article-title":"Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship","volume":"52","author":"Simoes","year":"2022","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"934113","DOI":"10.3389\/fnut.2022.934113","article-title":"Gut microbiota-mitochondrial inter-talk in non-alcoholic fatty liver disease","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"660179","DOI":"10.3389\/fimmu.2021.660179","article-title":"The Role of the Gut-Liver Axis in Metabolic Dysfunction-Associated Fatty Liver Disease","volume":"12","author":"Albillos","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"111125","DOI":"10.1016\/j.foodres.2022.111125","article-title":"Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota","volume":"155","author":"Yan","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.metabol.2017.03.013","article-title":"Non-alcoholic fatty liver disease: An update with special focus on the role of gut microbiota","volume":"71","author":"Doulberis","year":"2017","journal-title":"Metabolism"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"G256","DOI":"10.1152\/ajpgi.00550.2001","article-title":"Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation","volume":"283","author":"Su","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Mardinoglu, A., Shoaie, S., Bergentall, M., Ghaffari, P., Zhang, C., Larsson, E., Backhed, F., and Nielsen, J. (2015). The gut microbiota modulates host amino acid and glutathione metabolism in mice. Mol. Syst. Biol., 11.","DOI":"10.15252\/msb.20156487"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4161\/gmic.27917","article-title":"Redox signaling mediates symbiosis between the gut microbiota and the intestine","volume":"5","author":"Neish","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/hep.32705","article-title":"Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression","volume":"77","author":"Porras","year":"2023","journal-title":"Hepatology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"ref_124","first-page":"1","article-title":"Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats","volume":"51","author":"Zhao","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s42255-020-0261-2","article-title":"Fructose stimulated de novo lipogenesis is promoted by inflammation","volume":"2","author":"Todoric","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/hep.23535","article-title":"Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease","volume":"51","author":"Abdelmalek","year":"2010","journal-title":"Hepatology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/hep.30652","article-title":"Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol-Inducible Cytochrome P450-2E1-Mediated Oxidative and Nitrative Stress","volume":"73","author":"Cho","year":"2021","journal-title":"Hepatology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"100088","DOI":"10.1016\/j.crphar.2022.100088","article-title":"Simvastatin ameliorates oxidative stress levels in HepG2 cells and hyperlipidemic rats","volume":"3","author":"Verma","year":"2022","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Seo, H.Y., Lee, S.H., Park, J.Y., Han, E., Han, S., Hwang, J.S., Kim, M.K., and Jang, B.K. (2023). Lobeglitazone inhibits LPS-induced NLRP3 inflammasome activation and inflammation in the liver. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0290532"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1904609","DOI":"10.1155\/2020\/1904609","article-title":"Sodium Butyrate-Modulated Mitochondrial Function in High-Insulin Induced HepG2 Cell Dysfunction","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.livres.2021.03.004","article-title":"Vitamins and non-alcoholic fatty liver disease: A Molecular Insight (small star, filled)","volume":"5","author":"Raza","year":"2021","journal-title":"Liver Res."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Zeng, Q., Zhao, L., Meng, C., Zhao, X., Liu, Y., Shi, R., Han, X., Wang, T., and Li, J. (2020). Prophylactic and therapeutic effects of different doses of vitamin C on high-fat-diet-induced non-alcoholic fatty liver disease in mice. Biomed. Pharmacother., 131.","DOI":"10.1016\/j.biopha.2020.110792"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1080\/00365521.2022.2041085","article-title":"Association of serum vitamin C with liver fibrosis in adults with nonalcoholic fatty liver disease","volume":"57","author":"Zhao","year":"2022","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Lee, S.W., Lee, Y.J., Baek, S.M., Kang, K.K., Kim, T.U., Yim, J.H., Kim, H.Y., Han, S.H., Choi, S.K., and Park, S.J. (2022). Mega-Dose Vitamin C Ameliorates Nonalcoholic Fatty Liver Disease in a Mouse Fast-Food Diet Model. Nutrients, 14.","DOI":"10.3390\/nu14112195"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Skat-Rordam, J., Pedersen, K., Skovsted, G.F., Gregersen, I., Vangsgaard, S., Ipsen, D.H., Latta, M., Lykkesfeldt, J., and Tveden-Nyborg, P. (2021). Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig. Antioxidants, 11.","DOI":"10.3390\/antiox11010069"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/iub.1991","article-title":"Role of vitamin E in nonalcoholic fatty liver disease","volume":"71","author":"Nagashimada","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/postgradmedj-2018-136364","article-title":"Effect of vitamin E in non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomised controlled trials","volume":"95","author":"Amanullah","year":"2019","journal-title":"Postgrad. Med. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.nut.2014.08.007","article-title":"Vitamin E therapy for NAFLD\/NASH","volume":"31","author":"Yoneda","year":"2015","journal-title":"Nutrition"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3350\/cmh.2022.0237","article-title":"Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis","volume":"29","author":"Lee","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/MCO.0b013e328357f747","article-title":"Vitamin E and nonalcoholic fatty liver disease","volume":"15","author":"Pacana","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/hep.30368","article-title":"Vitamin E Improves Transplant-Free Survival and Hepatic Decompensation Among Patients With Nonalcoholic Steatohepatitis and Advanced Fibrosis","volume":"71","author":"Vuppalanchi","year":"2020","journal-title":"Hepatology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"S975","DOI":"10.1016\/j.dsx.2017.07.025","article-title":"The effects of vitamin D supplementation on metabolic profiles and liver function in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"Tabrizi","year":"2017","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1138078","DOI":"10.3389\/fendo.2023.1138078","article-title":"Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and beta-oxidation","volume":"14","author":"Du","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1507\/endocrj.EJ16-0542","article-title":"Active form of vitamin D ameliorates non-alcoholic fatty liver disease by alleviating oxidative stress in a high-fat diet rat model","volume":"64","author":"Zhu","year":"2017","journal-title":"Endocr. J."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Barchetta, I., Cimini, F.A., and Cavallo, M.G. (2020). Vitamin D and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): An Update. Nutrients, 12.","DOI":"10.3390\/nu12113302"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Saeed, A., Dullaart, R.P.F., Schreuder, T., Blokzijl, H., and Faber, K.N. (2017). Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients, 10.","DOI":"10.3390\/nu10010029"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2174\/1389450116666150325231015","article-title":"The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease","volume":"16","author":"Chen","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/BST20180420","article-title":"The chemistry of the vitamin B3 metabolome","volume":"47","author":"Makarov","year":"2019","journal-title":"Biochem. Soc. Trans."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.metabol.2015.05.002","article-title":"Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease","volume":"64","author":"Ganji","year":"2015","journal-title":"Metabolism"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"G320","DOI":"10.1152\/ajpgi.00181.2013","article-title":"Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease","volume":"306","author":"Ganji","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3109\/09637486.2011.649249","article-title":"Serum vitamin B12 and folate levels in patients with non-alcoholic fatty liver disease","volume":"63","author":"Polyzos","year":"2012","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1590\/s0004-2803.202100000-42","article-title":"Vitamin B12 and Homocysteine Levels in Patients with Nafld: A Systematic Review and Metanalysis","volume":"58","author":"Costa","year":"2021","journal-title":"Arq. Gastroenterol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"14047","DOI":"10.1038\/s41598-022-18195-8","article-title":"The effects of vitamin B12 supplementation on metabolic profile of patients with non-alcoholic fatty liver disease: A randomized controlled trial","volume":"12","author":"Talari","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"9834","DOI":"10.3390\/nu7125501","article-title":"The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression","volume":"7","author":"Botham","year":"2015","journal-title":"Nutrients"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Gutierrez-Mariscal, F.M., Arenas-de Larriva, A.P., Limia-Perez, L., Romero-Cabrera, J.L., Yubero-Serrano, E.M., and Lopez-Miranda, J. (2020). Coenzyme Q(10) Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217870"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Alhusaini, A.M., Alsoghayer, R., Alhushan, L., Alanazi, A.M., and Hasan, I.H. (2023). Acetyl-L-Carnitine and Liposomal Co-Enzyme Q(10) Attenuate Hepatic Inflammation, Apoptosis, and Fibrosis Induced by Propionic Acid. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411519"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"dmm034801","DOI":"10.1242\/dmm.034801","article-title":"Idebenone and coenzyme Q(10) are novel PPARalpha\/gamma ligands, with potential for treatment of fatty liver diseases","volume":"11","author":"Tiefenbach","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Sumbalova, Z., Kucharska, J., Rausova, Z., Gvozdjakova, A., Szantova, M., Kura, B., Mojto, V., and Slezak, J. (2023). The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q(10) Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512477"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/japplphysiol.00297.2009","article-title":"Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: Is there a role for dietary coenzyme Q?","volume":"107","author":"Cano","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1111\/jcmm.14293","article-title":"Aucubin inhibited lipid accumulation and oxidative stress via Nrf2\/HO-1 and AMPK signalling pathways","volume":"23","author":"Shen","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e21803","DOI":"10.1096\/fj.202002556RRR","article-title":"Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease","volume":"35","author":"Joshi","year":"2021","journal-title":"FASEB J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Liu, B., Deng, X., Jiang, Q., Li, G., Zhang, J., Zhang, N., Xin, S., and Xu, K. (2020). Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS\/P38\/Nrf2 axis and PI3K\/AKT\/mTOR pathway in macrophages. Biomed. Pharmacother., 125.","DOI":"10.1016\/j.biopha.2020.109895"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1049818","DOI":"10.3389\/fphar.2022.1049818","article-title":"Naringin attenuates fructose-induced NAFLD progression in rats through reducing endogenous triglyceride synthesis and activating the Nrf2\/HO-1 pathway","volume":"13","author":"Pengnet","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-030-12668-1_7","article-title":"miRNA Regulation of Glucose and Lipid Metabolism in Relation to Diabetes and Non-alcoholic Fatty Liver Disease","volume":"1134","author":"Suksangrat","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.numecd.2016.08.004","article-title":"Intracellular and extracellular miRNome deregulation in cellular models of NAFLD or NASH: Clinical implications","volume":"26","author":"Ragusa","year":"2016","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/2211536610666210716153929","article-title":"MicroRNAs Involved in Oxidative Stress Processes Regulating Physiological and Pathological Responses","volume":"10","author":"Xu","year":"2021","journal-title":"Microrna"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e70472","DOI":"10.7554\/eLife.70472","article-title":"Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA","volume":"10","author":"Lee","year":"2021","journal-title":"Elife"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s10020-019-0085-2","article-title":"miR-122 promotes hepatic lipogenesis via inhibiting the LKB1\/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease","volume":"25","author":"Long","year":"2019","journal-title":"Mol. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/hep.31805","article-title":"Exosomes and MicroRNA-223 at the Intersection of Inflammation and Fibrosis in NAFLD","volume":"74","author":"Szabo","year":"2021","journal-title":"Hepatology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopha.2018.11.018","article-title":"Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223\/keap1-Nrf2 pathway","volume":"110","author":"Ding","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Morrison, M.C., Gart, E., Duyvenvoorde, W.V., Snabel, J., Nielsen, M.J., Leeming, D.J., Menke, A., and Kleemann, R. (2022). Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-\/-.Leiden Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042325"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"104353","DOI":"10.1016\/j.micpath.2020.104353","article-title":"Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model","volume":"147","author":"Deng","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/13543784.2020.1763302","article-title":"Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH)","volume":"29","author":"Fiorucci","year":"2020","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Wang, X.X., Xie, C., Libby, A.E., Ranjit, S., Levi, J., Myakala, K., Bhasin, K., Jones, B.A., Orlicky, D.J., and Takahashi, S. (2022). The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2022.102530"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Kakiyama, G., Rodriguez-Agudo, D., and Pandak, W.M. (2023). Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised \u201cTwo-Hit\u201d Hypothesis. Cells, 12.","DOI":"10.3390\/cells12101434"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Luna-Marco, C., de Maranon, A.M., Hermo-Argibay, A., Rodriguez-Hernandez, Y., Hermenejildo, J., Fernandez-Reyes, M., Apostolova, N., Vila, J., Sola, E., and Morillas, C. (2023). Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes. Redox Biol., 66.","DOI":"10.1016\/j.redox.2023.102849"},{"key":"ref_179","first-page":"6813017","article-title":"Semaglutide Protects against 6-OHDA Toxicity by Enhancing Autophagy and Inhibiting Oxidative Stress","volume":"2022","author":"Liu","year":"2022","journal-title":"Parkinsons Dis."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fendo.2019.00155","article-title":"The Discovery and Development of Liraglutide and Semaglutide","volume":"10","author":"Knudsen","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/hepr.12634","article-title":"Liraglutide ameliorates non-alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1\/SIRT3-FOXO3a pathway","volume":"46","author":"Tong","year":"2016","journal-title":"Hepatol. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/s41401-022-00860-3","article-title":"Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis","volume":"43","author":"Yang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Tarantino, G., Crocetto, F., Di Vito, C., Creta, M., Martino, R., Pandolfo, S.D., Pesce, S., Napolitano, L., Capone, D., and Imbimbo, C. (2021). Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020346"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1210\/clinem\/dgab641","article-title":"Association of MAFLD With Diabetes, Chronic Kidney Disease, and Cardiovascular Disease: A 4.6-Year Cohort Study in China","volume":"107","author":"Liang","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S2468-1253(21)00308-3","article-title":"Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: An updated systematic review and meta-analysis","volume":"6","author":"Mantovani","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jhep.2017.09.012","article-title":"Association between nonalcoholic fatty liver disease and cancer incidence rate","volume":"68","author":"Kim","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"20420188221145549","DOI":"10.1177\/20420188221145549","article-title":"MAFLD: A multisystem disease","volume":"14","author":"Pipitone","year":"2023","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/gutjnl-2021-324191","article-title":"Nonalcoholic fatty liver disease and increased risk of incident extrahepatic cancers: A meta-analysis of observational cohort studies","volume":"71","author":"Mantovani","year":"2022","journal-title":"Gut"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/thy.2018.0664","article-title":"Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists","volume":"29","author":"Sinha","year":"2019","journal-title":"Thyroid"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/24\/17514\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:39:29Z","timestamp":1760132369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/24\/17514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":189,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["ijms242417514"],"URL":"https:\/\/doi.org\/10.3390\/ijms242417514","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]}}}