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This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, and cell signaling. Although the redox activity of Cu is crucial for enzymatic reactions, this property also makes it potentially toxic when found at high levels. Due to this dual action of Cu, highly regulated mechanisms are necessary to prevent both the deficiency and the accumulation of this metal since its dyshomeostasis may favor the development of multiple diseases, such as Menkes\u2019 and Wilson\u2019s diseases, neurodegenerative diseases, diabetes mellitus, and cancer. As the relationship between Cu and cancer has been the most studied, we analyze how this metal can affect three fundamental processes for tumor progression: cell proliferation, angiogenesis, and metastasis. Gynecological diseases are characterized by high prevalence, morbidity, and mortality, depending on the case, and mainly include benign and malignant tumors. The cellular processes that promote their progression are affected by Cu, and the mechanisms that occur may be similar. We analyze the crosstalk between Cu deregulation and gynecological diseases, focusing on therapeutic strategies derived from this metal.<\/jats:p>","DOI":"10.3390\/ijms242417578","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T03:59:24Z","timestamp":1702871964000},"page":"17578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Copper in Gynecological Diseases"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-2178","authenticated-orcid":false,"given":"Roc\u00edo A.","family":"Conforti","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), San Luis CP D5700HHW, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-1205","authenticated-orcid":false,"given":"Mar\u00eda B.","family":"Delsouc","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), San Luis CP D5700HHW, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Zorychta","sequence":"additional","affiliation":[{"name":"Experimental Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-3538","authenticated-orcid":false,"given":"Carlos M.","family":"Telleria","sequence":"additional","affiliation":[{"name":"Experimental Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada"},{"name":"Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilina","family":"Casais","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), San Luis CP D5700HHW, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bbamcr.2012.02.011","article-title":"Charting the Travels of Copper in Eukaryotes from Yeast to Mammals","volume":"1823","author":"Nevitt","year":"2012","journal-title":"Biochim. 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