{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:44:23Z","timestamp":1790844263639,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Labex Inflamex"},{"name":"ANR11 IDEX 00502"},{"name":"Transcan H2020 Fire CLL"},{"name":"University Paris 13"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. \u03b2-Catenin is a multifunctional protein that stabilizes cell\u2013cell interactions and regulates cell survival through its transcriptional activity. We used chronic lymphocytic leukemia (CLL) cells as a cellular model to study the role of \u03b2-catenin in regulating the adhesion of tumor cells to their microenvironment, which is necessary for tumor cell survival and accumulation. When co-cultured with a stromal cell line (HS-5), a fraction of the CLL cells adhere to stromal cells in a dynamic fashion regulated by the different levels of \u03b2-catenin expression. In non-adherent cells, \u03b2-catenin is stabilized in the cytosol and translocates into the nucleus, increasing the expression of cyclin D1. In adherent cells, the level of cytosolic \u03b2-catenin is low but membrane \u03b2-catenin helps to stabilize the adhesion of CLL to stromal cells. Indeed, the overexpression of \u03b2-catenin enhances the interaction of CLL with HS-5 cells, suggesting that this protein behaves as a regulator of cell adhesion to the stromal component and of the transcriptional regulation of cell survival. Inhibitors that block the stabilization of \u03b2-catenin alter this equilibrium and effectively disrupt the support that CLL cells receive from the cross-talk with the stroma.<\/jats:p>","DOI":"10.3390\/ijms242417623","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:04:47Z","timestamp":1702893887000},"page":"17623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of the Axis \u03b2-Catenin\u2013BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment"],"prefix":"10.3390","volume":"24","author":[{"given":"Imane","family":"Mihoub","sequence":"first","affiliation":[{"name":"INSERM, U978, 93000 Bobigny, France"},{"name":"UFR SMBH, LabEx INFLAMEX, Universit\u00e9 Paris 13\u2014\u00abSorbonne Paris Nord\u00bb, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-1776","authenticated-orcid":false,"given":"Tareck","family":"Rharass","sequence":"additional","affiliation":[{"name":"INSERM, U978, 93000 Bobigny, France"},{"name":"UFR SMBH, LabEx INFLAMEX, Universit\u00e9 Paris 13\u2014\u00abSorbonne Paris Nord\u00bb, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souha\u00efl","family":"Ouriemmi","sequence":"additional","affiliation":[{"name":"INSERM, U978, 93000 Bobigny, France"},{"name":"UFR SMBH, LabEx INFLAMEX, Universit\u00e9 Paris 13\u2014\u00abSorbonne Paris Nord\u00bb, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-1097","authenticated-orcid":false,"given":"Antonin","family":"Oudar","sequence":"additional","affiliation":[{"name":"INSERM, U978, 93000 Bobigny, France"},{"name":"UFR SMBH, LabEx INFLAMEX, Universit\u00e9 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