{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:16:00Z","timestamp":1769825760434,"version":"3.49.0"},"reference-count":69,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Office, University of Johannesburg, South Africa","award":["PSTD2203301202"],"award-info":[{"award-number":["PSTD2203301202"]}]},{"name":"National Research Foundation","award":["PSTD2203301202"],"award-info":[{"award-number":["PSTD2203301202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Type 2 diabetes (T2D) is a global health challenge with increased morbidity and mortality rates yearly. Herbal medicine has provided an alternative approach to treating T2D with limited access to formal healthcare. Tectona grandis is being used traditionally in the treatment of diabetes. The present study investigated the antidiabetic potential of T. grandis leaves in different solvent extractions, and the crude extract that demonstrated the best activity was further fractionated through solvent\u2013solvent partitioning. The ethyl acetate fraction of the ethanol crude extract showed the best antidiabetic activity in inhibiting \u03b1-glucosidase, delaying glucose absorption at the small intestine\u2019s lumen, and enhancing the muscle\u2019s postprandial glucose uptake. The ethyl acetate fraction was further elucidated for its ability to reduce hyperglycemia in diabetic rats. The ethyl acetate fraction significantly reduced high blood glucose levels in diabetic rats with concomitant modulation in stimulated insulin secretions through improved pancreatic \u03b2-cell function, insulin sensitivity by increasing liver glycogen content, and reduced elevated levels of liver glucose-6-phosphatase activity. These activities could be attributed to the phytochemical constituents of the plant.<\/jats:p>","DOI":"10.3390\/ijms25010028","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T06:03:11Z","timestamp":1702965791000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ethyl Acetate Fractions of Tectona Grandis Crude Extract Modulate Glucose Absorption and Uptake as Well as Antihyperglycemic Potential in Fructose\u2013Streptozotocin-Induced Diabetic Rats"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-9005","authenticated-orcid":false,"given":"Olakunle","family":"Sanni","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Physiology, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa"},{"name":"Department of Biochemistry, School of Life Sciences, University of Kwazulu-Natal (Westville Campus), Private Bag X54001, Durban 4000, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilani","family":"Nkomozepi","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Physiology, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Shahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Kwazulu-Natal (Westville Campus), Private Bag X54001, Durban 4000, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. 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