{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:19:46Z","timestamp":1791591586576,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cannabis has been used as an herbal remedy for thousands of years, and recent research indicates promising new uses in medicine. So far, some studies have shown cannabinoids to be safe in helping mitigate some cancer-associated complications, including chemotherapy-induced nausea and vomiting, cancer-associated pain, and tumor growth. Researchers have been particularly interested in the potential uses of cannabinoids in treating cancer due to their ability to regulate cancer-related cell cycle pathways, prompting many beneficial effects, such as tumor growth prevention, cell cycle obstruction, and cell death. Cannabinoids have been found to affect tumors of the brain, prostate, colon and rectum, breast, uterus, cervix, thyroid, skin, pancreas, and lymph. However, the full potential of cannabinoids is yet to be understood. This review discusses current knowledge on the promising applications of cannabinoids in treating three different side effects of cancer\u2014chemotherapy-induced nausea and vomiting, cancer-associated pain, and tumor development. The findings suggest that cannabinoids can be used to address some side effects of cancer and to limit the growth of tumors, though a lack of supporting clinical trials presents a challenge for use on actual patients. An additional challenge will be examining whether any of the over one hundred naturally occurring cannabinoids or dozens of synthetic compounds also exhibit useful clinical properties. Currently, clinical trials are underway; however, no regulatory agencies have approved cannabinoid use for any cancer symptoms beyond antinausea.<\/jats:p>","DOI":"10.3390\/ijms25010074","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T03:51:45Z","timestamp":1703044305000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting, Cancer-Associated Pain, and Tumor Growth"],"prefix":"10.3390","volume":"25","author":[{"given":"Pavana P.","family":"Bathula","sequence":"first","affiliation":[{"name":"School of Medicine, Stanford University, Palo Alto, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-8954","authenticated-orcid":false,"given":"M. Bruce","family":"Maciver","sequence":"additional","affiliation":[{"name":"School of Medicine, Stanford University, Palo Alto, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/08998280.2019.1603034","article-title":"A review of the anesthetic implications of marijuana use","volume":"32","author":"Alexander","year":"2019","journal-title":"Proc. Bayl. Univ. Med. Cent."},{"key":"ref_2","unstructured":"NIDA (2023, December 14). What Is Marijuana? 17 April 2023, Available online: https:\/\/nida.nih.gov\/publications\/research-reports\/marijuana\/what-marijuana."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11782218231172054","DOI":"10.1177\/11782218231172054","article-title":"The Impact of Recreational Cannabis Legalization on Cannabis Use and Associated Outcomes: A Systematic Review","volume":"17","author":"Farrelly","year":"2023","journal-title":"Subst. Abus. Res. Treat."},{"key":"ref_4","unstructured":"PDQ\u00ae Integrative, Alternative, and Complementary Therapies Editorial Board (2023, August 06). PDQ Cannabis and Cannabinoids. Bethesda, MD: National Cancer Institute. Updated <07\/20\/2023>, Available online: https:\/\/www.cancer.gov\/about-cancer\/treatment\/cam\/hp\/cannabis-pdq."},{"key":"ref_5","unstructured":"Mack, A., and Joy, J. (2000). Marijuana as Medicine?: The Science Beyond the Controversy, National Academies Press (US)."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An Introduction to the Endogenous Cannabinoid System","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.tplants.2020.05.005","article-title":"Phytocannabinoids: Origins and Biosynthesis","volume":"25","year":"2020","journal-title":"Trends Plant Sci."},{"key":"ref_8","unstructured":"NIDA (2018, February 05). Synthetic Cannabinoids (K2\/Spice) DrugFacts, Available online: https:\/\/nida.nih.gov\/publications\/drugfacts\/synthetic-cannabinoids-k2spice."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pagano, C., Navarra, G., Coppola, L., Avilia, G., Bifulco, M., and Laezza, C. (2022). Cannabinoids: Therapeutic Use in Clinical Practice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063344"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Heider, C.G., Itenberg, S.A., Rao, J., Ma, H., and Wu, X. (2022). Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review. Biology, 11.","DOI":"10.3390\/biology11060817"},{"key":"ref_11","first-page":"7491","article-title":"In the weeds: A retrospective study of patient interest in and experience with cannabis at a cancer center","volume":"30","author":"Raghunathan","year":"2022","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support Care Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/cncr.33906","article-title":"A Coala-T-Cannabis Survey Study of breast cancer patients\u2019 use of cannabis before, during, and after treatment","volume":"128","author":"Weiss","year":"2022","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s00432-022-04085-z","article-title":"Cannabinoid consumption among cancer patients receiving systemic anti-cancer treatment in the Netherlands","volume":"149","author":"Oelen","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/can.2021.0187","article-title":"Cannabinoids to Improve Health-Related Quality of Life in Patients with Neurological or Oncological Disease: A Meta-Analysis","volume":"8","author":"Belgers","year":"2023","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/cncr.33440","article-title":"Independent association of marijuana use and poor oral hygiene with HPV-negative but not HPV-positive head and neck squamous cell carcinomas","volume":"127","author":"Shewale","year":"2021","journal-title":"Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Schab, M., and Skoczen, S. (2022). The Role of Nutritional Status, Gastrointestinal Peptides, and Endocannabinoids in the Prognosis and Treatment of Children with Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095159"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Andradas, C., Truong, A., Byrne, J., and Endersby, R. (2021). The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology. Cancers, 13.","DOI":"10.3390\/cancers13010157"},{"key":"ref_18","unstructured":"The American Cancer Society Medical and Editorial Content Team (2020, August 04). \u201cMarijuana and Cancer\u201d. American Cancer Society. Available online: https:\/\/www.cancer.org\/treatment\/treatments-and-side-effects\/treatment-types\/complementary-and-integrative-medicine\/marijuana-and-cancer."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1200\/JCO.20.01296","article-title":"Antiemetics: ASCO Guideline Update","volume":"38","author":"Hesketh","year":"2020","journal-title":"Lyman J. Clin. Oncol."},{"key":"ref_20","unstructured":"Taylor, B.N., Mueller, M., and Sauls, R.S. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_21","unstructured":"Ng, T., Gupta, V., and Keshock, M.C. (2023, November 12). Tetrahydrocannabinol (THC) [Updated], StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK563174\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e27374","DOI":"10.1002\/pbc.27374","article-title":"Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: A multicenter, retrospective review","volume":"65","author":"Polito","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2147\/IJWH.S401938","article-title":"Oral Tetrahydrocannabinol (THC):Cannabinoid (CBD) Cannabis Extract Adjuvant for Reducing Chemotherapy-Induced Nausea and Vomiting (CINV): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial","volume":"15","author":"Sukpiriyagul","year":"2023","journal-title":"Int. J. Women\u2032s Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.annonc.2020.07.020","article-title":"Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: A randomised, placebo-controlled, phase II crossover trial","volume":"31","author":"Grimison","year":"2020","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/SPC.0000000000000493","article-title":"Cannabis and cannabinoids in cancer pain management","volume":"14","author":"Meng","year":"2020","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejim.2018.01.023","article-title":"Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer","volume":"49","author":"Mechoulam","year":"2018","journal-title":"Eur. J. Intern. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Clarke, S., Butcher, B.E., McLachlan, A.J., Henson, J.D., Rutolo, D., Hall, S., and Vitetta, L. (2022). Pilot clinical and pharmacokinetic study of \u03949-Tetrahydrocannabinol (THC)\/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0270543"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Afrin, F., Chi, M., Eamens, A.L., Duchatel, R.J., Douglas, A.M., Schneider, J., Gedye, C., Woldu, A.S., and Dun, M.D. (2020). Can Hemp Help? Low-THC Cannabis and Non-THC Cannabinoids for the Treatment of Cancer. Cancers, 12.","DOI":"10.3390\/cancers12041033"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lowe, H., Toyang, N., Steele, B., Bryant, J., and Ngwa, W. (2021). The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179472"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Li, D., Ilnytskyy, Y., Ghasemi Gojani, E., Kovalchuk, O., and Kovalchuk, I. (2022). Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC Cannabis Extracts. Molecules, 27.","DOI":"10.3390\/molecules27186057"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Loubaki, L., Rouabhia, M., Zahrani, M.A., Amri, A.A., and Semlali, A. (2022). Oxidative Stress and Autophagy Mediate Anti-Cancer Properties of Cannabis Derivatives in Human Oral Cancer Cells. Cancers, 14.","DOI":"10.3390\/cancers14194924"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kiskov\u00e1, T., Mungenast, F., Suv\u00e1kov\u00e1, M., J\u00e4ger, W., and Thalhammer, T. (2019). Future Aspects for Cannabinoids in Breast Cancer Therapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071673"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbrc.2022.12.073","article-title":"Comparative changes in breast cancer cell proliferation and signalling following somatostatin and cannabidiol treatment","volume":"643","author":"Oliveira","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bj3630183","article-title":"De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis","volume":"363","author":"Velasco","year":"2002","journal-title":"Biochem. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"713153","DOI":"10.3389\/fmed.2021.713153","article-title":"Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy","volume":"8","author":"Zaiachuk","year":"2021","journal-title":"Front. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00432-021-03710-7","article-title":"Cannabinoids in the landscape of cancer","volume":"147","author":"Mangal","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Peeri, H., and Koltai, H. (2022). Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities. Biomolecules, 12.","DOI":"10.3390\/biom12040491"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Schanknecht, E., Bachari, A., Nassar, N., Piva, T., and Mantri, N. (2023). Phytochemical Constituents and Derivatives of Cannabis sativa; Bridging the Gap in Melanoma Treatment. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010859"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Blal, K., Besser, E., Procaccia, S., Schwob, O., Lerenthal, Y., Abu Tair, J., Meiri, D., and Benny, O. (2023). The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy. Cancers, 15.","DOI":"10.3390\/cancers15020497"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10555-023-10078-2","article-title":"Tetrahydrocannabinols: Potential cannabimimetic agents for cancer therapy","volume":"42","author":"Prateeksha","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.bjc.6603236","article-title":"A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme","volume":"95","author":"Duarte","year":"2006","journal-title":"Br. J. Cancer"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/74\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:42:01Z","timestamp":1760132521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/74"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25010074"],"URL":"https:\/\/doi.org\/10.3390\/ijms25010074","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,20]]}}}