{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:12:48Z","timestamp":1785352368107,"version":"3.55.0"},"reference-count":108,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACYT, M\u00e9xico","award":["A3-S-47392"],"award-info":[{"award-number":["A3-S-47392"]}]},{"DOI":"10.13039\/501100003141","name":"Fondo Sectorial de Investigaci\u00f3n en Salud y Seguridad Social","doi-asserted-by":"publisher","award":["A3-S-47392"],"award-info":[{"award-number":["A3-S-47392"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute lymphoblastic leukemia (ALL) is the most common cancer in children worldwide. Although ALL patients\u2019 overall survival rates in wealthy countries currently surpass 80%, 15\u201320% of patients still experience relapse. The underlying mechanisms of relapse are still not fully understood, and little progress has been made in treating refractory or relapsed disease. Disease relapse and treatment failure are common causes of leukemia-related death. In ALL relapse, several gene signatures have been identified, but it is also important to study miRNAs involved in ALL relapse in an effort to avoid relapse and to achieve better survival rates since miRNAs regulate target genes that participate in signaling pathways involved in relapse, such as those related to drug resistance, survival signals, and antiapoptotic mechanisms. Several miRNAs, such as miR-24, miR-27a, miR-99\/100, miR-124, miR-1225b, miR-128b, miR-142-3p, miR-155 and miR-335-3p, are valuable biomarkers for prognosis and treatment response in ALL patients. Thus, this review aimed to analyze the primary miRNAs involved in pediatric ALL relapse and explore the underlying molecular mechanisms in an effort to identify miRNAs that may be potential candidates for anti-ALL therapy soon.<\/jats:p>","DOI":"10.3390\/ijms25010119","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:36:17Z","timestamp":1703129777000},"page":"119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Role of miRNAs in Childhood Acute Lymphoblastic Leukemia Relapse and the Associated Molecular Mechanisms"],"prefix":"10.3390","volume":"25","author":[{"given":"Dalia","family":"Barrios-Palacios","sequence":"first","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-7905","authenticated-orcid":false,"given":"Jorge","family":"Organista-Nava","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1978-248X","authenticated-orcid":false,"given":"Juan Carlos","family":"Balandr\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2074-4889","authenticated-orcid":false,"given":"Luz del Carmen","family":"Alarc\u00f3n-Romero","sequence":"additional","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-4585","authenticated-orcid":false,"given":"Ma Isabel","family":"Zubillaga-Guerrero","sequence":"additional","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-335X","authenticated-orcid":false,"given":"Berenice","family":"Illades-Aguiar","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alinne Ayulieth","family":"Rivas-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Julieth","family":"Diaz-Lucas","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-9730","authenticated-orcid":false,"given":"Yazm\u00edn","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3345-5859","authenticated-orcid":false,"given":"Marco Antonio","family":"Leyva-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39090, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/bjc.2017.256","article-title":"MiR-125b predicts childhood acute lymphoblastic leukaemia poor response to BFM chemotherapy treatment","volume":"117","author":"Piatopoulou","year":"2017","journal-title":"Br. 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