{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:11:53Z","timestamp":1793373113418,"version":"4.5.0"},"reference-count":102,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["BeiR20Prin"],"award-info":[{"award-number":["BeiR20Prin"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["E85F22000060006"],"award-info":[{"award-number":["E85F22000060006"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["Prot. 20205HZBP8_006"],"award-info":[{"award-number":["Prot. 20205HZBP8_006"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["E53D23013360006"],"award-info":[{"award-number":["E53D23013360006"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["Prot. 2022WBBTBC_002"],"award-info":[{"award-number":["Prot. 2022WBBTBC_002"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["D53D23013800001"],"award-info":[{"award-number":["D53D23013800001"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["Prot. 2022TXHFSA"],"award-info":[{"award-number":["Prot. 2022TXHFSA"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["E53D23001190006"],"award-info":[{"award-number":["E53D23001190006"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["Prot. 20223RRASS"],"award-info":[{"award-number":["Prot. 20223RRASS"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["P2022LZXNW"],"award-info":[{"award-number":["P2022LZXNW"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["RM12117A7F986146"],"award-info":[{"award-number":["RM12117A7F986146"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca, PRIN 2020","award":["RM12218166C5057A"],"award-info":[{"award-number":["RM12218166C5057A"]}]},{"name":"PRIN 2022","award":["BeiR20Prin"],"award-info":[{"award-number":["BeiR20Prin"]}]},{"name":"PRIN 2022","award":["E85F22000060006"],"award-info":[{"award-number":["E85F22000060006"]}]},{"name":"PRIN 2022","award":["Prot. 20205HZBP8_006"],"award-info":[{"award-number":["Prot. 20205HZBP8_006"]}]},{"name":"PRIN 2022","award":["E53D23013360006"],"award-info":[{"award-number":["E53D23013360006"]}]},{"name":"PRIN 2022","award":["Prot. 2022WBBTBC_002"],"award-info":[{"award-number":["Prot. 2022WBBTBC_002"]}]},{"name":"PRIN 2022","award":["D53D23013800001"],"award-info":[{"award-number":["D53D23013800001"]}]},{"name":"PRIN 2022","award":["Prot. 2022TXHFSA"],"award-info":[{"award-number":["Prot. 2022TXHFSA"]}]},{"name":"PRIN 2022","award":["E53D23001190006"],"award-info":[{"award-number":["E53D23001190006"]}]},{"name":"PRIN 2022","award":["Prot. 20223RRASS"],"award-info":[{"award-number":["Prot. 20223RRASS"]}]},{"name":"PRIN 2022","award":["P2022LZXNW"],"award-info":[{"award-number":["P2022LZXNW"]}]},{"name":"PRIN 2022","award":["RM12117A7F986146"],"award-info":[{"award-number":["RM12117A7F986146"]}]},{"name":"PRIN 2022","award":["RM12218166C5057A"],"award-info":[{"award-number":["RM12218166C5057A"]}]},{"name":"PRIN 2022 PNRR","award":["BeiR20Prin"],"award-info":[{"award-number":["BeiR20Prin"]}]},{"name":"PRIN 2022 PNRR","award":["E85F22000060006"],"award-info":[{"award-number":["E85F22000060006"]}]},{"name":"PRIN 2022 PNRR","award":["Prot. 20205HZBP8_006"],"award-info":[{"award-number":["Prot. 20205HZBP8_006"]}]},{"name":"PRIN 2022 PNRR","award":["E53D23013360006"],"award-info":[{"award-number":["E53D23013360006"]}]},{"name":"PRIN 2022 PNRR","award":["Prot. 2022WBBTBC_002"],"award-info":[{"award-number":["Prot. 2022WBBTBC_002"]}]},{"name":"PRIN 2022 PNRR","award":["D53D23013800001"],"award-info":[{"award-number":["D53D23013800001"]}]},{"name":"PRIN 2022 PNRR","award":["Prot. 2022TXHFSA"],"award-info":[{"award-number":["Prot. 2022TXHFSA"]}]},{"name":"PRIN 2022 PNRR","award":["E53D23001190006"],"award-info":[{"award-number":["E53D23001190006"]}]},{"name":"PRIN 2022 PNRR","award":["Prot. 20223RRASS"],"award-info":[{"award-number":["Prot. 20223RRASS"]}]},{"name":"PRIN 2022 PNRR","award":["P2022LZXNW"],"award-info":[{"award-number":["P2022LZXNW"]}]},{"name":"PRIN 2022 PNRR","award":["RM12117A7F986146"],"award-info":[{"award-number":["RM12117A7F986146"]}]},{"name":"PRIN 2022 PNRR","award":["RM12218166C5057A"],"award-info":[{"award-number":["RM12218166C5057A"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["BeiR20Prin"],"award-info":[{"award-number":["BeiR20Prin"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["E85F22000060006"],"award-info":[{"award-number":["E85F22000060006"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["Prot. 20205HZBP8_006"],"award-info":[{"award-number":["Prot. 20205HZBP8_006"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["E53D23013360006"],"award-info":[{"award-number":["E53D23013360006"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["Prot. 2022WBBTBC_002"],"award-info":[{"award-number":["Prot. 2022WBBTBC_002"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["D53D23013800001"],"award-info":[{"award-number":["D53D23013800001"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["Prot. 2022TXHFSA"],"award-info":[{"award-number":["Prot. 2022TXHFSA"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["E53D23001190006"],"award-info":[{"award-number":["E53D23001190006"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["Prot. 20223RRASS"],"award-info":[{"award-number":["Prot. 20223RRASS"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["P2022LZXNW"],"award-info":[{"award-number":["P2022LZXNW"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["RM12117A7F986146"],"award-info":[{"award-number":["RM12117A7F986146"]}]},{"name":"University of Rome \u201cSapienza\u201d Ateneo 2021 and Ateneo 2022","award":["RM12218166C5057A"],"award-info":[{"award-number":["RM12218166C5057A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The polyphenols Curcumin (CUR) and Resveratrol (RES) are widely described for their antitumoral effects. However, their low bioavailability is a drawback for their use in therapy. The aim of this study was to explore whether CUR and RES, used at a bioavailable concentration, could modulate immune responses while retaining antitumor activity and to determine whether CUR and RES effects on the immune responses of peripheral blood mononuclear cells (PBMCs) and tumor growth inhibition could be improved by their combination. We demonstrate that the low-dose combination of CUR and RES reduced the survival of cancer cell lines but had no effect on the viability of PBMCs. Although following CUR + RES treatment T lymphocytes showed an enhanced activated state, RES counteracted the increased IFN-\u03b3 expression induced by CUR in T cells and the polyphenol combination increased IL-10 production by T regulatory cells. On the other hand, the combined treatment enhanced NK cell activity through the up- and downregulation of activating and inhibitory receptors and increased CD68 expression levels on monocytes\/macrophages. Overall, our results indicate that the combination of CUR and RES at low doses differentially shapes immune cells while retaining antitumor activity, support the use of this polyphenol combinations in anticancer therapy and suggest its possible application as adjuvant for NK cell-based immunotherapies.<\/jats:p>","DOI":"10.3390\/ijms25010232","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T20:44:15Z","timestamp":1703450655000},"page":"232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-3966","authenticated-orcid":false,"given":"Chiara","family":"Focaccetti","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-1306","authenticated-orcid":false,"given":"Monica","family":"Benvenuto","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"},{"name":"Departmental Faculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Carrano","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Melaiu","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-7509","authenticated-orcid":false,"given":"Daniela","family":"Nardozi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-2956","authenticated-orcid":false,"given":"Valentina","family":"Angiolini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome \u201cSapienza\u201d, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Lucarini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome \u201cSapienza\u201d, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"K\u00ebrpi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Catholic University \u2018Our Lady of Good Counsel\u2019, 1000 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Masuelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome \u201cSapienza\u201d, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-430X","authenticated-orcid":false,"given":"Loredana","family":"Cifaldi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-8896","authenticated-orcid":false,"given":"Roberto","family":"Bei","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Catholic University \u2018Our Lady of Good Counsel\u2019, 1000 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ullah, A., Munir, S., Badshah, S.L., Khan, N., Ghani, L., Poulson, B.G., Emwas, A.-H., and Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules, 25.","DOI":"10.3390\/molecules25225243"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107700","DOI":"10.1016\/j.pharmthera.2020.107700","article-title":"Targeting the Tumor Immune Microenvironment with \u201cNutraceuticals\u201d: From Bench to Clinical Trials","volume":"219","author":"Masuelli","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9236","DOI":"10.3390\/ijms16059236","article-title":"In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment","volume":"16","author":"Fantini","year":"2015","journal-title":"IJMS"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Benvenuto, M., Mattera, R., Taffera, G., Giganti, M., Lido, P., Masuelli, L., Modesti, A., and Bei, R. (2016). The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium. Nutrients, 8.","DOI":"10.3390\/nu8050275"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.semcancer.2020.10.010","article-title":"Chemotherapeutic Efficacy of Curcumin and Resveratrol against Cancer: Chemoprevention, Chemoprotection, Drug Synergism and Clinical Pharmacokinetics","volume":"73","author":"Patra","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.2741\/4180","article-title":"Inhibition of ErbB Receptors, Hedgehog and NF-kappaB Signaling by Polyphenols in Cancer","volume":"18","author":"Benvenuto","year":"2013","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mishra, A.P., Singh, P., Yadav, S., Nigam, M., Seidel, V., and Rodrigues, C.F. (2023). Role of the Dietary Phytochemical Curcumin in Targeting Cancer Cell Signalling Pathways. Plants, 12.","DOI":"10.3390\/plants12091782"},{"key":"ref_8","first-page":"3059","article-title":"The Roles of Curcumin in Regulating the Tumor Immunosuppressive Microenvironment","volume":"19","author":"Wang","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Benvenuto, M., Albonici, L., Focaccetti, C., Ciuffa, S., Fazi, S., Cifaldi, L., Miele, M.T., De Maio, F., Tresoldi, I., and Manzari, V. (2020). Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186635"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e1356151","DOI":"10.1080\/2162402X.2017.1356151","article-title":"Chloroquine Supplementation Increases the Cytotoxic Effect of Curcumin against Her2\/Neu Overexpressing Breast Cancer Cells in Vitro and in Vivo in Nude Mice While Counteracts It in Immune Competent Mice","volume":"6","author":"Masuelli","year":"2017","journal-title":"Oncoimmunology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Focaccetti, C., Benvenuto, M., Ciuffa, S., Fazi, S., Scimeca, M., Nardi, A., Miele, M.T., Battisti, A., Bonanno, E., and Modesti, A. (2020). Curcumin Enhances the Antitumoral Effect Induced by the Recombinant Vaccinia Neu Vaccine (rV-neuT) in Mice with Transplanted Salivary Gland Carcinoma Cells. Nutrients, 12.","DOI":"10.3390\/nu12051417"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/09637486.2023.2251723","article-title":"Curcumin Potentiates the ErbB Receptors Inhibitor Afatinib for Enhanced Antitumor Activity in Malignant Mesothelioma","volume":"74","author":"Benvenuto","year":"2023","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Almatroodi, S.A., Alsahli, M.A., Aljohani, A.S.M., Alhumaydhi, F.A., Babiker, A.Y., Khan, A.A., and Rahmani, A.H. (2022). Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer. Molecules, 27.","DOI":"10.3390\/molecules27092665"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/nure.12114","article-title":"Dietary Factors Affecting Polyphenol Bioavailability","volume":"72","author":"Bohn","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17154","DOI":"10.3390\/molecules191117154","article-title":"Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability Is the Problem, What Is the Solution?","volume":"19","author":"Smoliga","year":"2014","journal-title":"Molecules"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dei Cas, M., and Ghidoni, R. (2019). Dietary Curcumin: Correlation between Bioavailability and Health Potential. Nutrients, 11.","DOI":"10.3390\/nu11092147"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hafez Ghoran, S., Calcaterra, A., Abbasi, M., Taktaz, F., Nieselt, K., and Babaei, E. (2022). Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment. Molecules, 27.","DOI":"10.3390\/molecules27165236"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","article-title":"Resveratrol for Cancer Therapy: Challenges and Future Perspectives","volume":"515","author":"Ren","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"112356","DOI":"10.1016\/j.ejmech.2020.112356","article-title":"Resveratrol\u2014A Comprehensive Review of Recent Advances in Anticancer Drug Design and Development","volume":"200","author":"Ahmadi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3892\/or.2013.2310","article-title":"Synergistic Anticancer Effects of Curcumin and Resveratrol in Hepa1-6 Hepatocellular Carcinoma Cells","volume":"29","author":"Du","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/01635580902752262","article-title":"Curcumin Synergizes with Resveratrol to Inhibit Colon Cancer","volume":"61","author":"Majumdar","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1080\/14786419.2022.2162517","article-title":"Comparative Analysis of the Molecular Mechanism of Inhibiting Proliferation and Migration in Cervical Cancer HeLa Cell by Curcumin and Resveratrol","volume":"37","author":"Wang","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1039\/C9FO01014A","article-title":"Pro-Apoptotic Genes as New Targets for Single and Combinatorial Treatments with Resveratrol and Curcumin in Colorectal Cancer","volume":"10","author":"Gavrilas","year":"2019","journal-title":"Food Funct."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/ptr.7794","article-title":"Co-Administration of Curcumin with Other Phytochemicals Improves Anticancer Activity by Regulating Multiple Molecular Targets","volume":"37","author":"Ghobadi","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Niedzwiecki, A., Roomi, M., Kalinovsky, T., and Rath, M. (2016). Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients, 8.","DOI":"10.3390\/nu8090552"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9603271221095929","DOI":"10.1177\/09603271221095929","article-title":"Curcumin and Resveratrol Inhibit Chemoresistance in Cisplatin-Resistant Epithelial Ovarian Cancer Cells via Targeting P13K Pathway","volume":"41","author":"Muhanmode","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2741\/3940","article-title":"Resveratrol and Diallyl Disulfide Enhance Curcumin-Induced Sarcoma Cell Apoptosis","volume":"17","author":"Masuelli","year":"2012","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10745","DOI":"10.18632\/oncotarget.2534","article-title":"Resveratrol Potentiates the in Vitro and in Vivo Anti-Tumoral Effects of Curcumin in Head and Neck Carcinomas","volume":"5","author":"Masuelli","year":"2014","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Arena, A., Romeo, M.A., Benedetti, R., Masuelli, L., Bei, R., Gilardini Montani, M.S., and Cirone, M. (2021). New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects. Pharmaceuticals, 14.","DOI":"10.3390\/ph14111068"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"175267","DOI":"10.1016\/j.ejphar.2022.175267","article-title":"Immunomodulatory Role of Nanocurcumin in COVID-19 Patients with Dropped Natural Killer Cells Frequency and Function","volume":"933","author":"Hazrati","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.canlet.2019.06.001","article-title":"Modulation of Regulatory T Cells by Natural Products in Cancer","volume":"459","author":"Bahrami","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/cmi.2010.11","article-title":"Curcumin Reverses T Cell-Mediated Adaptive Immune Dysfunctions in Tumor-Bearing Hosts","volume":"7","author":"Bhattacharyya","year":"2010","journal-title":"Cell Mol. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.coph.2021.08.005","article-title":"Polyphenols Affect the Humoral Response in Cancer, Infectious and Allergic Diseases and Autoimmunity by Modulating the Activity of TH1 and TH2 Cells","volume":"60","author":"Benvenuto","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s12013-015-0513-z","article-title":"Modification of Antitumor Immunity and Tumor Microenvironment by Resveratrol in Mouse Renal Tumor Model","volume":"72","author":"Chen","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1002\/ptr.7189","article-title":"Boosting Immune System against Cancer by Resveratrol","volume":"35","author":"Chen","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3892\/etm.2012.472","article-title":"Resveratrol Analogue HS-1793 Induces the Modulation of Tumor-Derived T Cells","volume":"3","author":"Choi","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/jsre.2000.5826","article-title":"Inhibition of Intestinal Tumors by Curcumin Is Associated with Changes in the Intestinal Immune Cell Profile","volume":"89","author":"Churchill","year":"2000","journal-title":"J. Surg. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"eaal3024","DOI":"10.1126\/scisignal.aal3024","article-title":"Resveratrol Stimulates the Metabolic Reprogramming of Human CD4+ T Cells to Enhance Effector Function","volume":"10","author":"Craveiro","year":"2017","journal-title":"Sci. Signal"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0024-3205(01)01367-4","article-title":"Effects of Resveratrol on Human Immune Cell Function","volume":"70","author":"Falchetti","year":"2001","journal-title":"Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.3390\/molecules20023020","article-title":"Curcumin and Omega-3 Fatty Acids Enhance NK Cell-Induced Apoptosis of Pancreatic Cancer Cells but Curcumin Inhibits Interferon-\u03b3 Production: Benefits of Omega-3 with Curcumin against Cancer","volume":"20","author":"Fiala","year":"2015","journal-title":"Molecules"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Focaccetti, C., Izzi, V., Benvenuto, M., Fazi, S., Ciuffa, S., Giganti, M.G., Potenza, V., Manzari, V., Modesti, A., and Bei, R. (2019). Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071714"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/biof.1776","article-title":"Targeting of the Tumor Microenvironment by Curcumin","volume":"47","author":"Fu","year":"2021","journal-title":"Biofactors"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"119359","DOI":"10.1016\/j.lfs.2021.119359","article-title":"Synergistic Efficacy of Curcumin and Anti-Programmed Cell Death-1 in Hepatocellular Carcinoma","volume":"279","author":"Guo","year":"2021","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.intimp.2012.07.018","article-title":"Resveratrol Analog, HS-1793 Enhance Anti-Tumor Immunity by Reducing the CD4+CD25+ Regulatory T Cells in FM3A Tumor Bearing Mice","volume":"14","author":"Jeong","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.intimp.2014.07.004","article-title":"Interferon Gamma Induced by Resveratrol Analog, HS-1793, Reverses the Properties of Tumor Associated Macrophages","volume":"22","author":"Jeong","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/1440-1681.13760","article-title":"Immunoregulation by Resveratrol; Implications for Normal Tissue Protection and Tumour Suppression","volume":"50","author":"Lalani","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"874","DOI":"10.4014\/jmb.1801.01074","article-title":"Improved Anti-Cancer Effect of Curcumin on Breast Cancer Cells by Increasing the Activity of Natural Killer Cells","volume":"28","author":"Lee","year":"2018","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000510315","article-title":"In Vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation","volume":"13","author":"Lee","year":"2021","journal-title":"J. Innate Immun."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lee, Y.-J., and Kim, J. (2020). Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249575"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.4049\/jimmunol.1300606","article-title":"Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells","volume":"191","author":"Bodogai","year":"2013","journal-title":"J. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10928","DOI":"10.1021\/jf502950u","article-title":"Concentration-Dependent Biphasic Effects of Resveratrol on Human Natural Killer Cells in Vitro","volume":"62","author":"Li","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.archoralbio.2018.04.015","article-title":"Curcumin Enhances Anti-Tumor Immune Response in Tongue Squamous Cell Carcinoma","volume":"92","author":"Liao","year":"2018","journal-title":"Arch. Oral. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.intimp.2016.07.035","article-title":"Inhibition of Curcumin on Myeloid-Derived Suppressor Cells Is Requisite for Controlling Lung Cancer","volume":"39","author":"Liu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jcp.22043","article-title":"Resveratrol Enhances Perforin Expression and NK Cell Cytotoxicity through NKG2D-Dependent Pathways","volume":"223","author":"Lu","year":"2010","journal-title":"J. Cell Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/mt.2015.165","article-title":"Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model","volume":"24","author":"Lu","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.intimp.2011.04.002","article-title":"Low-Dose Curcumin Leads to the Inhibition of Tumor Growth via Enhancing CTL-Mediated Antitumor Immunity","volume":"11","author":"Luo","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"42588","DOI":"10.3389\/fonc.2013.00137","article-title":"Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response","volume":"3","author":"Milano","year":"2013","journal-title":"Front. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13046-018-0792-5","article-title":"Phytosomal Curcumin Causes Natural Killer Cell-Dependent Repolarization of Glioblastoma (GBM) Tumor-Associated Microglia\/Macrophages and Elimination of GBM and GBM Stem Cells","volume":"37","author":"Mukherjee","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1002\/ijc.30398","article-title":"Curcumin Changes the Polarity of Tumor-Associated Microglia and Eliminates Glioblastoma","volume":"139","author":"Mukherjee","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Mukherjee, S., Baidoo, J.N.E., Sampat, S., Mancuso, A., David, L., Cohen, L.S., Zhou, S., and Banerjee, P. (2018). Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia\/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells. Molecules, 23.","DOI":"10.3390\/molecules23010201"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbrc.2017.11.039","article-title":"Direct Regulation of IL-2 by Curcumin","volume":"495","author":"Oh","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1080\/10408398.2018.1537237","article-title":"The Immunomodulatory Potential of Natural Compounds in Tumor-Bearing Mice and Humans","volume":"59","author":"Pan","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"675923","DOI":"10.3389\/fonc.2021.675923","article-title":"Curcumin as an Adjuvant to Cancer Immunotherapy","volume":"11","author":"Paul","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_65","first-page":"14","article-title":"Resveratrol Diminishes Platelet Aggregation and Increases Susceptibility of K562 Tumor Cells to Natural Killer Cells","volume":"50","author":"Toliopoulos","year":"2013","journal-title":"Indian. J. Biochem. Biophys."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"eaay7785","DOI":"10.1126\/sciadv.aay7785","article-title":"Dual pH-Sensitive Nanodrug Blocks PD-1 Immune Checkpoint and Uses T Cells to Deliver NF-\u03baB Inhibitor for Antitumor Immunotherapy","volume":"6","author":"Xiao","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_67","first-page":"1866","article-title":"Curcumin up Regulates T Helper 1 Cells in Patients with Colon Cancer","volume":"9","author":"Xu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13046-018-0929-6","article-title":"Apigenin Suppresses PD-L1 Expression in Melanoma and Host Dendritic Cells to Elicit Synergistic Therapeutic Effects","volume":"37","author":"Xu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.bbamcr.2007.04.015","article-title":"Curcumin Reverses Breast Tumor Exosomes Mediated Immune Suppression of NK Cell Tumor Cytotoxicity","volume":"1773","author":"Zhang","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.intimp.2012.06.016","article-title":"Curcumin Inhibits Suppressive Capacity of Naturally Occurring CD4+CD25+ Regulatory T Cells in Mice in Vitro","volume":"14","author":"Zhao","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/jcb.26302","article-title":"Curcumin Converts Foxp3+ Regulatory T Cells to T Helper 1 Cells in Patients with Lung Cancer","volume":"119","author":"Zou","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Shatrova, A.N., Mityushova, E.V., Vassilieva, I.O., Aksenov, N.D., Zenin, V.V., Nikolsky, N.N., and Marakhova, I.I. (2016). Time-Dependent Regulation of IL-2R \u03b1-Chain (CD25) Expression by TCR Signal Strength and IL-2-Induced STAT5 Signaling in Activated Human Blood T Lymphocytes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167215"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-020-01234-1","article-title":"Regulatory T Cells in Tumor Microenvironment: New Mechanisms, Potential Therapeutic Strategies and Future Prospects","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41568-022-00491-0","article-title":"Natural Killer Cells in Antitumour Adoptive Cell Immunotherapy","volume":"22","author":"Laskowski","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/labinvest.2016.116","article-title":"CD68\/Macrosialin: Not Just a Histochemical Marker","volume":"97","author":"Chistiakov","year":"2017","journal-title":"Lab. Invest."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/1871520621666210315092503","article-title":"Anti-Proliferative and Anti-Telomerase Effects of Blackberry Juice and Berry-Derived Polyphenols on HepG2 Liver Cancer Cells and Normal Human Blood Mononuclear Cells","volume":"22","author":"Moghadam","year":"2022","journal-title":"Anticancer. Agents Med. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbi.2016.07.021","article-title":"Redox Maintenance and Concerted Modulation of Gene Expression and Signaling Pathways by a Nanoformulation of Curcumin Protects Peripheral Blood Mononuclear Cells against Gamma Radiation","volume":"257","author":"Soltani","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.3892\/mmr.2016.5674","article-title":"Curcumin Inhibits Osteoclastogenic Potential in PBMCs from Rheumatoid Arthritis Patients via the Suppression of MAPK\/RANK\/c-Fos\/NFATc1 Signaling Pathways","volume":"14","author":"Shang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12013-014-9903-x","article-title":"Targeting IL-10 in Auto-Immune Diseases","volume":"70","author":"Tian","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1158\/2326-6066.CIR-13-0214","article-title":"IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity","volume":"2","author":"Oft","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10408398.2017.1358139","article-title":"Immune Modulation by Curcumin: The Role of Interleukin-10","volume":"59","author":"Mollazadeh","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"708955","DOI":"10.3389\/fimmu.2021.708955","article-title":"IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule","volume":"12","author":"Jaramillo","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"15512","DOI":"10.3390\/ijms150915512","article-title":"Resveratrol Induces the Expression of Interleukin-10 and Brain-Derived Neurotrophic Factor in BV2 Microglia under Hypoxia","volume":"15","author":"Song","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.intimp.2014.12.035","article-title":"IL-10 Plays a Pivotal Role in Anti-Inflammatory Effects of Resveratrol in Activated Microglia Cells","volume":"24","author":"Cianciulli","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_85","first-page":"226","article-title":"Effects of Resveratrol on Lymphocyte Proliferation and Cytokine Release","volume":"33","author":"Boscolo","year":"2003","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.bcp.2003.08.008","article-title":"Immunomodulatory Activity of Resveratrol: Discrepant in Vitro and in Vivo Immunological Effects","volume":"66","author":"Gao","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0006-2952(01)00775-4","article-title":"Immunomodulatory Activity of Resveratrol: Suppression of Lymphocyte Proliferation, Development of Cell-Mediated Cytotoxicity, and Cytokine Production","volume":"62","author":"Gao","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1111\/1750-3841.15821","article-title":"Curcuma Longa Enhances IFN-\u03b3 Secretion by Natural Killer Cells through Cytokines Secreted from Macrophages","volume":"86","author":"Seo","year":"2021","journal-title":"J. Food Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1158\/1535-7163.MCT-09-0377","article-title":"Curcumin Induces Proapoptotic Effects against Human Melanoma Cells and Modulates the Cellular Response to Immunotherapeutic Cytokines","volume":"8","author":"Bill","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"100870","DOI":"10.1016\/j.mam.2020.100870","article-title":"NK Cells and ILCs in Tumor Immunotherapy","volume":"80","author":"Sivori","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-019-0052-1","article-title":"NK Cells for Cancer Immunotherapy","volume":"19","author":"Shimasaki","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1098445","DOI":"10.3389\/fimmu.2022.1098445","article-title":"Natural Killer Cells Suppress Cancer Metastasis by Eliminating Circulating Cancer Cells","volume":"13","author":"Vyas","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1197053","DOI":"10.3389\/fimmu.2023.1197053","article-title":"DNAM-1 Chimeric Receptor-Engineered NK Cells: A New Frontier for CAR-NK Cell-Based Immunotherapy","volume":"14","author":"Cifaldi","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1194\/jlr.M015412","article-title":"Deletion of the Murine Scavenger Receptor CD68","volume":"52","author":"Song","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1021\/acsomega.2c07326","article-title":"Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?","volume":"8","author":"Hegde","year":"2023","journal-title":"ACS Omega"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.biopha.2018.11.075","article-title":"Resveratrol: From Enhanced Biosynthesis and Bioavailability to Multitargeting Chronic Diseases","volume":"109","author":"Pannu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Rudrapal, M., Mishra, A.K., Rani, L., Sarwa, K.K., Zothantluanga, J.H., Khan, J., Kamal, M., Palai, S., Bendale, A.R., and Talele, S.G. (2022). Nanodelivery of Dietary Polyphenols for Therapeutic Applications. Molecules, 27.","DOI":"10.3390\/molecules27248706"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Chimento, A., D\u2019Amico, M., De Luca, A., Conforti, F.L., Pezzi, V., and De Amicis, F. (2023). Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties. Life, 13.","DOI":"10.3390\/life13020261"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Lee, J., Han, Y., Wang, W., Jo, H., Kim, H., Kim, S., Yang, K.-M., Kim, S.-J., Dhanasekaran, D.N., and Song, Y.S. (2021). Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy. Biomolecules, 11.","DOI":"10.3390\/biom11081107"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/JLB.3MR0320-444R","article-title":"Natural Products and Their Derivatives: Promising Modulators of Tumor Immunotherapy","volume":"108","author":"Deng","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_101","first-page":"3199","article-title":"Characterization of a Human Malignant Mesothelioma Cell Line (H-MESO-1): A Biphasic Solid and Ascitic Tumor Model","volume":"47","author":"Reale","year":"1987","journal-title":"Cancer Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0002-9440(10)61743-9","article-title":"Methionine Aminopeptidase-2 Regulates Human Mesothelioma Cell Survival: Role of Bcl-2 Expression and Telomerase Activity","volume":"159","author":"Catalano","year":"2001","journal-title":"Am. J. Pathol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/232\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:40:54Z","timestamp":1760132454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,23]]},"references-count":102,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25010232"],"URL":"https:\/\/doi.org\/10.3390\/ijms25010232","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,23]]}}}