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Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rheumatoid arthritis, lupus erythematodes, or liver fibrosis. Moreover, TAM receptors exhibit prominent cell-transforming properties, promoting tumor progression, metastasis, and therapy resistance in various cancer entities. Emerging evidence shows that TAM receptors are involved in bone homeostasis by regulating osteoblastic bone formation and osteoclastic bone resorption. Therefore, TAM receptors emerge as new key players of the regulatory cytokine network of osteoblasts and osteoclasts and represent accessible targets for pharmacologic therapy for a broad set of different bone diseases, including primary and metastatic bone tumors, rheumatoid arthritis, or osteoporosis.<\/jats:p>","DOI":"10.3390\/ijms25010233","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T20:44:15Z","timestamp":1703450655000},"page":"233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of TAM Receptors in Bone"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9983-5058","authenticated-orcid":false,"given":"Janik","family":"Engelmann","sequence":"first","affiliation":[{"name":"Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"},{"name":"Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"},{"name":"DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany"},{"name":"Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), German Center for Lung Research (DZL), 69120 Heidelberg, Germany"},{"name":"Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-1872","authenticated-orcid":false,"given":"Deniz","family":"Ragipoglu","sequence":"additional","affiliation":[{"name":"DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany"},{"name":"Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), German Center for Lung Research (DZL), 69120 Heidelberg, Germany"},{"name":"Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ben-Batalla","sequence":"additional","affiliation":[{"name":"DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany"},{"name":"Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), German Center for Lung Research (DZL), 69120 Heidelberg, Germany"},{"name":"Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Loges","sequence":"additional","affiliation":[{"name":"DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany"},{"name":"Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), German Center for Lung Research (DZL), 69120 Heidelberg, Germany"},{"name":"Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nri2303","article-title":"Immunobiology of the TAM receptors","volume":"8","author":"Lemke","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lemke, G. (2013). Biology of the TAM Receptors. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a009076"},{"key":"ref_3","first-page":"4976","article-title":"The Protein Encoded by a Growth Arrest-Specific Gene (Gas6) Is a New Member of the Vitamin-K-Dependent Proteins Related to Protein-S, a Negative Coregulator in the Blood-Coagulation Cascade","volume":"13","author":"Manfioletti","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-immunol-032414-112103","article-title":"TAM receptor signaling in immune homeostasis","volume":"33","author":"Rothlin","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e03385","DOI":"10.7554\/eLife.03385","article-title":"Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities","volume":"3","author":"Lew","year":"2014","journal-title":"eLife"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"30022","DOI":"10.1074\/jbc.271.47.30022","article-title":"Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases","volume":"271","author":"Nagata","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"G899","DOI":"10.1152\/ajpgi.00382.2015","article-title":"TAM receptor tyrosine kinase function and the immunopathology of liver disease","volume":"310","author":"Mukherjee","year":"2016","journal-title":"Am. J. Physiol.-Gastrointest. Liver"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1084\/jem.20101157","article-title":"Find-me and eat-me signals in apoptotic cell clearance: Progress and conundrums","volume":"207","author":"Ravichandran","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cell.2007.10.034","article-title":"TAM receptors are pleiotropic inhibitors of the innate immune response","volume":"131","author":"Rothlin","year":"2007","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wium, M., Paccez, J.D., and Zerbini, L.F. (2018). The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An Overview. Cells, 7.","DOI":"10.3390\/cells7100166"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bellan, M., Pirisi, M., and Sainaghi, P.P. (2016). The Gas6\/TAM System and Multiple Sclerosis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111807"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nri957","article-title":"A blast from the past: Clearance of apoptotic cells regulates immune responses","volume":"2","author":"Savill","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35075603","article-title":"Phagocytosis and clearance of apoptotic cells is mediated by MER","volume":"411","author":"Scott","year":"2001","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12964-019-0461-0","article-title":"TAM receptors, Phosphatidylserine, inflammation, and Cancer","volume":"17","author":"Maimon","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fimmu.2018.00742","article-title":"Protective role of the Mer Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models","volume":"9","author":"Waterborg","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1186\/ar3316","article-title":"Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis","volume":"13","author":"Wu","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R212","DOI":"10.1186\/ar4407","article-title":"Circulating levels of soluble MER in lupus reflect M2c activation of monocytes\/macrophages, autoantibody specificities and disease activity","volume":"15","author":"Zizzo","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrc3847","article-title":"The TAM family: Phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer","volume":"14","author":"Graham","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2013-03-491431","article-title":"Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma","volume":"122","author":"Schultze","year":"2013","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"13091","DOI":"10.1073\/pnas.1302507110","article-title":"Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer","volume":"110","author":"Bosurgi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1038\/onc.2013.40","article-title":"Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia","volume":"32","author":"Eisenman","year":"2013","journal-title":"Oncogene"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1038\/onc.2012.355","article-title":"Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer","volume":"32","author":"Linger","year":"2013","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature10661","article-title":"A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells","volume":"481","author":"Png","year":"2012","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1038\/sj.onc.1210173","article-title":"A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors","volume":"26","author":"Mahadevan","year":"2007","journal-title":"Oncogene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1038\/s41467-022-33938-x","article-title":"Regulation of bone homeostasis by MERTK and TYRO3","volume":"13","author":"Engelmann","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_26","first-page":"1189","article-title":"MERTK is a target in the microenviroenment of osteolytic bone metastasis","volume":"83","author":"Engelmann","year":"2023","journal-title":"Am. Assoc. Cancer Res. Annu. Meet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/00220345231177996","article-title":"Inhibition of Mertk Signaling Enhances Bone Healing after Tooth Extraction","volume":"102","author":"Decker","year":"2023","journal-title":"J. Dent. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.2215\/CJN.04151206","article-title":"Normal Bone Anatomy and Physiology","volume":"3","author":"Clarke","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1182\/blood-2004-06-2480","article-title":"Blood and bone: Two tissues whose fates are intertwined to create the hematopoietic stem-cell niche","volume":"105","author":"Taichman","year":"2005","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/physiol.00061.2014","article-title":"Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement","volume":"31","author":"Siddiqui","year":"2016","journal-title":"Physiology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/ten.teb.2016.0454","article-title":"Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro","volume":"23","author":"Blair","year":"2017","journal-title":"Tissue Eng. Part. B-Rev."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Florencio-Silva, R., Sasso, G.R.D., Sasso-Cerri, E., Simoes, M.J., and Cerri, P.S. (2015). Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/421746"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jor.1100050217","article-title":"Osteoregulatory Nature of Mechanical Stimuli\u2014Function as a Determinant for Adaptive Remodeling in Bone","volume":"5","author":"Rubin","year":"1987","journal-title":"J. Orthop. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.4110\/in.2018.18.e8","article-title":"Regulation of Osteoclast Differentiation by Cytokine Networks","volume":"18","author":"Amarasekara","year":"2018","journal-title":"Immune Netw."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10585-021-10093-z","article-title":"Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling","volume":"38","author":"Tanaka","year":"2021","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood.2018880930","article-title":"A niche-dependent myeloid transcriptome signature defines dormant myeloma cells","volume":"134","author":"Khoo","year":"2019","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/stem.160229","article-title":"Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts","volume":"16","author":"Nakamura","year":"1998","journal-title":"Stem Cells"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/s10165-003-0257-2","article-title":"Osteoclastic bone resorption through receptor tyrosine kinase and extracellular signal-regulated kinase signaling in mature osteoclasts","volume":"14","author":"Kawaguchi","year":"2004","journal-title":"Mod. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"He, Y., Staser, K., Rhodes, S.D., Liu, Y., Wu, X., Park, S.J., Yuan, J., Yang, X., Li, X., and Jiang, L. (2011). Erk1 positively regulates osteoclast differentiation and bone resorptive activity. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024780"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Choi, E.B., Agidigbi, T.S., Kang, I.S., and Kim, C. (2022). ERK Inhibition Increases RANKL-Induced Osteoclast Differentiation in RAW 264.7 Cells by Stimulating AMPK Activation and RANK Expression and Inhibiting Anti-Osteoclastogenic Factor Expression. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113512"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/annrheumdis-2012-202907","article-title":"Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis","volume":"73","author":"Zhao","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/cei.13082","article-title":"Soluble TAM receptor tyrosine kinases in rheumatoid arthritis: Correlation with disease activity and bone destruction","volume":"192","author":"Xu","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13075-020-02308-7","article-title":"CD14(+)CD16(\u2212) monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK","volume":"22","author":"Xue","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41556-019-0437-8","article-title":"Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair","volume":"22","author":"Yahara","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"dev199908","DOI":"10.1242\/dev.199908","article-title":"The origins and roles of osteoclasts in bone development, homeostasis and repair","volume":"149","author":"Yahara","year":"2022","journal-title":"Development"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1073\/pnas.1218799110","article-title":"Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D","volume":"110","author":"Kikuta","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.4049\/jimmunol.0803627","article-title":"Role of CX3CL1\/fractalkine in osteoclast differentiation and bone resorption","volume":"183","author":"Koizumi","year":"2009","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1038\/emm.2017.100","article-title":"Stimulation of osteoclast migration and bone resorption by C-C chemokine ligands 19 and 21","volume":"49","author":"Lee","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1359\/jbmr.2003.18.8.1404","article-title":"Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration","volume":"18","author":"Yu","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1084\/jem.20101474","article-title":"Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo","volume":"207","author":"Ishii","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature07713","article-title":"Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis","volume":"458","author":"Ishii","year":"2009","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s10020-023-00638-1","article-title":"RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling","volume":"29","author":"Wang","year":"2023","journal-title":"Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1242\/jcs.02425","article-title":"A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclasts","volume":"118","author":"Destaing","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11993","DOI":"10.1074\/jbc.275.16.11993","article-title":"Rho-A is critical for osteoclast podosome organization, motility, and bone resorption","volume":"275","author":"Chellaiah","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"778078","DOI":"10.3389\/fimmu.2021.778078","article-title":"Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-019-1022-2","article-title":"Targeting Tyro3, Axl and MerTK (TAM receptors): Implications for macrophages in the tumor microenvironment","volume":"18","author":"Myers","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"17019","DOI":"10.1038\/boneres.2017.19","article-title":"RANKL-induced M1 macrophages are involved in bone formation","volume":"5","author":"Huang","year":"2017","journal-title":"Bone Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jbmr.3364","article-title":"Estrogen Deficiency-Mediated M2 Macrophage Osteoclastogenesis Contributes to M1\/M2 Ratio Alteration in Ovariectomized Osteoporotic Mice","volume":"33","author":"Dou","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/IAI.00461-16","article-title":"Proinflammatory M1 Macrophages Inhibit RANKL-Induced Osteoclastogenesis","volume":"84","author":"Yamaguchi","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1172\/JCI97354","article-title":"Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response","volume":"128","author":"Ubil","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e139576","DOI":"10.1172\/JCI139576","article-title":"Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction","volume":"131","author":"DeBerge","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/mi.2014.129","article-title":"The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung","volume":"8","author":"Fujimori","year":"2015","journal-title":"Mucosal Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Rigoni, T.S., Vellozo, N.S., Guimaraes-Pinto, K., Cabral-Piccin, M., Fabiano-Coelho, L., Matos-Silva, T.C., Filardy, A.A., Takiya, C.M., and Lopes, M.F. (2022). Axl receptor induces efferocytosis, dampens M1 macrophage responses and promotes heart pathology in Trypanosoma cruzi infection. Commun. Biol., 5.","DOI":"10.1038\/s42003-022-04401-w"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.oraloncology.2015.04.004","article-title":"Polarization of tumor-associated macrophages and Gas6\/Axl signaling in oral squamous cell carcinoma","volume":"51","author":"Chiu","year":"2015","journal-title":"Oral. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2024941","DOI":"10.1080\/2162402X.2021.2024941","article-title":"MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression","volume":"11","author":"Lin","year":"2022","journal-title":"Oncoimmunology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/stmcls\/sxad069","article-title":"Mesenchymal stem cells promote polarization of M2 macrophages in mice with acute-on-chronic liver failure via Mertk\/JAK1\/STAT6 signaling","volume":"41","author":"Li","year":"2023","journal-title":"Stem Cells"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.4049\/jimmunol.1200662","article-title":"Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction","volume":"189","author":"Zizzo","year":"2012","journal-title":"J. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1007\/s10753-018-0864-x","article-title":"Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: The Dual Role of CD14 at the Crossroads Between M1 and M2c Polarization","volume":"41","author":"Zizzo","year":"2018","journal-title":"Inflammation"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.2741\/2296","article-title":"Signaling and transcriptional regulation in osteoblast commitment and differentiation","volume":"12","author":"Huang","year":"2007","journal-title":"Front. Biosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.RES.0000074881.56564.46","article-title":"Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes","volume":"92","author":"Collett","year":"2003","journal-title":"Circ. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/0271678X15610340","article-title":"What is a pericyte?","volume":"36","author":"Attwell","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/01.RES.0000258854.03388.02","article-title":"Axl\/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells","volume":"100","author":"Collett","year":"2007","journal-title":"Circ. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","author":"Peng","year":"2003","journal-title":"Genes Dev."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kawamura, N., Kugimiya, F., Oshima, Y., Ohba, S., Ikeda, T., Saito, T., Shinoda, Y., Kawasaki, Y., Ogata, N., and Hoshi, K. (2007). Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0001058"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1073\/pnas.0604153104","article-title":"Lifelong accumulation of bone in mice lacking Pten in osteoblasts","volume":"104","author":"Liu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00018-016-2425-5","article-title":"Wnt signaling and cellular metabolism in osteoblasts","volume":"74","author":"Karner","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13619-020-00071-3","article-title":"RhoA\/Rock activation represents a new mechanism for inactivating Wnt\/beta-catenin signaling in the aging-associated bone loss","volume":"10","author":"Shi","year":"2021","journal-title":"Cell Regen."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"Shinohara","year":"2011","journal-title":"Nat. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab Treatment in Postmenopausal Women with Osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Russow, G., Jahn, D., Appelt, J., Mardian, S., Tsitsilonis, S., and Keller, J. (2018). Anabolic Therapies in Osteoporosis and Bone Regeneration. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010083"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"16069","DOI":"10.1038\/nrdp.2016.69","article-title":"Postmenopausal osteoporosis","volume":"2","author":"Eastell","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_84","first-page":"1017","article-title":"Osteoporosis: Pathophysiology and therapeutic options","volume":"19","author":"Dovjak","year":"2020","journal-title":"EXCLI J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1074\/jbc.M109.062430","article-title":"Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex","volume":"285","author":"Suzuki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/jth.12331","article-title":"Micro-ribonucleic Acid 494 regulation of protein S expression","volume":"11","author":"Tay","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1182\/blood.V68.4.881.881","article-title":"Functional and immunologic protein S levels are decreased during pregnancy","volume":"68","author":"Comp","year":"1986","journal-title":"Blood"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2141.1988.tb04232.x","article-title":"Changes in the plasma levels of vitamin K-dependent proteins C and S and of C4b-binding protein during pregnancy and oral contraception","volume":"68","author":"Malm","year":"1988","journal-title":"Br. J. Haematol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0037-1613960","article-title":"A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways","volume":"84","author":"Tans","year":"2000","journal-title":"Thromb. Haemost."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbrc.2006.12.018","article-title":"GAS6 is an estrogen-inducible gene in mammary epithelial cells","volume":"353","author":"Mo","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1074\/jbc.M109.055087","article-title":"Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification","volume":"285","author":"Son","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4103\/1008-682X.172825","article-title":"Serum sex hormone and growth arrest-specific protein 6 levels in male patients with coronary heart disease","volume":"18","author":"Zhao","year":"2016","journal-title":"Asian J. Androl."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2014.12.001","article-title":"Gender differences in plasma growth arrest-specific protein 6 levels in adult subjects","volume":"441","author":"Hung","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/jbmr.4904","article-title":"Genetic Correlation, Shared Loci, and Causal Association Between Sex Hormone-Binding Globulin and Bone Mineral Density: Insights From a Large-Scale Genomewide Cross-Trait Analysis","volume":"38","author":"Qu","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: Mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3389\/fimmu.2019.00713","article-title":"Immune Modulation to Enhance Bone Healing -A New Concept to Induce Bone Using Prostacyclin to Locally Modulate Immunity","volume":"10","author":"Wendler","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/bs.ircmb.2020.09.001","article-title":"TAM receptors and their ligand-mediated activation: Role in atherosclerosis","volume":"357","author":"Cai","year":"2020","journal-title":"Int. Rev. Cel. Mol. Bio"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107893","DOI":"10.1016\/j.pharmthera.2021.107893","article-title":"Resolving inflammation by TAM receptor activation","volume":"227","author":"Vago","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1111\/jcmm.14183","article-title":"The Pros1\/Tyro3 axis protects against periodontitis by modulating STAT\/SOCS signalling","volume":"23","author":"Jiang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"E337","DOI":"10.1073\/pnas.1614926114","article-title":"GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa","volume":"114","author":"Nassar","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"Silman","year":"2002","journal-title":"Arthritis Res. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4065\/75.1.69","article-title":"Current treatment strategies for rheumatoid arthritis","volume":"75","author":"Matteson","year":"2000","journal-title":"Mayo Clin. Proc."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jconrel.2020.09.016","article-title":"Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy","volume":"327","author":"Qindeel","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/ar2110","article-title":"Cells of the synovium in rheumatoid arthritis\u2014Osteoclasts","volume":"9","author":"Schett","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"ref_108","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"Gravallese","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P","article-title":"Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor","volume":"43","author":"Gravallese","year":"2000","journal-title":"Arthritis Rheum."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Yokota, K. (2023). Osteoclast differentiation in rheumatoid arthritis. Immunol. Med., 1\u20136.","DOI":"10.1080\/25785826.2023.2220931"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1006\/bbrc.2000.4223","article-title":"Regulation of osteoprotegerin secretion from primary cultures of human bone marrow stromal cells","volume":"280","author":"Brandstrom","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1006\/bbrc.2000.3379","article-title":"Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappa B ligand: Modulation of the expression by osteotropic factors and cytokines","volume":"275","author":"Nakashima","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.61.10.916","article-title":"Synovial macrophage-osteoclast differentiation in inflammatory arthritis","volume":"61","author":"Danks","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0002-9440(10)65369-2","article-title":"Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis\u2014Evidence for a novel endothelial cell survival pathway","volume":"154","author":"Harkes","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Vago, J.P., Valdrighi, N., Blaney-Davidson, E.N., Hornikx, D., Neefjes, M., Barba-Sarasua, M.E., Thielen, N.G.M., van den Bosch, M.H.J., van der Kraan, P.M., and Koenders, M.I. (2023). Gas6\/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050703"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12964-023-01133-0","article-title":"Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis","volume":"21","author":"Gao","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s40744-016-0046-y","article-title":"Review of Osteosarcoma and Current Management","volume":"3","author":"Durfee","year":"2016","journal-title":"Rheumatol. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/039463201302600117","article-title":"Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis","volume":"26","author":"Zhang","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbrc.2013.05.019","article-title":"Gas6\/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients","volume":"435","author":"Han","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"100419","DOI":"10.1016\/j.jbo.2022.100419","article-title":"Targeting the IGF\/PI3K\/mTOR pathway and AXL\/YAP1\/TAZ pathways in primary bone cancer","volume":"33","author":"Truong","year":"2022","journal-title":"J. Bone Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/s41417-020-00281-6","article-title":"Transcriptional activators YAP\/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma","volume":"28","author":"Mohiuddin","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/ajh.26590","article-title":"Multiple myeloma: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Rajkumar","year":"2022","journal-title":"Am. J. Hematol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41408-017-0037-4","article-title":"Pathogenesis of bone disease in multiple myeloma: From bench to bedside","volume":"8","author":"Terpos","year":"2018","journal-title":"Blood Cancer J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/leu.2014.236","article-title":"Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma","volume":"29","author":"Waizenegger","year":"2015","journal-title":"Leukemia"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1074\/jbc.M116.733030","article-title":"Autocrine and Paracrine Interactions between Multiple Myeloma Cells and Bone Marrow Stromal Cells by Growth Arrest-specific Gene 6 Cross-talk with Interleukin-6","volume":"292","author":"Furukawa","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"942640","DOI":"10.3389\/fimmu.2022.942640","article-title":"GAS6\/TAM signaling pathway controls MICA expression in multiple myeloma cells","volume":"13","author":"Kosta","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13045-022-01366-5","article-title":"CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression","volume":"15","author":"Beider","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41392-020-0134-x","article-title":"Molecular principles of metastasis: A hallmark of cancer revisited","volume":"5","author":"Fares","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrc1886","article-title":"Metastasis: A question of life or death","volume":"6","author":"Mehlen","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"6","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/sj.cr.7290266","article-title":"Mechanisms of cancer metastasis to the bone","volume":"15","author":"Yin","year":"2005","journal-title":"Cell Res."},{"key":"ref_132","first-page":"321","article-title":"Bone Metastases: An Overview","volume":"11","author":"Macedo","year":"2017","journal-title":"Oncol. Rev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"E172","DOI":"10.1073\/pnas.1521674112","article-title":"Functional screen identifies kinases driving prostate cancer visceral and bone metastasis","volume":"113","author":"Faltermeier","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"884024","DOI":"10.3389\/fimmu.2022.884024","article-title":"Bone Marrow Niches and Tumour Cells: Lights and Shadows of a Mutual Relationship","volume":"13","author":"Granata","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/s41416-021-01329-6","article-title":"Bone marrow niches in the regulation of bone metastasis","volume":"124","author":"Chen","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41413-020-00105-1","article-title":"Molecular mechanisms and clinical management of cancer bone metastasis","volume":"8","author":"Wang","year":"2020","journal-title":"Bone Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1600-0463.2008.01033.x","article-title":"Cancer micrometastasis and tumour dormancy","volume":"116","author":"Wikman","year":"2008","journal-title":"APMIS"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1158\/0008-5472.CAN-17-1051","article-title":"Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFbetaRIII-p38MAPK-pS249\/T252RB Pathway","volume":"78","author":"Yu","year":"2018","journal-title":"Cancer Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s11914-018-0471-7","article-title":"Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy","volume":"16","author":"Widner","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1038\/ncomms9983","article-title":"Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche","volume":"6","author":"Lawson","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1596\/neo.111740","article-title":"Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment","volume":"14","author":"Jung","year":"2012","journal-title":"Neoplasia"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1593\/neo.91384","article-title":"GAS6\/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche","volume":"12","author":"Shiozawa","year":"2010","journal-title":"Neoplasia"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Taichman, R.S., Patel, L.R., Bedenis, R., Wang, J., Weidner, S., Schumann, T., Yumoto, K., Berry, J.E., Shiozawa, Y., and Pienta, K.J. (2013). GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061873"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"12260","DOI":"10.1073\/pnas.97.22.12260","article-title":"Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6)","volume":"97","author":"Dormady","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"36520","DOI":"10.1038\/srep36520","article-title":"Axl is required for TGF-beta2-induced dormancy of prostate cancer cells in the bone marrow","volume":"6","author":"Yumoto","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/ncb2861","article-title":"TGF-beta2 dictates disseminated tumour cell fate in target organs through TGF-beta-RIII and p38alpha\/beta signalling","volume":"15","author":"Bragado","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1038\/ncomms7170","article-title":"NR2F1 controls tumour cell dormancy via SOX9- and RARbeta-driven quiescence programmes","volume":"6","author":"Sosa","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/jcb.25768","article-title":"Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy","volume":"118","author":"Cackowski","year":"2017","journal-title":"J. Cell. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:40:55Z","timestamp":1760132455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,23]]},"references-count":148,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25010233"],"URL":"https:\/\/doi.org\/10.3390\/ijms25010233","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,23]]}}}