{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:28:38Z","timestamp":1784140118760,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science","award":["Higher Education of the Republic of Poland"],"award-info":[{"award-number":["Higher Education of the Republic of Poland"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nanocomposites are an emerging technology for ensuring food safety and quality. Their unique properties, attributed to nanoparticle presence, facilitate the development of sophisticated sensors and biosensors for detecting harmful substances, microbial growth, and environmental changes in food products. Smart and\/or active food packaging development also benefits from the use of nanocomposites. This packaging, or portions of it, provide active protection for its contents and serve as sensors to promptly, simply, and safely identify any detrimental changes in stored food, without elaborate techniques or analyses. Films made from potato starch and chitosan were produced and quantum dots of zinc sulfide (ZnS) and cadmium sulfide (CdS)were synthesized in them for this study. The presence and dimensions of the QDs (quantum dots) were examined with scanning electron microscopy (SEM) and ultraviolet-visible (UV-VIS) spectroscopy. The study aimed to establish the toxicity profile of a starch\u2013chitosan bionanocomposite integrated with ZnS and CdS quantum dots. Cytotoxic and genotoxic features were assessed through cytogenetic instability assessments, consisting of the alkaline comet assay, erythrocyte micronucleus assay, and peripheral blood cell viability analysis of a laboratory mouse model.<\/jats:p>","DOI":"10.3390\/ijms25010361","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T02:58:12Z","timestamp":1703645892000},"page":"361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The In Vitro Toxicity Profile of ZnS and CdS Quantum Dots in Polysaccharide Carriers (Starch\/Chitosan)"],"prefix":"10.3390","volume":"25","author":[{"given":"Anna","family":"Grzesiakowska","sequence":"first","affiliation":[{"name":"Faculty of Animal Science, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Dzi\u00f3bek","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Horticulture, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-1543","authenticated-orcid":false,"given":"Marta","family":"Kuchta-G\u0142adysz","sequence":"additional","affiliation":[{"name":"Faculty of Animal Science, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-8944","authenticated-orcid":false,"given":"Joanna","family":"Wojciechowska-Pucha\u0142ka","sequence":"additional","affiliation":[{"name":"Faculty of Animal Science, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-5406","authenticated-orcid":false,"given":"Karen","family":"Khachatryan","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-7145","authenticated-orcid":false,"given":"Gohar","family":"Khachatryan","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-0939","authenticated-orcid":false,"given":"Magdalena","family":"Krystyjan","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rizeq, B.R., Younes, N.N., Rasool, K., and Nasrallah, G.K. (2019). Synthesis, bioapplications, and toxicity evaluation of chitosan-based nanoparticles. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225776"},{"key":"ref_2","first-page":"3351","article-title":"Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model","volume":"6","author":"Hu","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Le, N., Zhang, M., and Kim, K. (2022). Quantum dots and their interaction with biological systems. Int. J. Mol. 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