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While current therapeutic approaches primarily target symptom relief, their efficacy in repairing joint damage remains limited. Recent research has highlighted mesenchymal stem cells (MSCs) as potential contributors to cartilage repair, anti-inflammatory modulation, and immune regulation in OA patients. Notably, MSCs from different sources and their derivatives exhibit variations in their effectiveness in treating OA. Moreover, pretreatment and gene editing techniques of MSCs can enhance their therapeutic outcomes in OA. Additionally, the combination of novel biomaterials with MSCs has shown promise in facilitating the repair of damaged cartilage. This review summarizes recent studies on the role of MSCs in the treatment of OA, delving into their advantages and exploring potential directions for development, with the aim of providing fresh insights for future research in this critical field.<\/jats:p>","DOI":"10.3390\/ijms25010394","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T03:30:34Z","timestamp":1703734234000},"page":"394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Advances in Stem Cell-Based Therapies in the Treatment of Osteoarthritis"],"prefix":"10.3390","volume":"25","author":[{"given":"Ye","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Juan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.joca.2019.04.006","article-title":"Risk factors for falls in patients with total hip arthroplasty and total knee arthroplasty: A systematic review and meta-analysis","volume":"27","author":"Lo","year":"2019","journal-title":"Osteoarthr. 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