{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:14:03Z","timestamp":1790741643842,"version":"4.1.0"},"reference-count":133,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Australian National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["2002472"],"award-info":[{"award-number":["2002472"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington\u2019s disease (HD), Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and Machado\u2013Joseph disease (MJD), demands urgent disease-modifying therapeutics. Owing to the evolutionarily conserved molecular signalling pathways with mammalian species and facile genetic manipulation, the nematode Caenorhabditis elegans (C. elegans) emerges as a powerful and manipulative model system for mechanistic insights into neurodegenerative diseases. Herein, we review several representative C. elegans models established for five common neurodegenerative diseases, which closely simulate disease phenotypes specifically in the gain-of-function aspect. We exemplify applications of high-throughput genetic and drug screenings to illustrate the potential of C. elegans to probe novel therapeutic targets. This review highlights the utility of C. elegans as a comprehensive and versatile platform for the dissection of neurodegenerative diseases at the molecular level.<\/jats:p>","DOI":"10.3390\/ijms25010443","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T11:44:57Z","timestamp":1703763897000},"page":"443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans"],"prefix":"10.3390","volume":"25","author":[{"given":"Yingjie","family":"Wu","sequence":"first","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Chen","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Yu","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The Genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tma.2020.05.001","article-title":"Caenorhabditis elegans as a Model System for Studying Aging-Associated Neurodegenerative Diseases","volume":"4","author":"Truttmann","year":"2020","journal-title":"Transl. Med. Aging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41586-019-1352-7","article-title":"Whole-Animal Connectomes of Both Caenorhabditis elegans Sexes","volume":"571","author":"Cook","year":"2019","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/biot.201000183","article-title":"Modeling Human Diseases in Caenorhabditis elegans","volume":"5","author":"Markaki","year":"2010","journal-title":"Biotechnol. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/cge.12117","article-title":"Clinical and Genetic Heterogeneity of Amyotrophic Lateral Sclerosis","volume":"83","author":"Sabatelli","year":"2013","journal-title":"Clin. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/17482960802295192","article-title":"High Metabolic Level in Patients with Familial Amyotrophic Lateral Sclerosis","volume":"10","author":"Funalot","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"dmm046110","DOI":"10.1242\/dmm.046110","article-title":"Modeling Neurodegeneration in Caenorhabditiselegans","volume":"13","author":"Caldwell","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn Superoxide Dismutase Gene Are Associated with Familial Amyotrophic Lateral Sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Banci, L., Bertini, I., Boca, M., Girotto, S., Martinelli, M., Valentine, J.S., and Vieru, M. (2008). SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001677"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.gene.2015.11.049","article-title":"Mutant SOD1 Mediated Pathogenesis of Amyotrophic Lateral Sclerosis","volume":"577","author":"Kaur","year":"2016","journal-title":"Gene"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/gtc.12125","article-title":"Dysregulation of the Proteasome Increases the Toxicity of ALS-Linked Mutant SOD1","volume":"19","author":"Kitamura","year":"2014","journal-title":"Genes Cells"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Tokuda, E., and Furukawa, Y. (2016). Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050636"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/aps.2012.190","article-title":"Establishing a Novel C. elegans Model to Investigate the Role of Autophagy in Amyotrophic Lateral Sclerosis","volume":"34","author":"Li","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neurobiolaging.2013.09.003","article-title":"Human Superoxide Dismutase 1 Overexpression in Motor Neurons of Caenorhabditis elegans Causes Axon Guidance Defect and Neurodegeneration","volume":"35","author":"Li","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Boccitto, M., Lamitina, T., and Kalb, R.G. (2012). Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033494"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wang, J., Farr, G.W., Hall, D.H., Li, F., Furtak, K., Dreier, L., and Horwich, A.L. (2009). An Als-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000350"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/hmg\/10.19.2013","article-title":"Oxidative Stress Causes Abnormal Accumulation of Familial Amyotrophic Lateral Sclerosis-Related Mutant SOD1 in Transgenic Caenorhabditis elegans","volume":"10","author":"Oeda","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yang, X., Ji, Y., Wang, W., Zhang, L., Chen, Z., Yu, M., Shen, Y., Ding, F., Gu, X., and Sun, H. (2021). Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies. Antioxidants, 10.","DOI":"10.3390\/antiox10071012"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fnmol.2017.00119","article-title":"Protein Quality Control and the Amyotrophic Lateral Sclerosis\/Frontotemporal Dementia Continuum","volume":"10","author":"Shahheydari","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Silva, M.C., Fox, S., Beam, M., Thakkar, H., Amaral, M.D., and Morimoto, R.I. (2011). A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002438"},{"key":"ref_21","first-page":"233","article-title":"Torsina Rescues Er-Associated Stress and Locomotive Defects in C. elegans Models of ALS","volume":"7","author":"Thompson","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2022.01.030","article-title":"Activation of Autophagy Attenuates Motor Deficits and Extends Lifespan in a C. elegans Model of ALS","volume":"181","author":"Xu","year":"2022","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_23","unstructured":"(2023, December 22). Safety and Therapeutic Potential of the FDA-Approved Drug Metformin for C9orf72 ALS\/FTD. Identifier NCT04220021. U.S. National Library of Medicine, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04220021."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.03.006","article-title":"Rethinking Als: The Fus About Tdp-43","volume":"136","author":"Cleveland","year":"2009","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"Tdp-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00401-007-0261-2","article-title":"Co-Morbidity of Tdp-43 Proteinopathy in Lewy Body Related Diseases","volume":"114","author":"Uryu","year":"2007","journal-title":"Acta Neuropathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/brain\/awm065","article-title":"Tdp-43 Is Deposited in the Guam Parkinsonism-Dementia Complex Brains","volume":"130","author":"Hasegawa","year":"2007","journal-title":"Brain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/hmg\/ddr076","article-title":"Tdp-43 Neurotoxicity and Protein Aggregation Modulated by Heat Shock Factor and Insulin\/Igf-1 Signaling","volume":"20","author":"Zhang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16208","DOI":"10.1523\/JNEUROSCI.2911-10.2010","article-title":"Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of Tdp-43 Proteinopathy","volume":"30","author":"Liachko","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Vaccaro, A., Tauffenberger, A., Aggad, D., Rouleau, G., Drapeau, P., and Parker, J.A. (2012). Mutant Tdp-43 and Fus Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031321"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00401-016-1600-y","article-title":"The Phosphatase Calcineurin Regulates Pathological Tdp-43 Phosphorylation","volume":"132","author":"Liachko","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nbd.2018.06.013","article-title":"\u03b1-Methyl-\u03b1-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy","volume":"118","author":"Wong","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/emboj.2010.143","article-title":"ALS-Associated Fused in Sarcoma (FUS) Mutations Disrupt Transportin-Mediated Nuclear Import","volume":"29","author":"Dormann","year":"2010","journal-title":"EMBO J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/ddr417","article-title":"ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism","volume":"21","author":"Murakami","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tins.2011.05.002","article-title":"Tdp-43 and Fus: A Nuclear Affair","volume":"34","author":"Dormann","year":"2011","journal-title":"Trends Neurosci."},{"key":"ref_38","unstructured":"Labarre, A., Tossing, G., Maios, C., Doyle, J.J., and Parker, J.A. (2021). A Single Copy Transgenic Mutant Fus Strain Reproduces Age-Dependent ALS Phenotypes in C. elegans. MicroPubl. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"110195","DOI":"10.1016\/j.celrep.2021.110195","article-title":"Disrupted Autophagy and Neuronal Dysfunction in C. elegans Knockin Models of FUS Amyotrophic Lateral Sclerosis","volume":"38","author":"Baskoylu","year":"2022","journal-title":"Cell Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A Hexanucleotide Repeat Expansion in C9orf72 Is the Cause of Chromosome 9p21-Linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded Ggggcc Hexanucleotide Repeat in Noncoding Region of C9orf72 Causes Chromosome 9p-Linked FTD and ALS","volume":"72","author":"Mackenzie","year":"2011","journal-title":"Neuron"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00401-014-1253-7","article-title":"The C9ORF72 Expansion Mutation: Gene Structure, Phenotypic and Diagnostic Issues","volume":"127","author":"Woollacott","year":"2014","journal-title":"Acta Neuropathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1093\/hmg\/ddu068","article-title":"C9ORF72, Implicated in Amytrophic Lateral Sclerosis and Frontotemporal Dementia, Regulates Endosomal Trafficking","volume":"23","author":"Farg","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"661447","DOI":"10.3389\/fncel.2021.661447","article-title":"C9ORF72: What It Is, What It Does, and Why It Matters","volume":"15","author":"Smeyers","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fnmol.2016.00113","article-title":"Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes","volume":"9","author":"Wang","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1038\/s41467-021-26303-x","article-title":"A C. elegans Model of C9orf72-Associated ALS\/FTD Uncovers a Conserved Role for eIF2D in RAN Translation","volume":"12","author":"Sonobe","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jnc.15255","article-title":"Cellular and Physiological Functions of C9ORF72 and Implications for ALS\/FTD","volume":"157","author":"Pang","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.gde.2017.03.006","article-title":"New Developments in RAN Translation: Insights from Multiple Diseases","volume":"44","author":"Cleary","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1093\/hmg\/ddx372","article-title":"Nuclear Localized C9orf72-Associated Arginine-Containing Dipeptides Exhibit Age-Dependent Toxicity in C. elegans","volume":"26","author":"Rudich","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2104664118","DOI":"10.1073\/pnas.2104664118","article-title":"The Nuclear Ubiquitin Ligase Adaptor SPOP is a Conserved Regulator of C9orf72 Dipeptide Toxicity","volume":"118","author":"Snoznik","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-pathmechdis-012418-012857","article-title":"Polyglutamine Repeats in Neurodegenerative Diseases","volume":"14","author":"Lieberman","year":"2019","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington Disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/nature06909","article-title":"RNA Toxicity is a Component of Ataxin-3 Degeneration in Drosophila","volume":"453","author":"Li","year":"2008","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1093\/hmg\/ddg295","article-title":"Pathogenesis of Polyglutamine Disorders: Aggregation Revisited","volume":"12","author":"Michalik","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.neuron.2015.10.038","article-title":"RAN Translation in Huntington Disease","volume":"88","author":"Ayhan","year":"2015","journal-title":"Neuron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A Novel Gene Containing a Trinucleotide Repeat That Is Expanded and Unstable on Huntington\u2019s Disease Chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s Disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington\u2019s Disease: From Molecular Pathogenesis to Clinical Treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s Disease: A Clinical Review","volume":"25","author":"McColgan","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0092-8674(00)80514-0","article-title":"Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo","volume":"90","author":"Scherzinger","year":"1997","journal-title":"Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1073\/pnas.96.1.179","article-title":"Polyglutamine-Mediated Dysfunction and Apoptotic Death of a Caenorhabditis elegans Sensory Neuron","volume":"96","author":"Faber","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.231476398","article-title":"Expanded Polyglutamines in Caenorhabditis elegans Cause Axonal Abnormalities and Severe Dysfunction of PLM Mechanosensory Neurons without Cell Death","volume":"98","author":"Parker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1523\/JNEUROSCI.0990-06.2006","article-title":"Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model","volume":"26","author":"Brignull","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lee, A.L., Ung, H.M., Sands, L.P., and Kikis, E.A. (2017). A New Caenorhabditis elegans Model of Human Huntingtin 513 Aggregation and Toxicity in Body Wall Muscles. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173644"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The Threshold for Polyglutamine-Expansion Protein Aggregation and Cellular Toxicity Is Dynamic and Influenced by Aging in Caenorhabditis elegans","volume":"99","author":"Morley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddl017","article-title":"Suppression of Polyglutamine-Induced Toxicity in Cell and Animal Models of Huntington\u2019s Disease by Ubiquilin","volume":"15","author":"Wang","year":"2006","journal-title":"Hum Mol Genet Hum. Mol. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17131","DOI":"10.1073\/pnas.262544899","article-title":"Glutamine\/Proline-Rich Pqe-1 Proteins Protect Caenorhabditis elegans Neurons from Huntingtin Polyglutamine Neurotoxicity","volume":"99","author":"Faber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Lejeune, F.-X., Mesrob, L., Parmentier, F., Bicep, C., Vazquez-Manrique, R.P., Parker, J.A., Vert, J.-P., Tourette, C., and Neri, C. (2012). Large-scale Functional RNAi Screen in C. elegans Identifies Genes that Regulate the Dysfunction of Mutant Polyglutamine Neurons. BMC Genom., 13.","DOI":"10.1186\/1471-2164-13-91"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2010.07.020","article-title":"Identification of MOAG-4\/SERF as a Regulator of Age-Related Proteotoxicity","volume":"142","author":"Holmberg","year":"2010","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Rudich, P., Watkins, S., and Lamitina, T. (2020). Polyq-Independent Toxicity Associated with Novel Translational Products from Cag Repeat Expansions. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227464"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.410390411","article-title":"Spinocerebellar Ataxia 3 and Machado-Joseph Disease: Clinical, Molecular, and Neuropathological Features","volume":"39","author":"Durr","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/hmg\/4.6.1001","article-title":"Trinucleotide Expansion within the MJD1 Gene Presents Clinically as Spinocerebellar Ataxia and Occurs Most Frequently in German SCA patients","volume":"4","author":"Przuntek","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/archneur.57.4.540","article-title":"Frequency of SCA1, SCA2, SCA3\/MJD, SCA6, SCA7, and DRPLA CAG Trinucleotide Repeat Expansion in Patients with Hereditary Spinocerebellar Ataxia from Chinese Kindreds","volume":"57","author":"Tang","year":"2000","journal-title":"Arch. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng1194-221","article-title":"Cag Expansions in a Novel Gene for Machado-Joseph Disease at Chromosome 14q32.1","volume":"8","author":"Kawaguchi","year":"1994","journal-title":"Nat. Genet."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1001\/archneur.58.11.1821","article-title":"Improvement in the Molecular Diagnosis of Machado-Joseph Disease","volume":"58","author":"Maciel","year":"2001","journal-title":"Arch. Neurol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1750-1172-6-35","article-title":"Machado-Joseph Disease: From First Descriptions to New Perspectives","volume":"6","author":"Bettencourt","year":"2011","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pneurobio.2011.11.006","article-title":"Toward Understanding Machado-Joseph Disease","volume":"97","author":"Costa","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0896-6273(00)80943-5","article-title":"Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3","volume":"19","author":"Paulson","year":"1997","journal-title":"Neuron"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)81200-3","article-title":"Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila","volume":"93","author":"Warrick","year":"1998","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1471-4159.2006.03895.x","article-title":"Expanded Polyglutamines Impair Synaptic Transmission and Ubiquitin\u2013Proteasome System in Caenorhabditis elegans","volume":"98","author":"Khan","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1093\/hmg\/ddr203","article-title":"Neuron-Specific Proteotoxicity of Mutant ataxin-3 in C. elegans: Rescue by the DAF-16 and HSF-1 Pathways","volume":"20","author":"Ailion","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Christie, N.T.M., Lee, A.L., Fay, H.G., Gray, A.A., and Kikis, E.A. (2014). Novel Polyglutamine Model Uncouples Proteotoxicity from Aging. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096835"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"113544","DOI":"10.1016\/j.expneurol.2020.113544","article-title":"Overexpression of FKH-2\/FOXG1 is Neuroprotective in a C. elegans model of Machado-Joseph Disease","volume":"337","author":"Fardghassemi","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Pereira-Sousa, J., Ferreira-Lomba, B., Bellver-Sanchis, A., Vilasboas-Campos, D., Fernandes, J.H., Costa, M.D., Varney, M.A., Newman-Tancredi, A., Maciel, P., and Teixeira-Castro, A. (2021). Identification of the 5-HT1A Serotonin Receptor as a Novel Therapeutic Target in a C. elegans Model of Machado-Joseph Disease. Neurobiol. Dis., 152.","DOI":"10.1016\/j.nbd.2021.105278"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clinbiochem.2019.04.015","article-title":"Clinical Aspects of Alzheimer\u2019s Disease","volume":"72","author":"Zverova","year":"2019","journal-title":"Clin. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fnagi.2016.00250","article-title":"Impaired White Matter Connections of the Limbic System Networks Associated with Impaired Emotional Memory in Alzheimer\u2019s Disease","volume":"8","author":"Li","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e12203","DOI":"10.1002\/trc2.12203","article-title":"Understanding Alzheimer\u2019s Disease as a Disorder of Consciousness","volume":"7","author":"Huntley","year":"2021","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The Neuropathological Diagnosis of Alzheimer\u2019s Disease","volume":"14","author":"Dickson","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and A\u03b2 in Alzheimer\u2019s Disease: Accidental Encounters or Partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Jurc\u0103u, M.C., Andronie-Cioara, F.L., Jurc\u0103u, A., Marcu, F., \u0162i\u021b, D.M., Pa\u0219cal\u0103u, N., and Nistor-Cseppent\u00f6, D.C. (2022). The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer\u2019s Disease: Therapeutic Implications and Future Perspectives. Antioxidants, 11.","DOI":"10.3390\/antiox11112167"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnagi.2018.00004","article-title":"Autophagy and Alzheimer\u2019s Disease: From Molecular Mechanisms to Therapeutic Implications","volume":"10","author":"Uddin","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"22697","DOI":"10.1074\/jbc.C109.028514","article-title":"The Caenorhabditis elegans A\u03b21\u201342 Model of Alzheimer Disease Predominantly Expresses A \u03b23\u201342","volume":"284","author":"McColl","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Sinnige, T., Ciryam, P., Casford, S., Dobson, C.M., de Bono, M., and Vendruscolo, M. (2019). Expression of the Amyloid-\u03b2 Peptide in a Single Pair of C. elegans Sensory Neurons Modulates the Associated Behavioural Response. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217746"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1750-1326-7-57","article-title":"Utility of an Improved Model of Amyloid-Beta (A\u03b21-42) Toxicity in Caenorhabditis elegans for Drug Screening for Alzheimer\u2019s Disease","volume":"7","author":"McColl","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jtcme.2022.10.006","article-title":"Holothuria Scabra Extracts Confer Neuroprotective Effect in C. elegans Model of Alzheimer\u2019s Disease by Attenuating Amyloid-\u03b2 Aggregation and Toxicity","volume":"13","author":"Kleawyothatis","year":"2023","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Alvarez, J., Alvarez-Illera, P., Santo-Domingo, J., Fonteriz, R.I., and Montero, M. (2022). Modeling Alzheimer\u2019s Disease in Caenorhabditis elegans. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020288"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Gallrein, C., Iburg, M., Michelberger, T., Ko\u00e7ak, A., Puchkov, D., Liu, F., Mariscal, S.M.A., Nayak, T., Schierle, G.S.K., and Kirstein, J. (2021). Novel Amyloid-Beta Pathology C. elegans Model Reveals Distinct Neurons as Seeds of Pathogenicity. Prog. Neurobiol., 198.","DOI":"10.1016\/j.pneurobio.2020.101907"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature13163","article-title":"REST and Stress Resistance in Ageing and Alzheimer\u2019s Disease","volume":"507","author":"Lu","year":"2014","journal-title":"Nature"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e83465","DOI":"10.7554\/eLife.83465","article-title":"Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans","volume":"12","author":"Jongsma","year":"2023","journal-title":"eLife"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2018.06.011","article-title":"Mitoferrin-1 is Involved in the Progression of Alzheimer\u2019s Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer\u2019s Disease","volume":"385","author":"Huang","year":"2018","journal-title":"Neuroscience"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Long, T., Chen, X., Zhang, Y., Zhou, Y.-J., He, Y.-N., Zhu, Y.-F., Fu, H.-J., Yu, L., Yu, C.-L., and Law, B.Y.-K. (2023). Protective Effects of Radix Stellariae Extract against Alzheimer\u2019s Disease via Autophagy Activation in Caenorhabditis elegans and Cellular Models. Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115261"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Azab, A. (2022). D-Pinitol-Active Natural Product from Carob with Notable Insulin Regulation. Nutrients, 14.","DOI":"10.3390\/nu14071453"},{"key":"ref_104","first-page":"2079","article-title":"Ptl-1 Regulates Neuronal Integrity and Lifespan in C. elegans","volume":"126","author":"Chew","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1073\/pnas.1533448100","article-title":"Neurodegeneration and Defective Neurotransmission in a Caenorhabditis elegans Model of Tauopathy","volume":"100","author":"Kraemer","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Natale, C., Barzago, M.M., and Diomede, L. (2020). Caenorhabditis elegans Models to Investigate the Mechanisms Underlying Tau Toxicity in Tauopathies. Brain Sci., 10.","DOI":"10.3390\/brainsci10110838"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/hmg\/ddl067","article-title":"Molecular Pathways that Influence Human Tau-Induced Pathology in Caenorhabditis elegans","volume":"15","author":"Kraemer","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1093\/hmg\/dds190","article-title":"Inhibition of Tau Aggregation in a Novel Caenorhabditis elegans Model of Tauopathy Mitigates Proteotoxicity","volume":"21","author":"Fatouros","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"928574","DOI":"10.3389\/fragi.2022.928574","article-title":"Age-Dependent Accumulation of Tau Aggregation in Caenorhabditis elegans","volume":"3","author":"Nunez","year":"2022","journal-title":"Front Aging"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13024-020-00410-7","article-title":"Tauopathy-Associated Tau Modifications Selectively Impact Neurodegeneration and Mitophagy in a Novel C. elegans Single-Copy Transgenic Model","volume":"15","author":"Guha","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13024-016-0096-1","article-title":"Tau Mutant A152t, a Risk Factor for FTD\/PSP, Induces Neuronal Dysfunction and Reduced Lifespan Independently of Aggregation in a C. elegans Tauopathy Model","volume":"11","author":"Pir","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neurobiolaging.2007.05.011","article-title":"A Caenorhabditis elegans Model of Tau Hyperphosphorylation: Induction of Developmental Defects by Transgenic Overexpression of Alzheimer\u2019s Disease-Like Modified Tau","volume":"30","author":"Brandt","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neurobiolaging.2015.11.004","article-title":"Curcumin Improves Tau-Induced Neuronal Dysfunction of Nematodes","volume":"39","author":"Miyasaka","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","article-title":"Molecular Pathways of Neurodegeneration in Parkinson\u2019s Disease","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s Disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1042\/EBC20170023","article-title":"Autophagy impairment in Parkinson\u2019s disease","volume":"61","author":"Karabiyik","year":"2017","journal-title":"Essays Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40035-016-0060-6","article-title":"Mitochondrial Dysfunction in Parkinson\u2019s Disease","volume":"5","author":"Hu","year":"2016","journal-title":"Transl. Neurodegener."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Lesage, S., and Trinh, J. (2023). Special Issue \u201cParkinson\u2019s Disease: Genetics and Pathogenesis\u201d. Genes, 14.","DOI":"10.3390\/genes14030737"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41531-019-0095-3","article-title":"Endogenous Alpha-Synuclein Monomers, Oligomers and Resulting Pathology: Let\u2019s Talk About the Lipids in the Room","volume":"5","author":"Killinger","year":"2019","journal-title":"npj Park. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e3056","DOI":"10.1038\/cddis.2017.427","article-title":"Pink1 Interacts with \u03b1-Synuclein and Abrogates \u03b1-Synuclein-Induced Neurotoxicity by Activating Autophagy","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"894620","DOI":"10.3389\/fnins.2022.894620","article-title":"Parkinson\u2019s Disease: Overview of Transcription Factor Regulation, Genetics, and Cellular and Animal Models","volume":"16","author":"Xia","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.0711018105","article-title":"Hypothesis-Based RNAi Screening Identifies Neuroprotective Genes in a Parkinson\u2019s Disease Model","volume":"105","author":"Hamamichi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"van Ham, T.J., Thijssen, K.L., Breitling, R., Hofstra, R.M., Plasterk, R.H.A., and Nollen, E.A.A. (2008). C. elegans Model Identifies Genetic Modifiers of \u03b1-Synuclein Inclusion Formation During Aging. PLoS Genet., 4.","DOI":"10.1371\/journal.pgen.1000027"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"E1009","DOI":"10.1073\/pnas.1610586114","article-title":"A Natural Product Inhibits the Initiation of \u03b1-Synuclein Aggregation and Suppresses Its Toxicity","volume":"114","author":"Perni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/hmg\/ddn198","article-title":"A Systematic RNAi Screen Reveals Involvement of Endocytic Pathway in Neuronal Dysfunction in \u03b1-Synuclein Transgenic C. elegans","volume":"17","author":"Kuwahara","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cmet.2014.04.017","article-title":"The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson\u2019s Models","volume":"20","author":"Knight","year":"2014","journal-title":"Cell Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"14912","DOI":"10.1073\/pnas.1203083109","article-title":"Delaying Aging and the Aging-Associated Decline in Protein Homeostasis by Inhibition of Tryptophan Degradation","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"806000","DOI":"10.3389\/fnagi.2022.806000","article-title":"Functional Screening of Parkinson\u2019s Disease Susceptibility Genes to Identify Novel Modulators of \u03b1-Synuclein Neurotoxicity in Caenorhabditis elegans","volume":"14","author":"Vozdek","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1007\/s12035-015-9517-3","article-title":"A Systematic RNAi Screen of Neuroprotective Genes Identifies Novel Modulators of Alpha-Synuclein-Associated Effects in Transgenic Caenorhabditis elegans","volume":"53","author":"Jadiya","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/17460441.2018.1428556","article-title":"Novel Models for Parkinson\u2019s Disease and Their Impact on Future Drug Discovery","volume":"13","author":"Blesa","year":"2018","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"10481","DOI":"10.1073\/pnas.1804198115","article-title":"Small Molecule Inhibits \u03b1-Synuclein Aggregation, Disrupts Amyloid Fibrils, and Prevents Degeneration of Dopaminergic Neurons","volume":"115","author":"Pujols","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1021\/acschemneuro.1c00548","article-title":"Anti-\u03b1-Synuclein Toxicity and Anti-Neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson\u2019s Disease","volume":"13","author":"Muhammad","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1007\/s12035-015-9205-3","article-title":"Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?","volume":"53","author":"Ettle","year":"2016","journal-title":"Mol. Neurobiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/443\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:43:43Z","timestamp":1760132623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":133,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25010443"],"URL":"https:\/\/doi.org\/10.3390\/ijms25010443","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,28]]}}}