{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:11:49Z","timestamp":1783487509313,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Laboratory on Human Reproduction has been implemented with the support provided by the Recovery and Resilience Facility of the European Union within the framework of Program Sz\u00e9chenyi Plan Plus","award":["RRF-2.3.1-21-2022-00012"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Infertility affects millions worldwide, posing a significant global health challenge. The proteomic analysis of follicular fluid provides a comprehensive view of the complex molecular landscape within ovarian follicles, offering valuable information on the factors influencing oocyte development and on the overall reproductive health. The follicular fluid is derived from the plasma and contains various proteins that can have different roles in oocyte health and infertility, and this fluid is a critical microenvironment for the developing oocytes as well. Using the high-performance liquid chromatography-mass spectrometry method, we investigated the protein composition of the follicular fluid, and after classification, we carried out relative quantification of the identified proteins in the pregnant (P) and non-pregnant (NP) groups. Based on the protein\u2013protein interaction analysis, albumin and apolipoprotein A1 (ApoA1) were found to be hub proteins, and the quantitative comparison of the P and NP groups resulted in a significantly lower concentration of ApoA1 and high-density lipoprotein cholesterol in the P group. As both molecules are involved in the cholesterol transport, we also investigated their role in the development of oocytes and in the prediction of fertility.<\/jats:p>","DOI":"10.3390\/ijms25010486","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T11:19:21Z","timestamp":1703848761000},"page":"486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Follicular Fluid Proteomic Analysis of Women Undergoing Assisted Reproduction Suggests That Apolipoprotein A1 Is a Potential Fertility Marker"],"prefix":"10.3390","volume":"25","author":[{"given":"Csilla","family":"Kurdi","sequence":"first","affiliation":[{"name":"J\u00e1nos Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Schmidt","sequence":"additional","affiliation":[{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Biochemistry and Medical Chemistry, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4568-6858","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Horv\u00e1th-Szalai","sequence":"additional","affiliation":[{"name":"J\u00e1nos Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Mauchart","sequence":"additional","affiliation":[{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"G\u00f6d\u00f6ny","sequence":"additional","affiliation":[{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e1rnagy","sequence":"additional","affiliation":[{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-5401","authenticated-orcid":false,"given":"G\u00e1bor L.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"J\u00e1nos Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-5745","authenticated-orcid":false,"given":"Tam\u00e1s","family":"K\u0151szegi","sequence":"additional","affiliation":[{"name":"J\u00e1nos Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fertnstert.2017.06.005","article-title":"The International Glossary on Infertility and Fertility Care","volume":"108","author":"Adamson","year":"2017","journal-title":"Fertil. 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