{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:48:14Z","timestamp":1767008894250,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ISCIII-FEDER (Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional)","award":["PI 15\/00048","PI19\/01263"],"award-info":[{"award-number":["PI 15\/00048","PI19\/01263"]}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Health, Spain","doi-asserted-by":"publisher","award":["PI 15\/00048","PI19\/01263"],"award-info":[{"award-number":["PI 15\/00048","PI19\/01263"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ISCIII through the project RICORS \u201cRD21\/0017; TERAV\u201d (Groups: 0003 and 0027)","award":["PI 15\/00048","PI19\/01263"],"award-info":[{"award-number":["PI 15\/00048","PI19\/01263"]}]},{"name":"Next Generation EU program (Plan de Recuperaci\u00f3n, Transformaci\u00f3n y Resiliencia","award":["PI 15\/00048","PI19\/01263"],"award-info":[{"award-number":["PI 15\/00048","PI19\/01263"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis due to peritonitis is a process associated with an inflammatory state. Mesenchymal stromal cells (MSCs) modulate the immune system due to the paracrine factors released and may be a therapeutic alternative. Three treatment groups were developed in a murine model of peritonitis to verify the effect of human adipose mesenchymal stem cell (hASCs). Additionally, a temporary modification was carried out on them to improve their arrival in inflamed tissues (CXCR4), as well as their anti-inflammatory activity (IL-10). The capacity to reduce systemic inflammation was studied using a local application (peritoneal injection) as a treatment route. Comparisons involving the therapeutic effect of wild-type ASCs and ASCs transiently expressing CXCR4 and IL-10 were carried out with the aim of generating an improved anti-inflammatory response for sepsis in addition to standard antibiotic treatment. However, under the experimental conditions used in these studies, no differences were found between both groups with ASCs. The peritoneal administration of hASCs or genetically modified hASCs constitutes an efficient and safe therapy in our model of mouse peritonitis.<\/jats:p>","DOI":"10.3390\/ijms25010520","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T06:37:12Z","timestamp":1704004632000},"page":"520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study of the Effect of Wild-Type and Transiently Expressing CXCR4 and IL-10 Mesenchymal Stromal Cells in a Mouse Model of Peritonitis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-3714","authenticated-orcid":false,"given":"Soledad","family":"Garcia G\u00f3mez-Heras","sequence":"first","affiliation":[{"name":"Department of Basic Health Science, Faculty of Health Sciences, Rey Juan Carlos University, 28922 Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-1373","authenticated-orcid":false,"given":"Mariano","family":"Garcia-Arranz","sequence":"additional","affiliation":[{"name":"New Therapy Laboratory, Health Research Institute Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28033 Madrid, Spain"},{"name":"Department of Surgery, Faculty of Medicine, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Vega-Clemente","sequence":"additional","affiliation":[{"name":"New Therapy Laboratory, Health Research Institute Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28033 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Olivera-Salazar","sequence":"additional","affiliation":[{"name":"New Therapy Laboratory, Health Research Institute Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28033 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6828-6031","authenticated-orcid":false,"given":"Juan Felipe","family":"V\u00e9lez Pinto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-8475","authenticated-orcid":false,"given":"Mar\u00eda","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Biomedical Innovation Unit, Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energ\u00e9ticas Medioambientales y Tecnol\u00f3gicas (CIEMAT), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-9347","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Guadalajara","sequence":"additional","affiliation":[{"name":"New Therapy Laboratory, Health Research Institute Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28033 Madrid, Spain"},{"name":"Surgery Department, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, 28033 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-3402","authenticated-orcid":false,"given":"Rosa","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Biomedical Innovation Unit, Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energ\u00e9ticas Medioambientales y Tecnol\u00f3gicas (CIEMAT), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez 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