{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:48Z","timestamp":1787028528556,"version":"build-2736575974"},"reference-count":76,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atrial fibrillation (AF) is a cardiac arrhythmia caused by electrophysiological anomalies in the atrial tissue, tissue degradation, structural abnormalities, and comorbidities. A direct relationship exists between AF and altered mitochondrial activity resulting from membrane potential loss, contractile dysfunction, or decreased ATP levels. This review aimed to elucidate the role of mitochondrial oxidative mechanisms in AF pathophysiology, the impact of mitochondrial oxidative stress on AF initiation and perpetuation, and current therapies. This review followed the Preferred Reporting Items for Systematic Reviews and the Meta-Analysis Extension for Scoping Reviews. PubMed, Excerpta Medica Database, and Scopus were explored until June 2023 using \u201cMESH terms\u201d. Bibliographic references to relevant papers were also included. Oxidative stress is an imbalance that causes cellular damage from excessive oxidation, resulting in conditions such as AF. An imbalance in reactive oxygen species production and elimination can cause mitochondrial damage, cellular apoptosis, and cardiovascular diseases. Oxidative stress and inflammation are intrinsically linked, and inflammatory pathways are highly correlated with the occurrence of AF. AF is an intricate cardiac condition that requires innovative therapeutic approaches. The involvement of mitochondrial oxidative stress in the pathophysiology of AF introduces novel strategies for clinical treatment.<\/jats:p>","DOI":"10.3390\/ijms25010535","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T06:37:12Z","timestamp":1704004632000},"page":"535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-5206","authenticated-orcid":false,"given":"Ant\u00f4nio da Silva","family":"Menezes J\u00fanior","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Medicine School, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-020, GO, Brazil"},{"name":"Medicine Department, Medical and Life School, Pontifical Catholic University of Goi\u00e1s, Avenida Universit\u00e1ria, 1440, Sector Universitario, Goi\u00e2nia 74605-010, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-1720","authenticated-orcid":false,"given":"Ana Lu\u00edsa Guedes de","family":"Fran\u00e7a-e-Silva","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medicine School, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-020, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7084-8162","authenticated-orcid":false,"given":"Joyce Monteiro de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Medicine Department, Medical and Life School, Pontifical Catholic University of Goi\u00e1s, Avenida Universit\u00e1ria, 1440, Sector Universitario, Goi\u00e2nia 74605-010, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-0988","authenticated-orcid":false,"given":"Daniela Melo da","family":"Silva","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medicine School, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-020, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1093\/eurheartj\/ehy622","article-title":"Atrial fibrillation hospitalization, mortality, and therapy","volume":"39","author":"John","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1111\/jcmm.17405","article-title":"CXCR4 and TYROBP mediate the development of atrial fibrillation via inflammation","volume":"26","author":"Zhang","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1001\/jama.2020.23700","article-title":"Atrial fibrillation","volume":"325","author":"Baman","year":"2021","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"eabc6800","DOI":"10.1126\/sciadv.abc6800","article-title":"Multilayer fabrication of durable catheter-deployable soft robotic sensor arrays for efficient left atrial mapping","volume":"6","author":"Kashyap","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e141213","DOI":"10.1172\/jci.insight.141213","article-title":"Atrial AMP-activated protein kinase is critical for preventing dysregulation of electrical excitability and atrial fibrillation","volume":"7","author":"Su","year":"2022","journal-title":"JCI Insight"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1172\/JCI39942","article-title":"Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts","volume":"120","author":"Liao","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.mcna.2015.02.007","article-title":"Management of atrial fibrillation","volume":"99","author":"Moukabary","year":"2015","journal-title":"Med. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cmet.2016.11.005","article-title":"Defective branched-chain amino acid catabolism disrupts glucose metabolism and sensitizes the heart to ischemia-reperfusion injury","volume":"25","author":"Li","year":"2017","journal-title":"Cell Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2009","article-title":"Pathophysiological mechanisms of atrial fibrillation: A translational appraisal","volume":"91","author":"Schotten","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/cvr\/cvw007","article-title":"Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation","volume":"109","author":"Opacic","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1111\/jcmm.14165","article-title":"TGFbeta1 and HGF regulate CTGF expression in human atrial fibroblasts and are involved in atrial remodelling in patients with rheumatic heart disease","volume":"23","author":"Chen","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.CIR.104.2.174","article-title":"Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation","volume":"104","author":"Mihm","year":"2001","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xie, Y., Zhang, Y., Sun, A., Peng, Y., Hou, W., Xiang, C., Zhang, G., Lai, B., Hou, X., and Zheng, F. (2022). The coupling of mitoproteolysis and oxidative phosphorylation enables tracking of an active mitochondrial state through MitoTimer fluorescence. Redox Biol., 56.","DOI":"10.1016\/j.redox.2022.102447"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"919038","DOI":"10.3389\/fimmu.2022.919038","article-title":"Reduced immunity regulator MAVS contributes to non-hypertrophic cardiac dysfunction by disturbing energy metabolism and mitochondrial homeostasis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"H54","DOI":"10.1152\/ajpheart.00699.2015","article-title":"Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation","volume":"311","author":"Emelyanova","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1253\/circj.CJ-15-0138","article-title":"Role of inflammation in atrial fibrillation pathophysiology and management","volume":"79","author":"Harada","year":"2015","journal-title":"Circ. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pharmthera.2015.06.009","article-title":"Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery","volume":"154","author":"Zakkar","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1016\/j.ijcard.2013.11.103","article-title":"Relaxin as novel strategy in the management of atrial fibrillation: Potential roles and future perspectives","volume":"171","author":"Zhao","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1089\/ars.2013.5542","article-title":"Targeting inflammation and oxidative stress in atrial fibrillation: Role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins","volume":"20","author":"Reilly","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/CIRCULATIONAHA.105.538108","article-title":"Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: Role of the NADPH and xanthine oxidases","volume":"112","author":"Dudley","year":"2005","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fphys.2012.00150","article-title":"Xanthine oxidase and uric acid in atrial fibrillation","volume":"3","author":"Korantzopoulos","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.fjc.0000249961.61451.da","article-title":"Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure","volume":"48","author":"Hou","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jphs.2016.03.009","article-title":"Effects of urate-lowering agents on arrhythmia vulnerability in post-infarcted rat hearts","volume":"131","author":"Lee","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.thromres.2016.11.011","article-title":"Febuxostat attenuates paroxysmal atrial fibrillation-induced regional endothelial dysfunction","volume":"149","author":"Li","year":"2017","journal-title":"Thromb. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1540-8167.2012.02356.x","article-title":"Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction","volume":"23","author":"Sakabe","year":"2012","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/hearts2010014","article-title":"Molecular basis of atrial fibrillation initiation and maintenance","volume":"2","author":"Beneke","year":"2021","journal-title":"Hearts"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Muszy\u0144ski, P., and Bonda, T.A. (2021). Mitochondrial Dysfunction in Atrial Fibrillation-Mechanisms and Pharmacological Interventions. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112385"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.2174\/1381612824666180903144042","article-title":"Mechanisms and treatments of oxidative stress in atrial fibrillation","volume":"24","author":"Ren","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijcard.2006.04.026","article-title":"The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation","volume":"115","author":"Korantzopoulos","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"ref_30","first-page":"379","article-title":"Atrial fibrillation in the elderly: The potential contribution of reactive oxygen species","volume":"9","author":"Schillinger","year":"2012","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00395-020-00827-7","article-title":"Cellular and mitochondrial mechanisms of atrial fibrillation","volume":"115","author":"Mason","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10741-020-10000-w","article-title":"Correction to: Angiotensin II and angiotensin 1\u20137: Which is their role in atrial fibrillation?","volume":"25","author":"Mascolo","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"ref_33","first-page":"625","article-title":"New aspects of pathogenesis of atrial fibrillation: Remodelling of intercalated discs","volume":"66","author":"Tribulova","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pool, L., Wijdeveld, L.F.J.M., de Groot, N.M.S., and Brundel, B.J.J.M. (2021). The role of mitochondrial dysfunction in atrial fibrillation: Translation to druggable target and biomarker discovery. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168463"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/emm.2003.45","article-title":"Gene expression profiling of oxidative stress on atrial fibrillation in humans","volume":"35","author":"Kim","year":"2003","journal-title":"Exp. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/FJC.0b013e31817f9398","article-title":"Oxidative stress and inflammation in atrial fibrillation: Role in pathogenesis and potential as a therapeutic target","volume":"52","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3892\/br.2015.504","article-title":"Serum levels of nicotinamide-adenine dinucleotide phosphate oxidase 4 are associated with non-valvular atrial fibrillation","volume":"3","author":"Liu","year":"2015","journal-title":"Biomed. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1136\/heartjnl-2012-301952","article-title":"Different behaviour of NOX2 activation in patients with paroxysmal\/persistent or permanent atrial fibrillation","volume":"98","author":"Cangemi","year":"2012","journal-title":"Heart"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bode, D., Semmler, L., Oeing, C.U., Alogna, A., Schiattarella, G.G., MPieske, B., Heinzel, F.R., and Hohendanner, F. (2021). Implications of SGLT inhibition on redox signalling in atrial fibrillation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115937"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e017483","DOI":"10.1161\/JAHA.119.017483","article-title":"Canagliflozin suppresses atrial remodeling in a canine atrial fibrillation model","volume":"10","author":"Nishinarita","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1005408","DOI":"10.3389\/fcvm.2023.1005408","article-title":"Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats","volume":"10","author":"Koizumi","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"22287","DOI":"10.1038\/s41598-022-26836-1","article-title":"Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers","volume":"12","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"104600","DOI":"10.1016\/j.mvr.2023.104600","article-title":"Costunolide ameliorates angiotensin II-induced atrial inflammation and fibrosis by regulating mitochondrial function and oxidative stress in mice: A possible therapeutic approach for atrial fibrillation","volume":"151","author":"Liu","year":"2023","journal-title":"Microvasc. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1042\/CS20210405","article-title":"Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats","volume":"135","author":"Xu","year":"2021","journal-title":"Clin. Sci."},{"key":"ref_45","first-page":"540","article-title":"Effects of febuxostat on atrial remodeling in a rabbit model of atrial fibrillation induced by rapid atrial pacing Yong-Yan; et al","volume":"16","author":"Fan","year":"2019","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2468031","DOI":"10.1155\/2020\/2468031","article-title":"Wenxin Keli regulates mitochondrial oxidative stress and homeostasis and improves atrial remodeling in diabetic rats","volume":"2020","author":"Gong","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1631\/jzus.B2300086","article-title":"Andrographolide protects against atrial fibrillation by alleviating oxidative stress injury and promoting impaired mitochondrial bioenergetics","volume":"24","author":"Yu","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3181\/0706-RM-155","article-title":"Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia","volume":"233","author":"Bukowska","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/JIR.S10095","article-title":"An Inflammatory cytokines and atrial fibrillation: Current and prospective views","volume":"3","author":"Hadi","year":"2010","journal-title":"J. Inflamm. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10557-020-07002-z","article-title":"Attenuation of atrial remodeling by aliskiren via affecting oxidative stress, inflammation and PI3K\/Akt signaling pathway","volume":"35","author":"Zhao","year":"2021","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.3892\/mmr.2020.11291","article-title":"Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K\/Akt\/eNOS pathway","volume":"22","author":"Xue","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.hrthm.2009.12.009","article-title":"Role of inflammation and oxidative stress in atrial fibrillation","volume":"7","author":"Li","year":"2010","journal-title":"Heart Rhythm."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Andelova, K., Bacova, B.S., Sykora, M., Hlivak, P., Barancik, M., and Tribulova, N. (2022). Mechanisms underlying antiarrhythmic properties of cardioprotective agents impacting inflammation and oxidative stress. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031416"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijcard.2008.02.026","article-title":"Nitric oxide overproduction derived from inducible nitric oxide synthase increases cardiomyocyte apoptosis in human atrial fibrillation","volume":"130","author":"Han","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.carpath.2008.12.014","article-title":"Atrial expression of endothelial nitric oxide synthase in patients with and without atrial fibrillation","volume":"19","author":"Bukowska","year":"2010","journal-title":"Cardiovasc. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1373\/clinchem.2006.083923","article-title":"Oxidative stress markers are associated with persistent atrial fibrillation","volume":"53","author":"Neuman","year":"2007","journal-title":"Clin. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/10641969809052125","article-title":"Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats","volume":"20","author":"Tofovic","year":"1998","journal-title":"Clin Exp Hypertens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e147371","DOI":"10.1172\/jci.insight.147371","article-title":"Attenuating persistent sodium current\u2013induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress","volume":"6","author":"Avula","year":"2021","journal-title":"JCI Insight"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.3892\/mmr.2020.11593","article-title":"Effect of TFAM on ATP content in tachypacing primary cultured cardiomyocytes and atrial fibrillation patients","volume":"22","author":"Liu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e31553","DOI":"10.1097\/MD.0000000000031553","article-title":"Paraoxonase 1 and atrial fibrillation: Is there a relationship?","volume":"101","author":"Istratoaie","year":"2022","journal-title":"Medicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.hrthm.2017.07.028","article-title":"Association between oxidative stress and atrial fibrillation","volume":"14","author":"Sandesara","year":"2017","journal-title":"Heart Rhythm"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Liu, D., Han, X., Zhang, Z., Tse, G., Shao, Q., and Liu, T. (2022). Role of heat shock proteins in atrial fibrillation: From molecular mechanisms to diagnostic and therapeutic opportunities. Cells, 12.","DOI":"10.3390\/cells12010151"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.repc.2020.05.011","article-title":"Relationships between paroxysmal atrial fibrillation, total oxidant status, and DNA damage","volume":"40","author":"Tascanov","year":"2021","journal-title":"Rev. Port. Cardiol. (Engl. Ed.)"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1080\/10715762.2018.1500696","article-title":"Oxidative stress and atrial fibrillation: An update","volume":"52","author":"Korantzopoulos","year":"2018","journal-title":"Free Radic. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1038\/srep11427","article-title":"Mitochondrial oxidative stress promotes atrial fibrillation","volume":"5","author":"Xie","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/jhh.2017.6","article-title":"Renin-angiotensin blockade in atrial fibrillation: Where are we now?","volume":"31","author":"Shahid","year":"2017","journal-title":"J. Hum. Hypertens."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Wang, W., and Kang, P.M. (2020). Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases. Antioxidants, 9.","DOI":"10.3390\/antiox9121292"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Gutierrez-Mariscal, F.M., de la Cruz-Ares, S., Torres-Pe\u00f1a, J.D., Alcal\u00e1-Diaz, J.F., Yubero-Serrano, E.M., and L\u00f3pez-Miranda, J. (2021). Coenzyme Q10 and cardiovascular diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10060906"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3389\/fneur.2018.00552","article-title":"KL1333, a novel NAD+ modulator, improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts","volume":"9","author":"Seo","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6577","DOI":"10.1038\/s41598-018-24900-3","article-title":"KH176 safeguards mitochondrial diseased cells from redox stress-induced cell death by interacting with the thioredoxin system\/peroxiredoxin enzyme machinery","volume":"8","author":"Beyrath","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1089\/ars.2009.2595","article-title":"Redox regulation, NF-kappaB, and atrial fibrillation","volume":"11","author":"Gao","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yjmcc.2013.04.019","article-title":"Oxidative stress in atrial fibrillation: An emerging role of NADPH oxidase","volume":"62","author":"Youn","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/4556671","article-title":"Markers of inflammation, oxidative stress, and fibrosis in patients with atrial fibrillation","volume":"2022","author":"Pauklin","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1111\/dom.15222","article-title":"In praise of pioglitazone: An economically efficacious therapy for Type 2 diabetes and other manifestations of the metabolic syndrome","volume":"25","author":"Bell","year":"2023","journal-title":"Diabetes Obes. Metab. August"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Godoy-Mar\u00edn, H., Duroux, R., Jacobson, K.A., Soler, C., Colino-Lage, H., Jim\u00e9nez-S\u00e1bado, V., Montiel, J., Hove-Madsen, L., and Ciruela, F. (2021). Adenosine A2a receptors are upregulated in peripheral blood mononuclear cells from atrial fibrillation patients. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073467"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.freeradbiomed.2003.07.002","article-title":"Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation","volume":"35","author":"Lin","year":"2003","journal-title":"Free Radic. Biol. 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