{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:12:02Z","timestamp":1789143122920,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902223"],"award-info":[{"award-number":["31902223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021JQ-159"],"award-info":[{"award-number":["2021JQ-159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Basic Research Plan in Shaanxi Province of China","award":["31902223"],"award-info":[{"award-number":["31902223"]}]},{"name":"Natural Science Basic Research Plan in Shaanxi Province of China","award":["2021JQ-159"],"award-info":[{"award-number":["2021JQ-159"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Zearalenone (ZEA) is present worldwide as a serious contaminant of food and feed and causes male reproductive toxicity. The implication of paraptosis, which is a nonclassical paradigm of cell death, is unclear in ZEA-induced male reproductive disorders. In this study, the toxic effects of ZEA on the blood-testis barrier (BTB) and the related mechanisms of paraptosis were detected in goats. ZEA exposure, in vivo, caused a significant decrease in spermatozoon quality, the destruction of seminiferous tubules, and damage to the BTB integrity. Furthermore, ZEA exposure to Sertoli cells (SCs) in vitro showed similar dysfunction in structure and barrier function. Importantly, the formation of massive cytoplasmic vacuoles in ZEA-treated SCs corresponded to the highly swollen and dilative endoplasmic reticulum (ER), and paraptosis inhibition significantly alleviated ZEA-induced SC death and vacuolization, which indicated the important contribution of paraptosis in ZEA-induced BTB damage. Meanwhile, the expression of ER stress marker proteins was increased after ZEA treatment but decreased under the inhibition of paraptosis. The vacuole formation and SC death, induced by ZEA, were remarkably blocked by ER stress inhibition. In conclusion, these results facilitate the exploration of the mechanisms of the SC paraptosis involved in ZEA-induced BTB damage in goats.<\/jats:p>","DOI":"10.3390\/ijms25010553","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T06:37:12Z","timestamp":1704004632000},"page":"553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Zearalenone Induces Blood-Testis Barrier Damage through Endoplasmic Reticulum Stress-Mediated Paraptosis of Sertoli Cells in Goats"],"prefix":"10.3390","volume":"25","author":[{"given":"Tengfei","family":"Liu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengchen","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghuan","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1080\/10408398.2021.1879730","article-title":"Microbial detoxification of mycotoxins in food and feed","volume":"62","author":"Xu","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ne\u0161i\u0107, K., Habschied, K., and Mastanjevi\u0107, K. (2023). Modified Mycotoxins and Multitoxin Contamination of Food and Feed as Major Analytical Challenges. Toxins, 15.","DOI":"10.3390\/toxins15080511"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1080\/10408398.2019.1655388","article-title":"Occurrence and toxicity of a fusarium mycotoxin, zearalenone","volume":"60","author":"Rai","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ball\u00f3, A., Buszny\u00e1kn\u00e9 Sz\u00e9kv\u00e1ri, K., Cz\u00e9t\u00e1ny, P., M\u00e1rk, L., T\u00f6r\u00f6k, A., Sz\u00e1nt\u00f3, \u00c1., and M\u00e1t\u00e9, G. (2023). Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021578"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Han, X., Huangfu, B., Xu, T., Xu, W., Asakiya, C., Huang, K., and He, X. (2022). Research Progress of Safety of Zearalenone: A Review. Toxins, 14.","DOI":"10.3390\/toxins14060386"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.fct.2019.02.031","article-title":"Effects of zearalenone and its derivatives on the synthesis and secretion of mammalian sex steroid hormones: A review","volume":"126","author":"Zheng","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"112457","DOI":"10.1016\/j.ecoenv.2021.112457","article-title":"Male reproductive toxicity of zearalenone-meta-analysis with mechanism review","volume":"221","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxicon.2019.04.004","article-title":"The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice","volume":"165","author":"Jesse","year":"2019","journal-title":"Toxicon"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/tox.23694","article-title":"Zearalenone damages the male reproductive system of rats by destroying testicular focal adhesion","volume":"38","author":"Cai","year":"2023","journal-title":"Environ. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"122087","DOI":"10.1016\/j.jhazmat.2020.122087","article-title":"Effects of mycotoxin-contaminated feed on farm animals","volume":"389","author":"Yang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Liu, J., and Applegate, T. (2020). Zearalenone (ZEN) in Livestock and Poultry: Dose, Toxicokinetics, Toxicity and Estrogenicity. Toxins, 12.","DOI":"10.3390\/toxins12060377"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.aninu.2021.01.002","article-title":"The insensitive mechanism of poultry to zearalenone: A review","volume":"7","author":"Wu","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"114571","DOI":"10.1016\/j.ecoenv.2023.114571","article-title":"Zearalenone induces oxidative stress and autophagy in goat Sertoli cells","volume":"252","author":"Liu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.reprotox.2016.12.005","article-title":"Apoptosis inducing factor gene depletion inhibits zearalenone-induced cell death in a goat Leydig cell line","volume":"67","author":"Yang","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The Mammalian Blood-Testis Barrier: Its Biology and Regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Luaces, J.P., Toro-Urrego, N., Otero-Losada, M., and Capani, F. (2023). What do we know about blood-testis barrier? current understanding of its structure and physiology. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1114769"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fct.2018.06.003","article-title":"Toxic effects of zearalenone on gametogenesis and embryonic development: A molecular point of review","volume":"119","author":"Yang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"El Khoury, D., Fayjaloun, S., Nassar, M., Sahakian, J., and Aad, P.Y. (2019). Updates on the Effect of Mycotoxins on Male Reproductive Efficiency in Mammals. Toxins, 11.","DOI":"10.3390\/toxins11090515"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"114748","DOI":"10.1016\/j.envpol.2020.114748","article-title":"Deoxynivalenol induced spermatogenesis disorder by blood-testis barrier disruption associated with testosterone deficiency and inflammation in mice","volume":"264","author":"Cao","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111972","DOI":"10.1016\/j.fct.2021.111972","article-title":"Aflatoxin B1 disrupts blood-testis barrier integrity by reducing junction protein and promoting apoptosis in mice testes","volume":"148","author":"Huang","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.etap.2017.10.005","article-title":"T-2 toxin induces cytotoxicity and disrupts tight junction barrier in SerW3 cells","volume":"56","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"She, J., Feng, N., Zheng, W., Zheng, H., Cai, P., Zou, H., Yuan, Y., Gu, J., Liu, Z., and Bian, J. (2021). Zearalenone Exposure Disrupts Blood-Testis Barrier Integrity through Excessive Ca2+-Mediated Autophagy. Toxins, 13.","DOI":"10.3390\/toxins13120875"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"27235","DOI":"10.1007\/s11356-017-0299-1","article-title":"Characterization of semen quality, testicular marker enzyme activities and gene expression changes in the blood testis barrier of Kunming mice following acute exposure to zearalenone","volume":"24","author":"Long","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2131\/jts.47.257","article-title":"Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells","volume":"47","author":"Chao","year":"2022","journal-title":"J. Toxicol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Xu, C.C., Lin, Y.F., Huang, M.Y., Zhang, X.L., Wang, P., Huang, M.Q., and Lu, J.J. (2023). Paraptosis: A non-classical paradigm of cell death for cancer therapy. Acta Pharmacol. Sin., 1\u201315.","DOI":"10.1038\/s41401-023-01159-7"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fontana, F., Raimondi, M., Marzagalli, M., Di Domizio, A., and Limonta, P. (2020). The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds. Biochim. Biophys. Acta Rev. Cancer, 1873.","DOI":"10.1016\/j.bbcan.2020.188338"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1159409","DOI":"10.3389\/fphar.2023.1159409","article-title":"Paraptosis: A unique cell death mode for targeting cancer","volume":"14","author":"Hanson","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: Structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","article-title":"Endoplasmic reticulum stress signals in the tumour and its microenvironment","volume":"21","author":"Chen","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.cell.2016.12.004","article-title":"Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer","volume":"168","author":"Bettigole","year":"2017","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ccell.2022.08.016","article-title":"Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses","volume":"40","author":"Mandula","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41392-022-01131-7","article-title":"Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kim, E., Lee, D.M., Seo, M.J., Lee, H.J., and Choi, K.S. (2021). Intracellular Ca2+ Imbalance Critically Contributes to Paraptosis. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.607844"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.tiv.2011.09.005","article-title":"Paraptosis-like cell death induced by yessotoxin","volume":"25","author":"Korsnes","year":"2011","journal-title":"Toxicol. Vitro"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"715285","DOI":"10.3389\/fphar.2021.715285","article-title":"Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10495-020-01655-9","article-title":"Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation","volume":"26","author":"Liu","year":"2021","journal-title":"Apoptosis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/tox.22175","article-title":"Exploration of intrinsic and extrinsic apoptotic pathways in zearalenone-treated rat sertoli cells","volume":"31","author":"Xu","year":"2016","journal-title":"Environ. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhu, Z., Cui, H., Ding, K., Zhao, Y., Ma, X., Adetunji, A.O., and Min, L. (2022). Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis. Animals, 12.","DOI":"10.3390\/ani12213026"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41580-022-00542-2","article-title":"The mechanisms and roles of selective autophagy in mammals","volume":"24","author":"Vargas","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ketelut-Carneiro, N., and Fitzgerald, K.A. (2022). Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die. J. Mol. Biol., 434.","DOI":"10.1016\/j.jmb.2021.167378"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.cdd.4401465","article-title":"Paraptosis: Mediation by MAP kinases and inhibition by AIP-1\/Alix","volume":"11","author":"Sperandio","year":"2004","journal-title":"Cell Death Differ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/bcpt.13243","article-title":"Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications","volume":"125","author":"Men","year":"2019","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2019.08.007","article-title":"Pubertal exposure to low doses of zearalenone disrupting spermatogenesis through ER\u03b1 related genetic and epigenetic pathways","volume":"315","author":"Gao","year":"2019","journal-title":"Toxicol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-065X.2006.00438.x","article-title":"The testis in immune privilege","volume":"213","author":"Fijak","year":"2006","journal-title":"Immunol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"26724","DOI":"10.1007\/s11356-017-0123-y","article-title":"Protective effect of proanthocyanidin on mice Sertoli cell apoptosis induced by zearalenone via the Nrf2\/ARE signalling pathway","volume":"24","author":"Long","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ma, L., Chen, C., Hai, S., Wang, C., Rahman, S.U., Huang, W., Zhao, C., Feng, S., and Wang, X. (2023). Inhibition of Mitochondrial Fission Alleviates Zearalenone-Induced Mitochondria-Associated Endoplasmic Reticulum Membrane Dysfunction in Piglet Sertoli Cells. Toxins, 15.","DOI":"10.3390\/toxins15040253"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000342221","article-title":"Genetic control of testis development","volume":"7","author":"Sekido","year":"2013","journal-title":"Sex. Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2021.06.016","article-title":"Sertoli cells as key drivers of testis function","volume":"121","author":"Smith","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"60276","DOI":"10.1007\/s11356-021-14052-9","article-title":"N-acetylcysteine ameliorate cytotoxic injury in piglets sertoli cells induced by zearalenone and deoxynivalenol","volume":"28","author":"Cao","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10495-022-01737-w","article-title":"A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis","volume":"27","author":"Ma","year":"2022","journal-title":"Apoptosis"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhao, L., Zhong, B., Zhu, Y., Zheng, H., Wang, X., Hou, Y., Lu, J.J., Ai, N., Guo, X., and Ge, W. (2023). Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). Biochem. Pharmacol., 210.","DOI":"10.1016\/j.bcp.2023.115487"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/01635581.2019.1685113","article-title":"Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage","volume":"73","author":"Nedungadi","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Kaufman","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.trecan.2016.03.007","article-title":"Endoplasmic Reticulum Stress and the Hallmarks of Cancer","volume":"2","author":"Urra","year":"2016","journal-title":"Trends Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physiol.00050.2006","article-title":"Endoplasmic reticulum stress: Signaling the unfolded protein response","volume":"22","author":"Lai","year":"2007","journal-title":"Physiology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1158\/2159-8290.CD-14-1490","article-title":"Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis","volume":"5","author":"Chevet","year":"2015","journal-title":"Cancer Discov."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Binoy, A., Nedungadi, D., Katiyar, N., Bose, C., Shankarappa, S.A., Nair, B.G., and Mishra, N. (2019). Plumbagin induces paraptosis in cancer cells by disrupting the sulfhydryl homeostasis and proteasomal function. Chem. Biol. Interact., 310.","DOI":"10.1016\/j.cbi.2019.108733"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/dgd.12322","article-title":"Paraptosis-like cell death in Wistar rat granulosa cells","volume":"58","author":"Escobar","year":"2016","journal-title":"Dev. Growth Differ."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41420-023-01632-6","article-title":"Osimertinib induces paraptosis and TRIP13 confers resistance in glioblastoma cells","volume":"9","author":"Hu","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.theriogenology.2023.05.004","article-title":"Use of the flavonoid taxifolin for sperm cryopreservation from the threatened Bermeya goat breed","volume":"206","author":"Tamargo","year":"2023","journal-title":"Theriogenology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"152247","DOI":"10.1016\/j.scitotenv.2021.152247","article-title":"Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice","volume":"810","author":"Zhou","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"175430","DOI":"10.1016\/j.ejphar.2022.175430","article-title":"Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity","volume":"938","author":"Wei","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zeng, Y., Yang, Q., Ouyang, Y., Lou, Y., Cui, H., Deng, H., Zhu, Y., Geng, Y., Ouyang, P., and Chen, L. (2023). Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice. Redox Biol., 67.","DOI":"10.1016\/j.redox.2023.102886"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111505","DOI":"10.1016\/j.mce.2021.111505","article-title":"FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells","volume":"540","author":"Xi","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jare.2022.09.001","article-title":"Connexin-43 is a promising target for lycopene preventing phthalate-induced spermatogenic disorders","volume":"49","author":"Zhao","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41401-019-0351-4","article-title":"Chalcomoracin inhibits cell proliferation and increases sensitivity to radiotherapy in human non-small cell lung cancer cells via inducing endoplasmic reticulum stress-mediated paraptosis","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol. 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